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Timothy D. Craggs · SciRah

Researcher profile · Semantic Scholar

Timothy D. Craggs

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Timothy D. Craggs — researcher profile on SciRah

h-index: 25
Works: 81
Citations: 4,254

Most-cited papers

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles
T. Nott, E. Petsalaki, Patrick J. Farber, D. Jervis +7 more
2015Molecules and Cells1,630 citations Open access
Semantic Scholar
Precision and accuracy of single-molecule FRET measurements – a multi-laboratory benchmark study
B. Hellenkamp, Sonja Schmid, Olga Doroshenko, O. Opanasyuk +59 more
2017Nature Methods437 citations Open access
Semantic Scholar
Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters.
T. Nott, Timothy D. Craggs, Andrew J. Baldwin
2016Nature Chemistry338 citations
Semantic Scholar
Green fluorescent protein: structure, folding and chromophore maturation.
Timothy D. Craggs
2009Chemical Society Reviews275 citations
Semantic Scholar
Alternating-laser excitation: single-molecule FRET and beyond.
J. Hohlbein, Timothy D. Craggs, T. Cordes
2014Chemical Society Reviews158 citations Open access
Semantic Scholar
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins
G. Agam, C. Gebhardt, Milana Popara, Rebecca Mächtel +43 more
2022bioRxiv145 citations Open access
Semantic Scholar
FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices
Eitan Lerner, Anders Barth, Jelle Hendrix, Benjamin Ambrose +42 more
2021eLife142 citations Open access
Semantic Scholar
Stable intermediate states and high energy barriers in the unfolding of GFP.
Jie-rong Huang, Timothy D. Craggs, J. Christodoulou, S. Jackson
2007Journal of Molecular Biology99 citations
Semantic Scholar
Conformational landscapes of DNA polymerase I and mutator derivatives establish fidelity checkpoints for nucleotide insertion
J. Hohlbein, Louise Aigrain, Timothy D. Craggs, Oya Bermek +5 more
2013Nature Communications90 citations Open access
Semantic Scholar
The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere
G. Fisher, C. L. Pastrana, V. Higman, Alan Koh +8 more
2017eLife83 citations Open access
Semantic Scholar
The Transcription Bubble of the RNA Polymerase–Promoter Open Complex Exhibits Conformational Heterogeneity and Millisecond-Scale Dynamics: Implications for Transcription Start-Site Selection
Nicole C. Robb, T. Cordes, L. Hwang, Kristofer Gryte +6 more
2012Journal of Molecular Biology79 citations Open access
Semantic Scholar
The FRET-based structural dynamics challenge -- community contributions to consistent and open science practices
Eitan Lerner, Benjamin Ambrose, Anders Barth, V. Birkedal +22 more
202077 citations Open access
Semantic Scholar
19F NMR studies of the native and denatured states of green fluorescent protein.
F. Khan, I. Kuprov, Timothy D. Craggs, P. Hore +1 more
2006Journal of the American Chemical Society77 citations
Semantic Scholar
Understanding the folding of GFP using biophysical techniques
S. Jackson, Timothy D. Craggs, Jie-rong Huang
2006Espert Review of Proteomics58 citations
Semantic Scholar
Evidence of an intermediate and parallel pathways in protein unfolding from single-molecule fluorescence.
Á. Orte, Timothy D. Craggs, Samuel S White, S. Jackson +1 more
2008Journal of the American Chemical Society49 citations
Semantic Scholar
The smfBox is an open-source platform for single-molecule FRET
Benjamin Ambrose, James M. Baxter, John Cully, Matthew Willmott +7 more
2020Nature Communications44 citations Open access
Semantic Scholar
Real-time single-molecule studies of the motions of DNA polymerase fingers illuminate DNA synthesis mechanisms
