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S. Tsubuki · SciRah

Researcher profile · Semantic Scholar

S. Tsubuki

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S. Tsubuki — researcher profile on SciRah

h-index: 30
Works: 50
Citations: 6,433

Most-cited papers

Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
N. Iwata, S. Tsubuki, Y. Takaki, Kaori Watanabe +7 more
2000Nature Medicine902 citations
Semantic Scholar
Metabolic Regulation of Brain Aβ by Neprilysin
N. Iwata, S. Tsubuki, Y. Takaki, K. Shirotani +6 more
2001Science890 citations
Semantic Scholar
Aβ secretion and plaque formation depend on autophagy.
P. Nilsson, Krishnapriya Loganathan, Misaki Sekiguchi, Y. Matsuba +6 more
2013Cell Reports462 citations Open access
Semantic Scholar
Metabolic regulation of brain Abeta by neprilysin.
N. Iwata, S. Tsubuki, Y. Takaki, K. Shirotani +6 more
2001Science392 citations
Semantic Scholar
Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine.
S. Tsubuki, Y. Saito, Masanori Tomioka, H. Ito +1 more
1996Journal of Biochemistry (Tokyo)317 citations
Semantic Scholar
Neprilysin Degrades Both Amyloid β Peptides 1–40 and 1–42 Most Rapidly and Efficiently among Thiorphan- and Phosphoramidon-sensitive Endopeptidases*
K. Shirotani, S. Tsubuki, N. Iwata, Y. Takaki +8 more
2001Journal of Biological Chemistry314 citations Open access
Semantic Scholar
Reply to: 'Clearance of amyloid β-peptide from brain: transport or metabolism?'
N. Iwata, S. Tsubuki, E. Hama, Y. Takaki +2 more
2000Nature Medicine278 citations
Semantic Scholar
Somatostatin regulates brain amyloid β peptide Aβ42 through modulation of proteolytic degradation
T. Saito, N. Iwata, S. Tsubuki, Y. Takaki +5 more
2005Nature Medicine264 citations
Semantic Scholar
Region‐specific reduction of Aβ‐degrading endopeptidase, neprilysin, in mouse hippocampus upon aging
N. Iwata, Y. Takaki, Shinjiro Fukami, S. Tsubuki +1 more
2002Journal of Neuroscience Research209 citations Open access
Semantic Scholar
MST, a Physiological Caspase Substrate, Highly Sensitizes Apoptosis Both Upstream and Downstream of Caspase Activation*
Kyung-Kwon Lee, T. Ohyama, N. Yajima, S. Tsubuki +1 more
2001Journal of Biological Chemistry207 citations Open access
Semantic Scholar
Calpain Mediates Excitotoxic DNA Fragmentation via Mitochondrial Pathways in Adult Brains
Jiro Takano, Masanori Tomioka, S. Tsubuki, M. Higuchi +4 more
2005Journal of Biological Chemistry201 citations Open access
Semantic Scholar
Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation.
S. Tsubuki, Yoshie Takai, T. Saido
2003The Lancet166 citations
Semantic Scholar
Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.
T. Saito, N. Iwata, S. Tsubuki, Y. Takaki +5 more
2005Nature Medicine165 citations
Semantic Scholar
Calpain Cleavage of the Cytoplasmic Domain of the Integrin β2 Subunit (*)
Xiao-Ping Du, T. Saido, S. Tsubuki, F. Indig +2 more
1995Journal of Biological Chemistry155 citations Open access
Semantic Scholar
Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis
Kyung-Kwon Lee, M. Murakawa, E. Nishida, S. Tsubuki +3 more
1998Oncogene139 citations
Semantic Scholar
Recent Advances in the Modeling of Alzheimer’s Disease
H. Sasaguri, Shoko Hashimoto, Naoto Watamura, Kaori Sato +14 more
2022Frontiers in Neuroscience127 citations Open access
Semantic Scholar
Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome.
S. Tsubuki, Hiroshi Kawasaki, Yumiko Saito, N. Miyashita +2 more
1993Biochemical and Biophysical Research Communications - BBRC127 citations
Semantic Scholar
Identification, Characterization, and Intracellular Distribution of Cofilin in Dictyostelium discoideum(*)
