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N. Kieffer · SciRah

Researcher profile · Semantic Scholar

N. Kieffer

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N. Kieffer — researcher profile on SciRah

h-index: 40
Works: 117
Citations: 5,270

Most-cited papers

Periodic lamellipodial contractions correlate with rearward actin waves.
Grégory Giannone, Benjamin J. Dubin-Thaler, H. Döbereiner, N. Kieffer +2 more
2004Cell582 citations Open access
Semantic Scholar
Platelet membrane glycoproteins: functions in cellular interactions.
N. Kieffer, D. Phillips
1990Annual Review of Cell Biology289 citations
Semantic Scholar
A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes
Andrew Smith, Y. Carrasco, P. Stanley, N. Kieffer +2 more
2005Journal of Cell Biology230 citations Open access
Semantic Scholar
Integrin αvβ3 expression confers on tumor cells a greater propensity to metastasize to bone
Isabelle Pécheur, O. Peyruchaud, C. Serre, J. Guglielmi +7 more
2002The FASEB Journal218 citations
Semantic Scholar
Redox Control of the Survival of Healthy and Diseased Cells
Yuxing Zhang, Yanzhi Du, W. Le, Kankan Wang +2 more
2011Antioxidants and Redox Signaling159 citations Open access
Semantic Scholar
Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis
M. Schmitz, Gérard Grignard, C. Margue, Walter Dippel +6 more
2007International Journal of Cancer143 citations Open access
Semantic Scholar
The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens
K. Gatter, J. Cordell, H. Turley, A. Heryet +3 more
1988Histopathology142 citations
Semantic Scholar
A calreticulin‐like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins
G. Kasper, Alan P. Brown, M. Eberl, L. Vallar +6 more
2001Parasite immunology (Print)122 citations
Semantic Scholar
Autocrine TGF‐β‐regulated expression of adhesion receptors and integrin‐linked kinase in HT‐144 melanoma cells correlates with their metastatic phenotype
B. Janji, C. Melchior, V. Gouon, L. Vallar +1 more
1999International Journal of Cancer109 citations Open access
Semantic Scholar
A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia.
C. Ghevaert, A. Salsmann, N. Watkins, E. Schaffner-Reckinger +11 more
2008Blood107 citations Open access
Semantic Scholar
Structure of the human blood platelet membrane glycoprotein Ibα gene
Roland H. Wenger, N. Kieffer, A. Wicki, K. J. Clemetson
1988102 citations
Semantic Scholar
The intermediate filament protein vimentin binds specifically to a recombinant integrin α2/β1 cytoplasmic tail complex and co-localizes with native α2/β1 in endothelial cell focal adhesions
S. Kreis, H. Schönfeld, C. Melchior, B. Steiner +1 more
200590 citations
Semantic Scholar
cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins.
F. Lanza, D. Wolf, C. Fox, N. Kieffer +5 more
1991Journal of Biological Chemistry88 citations Open access
Semantic Scholar
Divalent Cations Differentially Regulate Integrin αIIb Cytoplasmic Tail Binding to β3 and to Calcium- and Integrin-binding Protein*
L. Vallar, C. Melchior, S. Plançon, H. Drobecq +3 more
1999Journal of Biological Chemistry87 citations Open access
Semantic Scholar
Distinct Involvement of β3 Integrin Cytoplasmic Domain Tyrosine Residues 747 and 759 in Integrin-mediated Cytoskeletal Assembly and Phosphotyrosine Signaling*
E. Schaffner-Reckinger, V. Gouon, C. Melchior, S. Plançon +1 more
1998Journal of Biological Chemistry82 citations Open access
Semantic Scholar
Human Neutrophil Elastase Proteolytically Activates the Platelet Integrin αIIbβ3 through Cleavage of the Carboxyl Terminus of the αIIb Subunit Heavy Chain
M. Si-Tahar, D. Pidard, V. Balloy, M. Moniatte +3 more
1997Journal of Biological Chemistry81 citations Open access
Semantic Scholar
Human platelet alpha granules contain a nonspecific inhibitor of megakaryocyte colony formation: Its relationship to type β transforming growth factor (TGF‐β)
M. Mitjavila, G. Vinci, J. Villeval, N. Kieffer +4 more
198880 citations
Semantic Scholar
R to Q amino acid substitution in the GFFKR sequence of the cytoplasmic domain of the integrin IIb subunit in a patient with a Glanzmann's thrombasthenia-like syndrome.