G. Evans, J. Hohlbein, Timothy D. Craggs, Louise Aigrain +1 more
2015Nucleic Acids Research44 citations Open access
Semantic Scholar
Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substrates
Timothy D. Craggs, R. Hutton, Alfonso Brenlla, M. White +1 more
2013Nucleic Acids Research40 citations Open access
Semantic Scholar
Substrate conformational dynamics facilitate structure-specific recognition of gapped DNA by DNA polymerase
Timothy D. Craggs, M. Sustarsic, A. Plochowietz, M. Mosayebi +7 more
2019Nucleic Acids Research38 citations Open access
Semantic Scholar
Publisher Correction: Image Data Resource: a bioimage data integration and publication platform
B. Hellenkamp, Sonja Schmid, Olga Doroshenko, O. Opanasyuk +59 more
2018Nature Methods36 citations Open access
Semantic Scholar
Six steps closer to FRET-driven structural biology
Timothy D. Craggs, A. Kapanidis
2012Nature Methods28 citations
Semantic Scholar
PCNA and XPF cooperate to distort DNA substrates
R. Hutton, Timothy D. Craggs, M. White, J. Penedo
2009Nucleic Acids Research28 citations Open access
Semantic Scholar
High-Force Application by a Nanoscale DNA Force Spectrometer
Michael A Darcy, Kyle Crocker, Yu-Chen Wang, Jenny V. Le +6 more
2022ACS Nano25 citations Open access
Semantic Scholar
Multimodal single-molecule microscopy with continuously controlled spectral resolution
J. Jeffet, A. Ionescu, Yael Michaeli, Dmitry Torchinsky +3 more
2021Biophysics Reports25 citations Open access
Semantic Scholar
Functional Studies of DNA-Protein Interactions Using FRET Techniques.
S. Blouin, Timothy D. Craggs, D. Lafontaine, J. Penedo
2015Methods in molecular biology25 citations
Semantic Scholar
Spin relaxation effects in photochemically induced dynamic nuclear polarization spectroscopy of nuclei with strongly anisotropic hyperfine couplings.
I. Kuprov, Timothy D. Craggs, S. Jackson, P. Hore
2007Journal of the American Chemical Society25 citations Open access
Semantic Scholar
DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction*
Sana I. Algasaier, J. Exell, Ian A. Bennet, M. J. Thompson +5 more
2016Journal of Biological Chemistry20 citations Open access
Semantic Scholar
DNA Polymerase Conformational Dynamics and the Role of Fidelity-Conferring Residues: Insights from Computational Simulations
M. Meli, M. Sustarsic, Timothy D. Craggs, A. Kapanidis +1 more
2016Frontiers in Molecular Biosciences19 citations Open access
Semantic Scholar
The Stringent Response Inhibits 70S Ribosome Formation in Staphylococcus aureus by Impeding GTPase-Ribosome Interactions
D. J. Bennison, J. A. Nakamoto, Timothy D. Craggs, Pohl Milón +2 more
2021mBio15 citations Open access
Semantic Scholar
Functional studies of DNA-protein interactions using FRET techniques.
S. Blouin, Timothy D. Craggs, D. Lafontaine, J. Penedo
2009Methods in molecular biology15 citations
Semantic Scholar
DNA replication initiation in Bacillus subtilis: structural and functional characterization of the essential DnaA–DnaD interaction
E. Martin, Huw E. L. Williams, M. Pitoulias, Daniel Stevens +5 more
2018bioRxiv14 citations Open access
Semantic Scholar
Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1
Ian A. Bennet, L. Finger, N. J. Baxter, Benjamin Ambrose +7 more
2018Nucleic Acids Research10 citations Open access
Semantic Scholar
CHARMM-DYES: Parameterization of Fluorescent Dyes for Use with the CHARMM Force Field.
R. Shaw, Tristan Johnston-Wood, Benjamin Ambrose, Timothy D. Craggs +1 more
2020Journal of Chemical Theory and Computation8 citations Open access
Semantic Scholar
