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B. Renga · SciRah

Researcher profile · Semantic Scholar

B. Renga

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B. Renga — researcher profile on SciRah

h-index: 49
Works: 149
Citations: 8,152

Most-cited papers

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
S. Cipriani, A. Mencarelli, M. G. Chini, E. Distrutti +5 more
2011PLoS ONE373 citations Open access
Semantic Scholar
Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP
E. Distrutti, Julie-Ann O’Reilly, Claire L. McDonald, S. Cipriani +3 more
2014PLoS ONE219 citations Open access
Semantic Scholar
The bile acid sensor FXR regulates insulin transcription and secretion.
B. Renga, A. Mencarelli, P. Vavassori, V. Brancaleone +1 more
2010Biochimica et Biophysica Acta189 citations Open access
Semantic Scholar
Efficacy of the CCR5 Antagonist Maraviroc in Reducing Early, Ritonavir-Induced Atherogenesis and Advanced Plaque Progression in Mice
S. Cipriani, D. Francisci, A. Mencarelli, B. Renga +4 more
2013Circulation152 citations Open access
Semantic Scholar
Hydrogen sulfide generation in mammals: the molecular biology of cystathionine-β- synthase (CBS) and cystathionine-γ-lyase (CSE).
B. Renga
2011Inflammation & Allergy - Drug Targets133 citations
Semantic Scholar
VSL#3 Resets Insulin Signaling and Protects against NASH and Atherosclerosis in a Model of Genetic Dyslipidemia and Intestinal Inflammation
A. Mencarelli, S. Cipriani, B. Renga, Angela M. Bruno +3 more
2012PLoS ONE115 citations Open access
Semantic Scholar
Inhibition of NF-κB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells.
A. Mencarelli, B. Renga, G. Palladino, D. Claudio +5 more
2011European Journal of Pharmacology110 citations
Semantic Scholar
Probiotics VSL#3 Protect against Development of Visceral Pain in Murine Model of Irritable Bowel Syndrome
E. Distrutti, S. Cipriani, A. Mencarelli, B. Renga +1 more
2013PLoS ONE105 citations Open access
Semantic Scholar
The Bile Acid Sensor FXR Is Required for Immune-Regulatory Activities of TLR-9 in Intestinal Inflammation
B. Renga, A. Mencarelli, S. Cipriani, Claudio D'Amore +6 more
2013PLoS ONE104 citations Open access
Semantic Scholar
Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells.
A. Mencarelli, M. Migliorati, M. Barbanti, S. Cipriani +4 more
2010Biochemical Pharmacology100 citations
Semantic Scholar
Probiotics Modulate Intestinal Expression of Nuclear Receptor and Provide Counter-Regulatory Signals to Inflammation-Driven Adipose Tissue Activation
A. Mencarelli, E. Distrutti, B. Renga, Claudio D'Amore +5 more
2011PLoS ONE91 citations Open access
Semantic Scholar
Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors.
Claudio D'Amore, F. S. Di Leva, V. Sepe, B. Renga +5 more
2014Journal of Medicinal Chemistry90 citations Open access
Semantic Scholar
Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands.
C. Festa, B. Renga, Claudio D'Amore, V. Sepe +7 more
2014Journal of Medicinal Chemistry82 citations Open access
Semantic Scholar
Quantitative NMR-derived interproton distances combined with quantum mechanical calculations of 13C chemical shifts in the stereochemical determination of conicasterol F, a nuclear receptor ligand from Theonella swinhoei.
M. G. Chini, Catharine R. Jones, A. Zampella, M. D'Auria +4 more
2012Journal of Organic Chemistry81 citations
Semantic Scholar
Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter.
B. Renga, M. Migliorati, A. Mencarelli, S. Cipriani +3 more
2011Biochimica et Biophysica Acta80 citations
Semantic Scholar
Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1).
V. Sepe, B. Renga, C. Festa, Claudio D'Amore +8 more
2014Journal of Medicinal Chemistry76 citations Open access
Semantic Scholar
Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis
B. Renga, A. Mencarelli, Claudio D'Amore, S. Cipriani +7 more
2012PLoS ONE75 citations Open access
