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S. Malik · SciRah

Researcher profile · Semantic Scholar

S. Malik

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S. Malik — researcher profile on SciRah

h-index: 25
Works: 53
Citations: 2,031

Most-cited papers

Differential Targeting of Gßγ-Subunit Signaling with Small Molecules
T. M. Bonacci, Jennifer L. Mathews, Chujun Yuan, D. Lehmann +5 more
2006Science225 citations
Semantic Scholar
Epac and Phospholipase Cϵ Regulate Ca2+ Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II*
Emily A. Oestreich, S. Malik, Sanjeewa A. Goonasekera, B. Blaxall +3 more
2009Journal of Biological Chemistry170 citations Open access
Semantic Scholar
Epac-mediated Activation of Phospholipase Cϵ Plays a Critical Role in β-Adrenergic Receptor-dependent Enhancement of Ca2+ Mobilization in Cardiac Myocytes*
Emily A. Oestreich, Huan Wang, S. Malik, K. Kaproth-Joslin +4 more
2007Journal of Biological Chemistry165 citations Open access
Semantic Scholar
Phospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy
Lianghui Zhang, S. Malik, Jin-Jiang Pang, Huan Wang +4 more
2013Cell150 citations Open access
Semantic Scholar
Regulation of Epidermal Growth Factor-induced Connexin 43 Gap Junction Communication by Big Mitogen-activated Protein Kinase 1/ERK5 but Not ERK1/2 Kinase Activation*
S. Cameron, S. Malik, M. Akaike, N. Lerner‐Marmarosh +4 more
2003Journal of Biological Chemistry116 citations Open access
Semantic Scholar
Differential targeting of Gbetagamma-subunit signaling with small molecules.
T. M. Bonacci, Jennifer L. Mathews, Chujun Yuan, D. Lehmann +5 more
2006Science103 citations
Semantic Scholar
Phospholipase Cϵ Scaffolds to Muscle-specific A Kinase Anchoring Protein (mAKAPβ) and Integrates Multiple Hypertrophic Stimuli in Cardiac Myocytes*
Lianghui Zhang, S. Malik, G. Kelley, M. Kapiloff +1 more
2011Journal of Biological Chemistry97 citations Open access
Semantic Scholar
Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes.
Emily A. Oestreich, Huan Wang, S. Malik, K. Kaproth-Joslin +4 more
2007Journal of Biological Chemistry90 citations
Semantic Scholar
Induction of Ca++ influx and intracellular Ca++ release in isolated rat aorta and mesenteric resistance vessels by norepinephrine activation of alpha-1 receptors.
C. Cauvin, S. Malik
1984Journal of Pharmacology and Experimental Therapeutics77 citations
Semantic Scholar
Phospholipase Cε is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation
Simona Citro, S. Malik, Emily A. Oestreich, J. Radeff‐Huang +3 more
2007Proceedings of the National Academy of Sciences of the United States of America76 citations Open access
Semantic Scholar
Stimulation of Cellular Signaling and G Protein Subunit Dissociation by G Protein βγ Subunit-binding Peptides*
Farida Goubaeva, M. Ghosh, S. Malik, J. Yang +4 more
2003Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Epac2‐dependent mobilization of intracellular Ca2+ by glucagon‐like peptide‐1 receptor agonist exendin‐4 is disrupted in β‐cells of phospholipase C‐ɛ knockout mice
I. Dzhura, O. Chepurny, G. Kelley, C. A. Leech +9 more
2010Journal of Physiology66 citations Open access
Semantic Scholar
Transverse tubule remodeling enhances Orai1-dependent Ca2+ entry in skeletal muscle
A. Michelucci, S. Boncompagni, L. Pietrangelo, M. García-Castañeda +4 more
2019eLife47 citations Open access
Semantic Scholar
Regulatory Interactions between the Amino Terminus of G-protein βγ Subunits and the Catalytic Domain of Phospholipase Cβ2*
T. M. Bonacci, M. Ghosh, S. Malik, A. Smrcka
2005Journal of Biological Chemistry46 citations Open access
