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E. van der Burg · SciRah

Researcher profile · Semantic Scholar

E. van der Burg

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E. van der Burg — researcher profile on SciRah

h-index: 21
Works: 41
Citations: 2,904

Most-cited papers

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
S. Rottenberg, J. Jaspers, A. Kersbergen, E. van der Burg +12 more
2008Proceedings of the National Academy of Sciences of the United States of America972 citations Open access
Semantic Scholar
Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth by AZD2281 and Cisplatin
B. Evers, R. Drost, Eva Schut, M. de Bruin +11 more
2008Clinical Cancer Research333 citations Open access
Semantic Scholar
Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer.
Petra ter Brugge, P. Kristel, E. van der Burg, U. Boon +18 more
2016Journal of the National Cancer Institute210 citations Open access
Semantic Scholar
BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1.
R. Drost, Kiranjit K. Dhillon, H. van der Gulden, I. van der Heijden +25 more
2016Journal of Clinical Investigation131 citations Open access
Semantic Scholar
Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice
P. Derksen, Tanya M. Braumuller, E. van der Burg, M. Hornsveld +4 more
2011Disease Models & Mechanisms131 citations Open access
Semantic Scholar
MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling
Dario Zimmerli, Chiara S. Brambillasca, Francien Talens, J. Bhin +25 more
2022Nature Communications121 citations Open access
Semantic Scholar
Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan.
Serge A. L. Zander, A. Kersbergen, E. van der Burg, Niels de Water +8 more
2010Cancer Research104 citations Open access
Semantic Scholar
Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer.
M. Pajic, J. Iyer, A. Kersbergen, E. van der Burg +4 more
2009Cancer Research99 citations
Semantic Scholar
CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer
J. Houthuijzen, Roebi de Bruijn, E. van der Burg, Anne Paulien Drenth +14 more
2022bioRxiv92 citations Open access
Semantic Scholar
A high throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors
B. Evers, Eva Schut, E. van der Burg, Tanya M. Braumuller +7 more
2009Clinical Cancer Research82 citations Open access
Semantic Scholar
Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation
F. Groenendijk, W. Mellema, E. van der Burg, Eva Schut +7 more
2014International Journal of Cancer70 citations Open access
Semantic Scholar
Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma
S. Kas, J. D. de Ruiter, Koen Schipper, S. Annunziato +12 more
2017Nature Genetics69 citations Open access
Semantic Scholar
Truncated FGFR2 is a clinically actionable oncogene in multiple cancers
D. Zingg, J. Bhin, Julia Yemelyanenko, S. Kas +44 more
2022Nature63 citations Open access
Semantic Scholar
Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer
S. Annunziato, J. D. de Ruiter, L. Henneman, Chiara S. Brambillasca +15 more
2019Nature Communications63 citations Open access
Semantic Scholar
TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development
Lisette M Cornelissen, Anne Paulien Drenth, E. van der Burg, Roebi de Bruijn +4 more
2019Genes & Development62 citations Open access
Semantic Scholar
Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors
S. Rottenberg, M. Vollebergh, B. de Hoon, J. D. de Ronde +17 more
2012Cancer Research53 citations Open access
Semantic Scholar
PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma
M. Boelens, M. Nethe, S. Klarenbeek, J. D. de Ruiter +8 more
2016Cell Reports48 citations Open access
Semantic Scholar
Homologous recombination deficiency derived from whole-genome sequencing predicts platinum response in triple-negative breast cancers
Petra ter Brugge, Sarah C. Moser, I. Bièche, P. Kristel +29 more
2023Nature Communications38 citations Open access
Semantic Scholar
Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin
Koen Schipper, Danielle Seinstra, Anne Paulien Drenth, E. van der Burg +5 more
2019Nature Communications34 citations Open access
Semantic Scholar
Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers
D. Zingg, J. Bhin, Julia Yemelyanenko, S. Kas +44 more
2022Nature33 citations Open access
Semantic Scholar
Selective Inhibition of BRCA 2-Deficient MammaryTumor Cell Growth byAZD 2281 and Cisplatin
B. Evers, R. Drost, Eva Schut, M. de Bruin +11 more
200831 citations
Semantic Scholar
A BRCA1 coiled-coil domain variant disrupting PALB2 interaction promotes the development of mammary tumors and confers a targetable defect in homologous recombination repair
Emilia M. Pulver, Chirantani Mukherjee, G. van de Kamp, Stefan J. Roobol +20 more
2021Cancer Research16 citations Open access
Semantic Scholar
BRCA 1 185 delAG tumors may acquire therapy resistance through expression of RINGless BRCA 1
R. Drost, Kiranjit K. Dhillon, H. van der Gulden, I. van der Heijden +25 more
201816 citations
Semantic Scholar
BRCA1‐associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling
M. van de Ven, Xiao-Ling Liu, E. van der Burg, S. Klarenbeek +5 more