Semantic Scholar
Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1
B. Renga, S. Cipriani, Adriana Carino, Michele Simonetti +2 more
2015PLoS ONE67 citations Open access
Semantic Scholar
Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor.
V. Sepe, G. Bifulco, B. Renga, Claudio D'Amore +2 more
2011Journal of Medicinal Chemistry67 citations
Semantic Scholar
Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors.
S. De Marino, Raffaella Ummarino, M. D'Auria, M. G. Chini +6 more
2011Journal of Medicinal Chemistry65 citations
Semantic Scholar
Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition
B. Renga, A. Mencarelli, Claudio D'Amore, S. Cipriani +4 more
2012The FASEB Journal61 citations
Semantic Scholar
Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids.
B. Renga, M. Bucci, S. Cipriani, Adriana Carino +6 more
2015American Journal of Physiology. Heart and Circulatory Physiology58 citations
Semantic Scholar
Total synthesis and pharmacological characterization of solomonsterol A, a potent marine pregnane-X-receptor agonist endowed with anti-inflammatory activity.
V. Sepe, Raffaella Ummarino, M. D'Auria, A. Mencarelli +4 more
2011Journal of Medicinal Chemistry58 citations Open access
Semantic Scholar
CCR5 Antagonism by Maraviroc Reduces the Potential for Gastric Cancer Cell Dissemination.
A. Mencarelli, L. Graziosi, B. Renga, S. Cipriani +6 more
2013Translational Oncology57 citations Open access
Semantic Scholar
Development of non-antibiotic macrolide that corrects inflammation-driven immune dysfunction in models of inflammatory bowel diseases and arthritis.
A. Mencarelli, E. Distrutti, B. Renga, S. Cipriani +7 more
2011European Journal of Pharmacology57 citations
Semantic Scholar
Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity.
C. Festa, S. De Marino, M. D'Auria, G. Bifulco +4 more
2011Journal of Medicinal Chemistry56 citations
Semantic Scholar
Interactions Between Nuclear receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice
H. Tsuchiya, K. da Costa, Sang-Min Lee, B. Renga +13 more
2015Gastroenterology55 citations Open access
Semantic Scholar
Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling
S. Cipriani, B. Renga, Claudio D'Amore, Michele Simonetti +6 more
2015PLoS ONE55 citations Open access
Semantic Scholar
Dissociation of Intestinal and Hepatic Activities of FXR and LXRα Supports Metabolic Effects of Terminal Ileum Interposition in Rodents
A. Mencarelli, B. Renga, Claudio D'Amore, C. Santorelli +7 more
2013Diabetes55 citations Open access
Semantic Scholar
Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.
C. Festa, G. Lauro, S. De Marino, M. D'Auria +9 more
2012Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts
B. Renga, A. Mencarelli, M. Migliorati, S. Cipriani +3 more
2011Inflammation Research52 citations
Semantic Scholar
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.
F. S. Di Leva, C. Festa, Claudio D'Amore, S. De Marino +6 more
2013Journal of Medicinal Chemistry51 citations Open access
Semantic Scholar
Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei.
V. Sepe, Raffaella Ummarino, M. D'Auria, M. G. Chini +6 more
2012Journal of Medicinal Chemistry48 citations
Semantic Scholar
Running Title : Nuclear receptors , lipid , glucose and drug metabolism Corresponding
Hollie I. Swanson, T. Wada, Wen Xie, B. Renga +11 more
201247 citations
Semantic Scholar
Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists
V. Sepe, C. Festa, B. Renga, Adriana Carino +7 more
2016Scientific Reports44 citations Open access
Semantic Scholar
4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity.
S. De Marino, Raffaella Ummarino, M. D'Auria, M. G. Chini +7 more
2012Steroids44 citations
Semantic Scholar
Oxygenated Polyketides from Plakinastrella mamillaris as a New Chemotype of PXR Agonists
C. Festa, Claudio D'Amore, B. Renga, G. Lauro +5 more
