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S. Downing · SciRah

Researcher profile · Semantic Scholar

S. Downing

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S. Downing — researcher profile on SciRah

h-index: 15
Works: 45
Citations: 4,381

Most-cited papers

Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing
G. Frampton, Alex M. Fichtenholtz, G. Otto, Kai Wang +41 more
2013Nature Biotechnology2,069 citations Open access
Semantic Scholar
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
D. Lipson, M. Capelletti, R. Yelensky, G. Otto +28 more
2012Nature Medicine874 citations Open access
Semantic Scholar
Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity
H. Beltran, R. Yelensky, G. Frampton, K. Park +10 more
2012European Urology444 citations Open access
Semantic Scholar
Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy
J. Ross, Kai Wang, R. Al-Rohil, T. Nazeer +15 more
2014Modern Pathology159 citations Open access
Semantic Scholar
A High Frequency of Activating Extracellular Domain ERBB2 (HER2) Mutation in Micropapillary Urothelial Carcinoma
J. Ross, Kai Wang, L. Gay, R. Al-Rohil +21 more
2013Clinical Cancer Research147 citations
Semantic Scholar
Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer
O. Straume, T. Shimamura, Michael Lampa, J. Carretero +18 more
2012Proceedings of the National Academy of Sciences of the United States of America133 citations Open access
Semantic Scholar
Relapsed Classic E-Cadherin (CDH1)–Mutated Invasive Lobular Breast Cancer Shows a High Frequency of HER2 (ERBB2) Gene Mutations
J. Ross, Kai Wang, Christine E. Sheehan, A. Boguniewicz +11 more
2013Clinical Cancer Research127 citations
Semantic Scholar
Alterations of p53 are common in early stage prostate cancer.
S. Downing, P. Russell, P. Jackson
2003The Canadian journal of urology70 citations
Semantic Scholar
Comprehensive Genomic Profiling of Relapsed and Metastatic Adenoid Cystic Carcinomas by Next-generation Sequencing Reveals Potential New Routes to Targeted Therapies
J. Ross, Kai Wang, J. Rand, Christine E. Sheehan +14 more
2014American Journal of Surgical Pathology63 citations
Semantic Scholar
Response of an ERBB2-mutated inflammatory breast carcinoma to human epidermal growth factor receptor 2-targeted therapy.
Siraj M. Ali, R. Alpaugh, S. Downing, P. Stephens +8 more
2014Journal of Clinical Oncology46 citations Open access
Semantic Scholar
Combination antiangiogenic therapy in advanced breast cancer: a phase 1 trial of vandetanib, a VEGFR inhibitor, and metronomic chemotherapy, with correlative platelet proteomics
E. Mayer, S. Isakoff, G. Klement, S. Downing +5 more
2012Breast Cancer Research and Treatment45 citations Open access
Semantic Scholar
The InSituPlex® Staining Method for Multiplexed Immunofluorescence Cell Phenotyping and Spatial Profiling of Tumor FFPE Samples.
Mael Manesse, Katir K. Patel, M. Bobrow, S. Downing
2020Methods in molecular biology42 citations
Semantic Scholar
Mutations within the tumour suppressor gene p53 are not confined to a late event in prostate cancer progression. a review of the evidence.
S. Downing, P. Jackson, P. Russell
2001Urologic oncology39 citations
Semantic Scholar
Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer.
S. Downing, Kristen T. Hennessy, Miyako Abe, J. Manola +2 more
2003Clinical Prostate Cancer19 citations
Semantic Scholar
Evidence for post‐transcriptional down‐regulation of the apoptosis‐related gene bcl‐2 in human colorectal cancer
C. Berney, S. Downing, Jia-Lin Yang, Pamela J. Russell +1 more
2000Journal of Pathology17 citations
Semantic Scholar
Isolation and Proteomic Analysis of Platelets by SELDI-TOF MS
S. Downing, G. Klement
