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R. Sprangers · SciRah

Researcher profile · Semantic Scholar

R. Sprangers

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R. Sprangers — researcher profile on SciRah

h-index: 33
Works: 85
Citations: 4,478

Most-cited papers

Quantitative dynamics and binding studies of the 20S proteasome by NMR
R. Sprangers, L. Kay
2007Nature516 citations
Semantic Scholar
SMN Tudor domain structure and its interaction with the Sm proteins
P. Selenko, R. Sprangers, G. Stier, D. Bühler +2 more
2001Nature Structural Biology350 citations
Semantic Scholar
Structural Basis for Recognition of the Intron Branch Site RNA by Splicing Factor 1
Zhihong Liu, I. Luyten, M. Bottomley, A. C. Messias +5 more
2001Science264 citations Open access
Semantic Scholar
Dynamic Regulation of Archaeal Proteasome Gate Opening As Studied by TROSY NMR
T. Religa, R. Sprangers, L. Kay
2010Science241 citations
Semantic Scholar
Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP.
P. Selenko, G. Gregorovic, R. Sprangers, G. Stier +3 more
2003Molecules and Cells219 citations Open access
Semantic Scholar
Quantitative NMR spectroscopy of supramolecular complexes: dynamic side pores in ClpP are important for product release.
R. Sprangers, Anna Gribun, P. Hwang, W. Houry +1 more
2005Proceedings of the National Academy of Sciences of the United States of America192 citations Open access
Semantic Scholar
High-resolution X-ray and NMR structures of the SMN Tudor domain: conformational variation in the binding site for symmetrically dimethylated arginine residues.
R. Sprangers, M. Groves, I. Sinning, M. Sattler
2003Journal of Molecular Biology174 citations
Semantic Scholar
Solution NMR of supramolecular complexes: providing new insights into function
R. Sprangers, Algirdas Velyvis, L. Kay
2007Nature Methods167 citations
Semantic Scholar
Modulations of DNA Contacts by Linker Histones and Post-translational Modifications Determine the Mobility and Modifiability of Nucleosomal H3 Tails.
Alexandra Stützer, Stamatios Liokatis, Anja Kiesel, D. Schwarzer +4 more
2016Molecules and Cells130 citations Open access
Semantic Scholar
The ClpP Double Ring Tetradecameric Protease Exhibits Plastic Ring-Ring Interactions, and the N Termini of Its Subunits Form Flexible Loops That Are Essential for ClpXP and ClpAP Complex Formation*
Anna Gribun, M. Kimber, R. Ching, R. Sprangers +2 more
2005Journal of Biological Chemistry130 citations Open access
Semantic Scholar
Methyl TROSY spectroscopy: A versatile NMR approach to study challenging biological systems.
S. Schütz, R. Sprangers
2020Progress in nuclear magnetic resonance spectroscopy123 citations Open access
Semantic Scholar
Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma
X. Mao, X. Li, R. Sprangers, X. Wang +10 more
2009Leukemia122 citations Open access
Semantic Scholar
Probing side-chain dynamics in the proteasome by relaxation violated coherence transfer NMR spectroscopy.
V. Tugarinov, R. Sprangers, L. Kay
2007Journal of the American Chemical Society120 citations
Semantic Scholar
The structural basis of Edc3‐ and Scd6‐mediated activation of the Dcp1:Dcp2 mRNA decapping complex
S. Fromm, V. Truffault, Julia Kamenz, J. Braun +3 more
2011EMBO Journal118 citations Open access
Semantic Scholar
In Vitro Reconstitution of a Cellular Phase-Transition Process that Involves the mRNA Decapping Machinery
S. Fromm, Julia Kamenz, Erik R. Nöldeke, A. Neu +2 more
2014Angewandte Chemie103 citations Open access
Semantic Scholar
A general method for rapid and cost-efficient large-scale production of 5′ capped RNA
Anna-Lisa Fuchs, A. Neu, R. Sprangers
