Researcher profile · Semantic Scholar

Roshanak Irannejad

h-index: 18
Works: 36
Citations: 2,324

Most-cited papers

Conformational biosensors reveal adrenoceptor signalling from endosomes
Roshanak Irannejad, Jin C. Tomshine, Jon R. Tomshine, Michael W. Chevalier +7 more
2013Nature802 citations Open access
Semantic Scholar
Functional selectivity of GPCR-directed drug action through location bias
Roshanak Irannejad, V. Pessino, D. Mika, Bo Huang +3 more
2017Nature Chemical Biology218 citations Open access
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GPCR signaling along the endocytic pathway
Roshanak Irannejad, M. von Zastrow
2013Current Opinion in Cell Biology197 citations Open access
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Assembly and trafficking of heterotrimeric G proteins.
Yannick Marrari, Marykate Crouthamel, Roshanak Irannejad, P. Wedegaertner
2007Biochemistry181 citations Open access
Semantic Scholar
Effects of endocytosis on receptor-mediated signaling
Roshanak Irannejad, Nikoleta G. Tsvetanova, Braden T. Lobingier, M. von Zastrow
2015Current Opinion in Cell Biology159 citations Open access
Semantic Scholar
G Protein-coupled Receptor (GPCR) Signaling via Heterotrimeric G Proteins from Endosomes*
Nikoleta G. Tsvetanova, Roshanak Irannejad, M. von Zastrow
2015Journal of Biological Chemistry156 citations Open access
Semantic Scholar
Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy
Craig A. Nash, Wen-Hui Wei, Roshanak Irannejad, A. Smrcka
2019bioRxiv77 citations Open access
Semantic Scholar
Regulation of Constitutive Cargo Transport from the trans-Golgi Network to Plasma Membrane by Golgi-localized G Protein βγ Subunits*
Roshanak Irannejad, P. Wedegaertner
2010Journal of Biological Chemistry67 citations Open access
Semantic Scholar
The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor*
Xufan Tian, Roshanak Irannejad, Shanna L. Bowman, Yang Du +3 more
2016Journal of Biological Chemistry63 citations Open access
Semantic Scholar
Retromer endosome exit domains serve multiple trafficking destinations and regulate local G protein activation by GPCRs
Katherine C. Varandas, Roshanak Irannejad, M. von Zastrow
2016Current Biology62 citations Open access
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G protein-regulated endocytic trafficking of adenylyl cyclase type 9
A. Lazar, Roshanak Irannejad, Tanya A. Baldwin, A. Sundaram +4 more
2020bioRxiv50 citations Open access
Semantic Scholar
Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools
Ting-Yu Lin, Quynh N. Mai, Hao Zhang, Emily E. Wilson +5 more
2023Nature Chemical Biology46 citations Open access
Semantic Scholar
cAMP signaling: a precise regional affair
Andreas Bock, Roshanak Irannejad, John D. Scott
2024TIBS -Trends in Biochemical Sciences. Regular ed45 citations Open access
Semantic Scholar
Emerging Role of Compartmentalized G Protein-Coupled Receptor Signaling in the Cardiovascular Field
B. Plouffe, A. R. B. Thomsen, Roshanak Irannejad
2020ACS Pharmacology & Translational Science42 citations Open access
Semantic Scholar
The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus
Natasha Puri, G. Romano, Ting-Yu Lin, Quynh N. Mai +1 more
2022eLife34 citations Open access
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Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies
S. Yee, A. Stecula, Huan-Chieh Chien, L. Zou +10 more
2019bioRxiv33 citations Open access
Semantic Scholar
G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway
S. Malik, R. G. deRubio, M. Trembley, Roshanak Irannejad +2 more
2015Molecular Biology of the Cell32 citations Open access
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Genetically Encoding Quinoline Reverses Chromophore Charge and Enables Fluorescent Protein Brightening in Acidic Vesicles
Caiyun Fu, Tomonori Kobayashi, Nanxi Wang, C. Hoppmann +3 more
2018Journal of the American Chemical Society21 citations Open access
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Investigating signaling consequences of GPCR trafficking in the endocytic pathway
