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E. Debold · SciRah

Researcher profile · Semantic Scholar

E. Debold

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E. Debold — researcher profile on SciRah

h-index: 24
Works: 102
Citations: 2,734

Most-cited papers

Validity of accelerometry for the assessment of moderate intensity physical activity in the field.
D. Hendelman, K. Miller, C. Baggett, E. Debold +1 more
2000Medicine & Science in Sports & Exercise839 citations Open access
Semantic Scholar
CALIBRATION OF THE COMPUTER SCIENCE AND APPLICATIONS, INC. (CSA) ACCELEROMETER 256
P. Freedson, J. Sirard, E. Debold, R. Pate +3 more
1997174 citations Open access
Semantic Scholar
Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay.
E. Debold, J. Schmitt, J. Patlak, Samantha Beck +4 more
2007American Journal of Physiology. Heart and Circulatory Physiology161 citations
Semantic Scholar
Fiber type and temperature dependence of inorganic phosphate: implications for fatigue.
E. Debold, H. Dave, R. Fitts
2004American Journal of Physiology - Cell Physiology128 citations
Semantic Scholar
Effect of low pH on single skeletal muscle myosin mechanics and kinetics.
E. Debold, Samantha Beck, D. Warshaw
2008American Journal of Physiology - Cell Physiology113 citations Open access
Semantic Scholar
Supplementary Information For “ Mechanical coupling between myosin molecules causes differences between ensemble and single molecule measurements ”
Sam Walcott, D. Warshaw, E. Debold
2012112 citations
Semantic Scholar
Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function
J. Schmitt, E. Debold, Ferhaan Ahmad, Amy Armstrong +7 more
2006Proceedings of the National Academy of Sciences of the United States of America100 citations Open access
Semantic Scholar
Muscle Fatigue from the Perspective of a Single Crossbridge.
E. Debold, R. Fitts, Christopher W. Sundberg, T. Nosek
2016Medicine & Science in Sports & Exercise99 citations Open access
Semantic Scholar
The depressive effect of Pi on the force-pCa relationship in skinned single muscle fibers is temperature dependent.
E. Debold, J. Romatowski, R. Fitts
2006American Journal of Physiology - Cell Physiology91 citations
Semantic Scholar
Slip sliding away: load-dependence of velocity generated by skeletal muscle myosin molecules in the laser trap.
E. Debold, J. Patlak, D. Warshaw
2005Biophysical Journal83 citations Open access
Semantic Scholar
Direct observation of phosphate inhibiting the force-generating capacity of a miniensemble of Myosin molecules.
E. Debold, Sam Walcott, Mike K. Woodward, Matthew A. Turner
2013Biophysical Journal74 citations Open access
Semantic Scholar
Recent Insights into Muscle Fatigue at the Cross-Bridge Level
E. Debold
2012Front. Physio.67 citations Open access
Semantic Scholar
Phosphate and acidosis act synergistically to depress peak power in rat muscle fibers.
C. R. Nelson, E. Debold, R. Fitts
2014American Journal of Physiology - Cell Physiology66 citations Open access
Semantic Scholar
Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro
E. Debold, W. Saber, Yaser Cheema, Carol S. Bookwalter +3 more
2009Journal of Molecular and Cellular Cardiology59 citations Open access
Semantic Scholar
Acidosis and Phosphate Directly Reduce Myosin’s Force-Generating Capacity Through Distinct Molecular Mechanisms
Mike K. Woodward, E. Debold
2018Frontiers in Physiology55 citations Open access
Semantic Scholar
Potential molecular mechanisms underlying muscle fatigue mediated by reactive oxygen and nitrogen species
E. Debold
2015Frontiers in Physiology55 citations Open access
Semantic Scholar
Phosphate enhances myosin-powered actin filament velocity under acidic conditions in a motility assay.
E. Debold, Matthew A. Turner, Jordan C. Stout, Sam Walcott
2011American Journal of Physiology. Regulatory Integrative and Comparative Physiology54 citations
Semantic Scholar
The effects of phosphate and acidosis on regulated thin-filament velocity in an in vitro motility assay.
E. Debold, Thomas J. Longyear, Matthew A. Turner