2016RNA: A publication of the RNA Society102 citations Open access
Semantic Scholar
Effect of noncompetitive proteasome inhibition on bortezomib resistance.
Xiaoming Li, Tabitha E. Wood, R. Sprangers, G. Jansen +19 more
2010Journal of the National Cancer Institute90 citations
Semantic Scholar
Refined solution structure of the c‐terminal DNA‐binding domain of human immunovirus‐1 integrase
A. Eijkelenboom, R. Sprangers, K. Hård, Ramon A. Puras Lutzke +3 more
1999Proteins: Structure, Function, and Bioinformatics90 citations
Semantic Scholar
A synergistic network of interactions promotes the formation of in vitro processing bodies and protects mRNA against decapping
S. Schütz, Erik R. Nöldeke, R. Sprangers
2017Nucleic Acids Research86 citations Open access
Semantic Scholar
TROSY-based NMR evidence for a novel class of 20S proteasome inhibitors.
R. Sprangers, Xiaoming Li, X. Mao, J. Rubinstein +2 more
2008Biochemistry81 citations
Semantic Scholar
Line narrowing in methyl-TROSY using zero-quantum 1H-13C NMR spectroscopy.
V. Tugarinov, R. Sprangers, L. Kay
2004Journal of the American Chemical Society81 citations
Semantic Scholar
NMR spectroscopy of soluble protein complexes at one mega-dalton and beyond.
A. Mainz, T. Religa, R. Sprangers, R. Linser +2 more
2013Angewandte Chemie79 citations
Semantic Scholar
Methyl groups as NMR probes for biomolecular interactions.
S. Wiesner, R. Sprangers
2015Current Opinion in Structural Biology71 citations Open access
Semantic Scholar
Experimental approaches for NMR studies of side-chain dynamics in high-molecular-weight proteins.
D. Sheppard, R. Sprangers, V. Tugarinov
2010Progress in nuclear magnetic resonance spectroscopy67 citations
Semantic Scholar
Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme
J. Wurm, I. Holdermann, J. H. Overbeck, Philipp H. O. Mayer +1 more
2017Proceedings of the National Academy of Sciences of the United States of America43 citations Open access
Semantic Scholar
Solid-state NMR H-N-(C)-H and H-N-C-C 3D/4D correlation experiments for resonance assignment of large proteins
H. Fraga, Charles-Adrien Arnaud, Diego F. Gauto, Maxime Audin +8 more
2017ChemPhysChem41 citations Open access
Semantic Scholar
Probing supramolecular structure from measurement of methyl (1)H-(13)C residual dipolar couplings.
R. Sprangers, L. Kay
2007Journal of the American Chemical Society41 citations
Semantic Scholar
Dcp2: an mRNA decapping enzyme that adopts many different shapes and forms
J. Wurm, R. Sprangers
2019Current Opinion in Structural Biology37 citations Open access
Semantic Scholar
A suite of 19F based relaxation dispersion experiments to assess biomolecular motions
Jan Overbeck, W. Kremer, R. Sprangers
2020Journal of Biomolecular NMR36 citations Open access
Semantic Scholar
Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX
Guillaume Thibault, Jovana Yudin, Philip G. Wong, V. Tsitrin +3 more
2006Proceedings of the National Academy of Sciences of the United States of America36 citations Open access
Semantic Scholar
Dynamic effects on j-couplings across hydrogen bonds in proteins.
P. Markwick, R. Sprangers, M. Sattler
2003Journal of the American Chemical Society36 citations
Semantic Scholar
Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy
Reinier Damman, S. Schütz, Yanzhang Luo, M. Weingarth +2 more
2019Nature Communications35 citations Open access
Semantic Scholar
Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex
J. Wurm, S. Sung, A. Kneuttinger, Enrico Hupfeld +3 more
2021Nature Communications34 citations Open access
Semantic Scholar
Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix
J. B. Heim, Edwin J. Squirewell, A. Neu, G. Zocher +17 more