H. Aizawa, K. Sutoh, S. Tsubuki, S. Kawashima +2 more
1995Journal of Biological Chemistry111 citations Open access
Semantic Scholar
The Tottori (D7N) and English (H6R) Familial Alzheimer Disease Mutations Accelerate Aβ Fibril Formation without Increasing Protofibril Formation*
Y. Hori, T. Hashimoto, Y. Wakutani, K. Urakami +6 more
2007Journal of Biological Chemistry105 citations Open access
Semantic Scholar
Matrix metalloproteinase (MMP) system in brain: identification and characterization of brain‐specific MMP highly expressed in cerebellum
Yoko Sekine‐Aizawa, E. Hama, Kaori Watanabe, S. Tsubuki +6 more
2001European Journal of Neuroscience98 citations
Semantic Scholar
Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain.
Y. Takaki, Nobuhisa Iwata, S. Tsubuki, Sayuri Taniguchi +7 more
2000Journal of Biochemistry (Tokyo)98 citations
Semantic Scholar
Purification, Molecular Cloning, and Characterization of TRP32, a Novel Thioredoxin-related Mammalian Protein of 32 kDa*
Kyung-Kwon Lee, M. Murakawa, S. Takahashi, S. Tsubuki +3 more
1998Journal of Biological Chemistry93 citations Open access
Semantic Scholar
Involvement of calpain in integrin-mediated signal transduction.
Mitsushi Inomata, M. Hayashi, Y. Ohno-Iwashita, S. Tsubuki +2 more
1996Archives of Biochemistry and Biophysics90 citations
Semantic Scholar
A major glycoprotein of Xenopus egg vitelline envelope, gp41, is a frog homolog of mammalian ZP3
H. Kubo, T. Kawano, S. Tsubuki, S. Kawashima +2 more
1997Development, Growth and Differentiation76 citations Open access
Semantic Scholar
Purification and characterization of an endogenous inhibitor specific to the Z‐Leu‐Leu‐Leu‐MCA degrading activity in proteasome and its identification as heat‐shock protein 90
S. Tsubuki, Y. Saito, S. Kawashima
1994FEBS Letters73 citations Open access
Semantic Scholar
Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage.
M. Yokota, E. Tani, S. Tsubuki, I. Yamaura +3 more
1999Brain Research58 citations
Semantic Scholar
Dual Roles of Proteasome in the Metabolism of Presenilin 1
T. Honda, K. Yasutake, N. Nihonmatsu, M. Mercken +8 more
1999Journal of Neurochemistry49 citations
Semantic Scholar
Structural and functional characterization of a novel tumor-derived rat galectin-1 having transforming growth factor (TGF) activity: the relationship between intramolecular disulfide bridges and TGF activity.
K. Yamaoka, A. Ingendoh, S. Tsubuki, Y. Nagai +1 more
1996Journal of Biochemistry (Tokyo)43 citations
Semantic Scholar
Cell Surface Expression of the Major Amyloid-β Peptide (Aβ)-degrading Enzyme, Neprilysin, Depends on Phosphorylation by Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK) and Dephosphorylation by Protein Phosphatase 1a
Naomasa Kakiya, T. Saito, P. Nilsson, Y. Matsuba +4 more
2012Journal of Biological Chemistry39 citations Open access
Semantic Scholar
Ab Secretion and Plaque Formation Depend on Autophagy
P. Nilsson, Krishnapriya Loganathan, Misaki Sekiguchi, Y. Matsuba +6 more
201635 citations
Semantic Scholar
Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-KATP channel pathway
Naoto Watamura, Naomasa Kakiya, P. Nilsson, S. Tsubuki +6 more
2021Molecular Psychiatry27 citations Open access
Semantic Scholar
Transient up-regulation of a prolyl endopeptidase activity in the microsomal fraction of rat liver during postnatal development.
Y. Matsubara, Tomio Ono, S. Tsubuki, Shinkichi Irie +1 more
1998European Journal of Biochemistry24 citations Open access
Semantic Scholar
Egg envelope glycoprotein gp37 as a Xenopus homolog of mammalian ZP1, based on cDNA cloning
H. Kubo, T. Kawano, S. Tsubuki, M. Kotani +2 more