2012Methods in molecular biology14 citations
Semantic Scholar
Simultaneous and exact interval estimates for the contrast of two groups based on an extremely high dimensional variable: application to mass spec data
Yuhyun Park, S. Downing, Dohyun Kim, W. Hahn +3 more
2007Bioinform.14 citations Open access
Semantic Scholar
Elevated levels of prostate‐specific antigen (PSA) in prostate cancer cells expressing mutant p53 is associated with tumor metastasis
S. Downing, Clare Bumak, S. Nixdorf, K. Ow +2 more
2003Molecular Carcinogenesis13 citations
Semantic Scholar
Elevated expression of FGF‐2 does not cause prostate cancer progression in LNCaP cells
P. Russell, S. Bennett, A. Joshua, Y. Yu +5 more
1999The Prostate12 citations
Semantic Scholar
Use of next-generation sequencing (NGS) to identify actionable genomic alterations (GA) in diverse solid tumor types: The Foundation Medicine (FMI) experience with 2,200+ clinical samples.
V. Miller, J. Ross, Kai Wang, Siraj M. Ali +8 more
20136 citations
Semantic Scholar
Relapsed classic E-cadherin (CDH1) mutated invasive lobular breast cancer demonstrates a high frequency of HER2 (ERBB2) gene mutations
J. Ross, Kai Wang, Christine E. Sheehan, A. Boguniewicz +11 more
20136 citations
Semantic Scholar
Comprehensive next-generation sequencing for clinically actionable mutations from formalin-fixed cancer tissues.
J. Ross, D. Lipson, R. Yelensky, M. Jarosz +9 more
2011Journal of Clinical Oncology6 citations
Semantic Scholar
Clinical application of comprehensive next-generation sequencing-based genomic profiling for identification of actionable genomic alterations in pediatric solid tumors and hematolymphoid malignancies: The Foundation Medicine pediatric experience.
Matthew J. Hawryluk, Kai Wang, J. Chmielecki, Siraj M. Ali +10 more
20144 citations
Semantic Scholar
Abstract 5657: Use of a novel immunofluorescence multiplexing technology, InSituPlex™, for the simultaneous detection of immune cells in multiple cancer types
S. Downing, Katir K. Patel, J. Buell, Courtney Hebert
2018Cancer Chemistry3 citations
Semantic Scholar
Human Cancer Biology Relapsed Classic E-Cadherin ( CDH 1 ) – Mutated Invasive Lobular Breast Cancer Shows a High Frequency of HER 2 ( ERBB 2 ) Gene Mutations
J. Ross, Kai Wang, Christine E. Sheehan, A. Boguniewicz +11 more
20133 citations
Semantic Scholar
Simultaneous and Exact Interval Estimates for the Contrast of Two Groups Based on an Extremely High Dimensional Response Variable: Application to Mass Spec Data Analysis
Yuhyun Park, S. Downing, Cheng Li, W. Hahn +2 more
20053 citations
Semantic Scholar
Development of a PD-L1 multiplex immunofluorescence assay with advanced visual analysis for understanding the tumor microenvironment.
S. Downing, Aditi Sharma, Courtney Hebert, J. Buell +1 more
2019Journal of Clinical Oncology2 citations
Semantic Scholar
Use of the FoundationOne next-generation sequencing (NGS) assay to detect actionable alterations leading to clinical benefit of targeted therapies for relapsed and refractory breast cancer.
J. Ross, M. Cristofanilli, S. Downing, R. Yelensky +6 more
20132 citations
Semantic Scholar
Use of next-generation sequencing (NGS) to detect a novel ALK fusion and a high frequency of other actionable alterations in colorectal cancer (CRC).
J. Ross, D. Lipson, Christine E. Sheehan, G. Otto +12 more
20122 citations
Semantic Scholar
Abstract 4699: Analytical validation of solid tumor fusion gene detection in a comprehensive NGS-based clinical cancer genomic test
R. Yelensky, Amy L. Donahue, G. Otto, M. Nahas +11 more
20141 citations
Semantic Scholar
Abstract LB-275: Measuring concordance of CD8 and PD-L1 expression in non-small cell lung cancer between a novel multiplex immunofluorescence assay and a brightfield laboratory developed test