2017Proceedings of the National Academy of Sciences of the United States of America30 citations Open access
Semantic Scholar
LEGO-NMR Spectroscopy: A Method to Visualize Individual Subunits in Large Heteromeric Complexes
M. Mund, Jan Overbeck, Jan Ullmann, R. Sprangers
2013Angewandte Chemie29 citations Open access
Semantic Scholar
The Archaeal Exosome: Identification and Quantification of Site-Specific Motions That Correlate with Cap and RNA Binding
Maxime Audin, G. Dorn, S. Fromm, K. Reiss +3 more
2013Angewandte Chemie28 citations Open access
Semantic Scholar
The S. pombe mRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface
J. Wurm, Jan Overbeck, R. Sprangers
2016RNA: A publication of the RNA Society27 citations Open access
Semantic Scholar
An excess of catalytically required motions inhibits the scavenger decapping enzyme
A. Neu, U. Neu, Anna-Lisa Fuchs, Benjamin Schlager +1 more
2015Nature Chemical Biology26 citations Open access
Semantic Scholar
Refinement of the protein backbone angle ψ in NMR structure calculations
R. Sprangers, Matthew J. Bottomley, J. Linge, J. Schultz +2 more
2000Journal of Biomolecular NMR24 citations
Semantic Scholar
Structural basis for the activation of the DEAD-box RNA helicase DbpA by the nascent ribosome
J. Wurm, Katarzyna Glowacz, R. Sprangers
2021Proceedings of the National Academy of Sciences of the United States of America21 citations Open access
Semantic Scholar
The Rrp4-exosome complex recruits and channels substrate RNA by a unique mechanism
M. Cvetkovic, J. Wurm, Maxime Audin, S. Schütz +1 more
2017Nature Chemical Biology21 citations Open access
Semantic Scholar
Conformational Modulation of a Mobile Loop Controls Catalysis in the (βα)8-Barrel Enzyme of Histidine Biosynthesis HisF
Enrico Hupfeld, S. Schlee, J. Wurm, C. Rajendran +6 more
2024bioRxiv20 citations Open access
Semantic Scholar
Multi‐Site Conformational Exchange in the Synthetic Neomycin‐Sensing Riboswitch Studied by 19F NMR
J. H. Overbeck, Jennifer Vögele, Felix Nussbaumer, E. Duchardt-Ferner +3 more
2023Angewandte Chemie20 citations Open access
Semantic Scholar
The oligomeric architecture of the archaeal exosome is important for processive and efficient RNA degradation
Maxime Audin, J. Wurm, M. Cvetkovic, R. Sprangers
2016Nucleic Acids Research20 citations Open access
Semantic Scholar
Observation of conformational changes that underlie the catalytic cycle of Xrn2
J. H. Overbeck, D. Stelzig, Anna-Lisa Fuchs, J. Wurm +1 more
2022Nature Chemical Biology19 citations Open access
Semantic Scholar
Definition of domain boundaries and crystallization of the SMN Tudor domain.
R. Sprangers, P. Selenko, M. Sattler, I. Sinning +1 more
2003Acta Crystallographica Section D: Biological Crystallography19 citations
Semantic Scholar
Structure of the LSm657 complex: an assembly intermediate of the LSm1-7 and LSm2-8 rings.
M. Mund, A. Neu, Jan Ullmann, U. Neu +1 more
2011Journal of Molecular Biology18 citations
Semantic Scholar
Assessing the applicability of 19F labeled tryptophan residues to quantify protein dynamics
Christina Krempl, R. Sprangers
2023Journal of Biomolecular NMR17 citations Open access
Semantic Scholar
Molecular basis of the selective processing of short mRNA substrates by the DcpS mRNA decapping enzyme
Anna-Lisa Fuchs, J. Wurm, A. Neu, R. Sprangers
2020Proceedings of the National Academy of Sciences of the United States of America17 citations Open access
Semantic Scholar
Local structure and anisotropic backbone dynamics from cross-correlated NMR relaxation in proteins.
P. Markwick, R. Sprangers, M. Sattler
2005Angewandte Chemie12 citations
Semantic Scholar

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