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C. Burgey · SciRah

Researcher profile · Semantic Scholar

C. Burgey

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C. Burgey — researcher profile on SciRah

h-index: 23
Works: 70
Citations: 2,217

Most-cited papers

C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Scope and Mechanism of Catalytic Enantioselective Aldol Additions of Enolsilanes to (Benzyloxy)acetaldehyde
D. Evans, M. Kozlowski, J. Murry, C. Burgey +3 more
1999272 citations
Semantic Scholar
C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Scope and Mechanism of the Catalytic Enantioselective Aldol Additions of Enolsilanes to Pyruvate Esters
D. Evans, C. Burgey, M. Kozlowski, Steven W. Tregay
1999176 citations
Semantic Scholar
Copper-facilitated Suzuki reactions: application to 2-heterocyclic boronates.
James Z. Deng, D. Paone, A. Ginnetti, H. Kurihara +4 more
2009Organic Letters166 citations
Semantic Scholar
Pharmacological Characterization of MK-0974 [N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of
C. Salvatore, J. C. Hershey, Halea A. Corcoran, John F. Fay +11 more
2008Journal of Pharmacology and Experimental Therapeutics146 citations
Semantic Scholar
Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974).
D. Paone, A. W. Shaw, Diem N. Nguyen, C. Burgey +12 more
2007Journal of Medicinal Chemistry136 citations Open access
Semantic Scholar
C2-SYMMETRIC COPPER(II) COMPLEXES AS CHIRAL LEWIS ACIDS. ENANTIOSELECTIVE CATALYSIS OF THE GLYOXYLATE-ENE REACTION
David A. Evans, C. Burgey, Nick A. Paras, T. Vojkovský +1 more
1998132 citations
Semantic Scholar
C2-SYMMETRIC COPPER(II) COMPLEXES AS CHIRAL LEWIS ACIDS. CATALYTIC ENANTIOSELECTIVE ALDOL ADDITIONS OF ENOLSILANES TO PYRUVATE ESTERS
D. Evans, M. Kozlowski, C. Burgey, D. W. C. MacMillan
1997122 citations
Semantic Scholar
C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Catalytic Enantioselective Carbonyl−Ene Reactions with Glyoxylate and Pyruvate Esters
D. Evans, Steven W. Tregay, C. Burgey, Nick A. Paras +1 more
2000119 citations
Semantic Scholar
Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.
C. Burgey, K. A. Robinson, T. Lyle, P. Sanderson +31 more
2003Journal of Medicinal Chemistry97 citations Open access
Semantic Scholar
Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene‒Related Peptide Receptor
E. L. Moore, Mark E. Fraley, I. M. Bell, C. Burgey +8 more
2020Journal of Pharmacology and Experimental Therapeutics71 citations Open access
Semantic Scholar
Reversal in enantioselectivity of tert-butyl versus phenyl-substituted bis(oxazoline) copper(II) catalyzed hetero Diels-Alder and ene reactions. Crystallographic and mechanistic studies
D. Evans, Jeffrey S. Johnson, C. Burgey, Kevin R. Campos
199969 citations
Semantic Scholar
Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.
B. Trotter, K. K. Nanda, C. Burgey, Craig M. Potteiger +16 more
2011Bioorganic & Medicinal Chemistry Letters56 citations Open access
Semantic Scholar
Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: optimization of the 4-substituted piperidine.
C. Burgey, Craig A. Stump, Diem N. Nguyen, James Z. Deng +11 more
2006Bioorganic & Medicinal Chemistry Letters49 citations Open access
Semantic Scholar
Synthesis of the (3R,6S)-3-amino-6-(2,3-difluorophenyl)azepan-2-one of telcagepant (MK-0974), a calcitonin gene-related peptide receptor antagonist for the treatment of migraine headache.
C. Burgey, D. Paone, A. W. Shaw, James Z. Deng +5 more
2008Organic Letters48 citations
Semantic Scholar
Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization.
James Z. Deng, D. McMasters, P. Rabbat, Peter D. Williams +10 more
2005Bioorganic & Medicinal Chemistry Letters40 citations Open access
Semantic Scholar
