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W. Mangel · SciRah

Researcher profile · Semantic Scholar

W. Mangel

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W. Mangel — researcher profile on SciRah

h-index: 28
Works: 82
Citations: 2,528

Most-cited papers

Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease.
K. Orth, Zhaohui Xu, M. Mudgett, Zhao-Qin Bao +5 more
2000Science565 citations
Semantic Scholar
Viral DNA and a viral peptide can act as cofactors of adenovirus virion proteinase activity
W. Mangel, W. Mcgrath, D. L. Toledo, C. W. Anderson
1993Nature181 citations
Semantic Scholar
Structure, Function and Dynamics in Adenovirus Maturation
W. Mangel, Carmen San Martín
2014Viruses128 citations Open access
Semantic Scholar
Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor.
Jian-Zhong Ding, W. Mcgrath, R. Sweet, W. Mangel
1996EMBO Journal127 citations Open access
Semantic Scholar
Studies of the binding of Escherichia coli RNA polymerase to DNA. IV. The effect of rifampicin on binding and on RNA chain initiation.
D. C. Hinkle, W. Mangel, M. Chamberlin
1972Journal of Molecular Biology101 citations
Semantic Scholar
The hydrolytic water molecule in trypsin, revealed by time-resolved Laue crystallography
P. Singer, A. Smalås, R. Carty, W. Mangel +1 more
1993Science88 citations
Semantic Scholar
Structure and uncoating of immature adenovirus
A. Perez-Berna, R. Marabini, S. Scheres, Rosa Menéndez-Conejero +5 more
2009Journal of Molecular Biology80 citations Open access
Semantic Scholar
Studies of ribonucleic acid chain initiation by Escherichia coli ribonucleic acid polymerase bound to T7 deoxyribonucleic acid. I. An assay for the rate and extent of ribonucleic acid chain initiation.
W. Mangel, M. Chamberlin
1974Journal of Biological Chemistry78 citations Open access
Semantic Scholar
SARS CoV main proteinase: The monomer-dimer equilibrium dissociation constant.
V. Graziano, W. Mcgrath, Lin Yang, W. Mangel
2006Biochemistry67 citations
Semantic Scholar
Studies of ribonucleic acid chain initiation by Escherichia coli ribonucleic acid polymerase bound to T7 deoxyribonucleic acid. 3. The effect of temperature on ribonucleic acid chain initiation and on the conformation of binary complexes.
W. Mangel, Michael J. Chamberlin
1974Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Characterization of Three Components of Human Adenovirus Proteinase Activity in Vitro(*)
W. Mangel, D. L. Toledo, Mark T. Brown, Jerri H. Martin +1 more
1996Journal of Biological Chemistry60 citations Open access
Semantic Scholar
Complete nucleotide sequence and deduced amino acid sequence of the ompT gene of Escherichia coli K-12.
Jennifer Grodberg, Michael D. Lundrigan, D. L. Toledo, W. Mangel +1 more
1988Nucleic Acids Research55 citations Open access
Semantic Scholar
Flow cytometric analysis of protease activities in vital cells.
Gregor Rothe, S. Klingel, I. Assfalg-Machleidt, W. Machleidt +4 more
1992Biological Chemistry Hoppe-Seyler49 citations
Semantic Scholar
Studies of ribonucleic acid chain initiation by Escherichia coli ribonucleic acid polymerase bound to T7 deoxyribonucleic acid. II. The effect of alterations in ionic strength of chain initiation and on the conformation of binary complexes.
W. Mangel, Michael J. Chamberlin
1974Journal of Biological Chemistry49 citations Open access
Semantic Scholar
PHOTOSENSITIZATION BY PORPHYRINS DELIVERED TO L CELL FIBROBLASTS BY HUMAN SERUM LOW DENSITY LIPOPROTEINS. A MICROSPECTROFLUOROMETRIC STUDY
Patrice Morlière, E. Kohen, J. P. Reyftmann, R. Santus +5 more
1987Photochemistry and Photobiology48 citations
Semantic Scholar
Processing of the L1 52/55k Protein by the Adenovirus Protease: a New Substrate and New Insights into Virion Maturation
