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V. Flemington · SciRah

Researcher profile · Semantic Scholar

V. Flemington

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V. Flemington — researcher profile on SciRah

h-index: 10
Works: 22
Citations: 793

Most-cited papers

Challenges and Opportunities in Cancer Drug Resistance.
R. Ward, S. Fawell, Nicolas Floc’h, V. Flemington +2 more
2020Chemical Reviews368 citations
Semantic Scholar
Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2.
R. Ward, N. Colclough, Mairi Challinor, J. Debreczeni +16 more
2015Journal of Medicinal Chemistry97 citations Open access
Semantic Scholar
Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors
Matthew J. Sale, Emma Minihane, N. Monks, Rebecca Gilley +14 more
2019Nature Communications70 citations Open access
Semantic Scholar
Discovery of a potent and selective oral inhibitor of ERK1/2 (AZD0364) that is efficacious in both monotherapy and combination therapy in models of non-small cell lung cancer (NSCLC).
R. Ward, M. Anderton, Paul A. Bethel, J. Breed +34 more
2019Journal of Medicinal Chemistry59 citations Open access
Semantic Scholar
Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells
M. King, I. Ganley, V. Flemington
2016Oncogene57 citations Open access
Semantic Scholar
Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
R. Ward, Paul A. Bethel, C. Cook, E. Davies +25 more
2017Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- but not β-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation.
M. Waring, D. Andrews, P. Faulder, V. Flemington +12 more
2014Chemical Communications30 citations Open access
Semantic Scholar
A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models
Dharaminder Singh, Sudhir P. Deosarkar, E. Cadogan, V. Flemington +18 more
2022PLoS Biology23 citations Open access
Semantic Scholar
AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib
V. Flemington, E. Davies, David M Robinson, Linda C. Sandin +26 more
2020Molecular Cancer Therapeutics18 citations
Semantic Scholar
Identification and optimization of a novel series of selective PIP5K inhibitors.
D. Andrews, Sharon Cartic, S. Cosulich, N. Divecha +14 more
2021Bioorganic & Medicinal Chemistry10 citations Open access
Semantic Scholar
High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS.
Mohamed Ismail, Gareth Davies, Graham Sproat, Tiziana Monteverde +12 more
2024SLAS discovery : advancing life sciences R & D6 citations Open access
Semantic Scholar
Development of isotope-enriched phosphatidylinositol-4- and 5-phosphate cellular mass spectrometry probes
Amélie M Joffrin, A. Saunders, D. Barneda, V. Flemington +3 more
2020Chemical Science4 citations Open access
Semantic Scholar
AZ14289671 is a highly selective and blood-brain barrier penetrant irreversible TKI that targets EGFRExon20 insertions
Aisha M Swaih, Sara Talbot, Adriana Savoca, H. Thorpe +20 more
2025Cell Reports Medicine1 citations Open access
Semantic Scholar
Abstract 1647: Discovery of AZD0364, a potent and selective oral inhibitor of ERK1/2 that is efficacious in both monotherapy and combination therapy in models of NSCLC
Iain Simpson, Mark J. Anderton, D. Andrews, J. Breed +18 more
2018Cancer Chemistry1 citations
Semantic Scholar
Abstract 2228: Phosphatidylinositol-4-kinase - Potent and selective inhibitors of PI4Kα and PI4Kβ.
M. Waring, D. Cross, D. Andrews, V. Flemington +7 more
20131 citations
Semantic Scholar
Abstract 1856: Combination of the novel ERK inhibitor AZD0364 with the MEK inhibitor selumetinib significantly enhances antitumor activity in KRAS mutant tumor models
V. Flemington, Iain Simpson, J. Breed, E. Davies +12 more
2018Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 4913: A PK/PD model quantitatively describes inhibition and down-regulation of p90RSK by ERK inhibitor AZD0364
F. Gibbons, Linda C. Sandin, Lyndsey Hanson, R. Whiteley +5 more
2018Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract B156: Discovery and characterization of AZ6197, a potent and selective ERK1/2 inhibitor
V. Flemington, Iain Simpson, E. Davies, David M Robinson +6 more
20180 citations
Semantic Scholar
Human Erk2 with an Erk1/2 inhibitor
J. Debreczeni, R. Ward, Paul A. Bethel, C. Cook +21 more
20170 citations
Semantic Scholar
Human ERK2 in complex with an inhibitor
R. Ward, N. Colclough, Mairi Challinor, J. Debreczeni +16 more
20150 citations
Semantic Scholar
Human ERK2 in complex with an irreversible inhibitor
R. Ward, N. Colclough, Mairi Challinor, J. Debreczeni +16 more
20150 citations
Semantic Scholar
275 Modulation of PIP2 levels through small molecule inhibition of PIP5K
D. Andrews, S. Cosulich, N. Divecha, D. Fitzgerald +16 more
20140 citations
Semantic Scholar

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