2018Journal of Pathology10 citations
Semantic Scholar
Truncated ASPP2 drives initiation and progression of invasive lobular carcinoma via distinct mechanisms
Koen Schipper, Anne Paulien Drenth, E. van der Burg, S. Cornelissen +3 more
2020Cancer Research8 citations Open access
Semantic Scholar
Prophylactic window therapy with the clinical poly(ADP‐ribose) polymerase inhibitor olaparib delays BRCA1‐deficient mammary tumour formation in mice
M. van de Ven, E. van der Burg, H. van der Gulden, S. Klarenbeek +2 more
2016Journal of Pathology7 citations
Semantic Scholar
MYC promotes immune-suppression in TNBC via inhibition of IFN signaling
Dario Zimmerli, Chiara S. Brambillasca, Francien Talens, J. Bhin +20 more
2021bioRxiv6 citations Open access
Semantic Scholar
Response of BRCA 1-Deficient Mammary Tumors Impact of Intertumoral Heterogeneity on Predicting Chemotherapy
S. Rottenberg, M. Vollebergh, B. de Hoon, J. D. de Ronde +16 more
20123 citations
Semantic Scholar
C-terminal Truncation and Fusion Partner Determine Oncogenicity of FGFR3.
Julia Yemelyanenko, J. Bhin, E. van der Burg, Anne Paulien Drenth +17 more
2025Cancer Research2 citations
Semantic Scholar
The C-terminal Kinase Domain-Binding and Suppression Motif Prevents Constitutive Activation of FGFR2.
D. Zingg, Chi-Chuan Lin, Julia Yemelyanenko, L. Wieteska +17 more
2025Cancer Research1 citations
Semantic Scholar
EZH2 inhibition sensitizes BRCA1-deficient breast tumors to the PI3K inhibitor BKM120
J. Puppe, M. van de Ven, E. van der Burg, U. Boon +6 more
20161 citations
Semantic Scholar
Abstract 2707: An ex vivo culture platform of invasive lobular breast cancer for the screening of novel drugs targeting the tumor microenvironment
Konstantina Strepi, Daisy Batenburg, M. V. van Miltenburg, Pim Kloosterman +9 more
2025Cancer Research0 citations
Semantic Scholar
Abstract 6624: MYC promotes lobuloalveologenesis and mammary tumorigenesis in male mice
Emilia M. Pulver, E. van der Burg, Anne Paulien Drenth, Julia Yemelyanenko +10 more
2024Cancer Research0 citations
Semantic Scholar
FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks
A. Mazouzi, S. Moser, F. Abascal, B. van den Broek +10 more
2023Science Advances0 citations Open access
Semantic Scholar
Abstract A47: Reducing actin contraction in E-cadherin inactivated mammary epithelial cells leads to the development of invasive lobular carcinoma
Koen Schipper, M. Nethe, S. Kas, J. D. de Ruiter +5 more
20180 citations
Semantic Scholar
Eine EZH2-Inhibition sensitiviert BRCA1-defiziente Mammakarzinome gegenüber einer Therapie mit dem PI3K-Inhibitor BKM120
J. Puppe, M. van den Ven, E. van der Burg, Ute Boon +6 more
2017Senologie - Zeitschrift für Mammadiagnostik und -therapie0 citations
Semantic Scholar
Combination therapy of the EZH2 inhibitor GSK126 and the PARP inhibitor Olaparib shows in vivo synergy in a patient-derived xenograft model of BRCA1-deficient breast cancer
J. Puppe, PJ ter Brugge, M. Seressi, O. van Tellingen +7 more
20140 citations
Semantic Scholar
Abstract PR02: Genomic rearrangements and promoter demethylation drive therapy resistance in patient-derived xenograft models of BRCA1-deficient breast cancer
Petra ter Brugge, E. van der Burg, P. Kristel, U. Boon +9 more
20130 citations
Semantic Scholar
Abstract PR3: Patient derived BRCA1-deficient triple-negative breast cancer xenografts develop resistance to DNA damaging agents via genetic and epigenetic mechanisms
Petra ter Brugge, J. Wesseling, J. Jonkers, E. van der Burg +7 more
2012Clinical Cancer Research0 citations
Semantic Scholar
Abstract P1-03-03: A Human in Mouse Model of Triple Negative Breast Carcinoma To Optimize Alkylating or Targeted Treatment
PJ ter Brugge, P. Kristel, E. van der Burg, J. Jonkers +1 more
20100 citations
Semantic Scholar
The impact of defined Brca1 mutations on tumor development, drug response and acquired resistance
R. Drost, P. Bouwman, H. van der Gulden, E. van der Burg +1 more
20080 citations
Semantic Scholar

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J. Jonkers×33
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J. Jonkers — researcher profile on SciRah
Anne Paulien Drenth×16
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S. Klarenbeek×14
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M. van de Ven×12
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Eva Schut — researcher profile on SciRah

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P. Bouwman — researcher profile on SciRah

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Roebi de Bruijn×10

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Roebi de Bruijn — researcher profile on SciRah

S. Annunziato×9

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S. Annunziato — researcher profile on SciRah

S. Rottenberg×8

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S. Rottenberg — researcher profile on SciRah

J. D. de Ruiter×8

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J. D. de Ruiter — researcher profile on SciRah

J. Wesseling×8

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