2000Development, Growth and Differentiation22 citations
Semantic Scholar
Generation of amyloid β peptide with pyroglutamate at position 3 in primary cortical neurons
K. Shirotani, S. Tsubuki, Hahn‐Jun Lee, K. Maruyama +1 more
200221 citations
Semantic Scholar
The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer's Disease
Takahiro Morito, Shoko Hashimoto, Risa Takamura, Naoto Watamura +13 more
2025Journal of Neuroscience14 citations Open access
Semantic Scholar
Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons.
K. Shirotani, S. Tsubuki, Hahn‐Jun Lee, K. Maruyama +1 more
2002Neuroscience Letters14 citations
Semantic Scholar
Involvement of calpain in osteoclastic bone resorption.
M. Hayashi, Y. Koshihara, H. Ishibashi, S. Yamamoto +4 more
2005Journal of Biochemistry (Tokyo)9 citations
Semantic Scholar
Somatostatin receptor subtypes 1 and 4 redundantly regulate neprilysin, the major amyloid-beta degrading enzyme in brain
P. Nilsson, K. Sörgjerd, Naomasa Kakiya, H. Sasaguri +12 more
2020bioRxiv8 citations Open access
Semantic Scholar
Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab
Nobuhisa Iwata, S. Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata +16 more
2024Life Science Alliance4 citations Open access
Semantic Scholar
The Synthesis and Properties of EF-hand Type Calcium-binding Peptides
Shigehiro Yokokawa, S. Tsubuki, H. Ito, H. Kasai
19893 citations
Semantic Scholar
Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-β degrading enzyme in brain
P. Nilsson, K. Sörgjerd, Naomasa Kakiya, H. Sasaguri +14 more
2025Journal of Alzheimer's Disease2 citations
Semantic Scholar
Metabolic resistance of Aβ3pE-42, target epitope of the anti-Alzheimer therapeutic antibody, donanemab
Nobuhisa Iwata, S. Tsubuki, Risa Takamura, Naoto Watamura +14 more
2024bioRxiv2 citations Open access
Semantic Scholar
Neprilysin-sensitive amyloidogenic Aβ versus IDE-sensitive soluble Aβ: a probable mechanistic cause for sporadic Alzheimer’s disease
H. Sasaguri, Risa Takamura, Naoto Watamura, Naomasa Kakiya +11 more
2021bioRxiv2 citations Open access
Semantic Scholar
α-Endosulfine regulates amyloid β 42 via the modulation of neprilysin activity
Naoto Watamura, Naomasa Kakiya, P. Nilsson, S. Tsubuki +6 more
2020bioRxiv1 citations Open access
Semantic Scholar
P1‐248: Reactive astrogliosis enhances pyroGlu‐Aβ formation via up regulation of glutaminyl cyclase, and reduced neprilysin activity exacerbates this process
N. Iwata, M. Higuchi, S. Tsubuki, M. Staufenbiel +1 more
20101 citations Open access
Semantic Scholar
P4‐139: Reduced neprilysin activity is associated with increased formation of pyroglutamylated amyloid‐β peptides through upregulation of aminopeptidases and glutaminyl cyclase in brain
N. Iwata, S. Tsubuki, M. Staufenbiel, T. Saido
20090 citations Open access
Semantic Scholar
P1‐434: Accumulation of Aβ starting with pyroglutamate at position 3 in the brain and its impact on amyloid pathology of Alzheimer's disease
N. Iwata, S. Tsubuki, M. Higuchi, Kaori Watanabe +3 more
20080 citations
Semantic Scholar
A method of measuring neprilysinaktivität
T. Saido, N. Iwata, S. Tsubuki, Y. Takaki +2 more
20030 citations
Semantic Scholar
cDNA CLONING OF GP37, ONE OF THE CONSTITUENTS OF XENOPUS EGG ENVELOPES(Developmental Biology)(Proceedings of the Seventieth Annual Meeting of the Zoological Society of Japan)
H. Kubo, T. Kawano, S. Tsubuki, S. Kawashima +1 more
19990 citations
Semantic Scholar
The Synthesis and Properties of Tripeptide Aldehydes Having Neurite-Extension Activity
H. Ito, S. Tsubuki, Yumiko Saito, S. Kawashima
19920 citations Open access
Semantic Scholar

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