2013Marine Drugs38 citations Open access
Semantic Scholar
Activation of the farnesoid‐X receptor protects against gastrointestinal injury caused by non‐steroidal anti‐inflammatory drugs in mice
S. Fiorucci, A. Mencarelli, S. Cipriani, B. Renga +3 more
2011British Journal of Pharmacology37 citations Open access
Semantic Scholar
Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei.
S. De Marino, V. Sepe, M. D'Auria, G. Bifulco +4 more
2011Organic and biomolecular chemistry35 citations
Semantic Scholar
FXR activation improves myocardial fatty acid metabolism in a rodent model of obesity-driven cardiotoxicity.
A. Mencarelli, S. Cipriani, B. Renga, Claudio D'Amore +4 more
2013NMCD. Nutrition Metabolism and Cardiovascular Diseases33 citations
Semantic Scholar
Bile acid activated receptors are targets for regulation of integrity of gastrointestinal mucosa
E. Distrutti, L. Santucci, S. Cipriani, B. Renga +4 more
2015Journal of gastroenterology32 citations Open access
Semantic Scholar
Non invasive prenatal diagnosis of fetal aneuploidy using cell free fetal DNA.
B. Renga
2018European Journal of Obstetrics, Gynecology, and Reproductive Biology31 citations
Semantic Scholar
Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis
A. Mencarelli, Claudio D'Amore, B. Renga, S. Cipriani +7 more
2013Marine Drugs30 citations Open access
Semantic Scholar
The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate.
B. Renga, A. Mencarelli, S. Cipriani, Claudio D'Amore +4 more
2011Biochimica et Biophysica Acta30 citations Open access
Semantic Scholar
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism
F. S. Di Leva, C. Festa, B. Renga, V. Sepe +4 more
2015Scientific Reports29 citations Open access
Semantic Scholar
Polyhydroxylated sterols from the Indonesian soft coral Sinularia sp. and their effect on farnesoid X-activated receptor.
M. Putra, G. Bavestrello, C. Cerrano, B. Renga +4 more
2012Steroids29 citations
Semantic Scholar
The HIV Matrix Protein p17 Subverts Nuclear Receptors Expression and Induces a STAT1-Dependent Proinflammatory Phenotype in Monocytes
B. Renga, D. Francisci, Claudio D'Amore, E. Schiaroli +4 more
2012PLoS ONE27 citations Open access
Semantic Scholar
Platelets and cardiovascular risk
B. Renga, Franco Scavizzi
2017Acta Cardiologica25 citations
Semantic Scholar
Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists.
B. Renga, C. Festa, S. De Marino, S. Di Micco +4 more
2015Steroids25 citations
Semantic Scholar
HIV-1 infection is associated with changes in nuclear receptor transcriptome, pro-inflammatory and lipid profile of monocytes
B. Renga, D. Francisci, Claudio D'Amore, E. Schiaroli +3 more
2012BMC Infectious Diseases25 citations Open access
Semantic Scholar

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S. Fiorucci×47
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S. Fiorucci — researcher profile on SciRah
Claudio D'Amore×28
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Claudio D'Amore — researcher profile on SciRah
S. Cipriani×27
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S. Cipriani — researcher profile on SciRah
A. Zampella×26
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A. Zampella — researcher profile on SciRah

×24

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A. Mencarelli — researcher profile on SciRah

E. Distrutti×19

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E. Distrutti — researcher profile on SciRah

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M. D'Auria — researcher profile on SciRah

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G. Bifulco — researcher profile on SciRah

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V. Sepe — researcher profile on SciRah

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C. Festa — researcher profile on SciRah

S. De Marino×9

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