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D. Boothman · SciRah

Researcher profile · Semantic Scholar

D. Boothman

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D. Boothman — researcher profile on SciRah

h-index: 77
Works: 303
Citations: 17K

Most-cited papers

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases
Julio C. Morales, Long-Shan Li, F. Fattah, Ying Dong +4 more
2014Critical Reviews in Eukaryotic Gene Expression534 citations Open access
Semantic Scholar
Superparamagnetic Iron Oxide Nanoparticles: Amplifying ROS Stress to Improve Anticancer Drug Efficacy
Gang Huang, Huabing Chen, Ying Dong, Xiuquan Luo +5 more
2013Theranostics288 citations Open access
Semantic Scholar
Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition
Lei Jiang, Ling Xiao, Hidekazu Sugiura, Xiumei Huang +4 more
2014Oncogene210 citations Open access
Semantic Scholar
An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis
Xiumei Huang, Ying Dong, E. Bey, Jessica A. Kilgore +9 more
2012Cancer Research122 citations Open access
Semantic Scholar
XRN2 Links Transcription Termination to DNA Damage and Replication Stress
Julio C. Morales, Patricia Richard, Praveen L. Patidar, Edward A. Motea +3 more
2016PLoS Genetics116 citations Open access
Semantic Scholar
Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase (PARP) Inhibitors
Xiumei Huang, Edward A. Motea, Zachary R. Moore, Jun Yao +20 more
2016Cancer Cell112 citations Open access
Semantic Scholar
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone
G. Chakrabarti, Zachary R. Moore, Xiuquan Luo, Mariya Ilcheva +11 more
2015Cancer & Metabolism110 citations Open access
Semantic Scholar
Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy
Xin-Peng Ma, Xiumei Huang, Zachary R. Moore, Gang Huang +6 more
2014Journal of Controlled Release97 citations Open access
Semantic Scholar
Constitutive and ligand-induced EGFR signaling triggers distinct and mutually exclusive downstream signaling networks
Sharmistha Chakraborty, Li Li, V. Puliyappadamba, G. Guo +11 more
2014Nature Communications93 citations Open access
Semantic Scholar
Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis
David E. Gerber, M. Beg, F. Fattah, A. Frankel +16 more
2018British Journal of Cancer89 citations Open access
Semantic Scholar
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance
Xiaoguang Li, Zhi-Da Liu, An-Li Zhang, Chuan-Hui Han +7 more
2019Nature Communications86 citations Open access
Semantic Scholar
Focal Adhesion Kinase regulates the DNA damage response and its inhibition radiosensitizes mutant KRAS lung cancer
Ke-jing Tang, Jerfiz D. Constanzo, Niranjan Venkateswaran, M. Melegari +6 more
2016Clinical Cancer Research83 citations Open access
Semantic Scholar
Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers
E. Bey, Kathryn E. Reinicke, Melissa C. Srougi, M. Varnes +15 more
2013Molecular Cancer Therapeutics82 citations Open access
Semantic Scholar
The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism
Molly A. Silvers, S. Deja, N. Singh, Robert A. Egnatchik +7 more
2017Journal of Biological Chemistry80 citations Open access
Semantic Scholar
NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone
Zachary R. Moore, G. Chakrabarti, Xiang-Ping Luo, Aktar Ali +6 more
2015Cell Death and Disease79 citations Open access
Semantic Scholar
Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors
Yunfeng Yan, Ke-Jin Zhou, Hu Xiong, Jason B. Miller +4 more
2016Biomaterials67 citations Open access
Semantic Scholar
Synthesis and Antitumor Activity of Selenium-Containing Quinone-based Triazoles Possessing Two Redox Centres, and their Mechanistic Insights
