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G. Klement · SciRah

Researcher profile · Semantic Scholar

G. Klement

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G. Klement — researcher profile on SciRah

h-index: 35
Works: 94
Citations: 7,276

Most-cited papers

Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released.
J. Italiano, Jennifer L. Richardson, S. Patel-Hett, E. Battinelli +5 more
2008Blood903 citations Open access
Semantic Scholar
Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity.
G. Klement, S. Baruchel, Janusz W. Rak, Shan Man +4 more
2000Journal of Clinical Investigation758 citations Open access
Semantic Scholar
Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
G. Klement, S. Baruchel, J. Rak, Shan Man +4 more
2000608 citations Open access
Semantic Scholar
Platelets actively sequester angiogenesis regulators.
G. Klement, Tai-Tung Yip, F. Cassiola, Lena Kikuchi +9 more
2009Blood358 citations Open access
Semantic Scholar
Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry.
Emily R. Christison-Lagay, P. Burrows, A. Alomari, J. Dubois +6 more
2007Journal of Pediatric Surgery346 citations
Semantic Scholar
Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles.
R. Flaumenhaft, J. Dilks, Jennifer L. Richardson, Evan C. Alden +5 more
2009Blood335 citations Open access
Semantic Scholar
Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts.
G. Klement, Ping Huang, B. Mayer, S. K. Green +4 more
2002Clinical Cancer Research260 citations
Semantic Scholar
Possible Mechanisms of Acquired Resistance to Anti-angiogenic Drugs: Implications for the Use of Combination Therapy Approaches
R. Kerbel, Joanne Yu, J. Tran, Shan Man +4 more
2004Cancer Metastasis Review255 citations
Semantic Scholar
Oncogenes and angiogenesis: signaling three-dimensional tumor growth.
J. Rak, Joanne Yu, G. Klement, R. Kerbel
2000Journal of Investigative Dermatology Symposium Proceedings248 citations Open access
Semantic Scholar
Metronomic chemotherapy: an attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance
I. Kareva, D. Waxman, G. Klement
2014Cancer Letters233 citations Open access
Semantic Scholar
VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients
Jon E. Peterson, D. Zurakowski, Joseph E. Jr Italiano, L. Michel +5 more
2012Angiogenesis230 citations
Semantic Scholar
A Feasibility Trial of Antiangiogenic (Metronomic) Chemotherapy in Pediatric Patients With Recurrent or Progressive Cancer
M. Kieran, C. Turner, J. Rubin, S. Chi +9 more
2005Journal of pediatric hematology/oncology206 citations
Semantic Scholar
Continuous low-dose anti-angiogenic/ metronomic chemotherapy: from the research laboratory into the oncology clinic.
R. S. Kerbel, G. Klement, K. Pritchard, B. Kamen
2002Annals of Oncology192 citations Open access
Semantic Scholar
'Accidental' anti-angiogenic drugs. anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples.
R. S. Kerbel, A. Viloria-Petit, G. Klement, J. Rak
2000European Journal of Cancer191 citations
Semantic Scholar
Cell Therapy, a New Standard in Management of Chronic Critical Limb Ischemia and Foot Ulcer
V. Procházka, J. Gumulec, F. Jalůvka, D. Šalounová +7 more
2010Cell Transplantation161 citations Open access
Semantic Scholar
Normal ranges of angiogenesis regulatory proteins in human platelets
Jon E. Peterson, D. Zurakowski, J. Italiano, Leah Michel +3 more
2010American journal of hematology/oncology158 citations Open access
Semantic Scholar
Platelet-associated PF-4 as a biomarker of early tumor growth.
D. Cervi, Tai-Tung Yip, N. Bhattacharya, V. Podust +8 more
2008Blood151 citations
Semantic Scholar
MicroCT scanner performance and considerations for vascular specimen imaging.
