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R. Cecchelli · SciRah

Researcher profile · Semantic Scholar

R. Cecchelli

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R. Cecchelli — researcher profile on SciRah

h-index: 61
Works: 191
Citations: 13K

Most-cited papers

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use
H. C. Helms, N. Abbott, M. Burek, R. Cecchelli +10 more
2016Journal of Cerebral Blood Flow and Metabolism655 citations Open access
Semantic Scholar
Modelling of the blood–brain barrier in drug discovery and development
R. Cecchelli, Vincent Bérézowski, S. Lundquist, M. Culot +3 more
2007Nature reviews. Drug discovery619 citations
Semantic Scholar
A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells
R. Cecchelli, Sezin Aday, E. Sevin, C. Almeida +6 more
2014PLoS ONE298 citations Open access
Semantic Scholar
P1‐011: Involvement of LRP1 and RAGE in the transport of β‐amyloid (Aβ) peptide across the blood‐brain barrier: Use of an in vitro model
Pietra Candela, Fabien Gosselet, M. Boucau, E. Sevin +2 more
2009Human Molecular Genetics274 citations Open access
Semantic Scholar
Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-Resistant T Cell Arrest, Polarization, and Directed Crawling on Blood–Brain Barrier Endothelium
Oliver Steiner, Caroline Coisne, R. Cecchelli, R. Boscacci +3 more
2010Journal of Immunology254 citations Open access
Semantic Scholar
Ca(2+) regulation of connexin 43 hemichannels in C6 glioma and glial cells.
E. De Vuyst, Nan Wang, E. Decrock, M. De Bock +9 more
2009Cell Calcium200 citations
Semantic Scholar
VEGF-Induced BBB Permeability is Associated with an MMP-9 Activity Increase in Cerebral ischemia: Both Effects Decreased by ANG-1
S. Valable, J. Montaner, A. Bellail, Vincent Bérézowski +7 more
2005Journal of Cerebral Blood Flow and Metabolism199 citations
Semantic Scholar
Mouse syngenic in vitro blood–brain barrier model: a new tool to examine inflammatory events in cerebral endothelium
Caroline Coisne, L. Dehouck, C. Faveeuw, Y. Delplace +7 more
2005Laboratory Investigation190 citations Open access
Semantic Scholar
Tissue-Type Plasminogen Activator Crosses the Intact Blood-Brain Barrier by Low-Density Lipoprotein Receptor–Related Protein-Mediated Transcytosis
K. Benchenane, Vincent Bérézowski, C. Ali, Mónica Fernández‐Monreal +9 more
2005Circulation175 citations Open access
Semantic Scholar
Endothelial calcium dynamics, connexin channels and blood-brain barrier function.
M. De Bock, Nan Wang, E. Decrock, Mélissa Bol +5 more
2013Progress in neurobiology164 citations
Semantic Scholar
Stem Cell-Based Human Blood-Brain Barrier Models for Drug Discovery and Delivery.
Sezin Aday, R. Cecchelli, D. Hallier-Vanuxeem, M. Dehouck +1 more
2016Trends in Biotechnology154 citations Open access
Semantic Scholar
Connexin Channels Provide a Target to Manipulate Brain Endothelial Calcium Dynamics and Blood—Brain Barrier Permeability
M. De Bock, M. Culot, Nan Wang, Mélissa Bol +13 more
2011Journal of Cerebral Blood Flow and Metabolism147 citations Open access
Semantic Scholar
Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts
Stefan Hamm, B. Dehouck, J. Kraus, K. Wolburg-Buchholz +5 more
2004Cell and Tissue Research146 citations Open access
Semantic Scholar
An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening.
M. Culot, S. Lundquist, Dorothée Vanuxeem, S. Nion +6 more
2008Toxicology in Vitro134 citations
Semantic Scholar
Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein
Pietra Candela, F. Gosselet, J. Saint-Pol, E. Sevin +4 more
2010Journal of Alzheimer's Disease126 citations
Semantic Scholar
Mycobacterium tuberculosis heparin-binding haemagglutinin adhesin (HBHA) triggers receptor-mediated transcytosis without altering the integrity of tight junctions.
F. Menozzi, V. Reddy, D. Cayet, D. Raze +4 more
2006Microbes and infection111 citations Open access
Semantic Scholar
Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro.
Pietra Candela, F. Gosselet, F. Miller, V. Buée-Scherrer +3 more
2008Endothelium-journal of Endothelial Cell Research107 citations Open access
Semantic Scholar