O. Peyruchaud, A. Nurden, S. Milet, L. Macchi +4 more
1998Blood75 citations
Semantic Scholar
The Integrin Binding Site 2 (IBS2) in the Talin Rod Domain Is Essential for Linking Integrin β Subunits to the Cytoskeleton*
M. Moes, Sophie Rodius, Stacey J. Coleman, Susan J. Monkley +6 more
2007Journal of Biological Chemistry74 citations Open access
Semantic Scholar
A Fluorescence Cell Biology Approach to Map the Second Integrin-binding Site of Talin to a 130-Amino Acid Sequence within the Rod Domain*
Laurent Tremuth, S. Kreis, C. Melchior, J. Hoebeke +4 more
2004Journal of Biological Chemistry74 citations Open access
Semantic Scholar
Interplay between αvβ3 Integrin and Nucleolin Regulates Human Endothelial and Glioma Cell Migration*
Marina Koutsioumpa, C. Polytarchou, J. Courty, Yue Zhang +6 more
2012Journal of Biological Chemistry68 citations Open access
Semantic Scholar
Integrin αvβ3 is a pleiotrophin receptor required for pleiotrophin‐induced endothelial cell migration through receptor protein tyrosine phosphatase β/ζ
Constantinos M Mikelis, Evanthia Sfaelou, Marina Koutsioumpa, N. Kieffer +1 more
2009The FASEB Journal67 citations
Semantic Scholar
The 5' flanking region and chromosomal localization of the gene encoding human platelet membrane glycoprotein Ib alpha.
R. Wenger, A. Wicki, N. Kieffer, S. Adolph +2 more
1989Gene66 citations
Semantic Scholar
The Talin Rod IBS2 α-Helix Interacts with the β3 Integrin Cytoplasmic Tail Membrane-proximal Helix by Establishing Charge Complementary Salt Bridges*
Sophie Rodius, O. Chaloin, M. Moes, E. Schaffner-Reckinger +5 more
2008Journal of Biological Chemistry63 citations Open access
Semantic Scholar
Characterization of the human platelet glycoprotein IIIa gene. Comparison with the fibronectin receptor beta-subunit gene.
F. Lanza, N. Kieffer, D. Phillips, L. Fitzgerald
1990Journal of Biological Chemistry60 citations Open access
Semantic Scholar
RGT, a synthetic peptide corresponding to the integrin beta 3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin alpha IIb beta 3 with Src kinase.
Xiao-Yu Su, Jianqing Mi, Jin-Song Yan, P. Flevaris +8 more
2008Blood58 citations Open access
Semantic Scholar
A New Functional Role of the Fibrinogen RGD Motif as the Molecular Switch That Selectively Triggers Integrin αIIbβ3-dependent RhoA Activation during Cell Spreading*
A. Salsmann, E. Schaffner-Reckinger, F. Kabile, S. Plançon +1 more
2005Journal of Biological Chemistry58 citations Open access
Semantic Scholar
Thyroid cancer in Luxembourg: a national population-based data report (1983–1999)
R. Scheiden, M. Keipes, C. Bock, Walter Dippel +2 more
2006BMC Cancer54 citations Open access
Semantic Scholar
The intermediate filament protein vimentin binds specifically to a recombinant integrin alpha2/beta1 cytoplasmic tail complex and co-localizes with native alpha2/beta1 in endothelial cell focal adhesions.
S. Kreis, H. Schönfeld, C. Melchior, B. Steiner +1 more
2005Experimental Cell Research54 citations
Semantic Scholar
The CXC-Chemokine CXCL4 Interacts with Integrins Implicated in Angiogenesis
S. Aidoudi, K. Bujakowska, N. Kieffer, A. Bikfalvi
2008PLoS ONE51 citations Open access
Semantic Scholar
Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library.
Roland H. Wenger, A. Wicki, Alfred Walz, N. Kieffer +1 more
1989Blood45 citations Open access
Semantic Scholar
Human neutrophil elastase proteolytically activates the platelet integrin alphaIIbbeta3 through cleavage of the carboxyl terminus of the alphaIIb subunit heavy chain. Involvement in the potentiation of platelet aggregation.
M. Si-Tahar, D. Pidard, V. Balloy, M. Moniatte +3 more
1997Journal of Biological Chemistry43 citations
Semantic Scholar
Identification of platelet membrane thrombospondin binding molecules using an anti-thrombospondin antibody.
N. Kieffer, A. Nurden, M. Hasitz, M. Titeux +1 more
1988Biochimica et Biophysica Acta43 citations
Semantic Scholar
Human platelets express the SERCA2-b isoform of Ca(2+)-transport ATPase.
J. Enouf, R. Bredoux, B. Papp, I. Djaffar +6 more
