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D. Pettibone · SciRah

Researcher profile · Semantic Scholar

D. Pettibone

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D. Pettibone — researcher profile on SciRah

h-index: 36
Works: 136
Citations: 5,740

Most-cited papers

International Union of Pharmacology. XLV. Classification of the Kinin Receptor Family: from Molecular Mechanisms to Pathophysiological Consequences
L. M. Fredrik Leeb-Lundberg, F. Marceau, W. Müller-Esterl, D. Pettibone +1 more
2005Pharmacological Reviews982 citations
Semantic Scholar
Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes.
David L. Williams, Kathryn L. Jones, D. Pettibone, E. V. Lis +1 more
1991Biochemical and Biophysical Research Communications - BBRC379 citations
Semantic Scholar
A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models
G. Kinney, Julie A. O'Brien, Wei Lemaire, M. Burno +13 more
2005Journal of Pharmacology and Experimental Therapeutics306 citations
Semantic Scholar
N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-d-aspartate receptor activity
C. Sur, P. Mallorga, M. Wittmann, M. Jacobson +6 more
2003Proceedings of the National Academy of Sciences of the United States of America301 citations Open access
Semantic Scholar
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.
Julie A. O'Brien, Wei Lemaire, Tsing-Bau Chen, R. Chang +8 more
2003Molecular Pharmacology210 citations
Semantic Scholar
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
C. Lindsley, David D. Wisnoski, William H. Leister, J. O'Brien +12 more
2004Journal of Medicinal Chemistry178 citations Open access
Semantic Scholar
A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain
Julie A. O'Brien, Wei Lemaire, M. Wittmann, M. Jacobson +10 more
2004Journal of Pharmacology and Experimental Therapeutics174 citations
Semantic Scholar
A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066.
B. Clineschmidt, D. Pettibone, V. J. Lotti, H. Hucker +5 more
1988Journal of Pharmacology and Experimental Therapeutics144 citations
Semantic Scholar
The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin.
D. Pettibone, J. F. Hess, Patricia J. Hey, M. Jacobson +7 more
2002Journal of Pharmacology and Experimental Therapeutics128 citations Open access
Semantic Scholar
Development of an intact cell reporter gene beta-lactamase assay for G protein-coupled receptors for high-throughput screening.
P. Kunapuli, R. Ransom, Kathy L. Murphy, D. Pettibone +8 more
2003Analytical Biochemistry81 citations
Semantic Scholar
Proline bis-amides as potent dual orexin receptor antagonists.
J. Bergman, A. J. Roecker, Swati P. Mercer, R. A. Bednar +13 more
2008Bioorganic & Medicinal Chemistry Letters68 citations Open access
Semantic Scholar
Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.
Zhi-Jian Zhao, David D. Wisnoski, J. O'Brien, Wei Lemaire +11 more
2007Bioorganic & Medicinal Chemistry Letters68 citations Open access
Semantic Scholar
A structurally unique, potent, and selective oxytocin antagonist derived from Streptomyces silvensis.
D. Pettibone, B. Clineschmidt, P. S. Anderson, R. Freidinger +8 more
1989Endocrinology67 citations
Semantic Scholar
Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine.
P. Mallorga, Jacinta B. Williams, M. Jacobson, Rosemary Marques +4 more
2003Neuropharmacology61 citations
Semantic Scholar
Radioligand binding studies reveal marked species differences in the vasopressin V1 receptor of rat, rhesus and human tissues.
D. Pettibone, Maribeth T. Kishel, Carla J. Woyden, B. Clineschmidt +4 more
1992Life Science58 citations
Semantic Scholar
Unusual cyclopropane-containing hapalindolinones from a cultured cyanobacterium
R. Schwartz, C. F. Hirsch, J. P. Springer, D. Pettibone +1 more
198758 citations
Semantic Scholar
Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists.
S. Kuduk, C. D. Di Marco, Ronald K. Chang, M. Wood +17 more
2007Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Benzodiazepines as potent and selective bradykinin B1 antagonists.
M. Wood, June J. Kim, W. Han, B. Dorsey +20 more
2003Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Effects of typical and atypical antipsychotics on human glycine transporters.
Jacinta B. Williams, P. Mallorga, P. Conn, D. Pettibone +1 more
2004Schizophrenia Research50 citations
Semantic Scholar
1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist.
P. D. Williams, B. Clineschmidt, J. M. Erb, R. Freidinger +6 more
1995Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Development of orally active oxytocin antagonists: studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl]piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines.
I. M. Bell, J. M. Erb, R. Freidinger, S. N. Gallicchio +15 more
1998Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Small molecule ligands for oxytocin and vasopressin receptors
R. Freidinger, D. Pettibone
1997Medicinal research reviews (Print)43 citations
Semantic Scholar
Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells.
Jeffrey R. Jasper, C. Harrell, J. O'Brien, D. Pettibone
1995Life Science39 citations
Semantic Scholar
Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist.
David L. Williams, K. L. Murphy, N. A. Nolan, J. O'Brien +6 more
1995Journal of Pharmacology and Experimental Therapeutics39 citations
Semantic Scholar
Cyclopropylamino acid amide as a pharmacophoric replacement for 2,3-diaminopyridine. Application to the design of novel bradykinin B1 receptor antagonists.
M. Wood, Kathy M Schirripa, June J. Kim, Bang-Lin Wan +14 more
