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U. Fischer · SciRah

Researcher profile · Semantic Scholar

U. Fischer

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U. Fischer — researcher profile on SciRah

h-index: 54
Works: 122
Citations: 12K

Most-cited papers

SMN Tudor domain structure and its interaction with the Sm proteins
P. Selenko, R. Sprangers, G. Stier, D. Bühler +2 more
2001Nature Structural Biology350 citations
Semantic Scholar
The SARS-CoV-2 RNA–protein interactome in infected human cells
Nora Schmidt, C. Lareau, Hasmik Keshishian, Sabina Ganskih +17 more
2020Nature Microbiology310 citations Open access
Semantic Scholar
SMN-mediated assembly of RNPs: a complex story.
G. Meister, Christian Eggert, U. Fischer
2002Trends in Cell Biology255 citations
Semantic Scholar
An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.
A. Chari, M. Golas, Michael Klingenhäger, Nils Neuenkirchen +5 more
2008Cell246 citations Open access
Semantic Scholar
Reduced U snRNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy.
C. Winkler, Christian Eggert, D. Gradl, G. Meister +4 more
2005Genes & Development242 citations Open access
Semantic Scholar
Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.
R. Pillai, M. Grimmler, G. Meister, C. Will +3 more
2003Genes & Development238 citations Open access
Semantic Scholar
Assisted RNP assembly: SMN and PRMT5 complexes cooperate in the formation of spliceosomal UsnRNPs
G. Meister, U. Fischer
2002EMBO Journal231 citations Open access
Semantic Scholar
Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins
K. Tripsianes, T. Madl, Martin Machyna, D. Fessas +4 more
2011Nature Structural &Molecular Biology199 citations
Semantic Scholar
Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders
George Stoll, O. Pietiläinen, Bastian Linder, J. Suvisaari +29 more
2013Nature Neuroscience183 citations Open access
Semantic Scholar
The La‐related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes
Andreas Markert, M. Grimm, J. Martínez, J. Wiesner +4 more
2008EMBO Reports180 citations Open access
Semantic Scholar
RioK1, a New Interactor of Protein Arginine Methyltransferase 5 (PRMT5), Competes with pICln for Binding and Modulates PRMT5 Complex Composition and Substrate Specificity*
G. Guderian, Christoph Peter, J. Wiesner, A. Sickmann +3 more
2010Journal of Biological Chemistry154 citations Open access
Semantic Scholar
A Comprehensive Interaction Map of the Human Survival of Motor Neuron (SMN) Complex*
Simon Otter, M. Grimmler, Nils Neuenkirchen, A. Chari +2 more
2007Journal of Biological Chemistry154 citations Open access
Semantic Scholar
Translation and replication of hepatitis C virus genomic RNA depends on ancient cellular proteins that control mRNA fates
Nicoletta Scheller, L. Mina, R. P. Galão, A. Chari +5 more
2009Proceedings of the National Academy of Sciences of the United States of America153 citations Open access
Semantic Scholar
Biogenesis of spliceosomal small nuclear ribonucleoproteins
U. Fischer, Clemens Englbrecht, A. Chari
2011Wiley Interdisciplinary Reviews - RNA140 citations
Semantic Scholar
Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2.
Holger Dill, Bastian Linder, Alexander G. J. Fehr, U. Fischer
2012Genes & Development133 citations Open access
Semantic Scholar
Deciphering the mRNP Code: RNA-Bound Determinants of Post-Transcriptional Gene Regulation.
N. Gehring, E. Wahle, U. Fischer
2017TIBS -Trends in Biochemical Sciences. Regular ed123 citations
Semantic Scholar
Spinal muscular atrophy: the RNP connection.
Christian Eggert, A. Chari, B. Laggerbauer, U. Fischer
2006Trends in Molecular Medicine121 citations
Semantic Scholar
Molecular and functional analysis of intragenic SMN1 mutations in patients with spinal muscular atrophy
Yu-Li Sun, M. Grimmler, V. Schwarzer, F. Schoenen +2 more
2005Human Mutation121 citations Open access
Semantic Scholar
Deciphering the assembly pathway of Sm‐class U snRNPs
Nils Neuenkirchen, A. Chari, U. Fischer
2008FEBS Letters119 citations
Semantic Scholar
Evolution of an RNP assembly system: A minimal SMN complex facilitates formation of UsnRNPs in Drosophila melanogaster
M. Kroiss, J. Schultz, J. Wiesner, A. Chari +2 more
2008Proceedings of the National Academy of Sciences of the United States of America112 citations Open access
Semantic Scholar
IGHMBP2 is a ribosome-associated helicase inactive in the neuromuscular disorder distal SMA type 1 (DSMA1).
Ulf-Peter Guenther, Lusy Handoko, B. Laggerbauer, S. Jablonka +9 more
2009Human Molecular Genetics111 citations Open access
Semantic Scholar
Characterization of Ighmbp2 in motor neurons and implications for the pathomechanism in a mouse model of human spinal muscular atrophy with respiratory distress type 1 (SMARD1).
K. Grohmann, W. Rossoll, I. Kobsar, B. Holtmann +7 more
2004Human Molecular Genetics100 citations
Semantic Scholar
Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP.
Bastian Linder, Oliver Plöttner, M. Kroiss, E. Hartmann +4 more
2008Human Molecular Genetics96 citations
Semantic Scholar
Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization.
M. Grimmler, Simon Otter, Christoph Peter, F. Müller +2 more
2005Human Molecular Genetics88 citations Open access
Semantic Scholar
The role of RNP biogenesis in spinal muscular atrophy.
A. Chari, E. Paknia, U. Fischer