Shravani Shitole, Monique Johnson, Courtney Hebert, J. Buell +2 more
2020Bioinformatics, Convergence Science, and Systems Biology0 citations
Semantic Scholar
Abstract 4986: Utilizing image analysis to characterize an 8-plex immunofluorescence immune checkpoint biomarker panel within the tumor tissue microenvironment
A. Bigley, L. Sherry, Nicole Stillie, Douglas E. Wood +1 more
2020Tumor Biology0 citations
Semantic Scholar
Abstract 4989: Introduction of a robust workflow for the whole-side acquisition and co-registration of multiplex immunofluorescence tissue images for analysis of a 9-color, 8-marker immunophenotyping assay
Anne E. Hellebust, Kyla Teplitz, Katir K. Patel, K. Sharma +6 more
2020Tumor Biology0 citations
Semantic Scholar
Abstract 1677: Understanding the TME: Advanced analysis and visualization of multiplexed fluorescence images
Douglas O. Wood, Bonnie Phillips, Courtney Hebert, Aditi Sharma +2 more
2019Bioinformatics, Convergence Science, and Systems Biology0 citations
Semantic Scholar
Abstract 4569: Intra- and inter-run assessment of reproducibility and quantification of UltiMapper™ I/O APC and T-act kits for tissue multiplexing
Bonnie Phillips, Katir K. Patel, Courtney Hebert, Aditi Sharma +2 more
2019Tumor Biology0 citations Open access
Semantic Scholar
Abstract 5652: Validation of novel InSituPlex™ technology utilizing standard chromogenic IHC and multiplexed tyramide-based immunofluorescence
Katir K. Patel, Courtney Hebert, J. Buell, S. Downing
2018Cancer Chemistry0 citations
Semantic Scholar
Preliminary correlative analysis of PD-L1 expression from the SUNRISE study.
N. Kallinteris, R. Sanborn, L. Horn, D. Gerber +7 more
20170 citations
Semantic Scholar
New method for immunoprofiling of the tumor microenvironment of cancer patients by opal multiplex quantitative immunofluorescence (IF) assay
N. Kallinteris, J. Shan, J. Meyer, A. Yopp +8 more
2015Journal of Immunotherapy for Cancer0 citations Open access
Semantic Scholar
Abstract B122: A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma.
Kai Wang, J. Ross, R. Al-Rohil, T. Nazeer +20 more
20130 citations
Semantic Scholar
Abstract 2279: Bringing next generation sequencing (NGS) to the clinic: Analytical validation of a comprehensive NGS-based cancer gene test.
R. Yelensky, G. Frampton, Alex M. Fichtenholtz, S. Downing +12 more
20130 citations
Semantic Scholar
Abstract C22: Massively parallel DNA-sequencing of aggressive prostate cancer reveals disease heterogeneity and identifies targetable mutations
H. Beltran, P. Stephens, J. Mosquera, M. Cronin +9 more
20120 citations
Semantic Scholar
Abstract 967: Massively parallel sequencing of clinical FFPE cancer specimens enables comprehensive genomic assessment of patient eligibility for targeted therapy
R. Yelensky, M. Jarosz, S. Downing, Kai Wang +9 more
20120 citations
Semantic Scholar
Targeted next-generation sequencing (NGS) of advanced prostate cancer (PCA) using formalin-fixed tissue.
H. Beltran, R. Yelensky, G. Frampton, Kyung Park +9 more
20120 citations
Semantic Scholar
800 ORAL Comprehensive Next-Generation Sequencing (NGS) From Formalin-fixed NSCLC, CRC and Melanoma Cancer Tissues Identifies Novel Mutations With Potential Clinical Utility
G. Palmer, R. Yelensky, D. Lipson, M. Jarosz +6 more
20110 citations
Semantic Scholar
Can Angiogenesis Regulatory Proteins Guide Ultra-early Detection and Therapy of Recurrent Human Cancer?
J. Folkman, N. Almog, Monica Bertagnollli, F. Cassiola +10 more
20070 citations
Semantic Scholar

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J. Ross×18
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