The Rate-limiting Step of DNA Synthesis by DNA Polymerase Occurs in the Fingers-closed Conformation
G. Evans, Timothy D. Craggs, A. Kapanidis
2021Journal of Molecular Biology7 citations Open access
Semantic Scholar
Cool and dynamic: single-molecule fluorescence-based structural biology
Timothy D. Craggs
2017Nature Methods7 citations
Semantic Scholar
Supramolecular Recognition of a DNA Four‐Way Junction by an M2L4 Metallo‐Cage, Inspired by a Simulation‐Guided Design Approach
Samuel J. Dettmer, Hugo D. Williams, Richard Napier, J. Beames +3 more
2025Angewandte Chemie6 citations Open access
Semantic Scholar
Kinesin-1 is highly flexible and adopts an open conformation in the absence of cargo
E. Smith, Emma D. Turner, Mahmoud A. S. Abdelhamid, Timothy D. Craggs +1 more
2024bioRxiv6 citations Open access
Semantic Scholar
Substrate conformational dynamics drive structure-specific recognition of gapped DNA by DNA polymerase
Timothy D. Craggs, M. Sustarsic, A. Plochowietz, M. Mosayebi +7 more
2018bioRxiv6 citations Open access
Semantic Scholar
Alternative boronic acids in the detection of Mycolactone A/B using the thin layer chromatography (f-TLC) method for diagnosis of Buruli ulcer
G. A. Akolgo, B. Partridge, Timothy D. Craggs, R. Amewu
2023BMC Infectious Diseases4 citations Open access
Semantic Scholar
Making Precise and Accurate Single-Molecule FRET Measurements using the Open-Source smfBox.
Mahmoud A S Abdelhamid, Alice V. Rhind-Tutt, Benjamin Ambrose, Timothy D. Craggs
2021Journal of Visualized Experiments4 citations
Semantic Scholar
i-Motif, not G-quadruplex, stability regulates insulin expression
D. Guneri, Chris J Morris, Yiliang Ding, Timothy D. Craggs +2 more
2026Nucleic Acids Research3 citations Open access
Semantic Scholar
Democratizing Single-Molecule FRET: An Open-Source Microscope for Measuring Precise Distances and Biomolecular Dynamics
Benjamin Ambrose, James M. Baxter, John Cully, Matthew Willmott +6 more
20203 citations Open access
Semantic Scholar
The C-terminal domain of ParB is critical for dynamic DNA binding and bridging interactions which condense the bacterial centromere
G. Fisher, C. L. Pastrana, V. Higman, Alan Koh +8 more
2017bioRxiv3 citations Open access
Semantic Scholar
A protein-dependent riboswitch activates ribosomal frameshifting in cardioviruses
Jemma K. Betts, C. Jeffries, Tim C. Passchier, Hermia C. Y. Kung +9 more
2026bioRxiv2 citations Open access
Semantic Scholar
A Universal Protein Ladder for Standardization of Diverse FRET Assays
E. Smith, Katie L. Gelder, Lewis Hunter-Craig, Daniel A. Bose +2 more
2026bioRxiv2 citations Open access
Semantic Scholar
NMR Studies of the Native and Denatured States of Green Fluorescent Protein
F. Khan, I. Kuprov, Timothy D. Craggs, P. Hore +1 more
2 citations
Semantic Scholar
CBP-IDRs regulate acetylation and gene expression
Katie L. Gelder, Nicola A. Carruthers, Grace Gilbert, Laura J. Harrison +7 more
2026Cell Reports1 citations Open access
Semantic Scholar
G-Quadruplexes Act as an On/Off Switch While i-Motifs Regulate Insulin Expression in Reporter Gene Assays
D. Guneri, Chris J Morris, Yiliang Ding, Timothy D. Craggs +2 more
2025bioRxiv1 citations Open access
Semantic Scholar
CBP-IDRs regulate acetylation and gene expression
Katie L. Gelder, Nicola A. Carruthers, Grace Gilbert, Laura J. Harrison +7 more
2025bioRxiv1 citations Open access
Semantic Scholar
The transitional kinetics between open and closed Rep structures can be tuned by salt via two intermediate states
J. Howard, Benjamin Ambrose, Mahmoud A. S. Abdelhamid, Lewis Frame +9 more
2025bioRxiv1 citations Open access
Semantic Scholar

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