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K. Roberts · SciRah

Researcher profile · Semantic Scholar

K. Roberts

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K. Roberts — researcher profile on SciRah

h-index: 12
Works: 22
Citations: 561

Most-cited papers

The Brn-2 Transcription Factor Links Activated BRAF to Melanoma Proliferation
J. Goodall, C. Wellbrock, T. Dexter, K. Roberts +2 more
2004Molecular and Cellular Biology126 citations Open access
Semantic Scholar
Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2.
R. Ward, N. Colclough, Mairi Challinor, J. Debreczeni +16 more
2015Journal of Medicinal Chemistry97 citations Open access
Semantic Scholar
Discovery of a potent and selective oral inhibitor of ERK1/2 (AZD0364) that is efficacious in both monotherapy and combination therapy in models of non-small cell lung cancer (NSCLC).
R. Ward, M. Anderton, Paul A. Bethel, J. Breed +34 more
2019Journal of Medicinal Chemistry59 citations Open access
Semantic Scholar
Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
R. Ward, Paul A. Bethel, C. Cook, E. Davies +25 more
2017Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase.
R. Norman, A. Schott, D. Andrews, J. Breed +9 more
2012Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
ERK‐regulated differential expression of the Mitf 6a/b splicing isoforms in melanoma
Aline Primot, Ariane Mogha, Sébastien Corre, K. Roberts +8 more
2010Pigment Cell & Melanoma Research35 citations Open access
Semantic Scholar
Synthesis and pharmacological characterization of novel druglike corticotropin-releasing factor 1 antagonists.
R. Di Fabio, Y. St‐Denis, F. Sabbatini, D. Andreotti +24 more
2008Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
Phosphorylation of BRN2 Modulates Its Interaction with the Pax3 Promoter To Control Melanocyte Migration and Proliferation
Irina Berlin, L. Denat, Anne-Lise Steunou, I. Puig +10 more
2012Molecular and Cellular Biology31 citations Open access
Semantic Scholar
Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- but not β-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation.
M. Waring, D. Andrews, P. Faulder, V. Flemington +12 more
2014Chemical Communications30 citations Open access
Semantic Scholar
A Screening Assay Cascade to Identify and Characterize Novel Selective Estrogen Receptor Downregulators (SERDs)
R. Callis, A. Rabow, Michael Tonge, R. Bradbury +4 more
2015Journal of biomolecular screening29 citations Open access
Semantic Scholar
AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib
V. Flemington, E. Davies, David M Robinson, Linda C. Sandin +26 more
2020Molecular Cancer Therapeutics18 citations
Semantic Scholar
Synthesis and structure-activity relationship of new 1,5-dialkyl-1,5-benzodiazepines as cholecystokinin-2 receptor antagonists.
K. Roberts, A. Ursini, R. Barnaby, P. Cassarà +15 more
2011Bioorganic & Medicinal Chemistry12 citations Open access
Semantic Scholar
Abstract 1647: Discovery of AZD0364, a potent and selective oral inhibitor of ERK1/2 that is efficacious in both monotherapy and combination therapy in models of NSCLC
Iain Simpson, Mark J. Anderton, D. Andrews, J. Breed +18 more
2018Cancer Chemistry1 citations
Semantic Scholar
Selective targeting of non-centrosomal AURKA functions through use of a novel targeted protein degradation tool
Richard C Wang, A. Abdelbaki, C. Ascanelli, A. Fung +3 more
2020bioRxiv0 citations Open access
Semantic Scholar
Abstract 1856: Combination of the novel ERK inhibitor AZD0364 with the MEK inhibitor selumetinib significantly enhances antitumor activity in KRAS mutant tumor models
V. Flemington, Iain Simpson, J. Breed, E. Davies +12 more
2018Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract B156: Discovery and characterization of AZ6197, a potent and selective ERK1/2 inhibitor
V. Flemington, Iain Simpson, E. Davies, David M Robinson +6 more
20180 citations
Semantic Scholar
Human Erk2 with an Erk1/2 inhibitor
J. Debreczeni, R. Ward, Paul A. Bethel, C. Cook +21 more
20170 citations
Semantic Scholar
Human ERK2 in complex with an inhibitor
R. Ward, N. Colclough, Mairi Challinor, J. Debreczeni +16 more
20150 citations
Semantic Scholar
Human ERK2 in complex with an irreversible inhibitor
R. Ward, N. Colclough, Mairi Challinor, J. Debreczeni +16 more
20150 citations
Semantic Scholar
275 Modulation of PIP2 levels through small molecule inhibition of PIP5K
D. Andrews, S. Cosulich, N. Divecha, D. Fitzgerald +16 more
20140 citations
Semantic Scholar
Variation of Enzyme and Cellular Potency with Substituents R 1 , R 2 , and R 3 As Indicated
R. Norman, A. Schott, D. Andrews, J. Breed +9 more
20120 citations
Semantic Scholar
Regulation of melanocyte-specific transcription by the transcription factors BRN-2 and microphthalmia.
K. Roberts
19980 citations
Semantic Scholar

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