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C. Joyce · SciRah

Researcher profile · Semantic Scholar

C. Joyce

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C. Joyce — researcher profile on SciRah

h-index: 42
Works: 82
Citations: 6,448

Most-cited papers

Function and structure relationships in DNA polymerases.
C. Joyce, T. Steitz
1994Annual Review of Biochemistry560 citations
Semantic Scholar
DNA polymerase fidelity: kinetics, structure, and checkpoints.
C. Joyce, S. Benkovic
2004Biochemistry334 citations
Semantic Scholar
A unified polymerase mechanism for nonhomologous DNA and RNA polymerases.
T. Steitz, S. Smerdon, J. Jáger, C. Joyce
1994Science281 citations
Semantic Scholar
Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I.
V. Derbyshire, P. Freemont, M. Sanderson, L. Beese +3 more
1988Science279 citations
Semantic Scholar
Method for determining whether a gene of Escherichia coli is essential: application to the polA gene
C. Joyce, N. D. Grindley
1984Journal of Bacteriology246 citations Open access
Semantic Scholar
Conformational transitions in DNA polymerase I revealed by single-molecule FRET
Y. Santoso, C. Joyce, O. Potapova, Ludovic Le Reste +4 more
2009Proceedings of the National Academy of Sciences of the United States of America238 citations Open access
Semantic Scholar
Choosing the right sugar: how polymerases select a nucleotide substrate.
C. Joyce
1997Proceedings of the National Academy of Sciences of the United States of America225 citations Open access
Semantic Scholar
A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides.
M. Astatke, K. Ng, N. D. Grindley, C. Joyce
1998Proceedings of the National Academy of Sciences of the United States of America212 citations Open access
Semantic Scholar
The 3′‐5′ exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction.
V. Derbyshire, N. D. Grindley, C. Joyce
1991EMBO Journal211 citations Open access
Semantic Scholar
Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli.
A. Polesky, T. Steitz, N. D. Grindley, C. Joyce
1990Journal of Biological Chemistry209 citations Open access
Semantic Scholar
Polymerase structures and function: variations on a theme?
C. Joyce, T. Steitz
1995Journal of Bacteriology191 citations Open access
Semantic Scholar
The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I.
K. Bebenek, C. Joyce, Mary P. Fitzgerald, T. Kunkel
1990Journal of Biological Chemistry154 citations Open access
Semantic Scholar
Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli.
A. Polesky, Michael E. Dahlberg, S. Benkovic, N. D. Grindley +1 more
1992Journal of Biological Chemistry147 citations Open access
Semantic Scholar
Nucleotide sequence of the Escherichia coli polA gene and primary structure of DNA polymerase I.
C. Joyce, W. S. Kelley, N. D. Grindley
1982Journal of Biological Chemistry138 citations Open access
Semantic Scholar
Fingers-closing and other rapid conformational changes in DNA polymerase I (Klenow fragment) and their role in nucleotide selectivity.
C. Joyce, O. Potapova, A. Delucia, Xuanwei Huang +2 more
2008Biochemistry136 citations Open access
Semantic Scholar
Use of 2-aminopurine fluorescence to examine conformational changes during nucleotide incorporation by DNA polymerase I (Klenow fragment).
Vandana Purohit, N. D. Grindley, C. Joyce
2003Biochemistry125 citations
Semantic Scholar
Construction of a plasmid that overproduces the large proteolytic fragment (Klenow fragment) of DNA polymerase I of Escherichia coli.
C. Joyce, N. D. Grindley
1983Proceedings of the National Academy of Sciences of the United States of America123 citations Open access
Semantic Scholar
Side Chains That Influence Fidelity at the Polymerase Active Site of Escherichia coli DNA Polymerase I (Klenow Fragment)*
D. T. Minnick, K. Bebenek, W. Osheroff, R. M. Turner +4 more
1999Journal of Biological Chemistry119 citations Open access
Semantic Scholar
Novel blunt-end addition reactions catalyzed by DNA polymerase I of Escherichia coli.
James M. Clark, C. Joyce, G. Beardsley
1987Journal of Molecular Biology119 citations Open access
Semantic Scholar
DNA polymerase I: from crystal structure to function via genetics
C. Joyce, T. Steitz
1987118 citations
Semantic Scholar
Genetic and DNA sequence analysis of the kanamycin resistance transposon Tn903.
N. D. Grindley, C. Joyce
1980Proceedings of the National Academy of Sciences of the United States of America110 citations Open access
Semantic Scholar
How DNA travels between the separate polymerase and 3'-5'-exonuclease sites of DNA polymerase I (Klenow fragment).
C. Joyce
1989Journal of Biological Chemistry104 citations Open access
Semantic Scholar
Deoxynucleoside Triphosphate and Pyrophosphate Binding Sites in the Catalytically Competent Ternary Complex for the Polymerase Reaction Catalyzed by DNA Polymerase I (Klenow Fragment) (*)
M. Astatke, N. D. Grindley, C. Joyce
1995Journal of Biological Chemistry100 citations Open access
Semantic Scholar
How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotides.
M. Astatke, N. D. Grindley, C. Joyce
1998Journal of Molecular Biology99 citations
Semantic Scholar
Conformational landscapes of DNA polymerase I and mutator derivatives establish fidelity checkpoints for nucleotide insertion
J. Hohlbein, Louise Aigrain, Timothy D. Craggs, Oya Bermek +5 more
2013Nature Communications90 citations Open access
Semantic Scholar
An error-prone family Y DNA polymerase (DinB homolog from Sulfolobus solfataricus) uses a 'steric gate' residue for discrimination against ribonucleotides.