A. Perez-Berna, W. Mangel, W. Mcgrath, V. Graziano +2 more
2013Journal of Virology46 citations Open access
Semantic Scholar
Structure of an acyl-enzyme intermediate during catalysis: (guanidinobenzoyl)trypsin.
W. Mangel, P. Singer, D. Cyr, T. Umland +4 more
1990Biochemistry44 citations
Semantic Scholar
Membrane permeable fluorogenic rhodamine substrates for selective determination of cathepsin L.
I. Assfalg-Machleidt, G. Rothe, S. Klingel, R. Banati +3 more
1992Biological Chemistry Hoppe-Seyler41 citations
Semantic Scholar
Crystallographic structure at 1.6-A resolution of the human adenovirus proteinase in a covalent complex with its 11-amino-acid peptide cofactor: insights on a new fold.
W. Mcgrath, Jian-Zhong Ding, Aashish K. Didwania, R. Sweet +1 more
2003Biochimica et Biophysica Acta40 citations
Semantic Scholar
Interaction of the human adenovirus proteinase with its 11-amino acid cofactor pVIc.
M. Baniecki, William J. Mcgrath, Sarah M. McWhirter, Caroline M. Li +5 more
2001Biochemistry38 citations Open access
Semantic Scholar
Location of the sequences coding for capsid proteins VP1 and VP2 on polyoma virus DNA.
Alan E. Smith, R. Kamen, W. Mangel, H. Shure +1 more
1976Cell38 citations
Semantic Scholar
Characterization of human adenovirus proteinase activity in disrupted virus particles.
William J. Mcgrath, A. Abola, D. L. Toledo, Mark T. Brown +1 more
1996Virology37 citations Open access
Semantic Scholar
Enzymatic activity of the SARS coronavirus main proteinase dimer
V. Graziano, W. Mcgrath, Ann Marie DeGruccio, J. Dunn +1 more
2006FEBS Letters36 citations Open access
Semantic Scholar
DNA Binding Provides a Molecular Strap Activating the Adenovirus Proteinase*S
Sayan Gupta, W. Mangel, W. Mcgrath, Jennifer L Perek +3 more
2004Molecular & Cellular Proteomics34 citations Open access
Semantic Scholar
P guanidino benzoic acid esters of fluorescein as active site titrants of serine proteases
L. Melhado, S. Peltz, S. P. Leytus, W. Mangel
198234 citations
Semantic Scholar
Structure of alpha 2-macroglobulin from the arthropod Limulus polyphemus.
Peter Armstrong, W. Mangel, J. Wall, J. F. Hainfield +3 more
1991Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Nitric oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo
W. Cao, M. Baniecki, William J. Mcgrath, C. Bao +4 more
2003The FASEB Journal30 citations
Semantic Scholar
Actin Can Act as a Cofactor for a Viral Proteinase in the Cleavage of the Cytoskeleton*
Mark T. Brown, Kevin M. McBride, M. Baniecki, N. Reich +2 more
2002Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Nonisotopic DNA detection system employing elastase and fluorogenic rhodamine substrate.
A. F. Johnson, M. Struthers, Keith B. Pierson, W. Mangel +1 more
1993Analytical Chemistry23 citations
Semantic Scholar
Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA
W. Mangel, W. Mcgrath, Kan Xiong, V. Graziano +1 more
2016Nature Communications22 citations Open access
Semantic Scholar
Single-molecule imaging at high fluorophore concentrations by local activation of dye.
H. Geertsema, A. C. Schulte, L. Spenkelink, W. Mcgrath +5 more
2015Biophysical Journal21 citations Open access
Semantic Scholar
Plasminogen activators in human breast cancer cell lines: hormonal regulation and properties.
W. Mangel, D. L. Toledo, A. Nardulli, Georg C. A. Reiner +2 more
1988Journal of Steroid Biochemistry19 citations
Semantic Scholar
Initial steps in the large-scale purification of Escherichia coli deoxyribonucleic acid-dependent ribonucleic acid polymerase.
W. Mangel
1974Archives of Biochemistry and Biophysics17 citations
Semantic Scholar
P-GUANIDINOBENZOIC ACID ESTERS OF FLUORESCEIN AS ACTIVE-SITE TITRANTS OF SERINE PROTEASES