2012Journal of applied physiology44 citations
Semantic Scholar
Recent insights into the molecular basis of muscular fatigue.
E. Debold
2012Medicine & Science in Sports & Exercise41 citations Open access
Semantic Scholar
Magnesium Modulates Actin Binding and ADP Release in Myosin Motors*
Anja M. Swenson, Darshan V. Trivedi, A. Rauscher, Yuan Wang +5 more
2014Journal of Biological Chemistry35 citations Open access
Semantic Scholar
Acidosis affects muscle contraction by slowing the rates myosin attaches to and detaches from actin
K. Jarvis, Mike K. Woodward, E. Debold, Sam Walcott
2018Journal of Muscle Research and Cell Motility34 citations
Semantic Scholar
Active Self-Organization of Actin-Microtubule Composite Self-Propelled Rods
L. Farhadi, Carline Fermino Do Rosario, E. Debold, A. Baskaran +1 more
2018Frontiers of Physics31 citations Open access
Semantic Scholar
The molecular basis of thin filament activation: from single molecule to muscle
Thomas J. Longyear, Sam Walcott, E. Debold
2017Scientific Reports29 citations Open access
Semantic Scholar
Recent insights into the relative timing of myosin’s powerstroke and release of phosphate
E. Debold
2021Cytoskeleton24 citations Open access
Semantic Scholar
FRET and optical trapping reveal mechanisms of actin-activation of the power stroke and phosphate-release in myosin V.
Laura K. Gunther, John A. Rohde, Wanjian Tang, Joseph A. Cirilo +5 more
2020Journal of Biological Chemistry23 citations Open access
Semantic Scholar
New insights into the cellular and molecular mechanisms of skeletal muscle fatigue: The Marion J. Siegman Award Lectureships.
E. Debold, H. Westerblad
2024American Journal of Physiology - Cell Physiology20 citations
Semantic Scholar
Decreased Myofilament Calcium Sensitivity Plays a Significant Role in Muscle Fatigue
E. Debold
2016Exercise and sport sciences reviews16 citations
Semantic Scholar
Ca++-sensitizing mutations in troponin, P(i), and 2-deoxyATP alter the depressive effect of acidosis on regulated thin-filament velocity.
Thomas J. Longyear, Matthew A. Turner, Jonathan P. Davis, Joseph J. López +2 more
2014Journal of applied physiology13 citations Open access
Semantic Scholar
Faculty Opinions recommendation of Cryo-EM structure of the inhibited (10S) form of myosin II.
E. Debold
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature12 citations
Semantic Scholar
Cardiac Muscle Activation Blunted by a Mutation to the Regulatory Component, Troponin T*
Minae Kobayashi, E. Debold, Matthew A. Turner, Tomoyoshi Kobayashi
2013Journal of Biological Chemistry11 citations Open access
Semantic Scholar
Modeling Thick Filament Activation Suggests a Molecular Basis for Force Depression
Shuyue Liu, Christopher P. Marang, Mike K. Woodward, V. Joumaa +5 more
2023bioRxiv10 citations Open access
Semantic Scholar
Acidosis decreases the Ca++-sensitivity of thin filaments by preventing the first actomyosin interaction.
M. Unger, E. Debold
2019American Journal of Physiology - Cell Physiology10 citations
Semantic Scholar
Characterizing the concentration and load dependence of phosphate binding to rabbit fast skeletal actomyosin
Christopher P. Marang, Daniel J. Petersen, Brent D. Scott, Sam Walcott +1 more
2025Proceedings of the National Academy of Sciences of the United States of America9 citations Open access
Semantic Scholar
A mutation in switch I alters the load-dependent kinetics of myosin Va
Christopher P. Marang, Brent D. Scott, J. Chambers, Laura K. Gunther +2 more
2023Nature Communications8 citations Open access
Semantic Scholar
A human skeletal muscle cross‐bridge model to characterize the role of metabolite accumulation in muscle fatigue
John I Hendry, M. Erol, G. Layec, E. Debold +3 more
2025Experimental Physiology6 citations Open access
Semantic Scholar
In defense of Huxley.
Sam Walcott, Sean X. Sun, E. Debold, Walter Herzog
2024Biophysical Journal6 citations Open access
Semantic Scholar
Cellular and molecular contractile function in aged human skeletal muscle is altered by phosphate and acidosis and partially reversed with an ATP analog