Roshanak Irannejad, Sarah J. Kotowski, M. von Zastrow
2014Methods in Enzymology10 citations Open access
Semantic Scholar
Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist
F. Liccardo, Johannes Morstein, Ting-Yu Lin, Julius Pampel +3 more
2024Proceedings of the National Academy of Sciences of the United States of America8 citations Open access
Semantic Scholar
Functional selectivity of GPCR‐directed drug action through location bias
Roshanak Irannejad
2017The FASEB Journal5 citations Open access
Semantic Scholar
Inhibition of muscarinic receptor signaling protects human enteric inhibitory neurons against platin chemotherapy toxicity
Mikayla N Richter, Sina Farahvashi, Ryan M. Samuel, Homa Majd +23 more
2023bioRxiv4 citations Open access
Semantic Scholar
Anionic phospholipids determine G protein coupling selectivity at distinct subcellular membrane compartments
Evelyn Hernandez, A. Manglik, Roshanak Irannejad
2023bioRxiv3 citations Open access
Semantic Scholar
Inhibitory probes for spatiotemporal analysis of Gαs protein signaling
Jingyi Zhao, A. Luebbers, S. Savransky, Ting-Yu Lin +10 more
2026Nature Chemical Biology2 citations Open access
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Selective activation of intracellular β1AR using a spatially restricted antagonist
F. Liccardo, Johannes Morstein, Ting-Yu Lin, Julius Pampel +2 more
2023bioRxiv2 citations Open access
Semantic Scholar
Smoothened and ciliary GPCRs regulate ciliary protein kinase A activity involved in Hedgehog signal transduction
Thi D. Nguyen, Mia J. Konjikusic, Lorenzo M. del Castillo, Roshanak Irannejad +1 more
2026PLoS Biology1 citations Open access
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Cardiac contraction and relaxation are regulated by beta 1 adrenergic receptor-generated cAMP pools at distinct membrane locations
Ting-Yu Lin, Quynh N. Mai, Hao Zhang, Emily E. Wilson +5 more
2023bioRxiv1 citations Open access
Semantic Scholar
GPCR-dependent spatiotemporal cAMP generation confers functional specificity in cardiomyocytes and cardiac responses
Quynh N. Mai, Ting-Yu Lin, Hao Zhang, Emily E. Wilson +5 more
20221 citations
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The OCT2 Transporter Regulates Dopamine D1 Receptor Signaling at the Golgi Apparatus
Natasha Puri, G. Romano, Ting-Yu Lin, Quynh N. Mai +1 more
20211 citations
Semantic Scholar
Regulation of Dopamine D1 Receptor Signaling at the Golgi Apparatus by a Low Affinity Dopamine Transporter
Natasha Puri, G. Romano, Quynh N. Mai, Roshanak Irannejad
2020bioRxiv1 citations Open access
Semantic Scholar
Genetically Encoded Probes and Peptide-Based Compounds to Inhibit Gαs Signaling in Cells (Abstract ID: 228310)
Jingyi Zhao, A. Luebbers, S. Savransky, Ting-Yu Lin +10 more
2026Journal of Pharmacology and Experimental Therapeutics0 citations
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Author response: G protein-regulated endocytic trafficking of adenylyl cyclase type 9
A. Lazar, Roshanak Irannejad, Tanya A. Baldwin, A. Sundaram +4 more
20200 citations Open access
Semantic Scholar
Abstract 354: Golgi Localized β 1 -adrenergic Receptors Stimulate Golgi PI4P Hydrolysis by PLCε to Regulate Cardiac Hypertrophy
Wen-Hui Wei, Craig A. Nash, Roshanak Irannejad, A. Smrcka
2019Circulation Research0 citations
Semantic Scholar
Endocytic membrane traffic and cell signaling
M. Zastrow, Paul Temkin, Anastasia G. Henry, Roshanak Irannejad
20130 citations
Semantic Scholar
Faculty Opinions recommendation of Palmitoylated Ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis.
P. Wedegaertner, Roshanak Irannejad
20100 citations
Semantic Scholar
Determining The Role of Subcellular Localization of Heterotrimeric G Protein βγ Subunits in a Trans Golgi Network‐To‐Plasma Membrane Vesicle Formation Pathway
Roshanak Irannejad, Philip B. Wedegaertner
20090 citations
Semantic Scholar

Huan-Chieh Chien

×4

S. Yee×4

K. Giacomini×4

A. Smrcka×3

Ting-Yu Lin×3

Hao Zhang×3

Emily E. Wilson×3

J. Olgin×3