2009Current Opinion in Cell Biology87 citations
Semantic Scholar
ProteoPlex - stability optimization of macromolecular complexes by sparse-matrix screening of chemical space
A. Chari, D. Haselbach, J. Kirves, Juergen Ohmer +15 more
2015Nature Methods83 citations Open access
Semantic Scholar
Gene targeting of Gemin2 in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death
S. Jablonka, B. Holtmann, G. Meister, M. Bandilla +3 more
2002Proceedings of the National Academy of Sciences of the United States of America82 citations Open access
Semantic Scholar
SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy.
K. See, Preeti Yadav, Marieke Giegerich, P. S. Cheong +7 more
2014Human Molecular Genetics81 citations
Semantic Scholar
A stimulatory role for the La-related protein 4B in translation.
Katrin Schäffler, Kristin Schulz, Anja Hirmer, J. Wiesner +3 more
2010RNA: A publication of the RNA Society72 citations Open access
Semantic Scholar
Phosphorylation regulates the activity of the SMN complex during assembly of spliceosomal U snRNPs
M. Grimmler, Liane Bauer, M. Nousiainen, R. Körner +2 more
2005EMBO Reports72 citations Open access
Semantic Scholar
Systemic splicing factor deficiency causes tissue-specific defects: a zebrafish model for retinitis pigmentosa.
Bastian Linder, Holger Dill, Anja Hirmer, J. Brocher +6 more
2011Human Molecular Genetics68 citations Open access
Semantic Scholar
Epstein-Barr Virus Nuclear Antigen 2 Binds via Its Methylated Arginine-Glycine Repeat to the Survival Motor Neuron Protein
S. Barth, M. Liss, M. D. Voss, T. Dobner +3 more
2003Journal of Virology67 citations Open access
Semantic Scholar
The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness.
Daniele Hasler, R. Meduri, Maciej Bak, G. Lehmann +14 more
2020Molecules and Cells65 citations
Semantic Scholar
Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cγ governs Cajal body localization and stability of the SMN complex
Sebastian Petri, M. Grimmler, S. Over, U. Fischer +1 more
2007Journal of Cell Biology62 citations Open access
Semantic Scholar
LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice.
Xin Wang, Zhi-Tong Li, Yue Yan, Peng-Hui Lin +16 more
2020Molecules and Cells60 citations Open access
Semantic Scholar
Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization
Nils Neuenkirchen, Clemens Englbrecht, Jürgen Ohmer, Thomas Ziegenhals +2 more
2015EMBO Journal58 citations Open access
Semantic Scholar
Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes.
C. Grimm, H. S. Hillen, K. Bedenk, J. Bartuli +11 more
2019Cell57 citations Open access
Semantic Scholar
UsnRNP biogenesis: mechanisms and regulation
O. Gruss, R. Meduri, Maximilian T. Schilling, U. Fischer
2017Chromosoma56 citations
Semantic Scholar
Selective inhibition of miRNA processing by a herpesvirus-encoded miRNA
Thomas Hennig, A. Prusty, B. Kaufer, Adam W. Whisnant +15 more
2022Nature55 citations Open access
Semantic Scholar
Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes.
H. S. Hillen, J. Bartuli, C. Grimm, C. Dienemann +4 more
2019Cell55 citations Open access
Semantic Scholar
Mutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa
Jun Yin, J. Brocher, U. Fischer, C. Winkler
2011Molecular Neurodegeneration54 citations Open access
Semantic Scholar
LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation
M. Küspert, Yasuhiro Murakawa, Katrin Schäffler, J. Vanselow +5 more
2015RNA: A publication of the RNA Society48 citations Open access
Semantic Scholar
The 1D4 antibody labels outer segments of long double cone but not rod photoreceptors in zebrafish.
Jun Yin, J. Brocher, Bastian Linder, Anja Hirmer +3 more
2012Investigative Ophthalmology and Visual Science48 citations
Semantic Scholar
Cellular strategies for the assembly of molecular machines.
A. Chari, U. Fischer
2010TIBS -Trends in Biochemical Sciences. Regular ed47 citations
Semantic Scholar
Phylogenetic relationships ofBacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase β-subunit genes
Wolfgang Ludwig, J. Neumaier, Norbert Klugbauer, E. Brockmann +8 more
2004Antonie van Leeuwenhoek46 citations
Semantic Scholar
Identification of a PRPF4 Loss-of-Function Variant That Abrogates U4/U6.U5 Tri-snRNP Integration and Is Associated with Retinitis Pigmentosa
Bastian Linder, Anja Hirmer, A. Gal, K. Rüther +4 more
2014PLoS ONE45 citations Open access
Semantic Scholar
Mutations in SNRPE, which encodes a core protein of the spliceosome, cause autosomal-dominant hypotrichosis simplex.
Sandra M. Pasternack, M. Refke, E. Paknia, H. Hennies +12 more
2013American Journal of Human Genetics45 citations Open access
Semantic Scholar
MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts.
D. Papadopoulos, Daniel Solvie, Apoorva Baluapuri, Theresa Endres +13 more
2021Molecules and Cells44 citations Open access
Semantic Scholar
LSm1-7 complexes bind to specific sites in viral RNA genomes and regulate their translation and replication.
R. P. Galão, A. Chari, Isabel Alves-Rodrigues, D. Lobão +4 more
2010RNA: A publication of the RNA Society44 citations Open access
Semantic Scholar
Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I.
G. Martin, A. Ostareck-Lederer, A. Chari, Nils Neuenkirchen +5 more
2010RNA: A publication of the RNA Society38 citations Open access
Semantic Scholar

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