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Xiumei Huang · SciRah

Researcher profile · Semantic Scholar

Xiumei Huang

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Xiumei Huang — researcher profile on SciRah

h-index: 17
Works: 39
Citations: 1,226

Most-cited papers

Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition
Lei Jiang, Ling Xiao, Hidekazu Sugiura, Xiumei Huang +4 more
2014Oncogene210 citations Open access
Semantic Scholar
An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis
Xiumei Huang, Ying Dong, E. Bey, Jessica A. Kilgore +9 more
2012Cancer Research122 citations Open access
Semantic Scholar
Alzheimer’s β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid
Yao-Min Chen, Xiumei Huang, Yun-Wu Zhang, E. Rockenstein +4 more
2012Journal of Neuroscience115 citations Open access
Semantic Scholar
Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase (PARP) Inhibitors
Xiumei Huang, Edward A. Motea, Zachary R. Moore, Jun Yao +20 more
2016Cancer Cell112 citations Open access
Semantic Scholar
Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy
Xin-Peng Ma, Xiumei Huang, Zachary R. Moore, Gang Huang +6 more
2014Journal of Controlled Release97 citations Open access
Semantic Scholar
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance
Xiaoguang Li, Zhi-Da Liu, An-Li Zhang, Chuan-Hui Han +7 more
2019Nature Communications86 citations Open access
Semantic Scholar
Appoptosin is a Novel Proapoptotic Protein and Mediates Cell Death in Neurodegeneration
Han Zhang, Yun-Wu Zhang, Yao-Min Chen, Xiumei Huang +12 more
2012Journal of Neuroscience65 citations Open access
Semantic Scholar
Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway
Xiumei Huang, Yao-Min Chen, Han Zhang, Qi-Lin Ma +2 more
2011Neurobiology of Aging62 citations Open access
Semantic Scholar
A Functional Mouse Retroposed Gene Fg01 Reduces Alzheimer’s β-Amyloid Levels and Tau Phosphorylation
Yun-Wu Zhang, Shijie Liu, Xue Zhang, Wu-Bo Li +13 more
2009Neuron48 citations Open access
Semantic Scholar
Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in Pancreatic Cancer
M. Beg, Xiumei Huang, Molly A. Silvers, D. Gerber +9 more
2017Journal of Surgical Oncology34 citations Open access
Semantic Scholar
NQO1-dependent, tumor-selective radiosensitization of non-small cell lung cancers
Edward A. Motea, Xiumei Huang, N. Singh, Jessica A. Kilgore +6 more
2019Clinical Cancer Research30 citations Open access
Semantic Scholar
β-Lapachone Selectively Kills Hepatocellular Carcinoma Cells by Targeting NQO1 to Induce Extensive DNA Damage and PARP1 Hyperactivation
Wen-Xiu Zhao, Lingxiang Jiang, Ting Fang, Fei Fang +10 more
2021Frontiers in Oncology29 citations Open access
Semantic Scholar
Prodrug Strategy to Achieve Lyophilizable, High Drug Loading Micelle Formulations Through Diester Derivatives of β-Lapachone
Xin-Peng Ma, Xiumei Huang, Gang Huang, Long-Shan Li +4 more
2014Advanced Healthcare Materials27 citations Open access
Semantic Scholar
Neutrophils: Musketeers against immunotherapy
Kashif Rafiq Zahid, U. Raza, Soumya Tumbath, Lingxiang Jiang +2 more
2022Frontiers in Oncology24 citations Open access
Semantic Scholar
Nanotechnology-enabled delivery of NQO1 bioactivatable drugs
Xin-Peng Ma, Zachary R. Moore, Gang Huang, Xiumei Huang +2 more
2015Journal of drug targeting (Print)21 citations
Semantic Scholar
The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation.
Xiumei Huang, Yao-Min Chen, Wu-Bo Li, Stanley N. Cohen +4 more
2010Human Molecular Genetics21 citations Open access
Semantic Scholar
Modulators of Redox Metabolism in Head and Neck Cancer
Xiaofei Chen, Jade Mims, Xiumei Huang, N. Singh +8 more
2017Antioxidants and Redox Signaling19 citations Open access
Semantic Scholar
Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue.
L. Prabhu, Mat Martin, Lan Chen, Ö. Demir +14 more
2022Genes and Diseases17 citations Open access
Semantic Scholar
Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer
Colton L. Starcher, S. Pay, N. Singh, I-Ju Yeh +6 more
2020Frontiers in Oncology16 citations Open access
Semantic Scholar
PCNA Inhibition Enhances the Cytotoxicity of β-Lapachone in NQO1-Positive Cancer Cells by Augmentation of Oxidative Stress-induced DNA Damage
Xiaolin Su, Jiangwei Wang, Lingxiang Jiang, Yao-Min Chen +3 more
2021Cancer Letters15 citations Open access
Semantic Scholar