L. Melhado, S. Peltz, S. P. Leytus, W. Mangel
198314 citations
Semantic Scholar
Interaction of the adenovirus proteinase with protein cofactors with high negative charge densities.
Neil S Bajpayee, W. Mcgrath, W. Mangel
2005Biochemistry13 citations
Semantic Scholar
In the virion, the 11-amino-acid peptide cofactor pVIc is covalently linked to the adenovirus proteinase.
W. Mcgrath, Katharine S. Aherne, W. Mangel
2002Virology13 citations Open access
Semantic Scholar
An in situ study of beta‐glucosidase activity in normal and gaucher fibroblasts with fluorogenic probes
E. Kohen, C. Kohen, J. Hirschberg, R. Santus +4 more
1993Cell Biochemistry and Function13 citations
Semantic Scholar
Better reception for urokinase
W. Mangel
1990Nature11 citations
Semantic Scholar
A new form of antiviral combination therapy predicted to prevent resistance from arising, and a model system to test it.
W. Mangel, W. Mcgrath, M. T. Brown, M. Baniecki +2 more
2001Current Medicinal Chemistry10 citations
Semantic Scholar
Preparation and crystallization of a complex between human adenovirus serotype 2 proteinase and its 11-amino-acid cofactor pVIc.
William J. Mcgrath, Jian-Zhong Ding, R. M. Sweet, W. Mangel
1996Journal of Structural Biology9 citations
Semantic Scholar
Evidence for the functional similarity between tumour cell surface guanidinobenzoatase and tissue type plasminogen activator.
Frank S. Steven, M. Griffin, S. Cederholm-Williams, W. Mangel +1 more
1991Anticancer Research9 citations
Semantic Scholar
A MICROSPECTROFLUOROMETRIC STUDY OF PORPHYRIN‐PHOTOSENSITIZED SINGLE LIVING CELLS—II. METABOLIC ALTERATIONS
E. Kohen, J. P. Reyftmann, P. Morliére, R. Santus +4 more
1986Photochemistry and Photobiology9 citations
Semantic Scholar
Polyoma virus complementary RNA directs the in vitro synthesis of capsid proteins VP1 and VP2
W. Mangel, R. Hewick, S. T. Bayley, T. Wheeler +3 more
1978Journal of Virology9 citations Open access
Semantic Scholar
Inhibition of guanidinobenzoatase by a substrate for trypsin-like enzymes.
Frank S. Steven, M. Griffin, W. Mangel, H. Maier +1 more
1988Journal of enzyme inhibition (Print)8 citations
Semantic Scholar
Modulation of cell-associated plasminogen activator activity by cocultivation of a stem cell and its tumorigenic descendant
H.-Y. Liu, P.-P. Yang, D. L. Toledo, W. Mangel
1984Molecular and Cellular Biology8 citations Open access
Semantic Scholar
Speeding up biomolecular interactions by molecular sledding
Alexander Turkin, Lei Zhang, A. Marcozzi, W. Mangel +2 more
2015Chemical Science7 citations Open access
Semantic Scholar
Laue diffraction as a tool in dynamic studies: hydrolysis of a transiently stable intermediate in catalysis by trypsin
P. Singer, R. Carty, L. Berman, I. Schlichting +6 more
1992Philosophical Transactions of the Royal Society of London Series A Physical and Engineering Sciences7 citations Open access
Semantic Scholar
Regulation of a Viral Proteinase by a Peptide and DNA in One-dimensional Space
V. Graziano, W. Mcgrath, M. Suomalainen, U. Greber +5 more
2012Journal of Biological Chemistry6 citations Open access
Semantic Scholar
Studies on the activity of a protease associated with cells at the advancing edge of human tumour masses in frozen sections.
Frank S. Steven, M. Griffin, H. Maier, H. Weidauer +2 more
1988British Journal of Cancer6 citations Open access
Semantic Scholar
Modulation of the Plasminogen Activator Activity of a Transformed Cell Line by Cell Density
Ho-Yuan Liu, S. Peltz, W. Mangel
1982Molecular and Cellular Biology6 citations Open access
Semantic Scholar

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D. L. Toledo×8
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