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M. Culot · SciRah

Researcher profile · Semantic Scholar

M. Culot

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M. Culot — researcher profile on SciRah

h-index: 24
Works: 65
Citations: 2,826

Most-cited papers

Modelling of the blood–brain barrier in drug discovery and development
R. Cecchelli, Vincent Bérézowski, S. Lundquist, M. Culot +3 more
2007Nature reviews. Drug discovery619 citations
Semantic Scholar
A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells
R. Cecchelli, Sezin Aday, E. Sevin, C. Almeida +6 more
2014PLoS ONE298 citations Open access
Semantic Scholar
Ca(2+) regulation of connexin 43 hemichannels in C6 glioma and glial cells.
E. De Vuyst, Nan Wang, E. Decrock, M. De Bock +9 more
2009Cell Calcium200 citations
Semantic Scholar
Endothelial calcium dynamics, connexin channels and blood-brain barrier function.
M. De Bock, Nan Wang, E. Decrock, Mélissa Bol +5 more
2013Progress in neurobiology164 citations
Semantic Scholar
Connexin Channels Provide a Target to Manipulate Brain Endothelial Calcium Dynamics and Blood—Brain Barrier Permeability
M. De Bock, M. Culot, Nan Wang, Mélissa Bol +13 more
2011Journal of Cerebral Blood Flow and Metabolism147 citations Open access
Semantic Scholar
An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening.
M. Culot, S. Lundquist, Dorothée Vanuxeem, S. Nion +6 more
2008Toxicology in Vitro134 citations
Semantic Scholar
Central nervous system delivery of molecules across the blood-brain barrier.
F. Gosselet, R. Loiola, A. Roig, A. Rosell +1 more
2021Neurochemistry International96 citations Open access
Semantic Scholar
A new angle on blood–CNS interfaces: A role for connexins?
M. De Bock, R. E. Vandenbroucke, E. Decrock, M. Culot +2 more
2014FEBS Letters86 citations Open access
Semantic Scholar
Catalytic Site Inhibition of Insulin Degrading Enzyme by a Small Molecule Induces Glucose Intolerance in Mice
R. Deprez-Poulain, N. Hennuyer, D. Bosc, W. Liang +26 more
2015Nature Communications83 citations Open access
Semantic Scholar
Accelerated Caco-2 cell permeability model for drug discovery.
E. Sevin, L. Dehouck, A. F. Costa, R. Cecchelli +3 more
2013Journal of pharmacological and toxicological methods80 citations
Semantic Scholar
Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies
Liadys Mora Lagares, N. Minovski, Ana Yisel Caballero Alfonso, E. Benfenati +4 more
2020International Journal of Molecular Sciences72 citations Open access
Semantic Scholar
Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models.
Luise Schultz, M. Zurich, M. Culot, A. da Costa +15 more
2015Toxicology in Vitro66 citations Open access
Semantic Scholar
Peroxisome Proliferator-Activated Receptor-α Activation Protects Brain Capillary Endothelial Cells from Oxygen-Glucose Deprivation-Induced Hyperpermeability in the Blood-Brain Barrier
Caroline Mysiorek, M. Culot, L. Dehouck, B. Derudas +5 more
200956 citations
Semantic Scholar
Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model
A. R. Santa-Maria, Fruzsina R. Walter, R. Figueiredo, András Kincses +7 more
2021Journal of Cerebral Blood Flow and Metabolism53 citations Open access
Semantic Scholar
Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance.
M. Lasalle, Vanessa Hoguet, N. Hennuyer, F. Leroux +15 more
2017Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
Contribution of brain pericytes in blood–brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells
M. Heymans, R. Figueiredo, L. Dehouck, D. Francisco +8 more
2020Fluids and Barriers of the CNS47 citations Open access
Semantic Scholar
Transport study of interleukin-1 inhibitors using a human in vitro model of the blood-brain barrier