Semantic Scholar
Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production
Rafael Gil de Rubio, R. Ransom, S. Malik, D. Yule +2 more
2018Science Signaling41 citations Open access
Semantic Scholar
Adrenocorticotropic Hormone (ACTH) Responses Require Actions of the Melanocortin-2 Receptor Accessory Protein on the Extracellular Surface of the Plasma Membrane*
S. Malik, Terrance M. Dolan, Z. Maben, P. M. Hinkle
2015Journal of Biological Chemistry40 citations Open access
Semantic Scholar
Differential Role of MEK5α and MEK5β in BMK1/ERK5 Activation*
S. Cameron, J. Abe, S. Malik, W. Che +1 more
2003Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rat
M. Garry, S. Malik, Jie Yu, Michael A. Davis +1 more
2000NeuroReport37 citations
Semantic Scholar
Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ
Chinmay R. Surve, Jesi Y. To, S. Malik, Minsoo Kim +1 more
2016Science Signaling34 citations Open access
Semantic Scholar
Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiple Interaction Sites
C. Brand, Rachna Sadana, S. Malik, A. Smrcka +1 more
2015Molecular Pharmacology33 citations Open access
Semantic Scholar
G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway
S. Malik, R. G. deRubio, M. Trembley, Roshanak Irannejad +2 more
2015Molecular Biology of the Cell32 citations Open access
Semantic Scholar
Mouse model of severe recessive RYR1-related myopathy.
S. Brennan, M. García-Castañeda, A. Michelucci, N. Sabha +5 more
2019Human Molecular Genetics31 citations Open access
Semantic Scholar
Ric-8 Enhances G Protein βγ-Dependent Signaling in Response to βγ-Binding Peptides in Intact Cells
S. Malik, M. Ghosh, T. M. Bonacci, G. Tall +1 more
2005Molecular Pharmacology30 citations
Semantic Scholar
Compartmentalized Cyclic Nucleotides Have Opposing Effects on Regulation of Hypertrophic Phospholipase Cε Signaling in Cardiac Myocytes
Craig A. Nash, Loren M. Brown, S. Malik, Xiao-Dong Cheng +1 more
2018Journal of Molecular and Cellular Cardiology28 citations Open access
Semantic Scholar
Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides.
Farida Goubaeva, M. Ghosh, S. Malik, J. Yang +4 more
2003Journal of Biological Chemistry28 citations
Semantic Scholar
Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation.
S. Cameron, J. Abe, S. Malik, W. Che +1 more
2004Journal of Biological Chemistry22 citations
Semantic Scholar
Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy
M. García-Castañeda, A. Michelucci, Nan Zhao, S. Malik +1 more
2022The Journal of General Physiology18 citations Open access
Semantic Scholar
Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function
L. Terry, K. Alzayady, A. Wahl, S. Malik +1 more
2020Journal of Biological Chemistry18 citations Open access
Semantic Scholar
M3 Muscarinic Receptor Interaction with Phospholipase C β3 Determines Its Signaling Efficiency*
Wei Kan, M. Adjobo-Hermans, Michael Burroughs, Guy Faibis +3 more
2014Journal of Biological Chemistry18 citations Open access
Semantic Scholar
Potassium conservation is impaired in mice with reduced renal expression of Kir4.1.
S. Malik, Emily Lambert, Jun-Hui Zhang, Tong Wang +7 more
2018AJP - Renal Physiology17 citations Open access
Semantic Scholar
Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2.
T. M. Bonacci, M. Ghosh, S. Malik, A. Smrcka
2005Journal of Biological Chemistry16 citations
Semantic Scholar
Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+
Pragnya Chakraborty, B. K. Deb, Vikas Arige, Thasneem Musthafa +4 more
2023bioRxiv15 citations Open access
Semantic Scholar