Eduardo H. G. da Cruz, Molly A. Silvers, Guilherme A. M. Jardim, J. Resende +10 more
2016European journal of medicinal chemistry67 citations Open access
Semantic Scholar
The Mechanism of DAB2IP in Chemoresistance of Prostate Cancer Cells
Kai-Jie Wu, D. Xie, Yonglong Zou, Tingting Zhang +7 more
2013Clinical Cancer Research66 citations Open access
Semantic Scholar
Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone
G. Chakrabarti, Molly A. Silvers, Mariya Ilcheva, Yuliang Liu +11 more
2015Scientific Reports62 citations Open access
Semantic Scholar
Personalized Genome-Scale Metabolic Models Identify Targets of Redox Metabolism in Radiation-Resistant Tumors
Joshua E. Lewis, T. Forshaw, D. Boothman, C. Furdui +1 more
2020bioRxiv59 citations Open access
Semantic Scholar
Depleting tumor-NQO1 Potentiates Anoikis and Inhibits Growth of NSCLC
Brian Madajewski, Michael A. Boatman, G. Chakrabarti, D. Boothman +1 more
2015Molecular Cancer Research55 citations Open access
Semantic Scholar
ATM Regulates Insulin-Like Growth Factor 1-Secretory Clusterin (IGF-1-sCLU) Expression that Protects Cells against Senescence
Xiuquan Luo, Masatoshi Suzuki, S. Ghandhi, S. Amundson +1 more
2014PLoS ONE55 citations Open access
Semantic Scholar
NQO1-mediated tumor-selective lethality and radiosensitization for head and neck cancer
Long-Shan Li, S. Reddy, Zhen-Hua Lin, Shuangping Liu +10 more
2016Molecular Cancer Therapeutics46 citations Open access
Semantic Scholar
Phase 1 study of romidepsin plus erlotinib in advanced non-small cell lung cancer
D. Gerber, D. Boothman, F. Fattah, Ying Dong +10 more
2015Lung Cancer46 citations Open access
Semantic Scholar
Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair
Julio C. Morales, Patricia Richard, Amy Rommel, F. Fattah +9 more
2014Nucleic Acids Research46 citations Open access
Semantic Scholar
EGFR wild type antagonizes EGFRvIII-mediated activation of Met in glioblastoma
Li Li, V. Puliyappadamba, Sharmistha Chakraborty, A. Rehman +8 more
2013Oncogene44 citations Open access
Semantic Scholar
Opposing effect of EGFRwt on EGFRvIII-mediated NF-κB activation with RIP1 as a cell death switch
V. Puliyappadamba, Sharmistha Chakraborty, Sandili S. Chauncey, Li Li +7 more
2013Cell Reports44 citations Open access
Semantic Scholar
An EGFR wild type-EGFRvIII-HB-EGF feed forward loop regulates the activation of EGFRvIII
Li Li, Sharmistha Chakraborty, Chin-Rang Yang, K. Hatanpaa +14 more
2013Oncogene42 citations Open access
Semantic Scholar
Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone
L. Torrente, Nicolas Prieto-Farigua, Aimee Falzone, C. Elkins +3 more
2020Redox Biology41 citations Open access
Semantic Scholar
Fibulin-5 blocks microenvironmental ROS in pancreatic cancer
Miao Wang, M. Topalovski, Jason E. Toombs, Christopher M Wright +7 more
2015Cancer Research41 citations Open access
Semantic Scholar
The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability
F. Fattah, K. Hara, K. Fattah, Chenyi Yang +6 more
2014PLoS Genetics39 citations Open access
Semantic Scholar
Tumor-Selective, Futile Redox Cycle-Induced Bystander Effects Elicited by NQO1 Bioactivatable Radiosensitizing Drugs in Triple-Negative Breast Cancers
Lifen Cao, Long-Shan Li, C. Spruell, Ling Xiao +16 more
2014Antioxidants and Redox Signaling35 citations Open access
Semantic Scholar
Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in Pancreatic Cancer
M. Beg, Xiumei Huang, Molly A. Silvers, D. Gerber +9 more
2017Journal of Surgical Oncology34 citations Open access
Semantic Scholar
