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K. Giacomini · SciRah

Researcher profile · Semantic Scholar

K. Giacomini

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K. Giacomini — researcher profile on SciRah

h-index: 86
Works: 476
Citations: 28K

Most-cited papers

The Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for SLCO1B1, ABCG2, and CYP2C9 and statin-associated musculoskeletal symptoms
R. Cooper-DeHoff, M. Niemi, Laura B. Ramsey, Jasmine A. Luzum +17 more
2022Clinical pharmacology and therapy324 citations Open access
Semantic Scholar
Membrane Transporters in Drug Development and as Determinants of Precision Medicine
A. Galetin, K. R. Brouwer, D. Tweedie, Kenta Yoshida +17 more
2024Nature reviews. Drug discovery222 citations Open access
Semantic Scholar
A New Era in Pharmacovigilance: Towards real world data and digital monitoring
A. Lavertu, Bianca Vora, K. Giacomini, R. Altman +1 more
2021Clinical pharmacology and therapy121 citations Open access
Semantic Scholar
Artificial intelligence, ChatGPT, and other large language models for social determinants of health: Current state and future directions
J. Ong, Benjamin Jun Jie Seng, J. Law, Lian Leng Low +3 more
2024Cell Reports Medicine102 citations Open access
Semantic Scholar
A genome-wide association analysis reveals new pathogenic pathways in gout
T. J. Major, R. Takei, H. Matsuo, M. Leask +95 more
2024Nature Genetics91 citations Open access
Semantic Scholar
The activities of drug inactive ingredients on biological targets
J. Pottel, D. Armstrong, L. Zou, Alex Fekete +16 more
2020Science81 citations Open access
Semantic Scholar
Emerging Roles of the Human Solute Carrier 22 Family
S. Yee, K. Giacomini
2021Drug Metabolism And Disposition70 citations Open access
Semantic Scholar
Opportunities and challenges for the computational interpretation of rare variation in clinically important genes
G. McInnes, Andrew G. Sharo, Megan L. Koleske, Julie E. H. Brown +10 more
2021American Journal of Human Genetics64 citations Open access
Semantic Scholar
Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives
L. Zou, Peter Spanogiannopoulos, Lindsey M. Pieper, Huan-Chieh Chien +10 more
2019Proceedings of the National Academy of Sciences of the United States of America53 citations Open access
Semantic Scholar
Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools
Ting-Yu Lin, Quynh N. Mai, Hao Zhang, Emily E. Wilson +5 more
2023Nature Chemical Biology46 citations Open access
Semantic Scholar
Deorphaning a Solute Carrier 22 family member, SLC22A15, through functional genomic studies
S. Yee, Dina Buitrago, A. Stecula, H. Ngo +4 more
2020The FASEB Journal45 citations Open access
Semantic Scholar
New and emerging research on solute carrier (SLC) and ABC transporters in drug discovery and development: Outlook from the International Transporter Consortium
K. Giacomini, S. Yee, Megan L. Koleske, L. Zou +6 more
2022Clinical pharmacology and therapy38 citations Open access
Semantic Scholar
Structural and molecular basis of choline uptake into the brain by FLVCR2
R. Cater, Dibyanti Mukherjee, Eva Gil-Iturbe, S. Erramilli +19 more
2024Nature37 citations Open access
Semantic Scholar
Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas
A. Dawed, S. Yee, K. Zhou, N. van Leeuwen +25 more
2021Diabetes Care37 citations Open access
Semantic Scholar
Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies
S. Yee, A. Stecula, Huan-Chieh Chien, L. Zou +10 more
2019bioRxiv33 citations Open access
Semantic Scholar
The full spectrum of OCT1 (SLC22A1) mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics
S. Yee, Christian B. Macdonald, Darko Mitrovic, Xu-Jia Zhou +11 more
2024Molecules and Cells28 citations
Semantic Scholar
Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP
L. Zou, J. Pottel, Natalia Khuri, H. Ngo +6 more
2020Molecular Pharmaceutics27 citations Open access
Semantic Scholar
Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency
Megan L. Koleske, G. McInnes, Julie E. H. Brown, Neil Thomas +9 more
2022Proceedings of the National Academy of Sciences of the United States of America26 citations Open access
Semantic Scholar
Drugs in COVID19 clinical trials: Predicting transporter-mediated drug-drug interactions using in vitro assays and real-world data
S. Yee, Bianca Vora, T. Oskotsky, L. Zou +7 more
2021Clinical pharmacology and therapy25 citations Open access
Semantic Scholar
Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3
L. Zou, Par Matsson€, A. Stecula, H. Ngo +2 more
2020Journal of Pharmacy and Science25 citations Open access
Semantic Scholar
High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3
E. Chen, P. Matsson, Mina Azimi, Xu-Jia Zhou +4 more
2022Pharmaceutical Research20 citations Open access
Semantic Scholar
A Critical Overview of the Biological Effects of Excipients (Part I): Impact on Gastrointestinal Absorption
Marilyn N. Martinez, B. Sinkó, Fang Wu, T. Flanagan +3 more
2022AAPS Journal20 citations
Semantic Scholar
Human Mutation
Osatohanmwen J. Enogieru, P. Ung, S. Yee, A. Schlessinger +1 more
201918 citations
Semantic Scholar
Haploinsufficiency underlies the neurodevelopmental consequences of SLC6A1 variants
Dina Buitrago Silva, Marena I. Trinidad, A. Ljungdahl, J. Revalde +16 more
2024American Journal of Human Genetics17 citations Open access
Semantic Scholar
Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics
Bianca Vora, Deanna Brackman, L. Zou, M. García-Cremades +3 more
2021Clinical and Translational Science17 citations Open access
Semantic Scholar
Identification of Genetic Variation Influencing Metformin Response in a Multi-Ancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP).
Josephine H. Li, James A. Perry, K. Jablonski, Shylaja Srinivasan +19 more
2022Diabetes16 citations Open access
Semantic Scholar
Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)
Satoshi Asano, A. Galetin, Y. Tomita, K. Giacomini +5 more
2025Clinical pharmacology and therapy15 citations Open access
Semantic Scholar
Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein
Ruchika Bajaj, Lisa B. Chong, L. Zou, E. Tsakalozou +3 more
2021AAPS Journal14 citations Open access
Semantic Scholar
COVID‐19: A Defining Moment for Clinical Pharmacology?
Pieter H. Graaf, K. Giacomini
2020Clinical pharmacology and therapy13 citations
Semantic Scholar
Development and evaluation of a lightweight large language model chatbot for medication enquiry
K. Elangovan, J. Ong, Li-Yuan Jin, Benjamin Jun Jie Seng +8 more
2025PLOS Digital Health11 citations Open access
Semantic Scholar
The Impacts of Slc19a3 Deletion and Intestinal SLC19A3 Insertion on Thiamine Distribution and Brain Metabolism in the Mouse
Anita Wen, Ying Zhu, S. Yee, Brian I. Park +3 more
2023Metabolites10 citations Open access
Semantic Scholar
Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling
J. P. Hunt, Samuel Dubinsky, Autumn M. Mcknite, K. Cheung +5 more
2023CPT: Pharmacometrics & Systems Pharmacology10 citations Open access
Semantic Scholar
Trends in Clinical Pharmacology and Therapeutics
I. Minichmayr, D. M. Smith, K. Giacomini, P. H. van der Graaf
2023Clinical pharmacology and therapy10 citations Open access
Semantic Scholar
The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics
S. Yee, Christian B. Macdonald, Darko Mitrovic, Xu-Jia Zhou +11 more
2023bioRxiv10 citations Open access
Semantic Scholar
The Effect of Trimethoprim on Thiamine Absorption: A Transporter‐Mediated Drug‐Nutrient Interaction
Bianca Vora, Anita Wen, S. Yee, Kim Trinh +6 more
2023Clinical pharmacology and therapy10 citations Open access
Semantic Scholar
Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins
Claudia Neul, U. Hofmann, E. Schaeffeler, S. Winter +5 more
2021British Journal of Pharmacology10 citations Open access
Semantic Scholar
Scientific Considerations for Global Drug Development
Jennifer L. Wilson, K. Cheung, Lawrence Lin, Elizabeth A E Green +19 more
2020Science Translational Medicine10 citations Open access
Semantic Scholar
Clinical Pharmacology & Therapeutics 2030
Pieter H. Graaf, K. Giacomini
2020Clinical pharmacology and therapy10 citations
Semantic Scholar
Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter
Lin Lin, George A. Lemieux, Osatohanmwen J. Enogieru, K. Giacomini +1 more
2020Genes & Development9 citations Open access
Semantic Scholar
Rare Diseases Linked to Mutations in Vitamin Transporters Expressed in the Human Blood-Brain Barrier
S. Yee, Joanne Wang, K. Giacomini
2024Clinical pharmacology and therapy8 citations
Semantic Scholar
Diversity, Equity, and Inclusion: Translating Clinical Pharmacology for All
K. Venkatakrishnan, Karen E. Brown, K. Giacomini, P. H. van der Graaf
2023Clinical pharmacology and therapy8 citations Open access
Semantic Scholar
Advancing Precision Medicine Through the New Pharmacogenomics Global Research Network
K. Giacomini, Jason Karnes, K. Crews, Andrew A. Monte +5 more
2021Clinical pharmacology and therapy8 citations Open access
Semantic Scholar
Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ ABCG2 )
Andrew M Riselli, S. Yee, Jia Yang, C. Brett +13 more
2025Clinical pharmacology and therapy7 citations Open access
Semantic Scholar
Effect of Antioxidants in Medicinal Products on Intestinal Drug Transporters
Chetan P. Kulkarni, Jia Yang, Megan L. Koleske, Giovanni Lara +11 more
2024Pharmaceutics7 citations Open access
Semantic Scholar
Proteomic profiling reveals age-related changes in transporter proteins in the human blood–brain barrier
Xu-Jia Zhou, Mina Azimi, Niklas Handin, Andrew M Riselli +7 more
2025Scientific Reports6 citations Open access
Semantic Scholar
Lightweight Large Language Model for Medication Enquiry: Med-Pal
K. Elangovan, J. Ong, Li-Yuan Jin, Benjamin Jun Jie Seng +8 more
2024arXiv.org6 citations
Semantic Scholar
Characterization of P-glycoprotein orthologs from human, sheep, pig, dog, and cat.
Mina Azimi, S. Yee, Andrew M Riselli, Dina Buitrago Silva +3 more
2023Journal of Veterinary Pharmacology and Therapeutics6 citations
Semantic Scholar
TICBase: Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters
M. Michel, Christopher C. Wen, S. Yee, K. Giacomini +2 more
2023Clinical pharmacology and therapy6 citations Open access
Semantic Scholar
Oral Anticoagulants and Precision Medicine: Something Old, Something New
Mohamed H. Shahin, K. Giacomini
2020Clinical pharmacology and therapy6 citations Open access
Semantic Scholar
Charting the undiscovered metabolome with synthetic multiplexing implicates ibuprofen-carnitine in myotoxicity
Abubaker Patan, Shipei Xing, Vincent Charron-Lamoureux, Zhewen Hu +40 more
2025bioRxiv5 citations
Semantic Scholar

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