M. Marxen, M. Thornton, Cameron B. Chiarot, G. Klement +3 more
2004Medical Physics (Lancaster)139 citations
Semantic Scholar
A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice.
D. Voskas, N. Jones, P. van Slyke, C. Sturk +15 more
2005American Journal of Pathology94 citations Open access
Semantic Scholar
Serum proteome profiling detects myelodysplastic syndromes and identifies CXC chemokine ligands 4 and 7 as markers for advanced disease
M. Aivado, Dimitrios Spentzos, U. Germing, G. Alterovitz +16 more
2007Proceedings of the National Academy of Sciences of the United States of America92 citations Open access
Semantic Scholar
Vascular endothelial growth factor isoform expression as a determinant of blood vessel patterning in human melanoma xenografts.
Joanne Yu, J. Rak, G. Klement, R. Kerbel
2002Cancer Research90 citations
Semantic Scholar
Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets
J. Etulain, S. Negrotto, A. Carestia, R. Pozner +4 more
2011Thrombosis and Haemostasis87 citations Open access
Semantic Scholar
Multicellular gastric cancer spheroids recapitulate growth pattern and differentiation phenotype of human gastric carcinomas.
Barbara Mayer, G. Klement, M. Kaneko, Shan Man +3 more
2001Gastroenterology76 citations Open access
Semantic Scholar
Impact of Oncogenes and Tumor Suppressor Genes on Deregulation of Hemostasis and Angiogenesis in Cancer
J. Rak, G. Klement
2004Cancer Metastasis Review66 citations
Semantic Scholar
Cutaneovisceral Angiomatosis With Thrombocytopenia
V. Prasad, S. Fishman, J. Mulliken, V. Fox +10 more
2005Pediatric and Developmental Pathology60 citations
Semantic Scholar
Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
K. Pilátová, K. Greplová, R. Demlova, B. Bencsiková +2 more
2013Journal of Hematology & Oncology58 citations Open access
Semantic Scholar
Pharmacological Treatment of a Diffuse Arteriovenous Malformation of the Upper Extremity in a Child
P. Burrows, J. Mulliken, S. Fishman, G. Klement +1 more
2009The Journal of craniofacial surgery (Print)58 citations
Semantic Scholar
Autologous bone marrow stem cell transplantation in patients with end-stage chronical critical limb ischemia and diabetic foot.
V. Procházka, J. Gumulec, J. Chmelová, P. Klement +4 more
2009Vnitrni lekarstvi56 citations
Semantic Scholar
An oral ivermectin regimen that eradicates pinworms (Syphacia spp.) in laboratory rats and mice.
P. Klement, J. Augustine, K. H. Delaney, G. Klement +1 more
1996Laboratory animal science49 citations
Semantic Scholar
Hyperthermia inhibits platelet haemostatic functions and selectively regulates the release of alpha-granule proteins
J. Etulain, M. J. Lapponi, S. J. Patrucchi, M. A. Romaniuk +4 more
2011Journal of Thrombosis and Haemostasis48 citations Open access
Semantic Scholar
Normal Wound Healing and Tumor Angiogenesis as a Game of Competitive Inhibition
I. Kareva, Abdo Abou-Slaybi, Oliver Dodd, Olga Dashevsky +1 more
2014PLoS ONE46 citations Open access
Semantic Scholar
Combination antiangiogenic therapy in advanced breast cancer: a phase 1 trial of vandetanib, a VEGFR inhibitor, and metronomic chemotherapy, with correlative platelet proteomics
E. Mayer, S. Isakoff, G. Klement, S. Downing +5 more
2012Breast Cancer Research and Treatment45 citations Open access
Semantic Scholar
Tumors stimulate platelet delivery of angiogenic factors in vivo: an unexpected benefit.
G. Pietramaggiori, S. Scherer, D. Cervi, G. Klement +1 more
2008American Journal of Pathology44 citations Open access
Semantic Scholar
Channel density regulation of firing patterns in a cortical neuron model.
P. Århem, G. Klement, C. Blomberg