Ric-8 enhances G protein betagamma-dependent signaling in response to betagamma-binding peptides in intact cells.
S. Malik, M. Ghosh, T. M. Bonacci, G. Tall +1 more
2005Molecular Pharmacology12 citations
Semantic Scholar
Dual Topology of the Melanocortin-2 Receptor Accessory Protein Is Stable
Z. Maben, S. Malik, Li-Yi Jiang, P. M. Hinkle
2016Frontiers in Endocrinology10 citations Open access
Semantic Scholar
Missense mutations in inositol 1,4,5-trisphosphate receptor type 3 result in leaky Ca2+ channels and activation of store-operated Ca2+ entry
L. Terry, Vikas Arige, Julika Neumann, A. Wahl +7 more
2022iScience8 citations Open access
Semantic Scholar
Interleukin-1 b Inhibits g-Aminobutyric Acid Type A ( GABAA ) Receptor Current in Cultured Hippocampal Neurons
Sam Wang, Qing Cheng, S. Malik, J. Yang
20007 citations
Semantic Scholar
Characterization of ORAI1G100s/+ mouse model of tubular aggregate myopathy.
Nan Zhao, A. Michelucci, M. He, S. Malik +4 more
2023Biophysical Journal0 citations Open access
Semantic Scholar
Missense Mutations in Inositol 1,4,5-Trisphosphate Receptor Type 3 Result in Leaky Ca 2+ Channels and Inappropriate Activation of Store-Operated Ca 2+ Entry
L. Terry, Vikas Arige, Julika Neumann, A. Wahl +7 more
2022Social Science Research Network0 citations Open access
Semantic Scholar
Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function.
L. Terry, K. Alzayady, A. Wahl, S. Malik +1 more
2020Journal of Biological Chemistry0 citations Open access
Semantic Scholar
PLC‐Dependent Hydrolysis of Phosphatidylinositol 4‐Phosphate is Responsible for the Majority of Total Inositol Phosphate Production and PKC/D Activation Downstream of Multiple GPCRs
Rafael Rubio, S. Malik, A. Smrcka
2017The FASEB Journal0 citations Open access
Semantic Scholar
Identifying a Phospholipase C Epsilon Region that Interacts with Gbeta Gamma
J. Madukwe, S. Malik, A. Smrcka
2017The FASEB Journal0 citations Open access
Semantic Scholar
PI4P Hydrolysis is a Major Mechanism for GPCR‐dependent DAG Generation and PKC/PKD Activation
Rafael H. Gil de Rubio, S. Malik, A. Smrcka
2016The FASEB Journal0 citations Open access
Semantic Scholar
Beta Cell CICR Model
I. Dzhura, O. Chepurny, G. Kelley, C. A. Leech +9 more
20150 citations
Semantic Scholar
PI4P Hydrolysis Represents a General Mechanism for DAG Generation and PKC/PKD Activation
Rafael Gil de Rubio, S. Malik, Li-Wei Wang, A. Smrcka
20150 citations
Semantic Scholar
Epac2 KO Characterization
I. Dzhura, O. Chepurny, G. Kelley, C. A. Leech +9 more
20150 citations
Semantic Scholar
Direct Physical Scaffolding of Muscarinic M3 Receptor Signal Transduction Pathways
Kan Wei, S. Malik, Guy Faibis, A. Smrcka
20120 citations
Semantic Scholar
J Physiol 2010 Islam Perspective
I. Dzhura, O. Chepurny, G. Kelley, C. A. Leech +9 more
20120 citations
Semantic Scholar
Abstract 307: Phospholipase Cε Is Involved in Gq-Dependent Protein Kinase D Activation in Cardiac Myocytes
A. Smrcka, Lianghui Zhang, S. Malik
20120 citations
Semantic Scholar
Phospholipase Cε Regulates Multiple Agonists‐Induced Cardiomyocyte Hypertrophy in Neonatal Rat Ventricular Myocytes By Binding To mAKAP (Muscle A‐Kinase Anchoring Protein) And Generating Local IP3‐Dependent Nuclear Calcium Release
Lianghui Zhang, S. Malik, Keigan M. Park, Michael S. Kapiloff +2 more
20110 citations
Semantic Scholar
Phospholipase C-Epsilon Couples cAMP Production and Epac2 Activation to the Facilitation of Calcium-Induced Calcium Release (CICR) in Pancreatic Beta Cells
G. G. Holz, I. Dzhura, O. Chepurny, C. A. Leech +9 more
20110 citations Open access
Semantic Scholar

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