Carbohydrates to carbocycles: synthesis of the densely functionalized carbocyclic core of tetrodotoxin by radical cyclization of an anhydro sugar precursor
R. Alonso, C. Burgey, B. Rao, G. Vite +3 more
199336 citations
Semantic Scholar
Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins.
Rominder Singh, Maria V. Silva Elipe, P. Pearson, B. Arison +6 more
2003Chemical Research in Toxicology35 citations
Semantic Scholar
Caprolactams as potent CGRP receptor antagonists for the treatment of migraine.
A. W. Shaw, D. Paone, Diem N. Nguyen, Craig A. Stump +9 more
2007Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. Implementation of P3 pyridine N-oxides to deliver an orally bioavailable series containing P1 N-benzylamides.
C. Burgey, K. A. Robinson, T. Lyle, P. Nantermet +26 more
2003Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
Examining the binding properties of MK-0974: a CGRP receptor antagonist for the acute treatment of migraine.
E. L. Moore, C. Burgey, D. Paone, A. W. Shaw +3 more
2009European Journal of Pharmacology26 citations
Semantic Scholar
Armed/Disarmed Effects and Adamantyl Expansion of Some Caged Tricyclic Acetals en Route to Tetrodotoxin(1)(,)(2).
C. Burgey, R. Vollerthun, B. Fraser-Reid
1996Journal of Organic Chemistry25 citations
Semantic Scholar
Pharmacologic characterization of atogepant: A potent and selective calcitonin gene–related peptide receptor antagonist
Eric Moore, Ian M. Bell, Mark E. Fraley, C. Burgey +8 more
2024Cephalalgia23 citations Open access
Semantic Scholar
Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine.
Brendan M. Crowley, Craig A. Stump, Diem N. Nguyen, Craig M. Potteiger +21 more
2015Bioorganic & Medicinal Chemistry Letters23 citations
Semantic Scholar
Expanding the scope of the Cu assisted Suzuki–Miyaura reaction
Brendan M. Crowley, Craig M. Potteiger, James Z. Deng, Christopher K. Prier +2 more
201123 citations
Semantic Scholar
Decahydroquinoline amides as highly selective CB2 agonists: role of selectivity on in vivo efficacy in a rodent model of analgesia.
P. J. Manley, A. Zartman, D. Paone, C. Burgey +12 more
2011Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Nav1.7 target modulation and efficacy can be measured in nonhuman primate assays
R. Kraus, Fuqiang Zhao, Parul S. Pall, Dan Zhou +15 more
2021Science Translational Medicine19 citations
Semantic Scholar
Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: discovery of MK-2918.
D. Paone, Diem N. Nguyen, A. W. Shaw, C. Burgey +10 more
2011Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Mechanism of inhibition of human leucocyte elastase by beta-lactams. 3. Use of electrospray ionization mass spectrometry and two-dimensional NMR techniques to identify beta-lactam-derived E-I complexes.
D. Underwood, B. G. Green, R. Chabin, S. Mills +6 more
1995Biochemistry19 citations
Semantic Scholar
Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines.
C. Burgey, Craig M. Potteiger, James Z. Deng, S. Mosser +6 more
2009Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Carbohydrates to densely functionalized carbocycles: 'armed and disarmed' effects in an approach to tetrodotoxin
Bert Fraser-Reid, C. Burgey, Roland Vollerthun
199817 citations Open access
Semantic Scholar
Mechanism of inhibition of human leucocyte elastase by beta-lactams. 2. Stability, reactivation kinetics, and products of beta-lactam-derived E-I complexes.
B. G. Green, R. Chabin, S. Mills, D. Underwood +6 more
1995Biochemistry17 citations
Semantic Scholar
P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold.
P. Nantermet, C. Burgey, K. A. Robinson, J. M. Pellicore +19 more
2005Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