Synergistic Effect of β-Lapachone and Aminooxyacetic Acid on Central Metabolism in Breast Cancer
M. Chang, Rohit Mahar, Marc McLeod, A. Giacalone +3 more
2022Nutrients14 citations Open access
Semantic Scholar
RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits
Li Yan, Yao-Min Chen, Wu-Bo Li, Xiumei Huang +10 more
2016Scientific Reports12 citations Open access
Semantic Scholar
Retinoid X receptor-α mediates (R)-flurbiprofen’s effect on the levels of Alzheimer’s β–amyloid
Xiao-qing You, Yun-Wu Zhang, Yao-Min Chen, Xiumei Huang +6 more
2009Journal of Neurochemistry9 citations Open access
Semantic Scholar
KP372-1-Induced AKT Hyperactivation Blocks DNA Repair to Synergize With PARP Inhibitor Rucaparib via Inhibiting FOXO3a/GADD45α Pathway
Lingxiang Jiang, Yingchun Liu, Xiaolin Su, Jiangwei Wang +10 more
2022Frontiers in Oncology7 citations Open access
Semantic Scholar
Isopentyl-Deoxynboquinone Induces Mitochondrial Dysfunction and G2/M Phase Cell Cycle Arrest to Selectively Kill NQO1-Positive Pancreatic Cancer Cells
Lingxiang Jiang, Yingchun Liu, Soumya Tumbath, Matthew W. Boudreau +9 more
2023Antioxidants and Redox Signaling4 citations Open access
Semantic Scholar
Evaluation of the competence of an artificial intelligence-assisted colonoscopy system in clinical practice: A post hoc analysis
W. Zuo, Yong-Yu Dai, Xiumei Huang, Renqun Peng +2 more
2023Frontiers in Medicine3 citations Open access
Semantic Scholar
Anoikis resistance as a key driver of glioma malignancy: From ECM detachment to potential druggable targets.
Yu-Heng Zou, Chen Zou, Xiumei Huang, Yi-Peng Zhu +1 more
2026Biochimica et biophysica acta. Reviews on cancer2 citations
Semantic Scholar
Therapeutics , Targets , and Chemical Biology An NQO 1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP 1-Induced Programmed Necrosis
Xiumei Huang, Ying Dong, E. Bey, Jessica A. Kilgore +9 more
20122 citations
Semantic Scholar
Synergistic Lethality between Beta‐lapachone and Proliferating Cell Nuclear Antigen (PCNA) Inhibitor in NQO1‐positive Cancer Cells
Xiaolin Su, Jiangwei Wang, Lingxiang Jiang, Xiumei Huang
2021The FASEB Journal1 citations
Semantic Scholar
NQO1 bioactivatable drugs enhance radiation responses
E. Bey, J. Meade, Molly A. Silvers, Edward A. Motea +12 more
20161 citations
Semantic Scholar
Abstract 3344: Inhibiting base excision repair synergistically enhances beta-lapachone-mediated ‘kiss of death’ for tumor-selective therapy of pancreatic cancer.
Xiuquan Luo, Long-Shan Li, Xiumei Huang, Lifen Cao +6 more
20131 citations
Semantic Scholar
Abstract 5052: IB-DNQ enhances radiation induced ferroptosis in NQO1-positive cancer cells
Xiumei Huang, Xiaolin Su, Matthew W. Boudreau, P. Hergenrother
2023Cancer Research0 citations
Semantic Scholar
Abstract 6183: A novel NQO1 bioactivatable drug induces mitochondrial dysfunction and G2/M phase cell cycle arrest to selectively kill pancreatic cancer cells
Xiumei Huang, Lingxiang Jiang, Matthew W. Boudreau, P. Hergenrother
2022Cancer Research0 citations
Semantic Scholar
A Novel NQO1 Bioactivatable Drug β‐Lapachone Efficiently Inhibits Cancer Cell Growth in Hepatocellular Carcinoma
Lingxiang Jiang, Wen-Xiu Zhao, Ting Fang, Chengrong Xie +7 more
2021The FASEB Journal0 citations
Semantic Scholar
Abstract 1657: Tumor selective immunotherapy to overcome checkpoint blockade resistance
Lingxiang Jiang, P. Hergenrother, Xiumei Huang
2021Immunology0 citations
Semantic Scholar
NQO1-Bioactivatable Therapeutics as Radiosensitizers for Cancer Treatment
N. Singh, Edward A. Motea, Xiumei Huang, Colton L Starcher +7 more
2020Translational Research in Cancer0 citations Open access
Semantic Scholar
Abstract 787: DNA repair and metabolism inhibitors are tumor-selective when combined with NQO1 bioactivatable drugs for therapy against pancreatic and nonsmall cell lung cancers
Xiumei Huang, Zachary R. Moore, Xiuquan Luo, G. Chakrabarti +8 more
20140 citations
Semantic Scholar
P2‐312: The Rps23r1 gene family regulates Alzheimer's beta‐amyloid generation and tau phosphorylation
Yun-Wu Zhang, Xiumei Huang, Yao-Min Chen, F. Liao +2 more
20100 citations
Semantic Scholar
P2‐213: Appoptosin interacts with amyloid precursor protein and mediates neuronal toxicity via caspase depended pathway
Han Zhang, Yun-Wu Zhang, Xiumei Huang, Yao-Min Chen +1 more
20100 citations Open access
Semantic Scholar

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