A. Delucia, N. D. Grindley, C. Joyce
2003Nucleic Acids Research84 citations Open access
Semantic Scholar
Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-).
B. Eger, R. Kuchta, Steven S. Carroll, P. Benkovic +3 more
1991Biochemistry80 citations
Semantic Scholar
Base Miscoding and Strand Misalignment Errors by Mutator Klenow Polymerases with Amino Acid Substitutions at Tyrosine 766 in the O Helix of the Fingers Subdomain*
Juliette B. Bell, K. Eckert, C. Joyce, T. Kunkel
1997Journal of Biological Chemistry77 citations Open access
Semantic Scholar
A Thumb Subdomain Mutant of the Large Fragment of Escherichia coli DNA Polymerase I with Reduced DNA Binding Affinity, Processivity, and Frameshift Fidelity*
D. T. Minnick, M. Astatke, C. Joyce, T. Kunkel
1996Journal of Biological Chemistry75 citations Open access
Semantic Scholar
α-Tubulin gene family of maize (Zea mays L.). Evidence for two ancient α-tubulin genes in plants
R. Villemur, C. Joyce, N. Haas, R. H. Goddard +4 more
199273 citations
Semantic Scholar
Analysis of the structure and function of the kanamycin-resistance transposon Tn903.
N. D. Grindley, C. Joyce
1981Cold Spring Harbor Symposia on Quantitative Biology71 citations
Semantic Scholar
Tubulin gene expression in maize (Zea mays L.). Change in isotype expression along the developmental axis of seedling root.
C. Joyce, R. Villemur, D. Snustad, Carolyn D. Silflow
1992Journal of Molecular Biology69 citations
Semantic Scholar
A domain of the klenow fragment of Escherichia coli DNA polymerase I has polymerase but no exonuclease activity
P. Freemont, D. Ollis, T. Steitz, C. Joyce
1986Proteins: Structure, Function, and Bioinformatics68 citations
Semantic Scholar
Reactions at the polymerase active site that contribute to the fidelity of Escherichia coli DNA polymerase I (Klenow fragment).
C. Joyce, Xiao-Jun Chen Sun, N. D. Grindley
1992Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Structure-function analysis of 3'-->5'-exonuclease of DNA polymerases.
V. Derbyshire, J. Pinsonneault, C. Joyce
1995Methods in Enzymology62 citations
Semantic Scholar
Techniques used to study the DNA polymerase reaction pathway
C. Joyce
2009Biochimica et Biophysica Acta61 citations Open access
Semantic Scholar
Biochemical and mutational studies of the 5'-3' exonuclease of DNA polymerase I of Escherichia coli.
Yang Xu, V. Derbyshire, K. Ng, Xiao-Jun Chen Sun +2 more
1997Journal of Molecular Biology59 citations Open access
Semantic Scholar
Purification of Escherichia coli DNA polymerase I and Klenow fragment.
C. Joyce, V. Derbyshire
1995Methods in Enzymology57 citations
Semantic Scholar
The Mutational Specificity of the Dbh Lesion Bypass Polymerase and Its Implications*
O. Potapova, N. D. Grindley, C. Joyce
2002Journal of Biological Chemistry56 citations Open access
Semantic Scholar
Genetic mapping and DNA sequence analysis of mutations in the polA gene of Escherichia coli.
C. Joyce, D. Fujii, Helaina S. Laks, C. Hughes +1 more
1985Journal of Molecular Biology54 citations
Semantic Scholar
Interaction of DNA polymerase I (Klenow fragment) with the single-stranded template beyond the site of synthesis.
R. M. Turner, N. D. Grindley, C. Joyce
2003Biochemistry53 citations
Semantic Scholar
Use of fluorescence resonance energy transfer to investigate the conformation of DNA substrates bound to the Klenow fragment.
W. S. Furey, C. Joyce, M. A. Osborne, David Klenerman +2 more
1998Biochemistry43 citations
Semantic Scholar
Characterization of four new β-tubulin genes and their expression during male flower development in maize (Zea mays L.)
R. Villemur, N. Haas, C. Joyce, D. Snustad +1 more
2004Plant Molecular Biology41 citations
Semantic Scholar
Contacts between the 5′ Nuclease of DNA Polymerase I and Its DNA Substrate*
Yang Xu, O. Potapova, A. Leschziner, N. D. Grindley +1 more
2001Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Coordination between the Polymerase and 5′-Nuclease Components of DNA Polymerase I of Escherichia coli *
Yang Xu, N. D. Grindley, C. Joyce
2000Journal of Biological Chemistry40 citations Open access
Semantic Scholar
Identification of two genes immediately downstream from the polA gene of Escherichia coli
C. Joyce, N. D. Grindley
1982Journal of Bacteriology39 citations Open access
Semantic Scholar
Comparative Kinetics of Nucleotide Analog Incorporation by Vent DNA Polymerase*
A. F. Gardner, C. Joyce, W. Jack
2004Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Conformational changes during normal and error-prone incorporation of nucleotides by a Y-family DNA polymerase detected by 2-aminopurine fluorescence.
A. Delucia, N. D. Grindley, C. Joyce
2007Biochemistry37 citations
Semantic Scholar
Effects of mutations on the partitioning of DNA substrates between the polymerase and 3'-5' exonuclease sites of DNA polymerase I (Klenow fragment).
Wai-Chung Lam, Edwin J. C. Van der Schans, C. Joyce, David P. Millar
1998Biochemistry37 citations
Semantic Scholar
DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics.
O. Potapova, Chikio Chan, A. Delucia, Sandra A. Helquist +3 more
2006Biochemistry36 citations Open access
Semantic Scholar

Frequent co-authors

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O. Potapova×6
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V. Derbyshire×5
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P. Freemont — researcher profile on SciRah