2006Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Design, Synthesis, and In Vivo Efficacy of Glycine Transporter‐1 (GlyT1) Inhibitors Derived from a Series of [4‐Phenyl‐1‐(propylsulfonyl)piperidin‐4‐yl]methyl Benzamides
Craig W. Lindsley, Zhi-Jian Zhao, William H. Leister, J. O'Brien +15 more
2006ChemMedChem38 citations
Semantic Scholar
L‐368,899, a potent orally active oxytocin antagonist for potential use in preterm labor
D. Pettibone, B. Clineschmidt, Maribeth T. Guidotti, E. V. Lis +17 more
199337 citations
Semantic Scholar
Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist.
M. Nishikibe, Hisashi Ohta, Megumu Okada, K. Ishikawa +19 more
1999Journal of Pharmacology and Experimental Therapeutics36 citations Open access
Semantic Scholar
2,3-diaminopyridine bradykinin B1 receptor antagonists.
S. Kuduk, Christina Ng, D. Feng, J. Wai +13 more
2004Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Selective alpha1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones.
P. Nantermet, J. Barrow, H. Selnick, Carl F. Homnick +9 more
2000Bioorganic & Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
Molecular Cloning and Pharmacological Characterization of the Canine B1 and B2 Bradykinin Receptors
J. Hess, Patricia J. Hey, Tsing-Bau Chen, Julie A. OBrien +3 more
2001Biological chemistry31 citations
Semantic Scholar
Receptor ligands which bind the oxytocin receptor with selectivity and high affinity. Chemical modification of a Streptomyces silvensis derived cyclic hexapeptide.
Mark G. Bock, R. M. Dipardo, P. D. Williams, D. Pettibone +4 more
1990Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
[3H]L-657, 743 (MK-912): A new, high affinity, selective radioligand for brain α2-adrenoceptors
D. Pettibone, S. Flagg, J. A. Totarol, B. Clineschmidt +3 more
198928 citations
Semantic Scholar
Potent dual antagonists of endothelin and angiotensin II receptors derived from α-phenoxyphenylacetic acids (Part III)
T. F. Walsh, K. Fitch, David L. Williams, K. L. Murphy +7 more
199525 citations
Semantic Scholar
Identification of an orally active, nonpeptidyl oxytocin antagonist.
D. Pettibone, B. Clineschmidt, M. Kishel, E. V. Lis +6 more
1993Journal of Pharmacology and Experimental Therapeutics25 citations
Semantic Scholar
Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity.
Jacinta B. Williams, P. Mallorga, Wei Lemaire, David L. Williams +6 more
2003Analytical Biochemistry24 citations
Semantic Scholar
2,3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists.
D. Feng, J. Wai, S. Kuduk, Christina Ng +11 more
2005Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Potent, non-peptidic oxytocin receptor antagonists from a natural source
G. Salituro, D. Pettibone, B. Clineschmidt, J. Williamson +1 more
199323 citations
Semantic Scholar
Identification of functional oxytocin receptors in lactating rat mammary gland in vitro.
D. Pettibone, C. Woyden, J. A. Totaro
1990European Journal of Pharmacology23 citations
Semantic Scholar
In vitro pharmacological profile of a novel structural class of oxytocin antagonists.
D. Pettibone, B. Clineschmidt, E. V. Lis, D. Reiss +6 more
1990Journal of Pharmacology and Experimental Therapeutics23 citations Open access
Semantic Scholar
2-Heterocyclic indole-3-sulfones as inhibitors of HIV-1 reverse transcriptase
S. D. Young, M. Amblard, S. F. Britcher, Vanessa E. Grey +7 more
199522 citations
Semantic Scholar
Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.
S. Wolkenberg, Zhi-Jian Zhao, David D. Wisnoski, William H. Leister +14 more
2009Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Bradykinin B1 receptor antagonists: an alpha-hydroxy amide with an improved metabolism profile.
S. Kuduk, Ronald K. Chang, R. M. Dipardo, C. D. Di Marco +7 more
2008Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Cyclic hexapeptide oxytocin antagonists. Potency-, selectivity-, and solubility-enhancing modifications.
R. Freidinger, P. Williams, R. Tung, M. Bock +6 more
1990Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors.
Zhi-Jian Zhao, William H. Leister, J. O'Brien, Wei Lemaire +10 more
2009Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Identification of the critical residues of bradykinin receptor B1 for interaction with the kinins guided by site-directed mutagenesis and molecular modeling.
Sookhee N. Ha, Patricia J. Hey, R. Ransom, Mark G. Bock +6 more
2006Biochemistry20 citations
Semantic Scholar
Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model
J. Hess, R. Ransom, Zhi-Zhen Zeng, R. Chang +15 more
2004Journal of Pharmacology and Experimental Therapeutics20 citations
Semantic Scholar
Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist.
R. Ransom, C. M. Harrell, D. Reiss, K. L. Murphy +15 more
2004European Journal of Pharmacology19 citations
Semantic Scholar
Molecular and pharmacological diversity of the kinin B1 receptor.
J. Hess, Patricia J. Hey, Tsing-Bau Chen, D. Pettibone +1 more
2002International Immunopharmacology18 citations
Semantic Scholar
Discovery and development of non-peptide antagonists of peptide hormone receptors.
D. Pettibone, R. Freidinger
1997Biochemical Society Transactions18 citations
Semantic Scholar

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D. Reiss×14
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B. Clineschmidt×13
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B. Clineschmidt — researcher profile on SciRah
C. Sur×12
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R. Ransom — researcher profile on SciRah

David L. Williams×11

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E. V. Lis — researcher profile on SciRah

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M. Jacobson×10

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