2006Biophysical Journal39 citations Open access
Semantic Scholar
The splenic microenvironment is a source of proangiogenesis/inflammatory mediators accelerating the expansion of murine erythroleukemic cells.
Y. Shaked, D. Cervi, M. Neuman, Limor Chen +6 more
2005Blood37 citations Open access
Semantic Scholar
Nontoxic, Fiscally Responsible, Future of Oncology: Could it be Beginning in the Third World?
G. Klement, B. Kamen
2011Journal of pediatric hematology/oncology35 citations Open access
Semantic Scholar
Eco-evolution of cancer resistance
G. Klement
2016Science Translational Medicine34 citations
Semantic Scholar
Differences in vasculature between pilocytic and anaplastic astrocytomas of childhood.
B. Gesundheit, G. Klement, C. Senger, R. Kerbel +3 more
2003Medical and Pediatric Oncology33 citations Open access
Semantic Scholar
Cancer Therapy Targeting the HER2-PI3K Pathway: Potential Impact on the Heart
G. Klement, David A. Goukassian, L. Hlatky, J. Carrozza +2 more
2012Frontiers in Pharmacology30 citations Open access
Semantic Scholar
The Role of Platelets in Angiogenesis
G. Klement, E. Shai, D. Varon
201328 citations
Semantic Scholar
Mitral valve replacement in dogs. Surgical technique and postoperative management.
Petr Klement, C. Feindel, Hugh E. Scully, Eileen Mesher +3 more
1987Veterinary surgery22 citations
Semantic Scholar
Technique and postoperative management for successful cardiopulmonary bypass and open-heart surgery in dogs.
P. Klement, P. D. del Nido, L. Mickleborough, C. Mackay +2 more
1987Journal of the American Veterinary Medical Association22 citations
Semantic Scholar
Future paradigms for precision oncology
G. Klement, K. Arkun, D. Valík, T. Roffidal +19 more
2016OncoTarget21 citations Open access
Semantic Scholar
Personalized anticancer therapy selection using molecular landscape topology and thermodynamics
E. Rietman, Jacob G. Scott, J. Tuszynski, G. Klement
2016OncoTarget20 citations Open access
Semantic Scholar
The Role of Angiogenesis in the Transformation of Plexiform Neurofibroma into Malignant Peripheral Nerve Sheath Tumors in Children With Neurofibromatosis Type 1
B. Gesundheit, P. Parkin, M. Greenberg, S. Baruchel +4 more
2010Journal of pediatric hematology/oncology20 citations
Semantic Scholar
Early Tumor Detection Using Platelet Uptake of Angiogenesis Regulators.
G. Klement, Lena Kikuchi, M. Kieran, N. Almog +2 more
200420 citations
Semantic Scholar
Addition of platelet concentrate to Dermo-Epidermal Skin Graft in deep burn trauma reduces scarring and need for revision surgeries
V. Procházka, H. Klosova, J. Štětinský, J. Gumulec +10 more
2013Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia18 citations Open access
Semantic Scholar
Interdisciplinary management of congenital infiltrating lipomatosis.
Jeremiah C. Tracy, G. Klement, A. R. Scott
2013International Journal of Pediatric Otorhinolaryngology16 citations
Semantic Scholar
Chapter 130 – Vascular Anomalies: Hemangiomas and Malformations
G. Klement, S. Fishman
200616 citations
Semantic Scholar
Center of Cancer Systems Biology Second Annual Workshop – Tumor Metronomics: Timing and Dose Level Dynamics
P. Hahnfeldt, L. Hlatky, G. Klement
2013Cancer Research15 citations Open access
Semantic Scholar

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J. Rak×6
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J. Rak — researcher profile on SciRah
J. Italiano×5
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S. Baruchel — researcher profile on SciRah

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Shan Man — researcher profile on SciRah

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