Oxygen Glucose Deprivation Switches the Transport of tPA Across the Blood–Brain Barrier From an LRP-Dependent to an Increased LRP-Independent Process
K. Benchenane, Vincent Bérézowski, Mónica Fernández‐Monreal, J. Brillault +6 more
2005Stroke97 citations
Semantic Scholar
Modelling the neurovascular unit and the blood-brain barrier with the unique function of pericytes.
Elodie Vandenhaute, L. Dehouck, M. Boucau, E. Sevin +6 more
2011Current Neurovascular Research93 citations
Semantic Scholar
MiniAp‐4: A Venom‐Inspired Peptidomimetic for Brain Delivery
Benjamí Oller-Salvia, M. Sánchez-Navarro, Sonia Ciudad, M. Guiu +7 more
2015Angewandte Chemie88 citations Open access
Semantic Scholar
Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: use of an in vitro model.
F. Gosselet, Pietra Candela, E. Sevin, Vincent Bérézowski +2 more
2009Brain Research87 citations Open access
Semantic Scholar
A new angle on blood–CNS interfaces: A role for connexins?
M. De Bock, R. E. Vandenbroucke, E. Decrock, M. Culot +2 more
2014FEBS Letters86 citations Open access
Semantic Scholar
Accelerated Caco-2 cell permeability model for drug discovery.
E. Sevin, L. Dehouck, A. F. Costa, R. Cecchelli +3 more
2013Journal of pharmacological and toxicological methods80 citations
Semantic Scholar
Induction of blood‐brain barrier properties in cultured brain capillary endothelial cells: Comparison between primary glial cells and C6 cell line
Monica Boveri, Vincent Bérézowski, A. Price, S. Slupek +6 more
2005Glia78 citations
Semantic Scholar
Localization of organic cation/carnitine transporter (OCTN2) in cells forming the blood–brain barrier
Dorota Miecz, E. Januszewicz, M. Czeredys, Barry T. Hinton +3 more
2007Journal of Neurochemistry70 citations Open access
Semantic Scholar
Specific AHNAK expression in brain endothelial cells with barrier properties
Benoit J. Gentil, Christelle Benaud, C. Delphin, C. Rémy +5 more
2005Journal of Cellular Physiology70 citations
Semantic Scholar
Highly purified lipoteichoic acid from gram-positive bacteria induces in vitro blood-brain barrier disruption through glia activation: role of pro-inflammatory cytokines and nitric oxide.
Monica Boveri, A. Kinsner, Vincent Bérézowski, A. Lenfant +6 more
2006Neuroscience69 citations
Semantic Scholar
Maternal calorie restriction modulates placental mitochondrial biogenesis and bioenergetic efficiency: putative involvement in fetoplacental growth defects in rats.
S. Mayeur, S. Lancel, N. Theys, M. Lukaszewski +11 more
2013American Journal of Physiology. Endocrinology and Metabolism68 citations Open access
Semantic Scholar
Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models.
Luise Schultz, M. Zurich, M. Culot, A. da Costa +15 more
2015Toxicology in Vitro66 citations Open access
Semantic Scholar
Brain Pericytes ABCA1 Expression Mediates Cholesterol Efflux but not Cellular Amyloid-β Peptide Accumulation
J. Saint-Pol, Elodie Vandenhaute, M. Boucau, Pietra Candela +5 more
2012Journal of Alzheimer's Disease63 citations Open access
Semantic Scholar
Stroke-Induced Brain Parenchymal Injury Drives Blood–Brain Barrier Early Leakage Kinetics: A Combined in Vivo/in Vitro Study
Mélanie Kuntz, Caroline Mysiorek, Olivier Petrault, M. Pétrault +5 more
2014Journal of Cerebral Blood Flow and Metabolism60 citations Open access
Semantic Scholar
Evidence of lowest brain penetration of an antiemetic drug, metopimazine, compared to domperidone, metoclopramide and chlorpromazine, using an in vitro model of the blood-brain barrier.
P. Jolliet, S. Nion, G. Allain-Veyrac, L. Tilloy-Fenart +3 more
2007Pharmacological Research59 citations
Semantic Scholar
Recombinant Desmodus rotundus Salivary Plasminogen Activator Crosses the Blood–Brain Barrier Through a Low-Density Lipoprotein Receptor-Related Protein-Dependent Mechanism Without Exerting Neurotoxic Effects
J. López-Atalaya, B. D. Roussel, C. Ali, E. Maubert +5 more
2007Stroke57 citations Open access
Semantic Scholar
Peroxisome Proliferator-Activated Receptor-α Activation Protects Brain Capillary Endothelial Cells from Oxygen-Glucose Deprivation-Induced Hyperpermeability in the Blood-Brain Barrier
Caroline Mysiorek, M. Culot, L. Dehouck, B. Derudas +5 more