Aurora D Foster, Chad R. Straight, Philip C. Woods, Christopher Lee +4 more
2025American Journal of Physiology - Cell Physiology5 citations
Semantic Scholar
Modifications of myofilament protein phosphorylation and function in response to cardiac arrest induced in a swine model
Mike K. Woodward, M. Previs, T. Mader, E. Debold
2015Frontiers in Physiology5 citations Open access
Semantic Scholar
The order of things: phosphate release or the power stroke, which does actomyosin do first?
E. Debold, Christopher P. Marang, Brent D. Scott
2025Frontiers in Physiology4 citations
Semantic Scholar
FRET and optical trapping reveal mechanisms of actin activation of the power stroke and phosphate release in myosin V.
Laura K. Gunther, John A. Rohde, Wanjian Tang, Joseph A. Cirilo +5 more
2020Journal of Biological Chemistry4 citations Open access
Semantic Scholar
Skeletal Muscle Fatigue: Mechanisms And Mitigation At The Cellular And Molecular Levels In Older Adults
Aurora D Foster, C. Straight, E. Debold, Mark S. Miller
2019Medicine & Science in Sports & Exercise3 citations Open access
Semantic Scholar
VALIDATION OF ACCELEROMETRY TO ASSESS MODERATE INTENSITY PHYSICAL ACTIVITY IN THE FIELD
K. Miller, D. Hendelman, C. Baggett, E. Debold +1 more
19993 citations Open access
Semantic Scholar
Biological machines: Molecular motor teamwork.
E. Debold
2015Nature Nanotechnology2 citations
Semantic Scholar
Cross-bridge model-based quantification of muscle metabolite alterations leading to fatigue during all-out knee extension exercise
John I Hendry, M. Erol, G. Layec, E. Debold +2 more
2026Frontiers in Physiology1 citations Open access
Semantic Scholar
FRET and Optical Trapping Measurements Reveal Relationship between Phosphate Release and the Power Stroke in Myosin V
E. Debold, Laura K. Gunther, M. Unger, Brent D. Scott +2 more
20201 citations Open access
Semantic Scholar
Faculty Opinions recommendation of Acto-Myosin Cross-Bridge Stiffness Depends on the Nucleotide State of Myosin II.
E. Debold
2020Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature1 citations
Semantic Scholar
PREDICTION OF OXYGEN CONSUMPTION DURING TREADMILL EXERCISE IN CHILDREN AND ADOLESCENTS.
D. LaRoche, E. Debold, J. Sirard, D. Hendelman +1 more
19981 citations Open access
Semantic Scholar
BPS2026 – A slow myosin isoform makes gray squirrel jaw muscles fast or slow
Sam Walcott, Varun V. Dhorajia, Brandon P. Reder, Daniel Bartlett +5 more
2026Biophysical Journal0 citations
Semantic Scholar
Phosphate release from myosin Va occurs after the initial powerstroke but before the secondary powerstroke associated with ADP-release
Christopher P. Marang, Brent D. Scott, Christopher M. Yengo, E. Debold
2026Journal of Biological Chemistry0 citations Open access
Semantic Scholar
BPS2026 – MYO3A displays unique load-dependent detachment kinetics in a laser trap assay
Kayleigh J. Boos, Jing-Hua Ge, C. Yengo, E. Debold
2026Biophysical Journal0 citations
Semantic Scholar

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Brent D. Scott×8
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Brent D. Scott — researcher profile on SciRah
Sam Walcott×7
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Sam Walcott — researcher profile on SciRah
Christopher P. Marang×7
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D. Warshaw×6
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Mike K. Woodward×5

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Matthew A. Turner×5

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Matthew A. Turner — researcher profile on SciRah

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P. Freedson — researcher profile on SciRah

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R. Fitts — researcher profile on SciRah

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Laura K. Gunther — researcher profile on SciRah

D. Hendelman×3

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D. Hendelman — researcher profile on SciRah

Thomas J. Longyear×3

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