E. Sjöström, M. Culot, L. Leickt, Mikael Åstrand +3 more
2021Brain, Behavior, & Immunity - Health40 citations Open access
Semantic Scholar
Mimicking brain tissue binding in an in vitro model of the blood‐brain barrier illustrates differences between in vitro and in vivo methods for assessing the rate of brain penetration
M. Heymans, E. Sevin, F. Gosselet, S. Lundquist +1 more
2018European journal of pharmaceutics and biopharmaceutics40 citations Open access
Semantic Scholar
New strategy for alerting central nervous system toxicity: Integration of blood-brain barrier toxicity and permeability in neurotoxicity assessment.
D. Hallier-Vanuxeem, P. Prieto, M. Culot, H. Diallo +3 more
2009Toxicology in Vitro39 citations
Semantic Scholar
In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs.
D. Eigenmann, Carmen Dürig, E. Jähne, M. Smieško +9 more
2016European journal of pharmaceutics and biopharmaceutics37 citations Open access
Semantic Scholar
A Simple Method for Assessing Free Brain/Free Plasma Ratios Using an In Vitro Model of the Blood Brain Barrier
M. Culot, Anaëlle Fabulas-da Costa, E. Sevin, Erica Szorath +5 more
2013PLoS ONE34 citations Open access
Semantic Scholar
HMGB-1 promotes fibrinolysis and reduces neurotoxicity mediated by tissue plasminogen activator
B. D. Roussel, Caroline Mysiorek, A. Rouhiainen, Amandine Jullienne +8 more
2011Journal of Cell Science32 citations Open access
Semantic Scholar
Brain pericytes from stress-susceptible pigs increase blood-brain barrier permeability in vitro
Elodie Vandenhaute, M. Culot, F. Gosselet, L. Dehouck +6 more
2012Fluids and Barriers of the CNS31 citations Open access
Semantic Scholar
Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study.
M. Culot, Caroline Mysiorek, Mila Renftel, B. D. Roussel +7 more
2009Brain Research29 citations
Semantic Scholar
Transport Studies Using Blood-Brain Barrier In Vitro Models: A Critical Review and Guidelines.
A. R. Santa-Maria, M. Heymans, Fruzsina R. Walter, M. Culot +3 more
2020Handbook of Experimental Pharmacology23 citations
Semantic Scholar
Pharmacokinetics and In Vitro Blood-Brain Barrier Screening of the Plant-Derived Alkaloid Tryptanthrin
E. Jähne, D. Eigenmann, C. Sampath, V. Butterweck +8 more
2016Planta Medica23 citations
Semantic Scholar
Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier.
Caroline Mysiorek, M. Culot, L. Dehouck, B. Derudas +5 more
2009Current Neurovascular Research21 citations
Semantic Scholar
Challenges and Opportunities in the Oral Delivery of Recombinant Biologics
Solène Masloh, M. Culot, F. Gosselet, A. Chevrel +2 more
2023Pharmaceutics19 citations Open access
Semantic Scholar
Advancing brain barriers RNA sequencing: guidelines from experimental design to publication
D. Francisco, L. Marchetti, S. Rodríguez-Lorenzo, Eduardo Frías-Anaya +23 more
2020Fluids and Barriers of the CNS19 citations Open access
Semantic Scholar
Cyclosporine A kinetics in brain cell cultures and its potential of crossing the blood-brain barrier.
Patricia Bellwon, M. Culot, A. Wilmes, Tobias Schmidt +9 more
2015Toxicology in Vitro19 citations
Semantic Scholar
In vitro blood-brain barrier model adapted to repeated-dose toxicological screening.
A. F. Costa, R. Aijjou, J. Hachani, C. Landry +2 more
2013Toxicology in Vitro19 citations Open access
Semantic Scholar
Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound.
S. Wellens, L. Dehouck, V. Chandrasekaran, Pranika Singh +6 more
2021Toxicology in Vitro18 citations Open access
Semantic Scholar
An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat.
C. Nunes, Pranika Singh, Z. Mazidi, C. Murphy +17 more
2022Toxicology in Vitro15 citations Open access