In vitro metabolism of a thrombin inhibitor and quantitation of metabolically generated cyanide.
C. Lin, B. Wong, C. Burgey, C. Gibson +1 more
2005Journal of Pharmaceutical and Biomedical Analysis15 citations
Semantic Scholar
Calcitonin gene-related peptide (CGRP) receptor antagonists: investigations of a pyridinone template.
Diem N. Nguyen, D. Paone, A. W. Shaw, C. Burgey +10 more
2008Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Armed/disarmed effects in the solvolysis of caged 1,6-anhydro pyranoses
C. Burgey, R. Vollerthun, B. Fraser-Reid
199413 citations
Semantic Scholar
Identification of second-generation P2X3 antagonists for treatment of pain.
A. Ginnetti, D. Paone, S. Stauffer, Craig M. Potteiger +21 more
2018Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Discovery of Arylsulfonamide Nav1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile.
A. J. Roecker, M. E. Layton, Joseph E. Pero, M. Kelly +16 more
2021ACS Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Lead Optimization of Cathepsin K Inhibitors for the Treatment of Osteoarthritis.
A. Ginnetti, D. Paone, K. K. Nanda, Jing Li +13 more
2022Bioorganic & Medicinal Chemistry Letters9 citations
Semantic Scholar
A novel and efficient synthesis of 2,5-substituted 1,2,4-triazol-3-ones
James Z. Deng, C. Burgey
20059 citations
Semantic Scholar
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain.
Gregory L. Adams, Parul S. Pall, Steven M. Grauer, Xiaoping Zhou +43 more
2021Journal of Medicinal Chemistry7 citations Open access
Semantic Scholar
Translational Pharmacokinetic–Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose
Jeanine E. Ballard, Parul S. Pall, Joshua D. Vardigan, Fuqiang Zhao +10 more
2021Frontiers in Pharmacology7 citations Open access
Semantic Scholar
Humanized NaV1.8 rats overcome cross-species potency shifts in developing novel NaV1.8 inhibitors
Dillon S. Mcdevitt, Joshua D. Vardigan, Xiaoping Zhou, Thomas W. Rosahl +13 more
2025Neurobiology of Pain5 citations Open access
Semantic Scholar
Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate
Jeanine E. Ballard, Parul S. Pall, Joshua D. Vardigan, Fuqiang Zhao +7 more
2020Pharmaceutical Research5 citations Open access
Semantic Scholar
Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve
Rebecca M Klein, M. E. Layton, H. Regan, C. Regan +18 more
2022Channels3 citations Open access
Semantic Scholar
Calcitonin gene-related peptide receptor antagonists for the treatment of migraine.
T. Williams, C. Burgey, C. Salvatore
2009Progress in Medicinal Chemistry3 citations
Semantic Scholar
C2‐Symmetric Copper(II) Complexes as Chiral Lewis Acids. Scope and Mechanism of the Catalytic Enantioselective Aldol Additions of Enolsilanes to Pyruvate Esters.
D. Evans, C. Burgey, M. Kozlowski, Steven W. Tregay
19992 citations
Semantic Scholar
Carbohydrates to Carbocycles: Synthesis of the Densely Functionalized Carbocyclic Core of Tetrodotoxin by Radical Cyclization of an Anhydro Sugar Precursor.
R. Alonso, C. Burgey, B.-V.-V. Rao, G. Vite +3 more
19932 citations
Semantic Scholar
Discovery of MK-5661, a Once-Daily Oral NaV1.8 Inhibitor for the Treatment of Pain.
C. J. Bungard, Michael J. Breslin, Christopher W. Boyce, H. Chobanian +16 more
2026ACS Medicinal Chemistry Letters1 citations Open access
Semantic Scholar
Invention of novel 3-aminopiperidin-2-ones as calcitonin gene-related peptide receptor antagonists.
D. Staas, Ian M. Bell, C. Burgey, James Z. Deng +18 more
2024Bioorganic & Medicinal Chemistry Letters0 citations Open access
Semantic Scholar
Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene-Related Peptide Receptor (P4.10-021)
Eric Moore, C. Burgey, Mark E. Fraley, A. Danziger +5 more
2019Neurology0 citations
Semantic Scholar

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