1992Biochemical Journal42 citations Open access
Semantic Scholar
Fibrinogen and glycoprotein IIb/IIIa localization during platelet adhesion. Localization to the granulomere and at sites of platelet interaction.
J. Lewis, R. Hantgan, S. Stevenson, T. Thornburg +3 more
1990American Journal of Pathology42 citations
Semantic Scholar
Human megakaryocytopoiesis: in vitro regulation and characterization of megakaryocytic precursor cells by differentiation markers.
W. Vainchenker, N. Kieffer
1988Blood reviews42 citations
Semantic Scholar
Integrin receptor specificity for human red cell ICAM-4 ligand. Critical residues for alphaIIbeta3 binding.
P. Hermand, P. Gane, I. Callebaut, N. Kieffer +2 more
2004European Journal of Biochemistry41 citations
Semantic Scholar
The α3(IV)185–206 Peptide from Noncollagenous Domain 1 of Type IV Collagen Interacts with a Novel Binding Site on the β3Subunit of Integrin αvβ3 and Stimulates Focal Adhesion Kinase and Phosphatidylinositol 3-Kinase Phosphorylation*
S. Pasco, J. Monboisse, N. Kieffer
2000Journal of Biological Chemistry40 citations Open access
Semantic Scholar
αIIbβ3‐integrin mediated adhesion of human platelets to a fibrinogen matrix triggers phospholipase C activation and phosphatidylinositol 3′,4′‐bisphosphate accumulation
D. Gironcel, C. Racaud-Sultan, B. Payrastre, Martine Horicot +4 more
199639 citations Open access
Semantic Scholar
Structure of the human blood platelet membrane glycoprotein Ib alpha gene.
R. Wenger, N. Kieffer, A. Wicki, K. J. Clemetson
1988Biochemical and Biophysical Research Communications - BBRC39 citations
Semantic Scholar
RGD, the Rho'd to cell spreading.
A. Salsmann, E. Schaffner-Reckinger, N. Kieffer
2006European Journal of Cell Biology35 citations
Semantic Scholar
Thrombin binding to GPIbα induces platelet aggregation and fibrin clot retraction supported by resting αIIbβ3 interaction with polymerized fibrin
C. Dubois, B. Steiner, N. Kieffer, Sylvie Meyer Reigner
2003Thrombosis and Haemostasis34 citations
Semantic Scholar
HPA-1a phenotype-genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet beta 3 integrin that disrupts the HPA-1a epitope.
N. Watkins, E. Schaffner-Reckinger, D. Allen, G. Howkins +6 more
2002Blood34 citations
Semantic Scholar
Expression of platelet glycoprotein Ib by cultured human megakaryocytes: ultrastructural localization and biosynthesis.
N. Debili, N. Kieffer, M. Nakazawa, J. Guichard +4 more
1990Blood34 citations Open access
Semantic Scholar
Up‐regulated expression of the β3 integrin and the 92‐kDa gelatinase in human HT‐144 melanoma cell tumors grown in nude mice
V. Gouon, G. Tucker, L. Kraus-berthier, G. Atassi +1 more
1996International Journal of Cancer33 citations Open access
Semantic Scholar
Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-β1 stimulation
B. Janji, C. Melchior, L. Vallar, N. Kieffer
2000Oncogene31 citations Open access
Semantic Scholar
Use of a monoclonal antibody (GA3) to demonstrate lineage restricted O-glycosylation on leukosialin during terminal erythroid differentiation.
A. Bettaieb, F. Farace, M. Mitjavila, Z. Mishal +5 more
1988Blood30 citations
Semantic Scholar
Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor
Marina Koutsioumpa, Evangelia Poimenidi, Evangelia Pantazaka, Christina Theodoropoulou +7 more
2015Molecular Cancer27 citations Open access
Semantic Scholar
PML/RARα fusion protein transactivates the tissue factor promoter through a GAGC-containing element without direct DNA association
Jin-Song Yan, Kankan Wang, Lei-Ming Dong, Hong-chen Liu +8 more
2010Proceedings of the National Academy of Sciences of the United States of America27 citations Open access
Semantic Scholar
A Naturally Occurring Point Mutation in the β3 Integrin MIDAS-like Domain Affects Differently αvβ3 and αIIbβ3 Receptor Function
M. Morel-Kopp, C. Melchior, Ping Chen, W. Ammerlaan +3 more
2001Thrombosis and Haemostasis25 citations
Semantic Scholar

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C. Melchior — researcher profile on SciRah
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