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone
G. Chakrabarti, Zachary R. Moore, Xiuquan Luo, Mariya Ilcheva +11 more
2015Cancer & Metabolism31 citations Open access
Semantic Scholar
NQO1-dependent, tumor-selective radiosensitization of non-small cell lung cancers
Edward A. Motea, Xiumei Huang, N. Singh, Jessica A. Kilgore +6 more
2019Clinical Cancer Research30 citations Open access
Semantic Scholar
Combinatorial therapy of Zinc metallochaperones with mutant p53 reactivation and diminished copper binding
Saif Zaman, Xin Yu, A. Bencivenga, A. Blanden +9 more
2019Molecular Cancer Therapeutics28 citations Open access
Semantic Scholar
Prodrug Strategy to Achieve Lyophilizable, High Drug Loading Micelle Formulations Through Diester Derivatives of β-Lapachone
Xin-Peng Ma, Xiumei Huang, Gang Huang, Long-Shan Li +4 more
2014Advanced Healthcare Materials27 citations Open access
Semantic Scholar
The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair
Praveen L. Patidar, Edward A. Motea, F. Fattah, Yun-Yun Zhou +4 more
2016Nucleic Acids Research26 citations Open access
Semantic Scholar
Targeting NAD+ metabolism to enhance radiation therapy responses
Joshua E. Lewis, N. Singh, Reetta Holmila, B. Sumer +4 more
2019Seminars in Radiation Oncology25 citations Open access
Semantic Scholar
Genome-Scale Modeling of NADPH-Driven β-Lapachone Sensitization in Head and Neck Squamous Cell Carcinoma
Joshua E. Lewis, F. Costantini, Jade Mims, Xiaofei Chen +3 more
2017Antioxidants and Redox Signaling25 citations Open access
Semantic Scholar
Nanotechnology-enabled delivery of NQO1 bioactivatable drugs
Xin-Peng Ma, Zachary R. Moore, Gang Huang, Xiumei Huang +2 more
2015Journal of drug targeting (Print)21 citations
Semantic Scholar
Cytoplasmic TRADD confers a worse prognosis in glioblastoma.
Sharmistha Chakraborty, Li Li, Hao Tang, Yang Xie +7 more
2013Neoplasia21 citations Open access
Semantic Scholar
Galactic cosmic ray simulation at the NASA Space Radiation Laboratory
J. Norbury, W. Schimmerling, T. Slaba, E. Azzam +44 more
2016Life sciences and space research20 citations Open access
Semantic Scholar
Modulators of Redox Metabolism in Head and Neck Cancer
Xiaofei Chen, Jade Mims, Xiumei Huang, N. Singh +8 more
2017Antioxidants and Redox Signaling19 citations Open access
Semantic Scholar
The cancer cell ‘energy grid’: TGF-β1 signaling coordinates metabolism for migration
Lei Jiang, R. DeBerardinis, D. Boothman
2015Molecular & Cellular Oncology17 citations Open access
Semantic Scholar
Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer
Colton L. Starcher, S. Pay, N. Singh, I-Ju Yeh +6 more
2020Frontiers in Oncology16 citations Open access
Semantic Scholar
Synergistic Effect of β-Lapachone and Aminooxyacetic Acid on Central Metabolism in Breast Cancer
M. Chang, Rohit Mahar, Marc McLeod, A. Giacalone +3 more
2022Nutrients14 citations Open access
Semantic Scholar
MTHFD2 Blockade Enhances the Efficacy of β-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer
K. Shukla, N. Singh, Joshua E. Lewis, Allen W. Tsang +3 more
2020Frontiers in Oncology14 citations Open access
Semantic Scholar
Following Anticancer Drug Activity in Cell Lysates with DNA Devices
Dimithree Kahanda, N. Singh, D. Boothman, Jason D. Slinker
2018Biosensors & bioelectronics13 citations Open access
Semantic Scholar
Kub5-HeraRPRD1B deficiency promotes “BRCAness” and vulnerability to PARP inhibition in BRCA-proficient Breast Cancers
Edward A. Motea, F. Fattah, Ling Xiao, L. Girard +8 more
2018Clinical Cancer Research11 citations Open access
Semantic Scholar

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