Semantic Scholar
Application of in vitro data in physiologically-based kinetic models for quantitative in vitro-in vivo extrapolation: A case-study for baclofen.
E. Kasteel, L. Lautz, M. Culot, N. Kramer +1 more
2021Toxicology in Vitro15 citations Open access
Semantic Scholar
Predicting human neurotoxicity of propylene glycol methyl ether (PGME) by implementing in vitro neurotoxicity results into toxicokinetic modelling.
E. Reale, J. Sandström, M. Culot, J. Hechon +5 more
2023Science of the Total Environment13 citations Open access
Semantic Scholar
A Miniaturized Pump Out Method for Characterizing Molecule Interaction with ABC Transporters
E. Sevin, L. Dehouck, Romain Versele, M. Culot +1 more
2019International Journal of Molecular Sciences11 citations Open access
Semantic Scholar
GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice
D. Liśkiewicz, Aaron Novikoff, Ahmed Khalil, Seun Akindehin +49 more
2026Nature10 citations Open access
Semantic Scholar
Differential Blood–Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro
Erik Melander, C. Eriksson, S. Wellens, Kimia Hosseini +6 more
2023Pharmaceutics10 citations Open access
Semantic Scholar
Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.
Vanessa Hoguet, M. Lasalle, Mathieu Maingot, Geoffroy Dequirez +19 more
2021Journal of Medicinal Chemistry10 citations
Semantic Scholar
Discovery, Structure-Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5.
Sylvain Picon, R. Boulahjar, Vanessa Hoguet, Morgane Baron +24 more
2023Journal of Medicinal Chemistry9 citations
Semantic Scholar
Title : Development and validation of a LC-MS / MS method for assessment of an anti-inflammatory indolinone derivative by in vitro blood-brain barrier models
E. Jähne, D. Eigenmann, M. Culot, R. Cecchelli +9 more
20149 citations
Semantic Scholar
Development and validation of a LC-MS/MS method for assessment of an anti-inflammatory indolinone derivative by in vitro blood-brain barrier models.
E. Jähne, D. Eigenmann, M. Culot, R. Cecchelli +7 more
2014Journal of Pharmaceutical and Biomedical Analysis8 citations
Semantic Scholar
Cyclosporin A toxicity on endothelial cells differentiated from induced pluripotent stem cells: Assembling an adverse outcome pathway.
Z. Mazidi, M. Wieser, N. Spînu, A. Weidinger +20 more
2024Toxicology in Vitro3 citations Open access
Semantic Scholar
Challenges and opportunities in the use of transcriptomics characterization for human iPSC-derived BBB models.
S. Wellens, F. Gosselet, M. Culot
2022Toxicology in Vitro3 citations Open access
Semantic Scholar
Modelling the Blood–Brain Barrier
M. Dehouck, Elodie Vandenhaute, L. Dehouck, E. Sevin +5 more
20113 citations
Semantic Scholar
In vitro blood–brain barrier model adapted to repeated dose toxicological screening
A. da Costa, J. Hachani, C. Landry, R. Cecchelli +1 more
20113 citations
Semantic Scholar
Evaluation of the impact of iPSC differentiation protocols on transcriptomic signatures.
V. Chandrasekaran, S. Wellens, A. Bourguignon, Ivo Djidrovski +18 more
2024Toxicology in Vitro2 citations Open access
Semantic Scholar
Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model
Solène Masloh, A. Chevrel, M. Culot, Anaëlle Perrocheau +7 more
2024Pharmaceutics2 citations Open access
Semantic Scholar
A snapshot on the progress of in vitro toxicology for safety assessment.
P. Jennings, R. Corvi, M. Culot
2017Toxicology in Vitro2 citations Open access
Semantic Scholar
Pharmacokinetic, in vitro and in silico assessment of anti-inflammatory alkaloids from Isatis tinctoria L.
M. Hamburger, E. Jähne, V. Butterweck, M. Oufir +6 more
20152 citations
Semantic Scholar

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