200956 citations
Semantic Scholar
Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells
C. Praça, S. Rosa, E. Sevin, R. Cecchelli +2 more
2019Stem Cell Reports54 citations Open access
Semantic Scholar
ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier
Aurore Drolez, Elodie Vandenhaute, C. Delannoy, Justine H. Dewald +6 more
2016International Journal of Molecular Sciences48 citations Open access
Semantic Scholar
Methylated β-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood–brain barrier
S. Tilloy, V. Monnaert, L. Fenart, H. Bricout +2 more
200648 citations
Semantic Scholar
The MAP kinase pathway mediates transcytosis induced by TNF‐α in an in vitro blood–brain barrier model
F. Miller, L. Fenart, V. Landry, Caroline Coisne +3 more
2005European Journal of Neuroscience44 citations
Semantic Scholar
The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: results from the European Project ACuteTox.
P. Prieto, Agnieszka Kinsner-Ovaskainen, S. Stanzel, B. Albella +19 more
2013Toxicology in Vitro39 citations Open access
Semantic Scholar
New strategy for alerting central nervous system toxicity: Integration of blood-brain barrier toxicity and permeability in neurotoxicity assessment.
D. Hallier-Vanuxeem, P. Prieto, M. Culot, H. Diallo +3 more
2009Toxicology in Vitro39 citations
Semantic Scholar
Understanding the blood-brain barrier using gene and protein expression profiling technologies.
G. Pottiez, C. Flahaut, R. Cecchelli, Y. Karamanos
2009Brain Research Reviews38 citations
Semantic Scholar
Blood-Brain Barrier In Vitro Models and Their Application in Toxicology: The Report and Recommendations of ECVAM Workshop 491,2
P. Prieto, B. Blaauboer, A. G. de Boer, Monica Boveri +9 more
2004Alternatives to laboratory animals : ATLA38 citations
Semantic Scholar
A nanoformulation for the preferential accumulation in adult neurogenic niches
C. Praça, Akhilesh Rai, T. Santos, A. Cristóvão +5 more
2018Journal of Controlled Release37 citations Open access
Semantic Scholar
In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs.
D. Eigenmann, Carmen Dürig, E. Jähne, M. Smieško +9 more
2016European journal of pharmaceutics and biopharmaceutics37 citations Open access
Semantic Scholar
Selection of a Relevant In Vitro Blood-Brain Barrier Model to Investigate Pro-Metastatic Features of Human Breast Cancer Cell Lines
Aurore Drolez, Elodie Vandenhaute, S. Julien, F. Gosselet +5 more
2016PLoS ONE34 citations Open access
Semantic Scholar
A Simple Method for Assessing Free Brain/Free Plasma Ratios Using an In Vitro Model of the Blood Brain Barrier
M. Culot, Anaëlle Fabulas-da Costa, E. Sevin, Erica Szorath +5 more
2013PLoS ONE34 citations Open access
Semantic Scholar
Differential expression of selectins by mouse brain capillary endothelial cells in vitro in response to distinct inflammatory stimuli.
Caroline Coisne, C. Faveeuw, Y. Delplace, L. Dehouck +3 more
2006Neuroscience Letters34 citations
Semantic Scholar
Endothelial Cells and Astrocytes: A Concerto en Duo in Ischemic Pathophysiology
Vincent Bérézowski, A M Fukuda, R. Cecchelli, J. Badaut
2012International Journal of Cell Biology33 citations Open access
Semantic Scholar
Transport Screening of Drug Cocktails Through an in Vitro Blood-Brain Barrier: Is It a Good Strategy for Increasing the Throughput of the Discovery Pipeline?
Vincent Bérézowski, C. Landry, S. Lundquist, L. Dehouck +3 more
2004Pharmaceutical Research33 citations
Semantic Scholar
Involvement of OCTN2 and B0,+ in the transport of carnitine through an in vitro model of the blood–brain barrier
Vincent Bérézowski, Dorota Miecz, M. Marszałek, A. Bröer +3 more
2004Journal of Neurochemistry33 citations Open access
Semantic Scholar

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M. Dehouck×18
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Vincent Bérézowski×17
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L. Fenart×14
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M. Culot×13
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F. Gosselet — researcher profile on SciRah

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