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Seungkirl Ahn · SciRah

Researcher profile · Semantic Scholar

Seungkirl Ahn

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Seungkirl Ahn — researcher profile on SciRah

h-index: 49
Works: 75
Citations: 14K

Most-cited papers

β-Arrestins and Cell Signaling
S. Dewire, Seungkirl Ahn, R. Lefkowitz, Sudha K. Shenoy
20071,263 citations Open access
Semantic Scholar
Beta-arrestins and cell signaling.
S. Dewire, Seungkirl Ahn, R. Lefkowitz, Sudha K. Shenoy
2007Annual Review of Physiology707 citations
Semantic Scholar
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
Hui-Jun Wei, Seungkirl Ahn, Sudha K. Shenoy, S. Karnik +3 more
2003Proceedings of the National Academy of Sciences of the United States of America642 citations Open access
Semantic Scholar
Distinct Phosphorylation Sites on the β2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin
K. Nobles, K. Xiao, Seungkirl Ahn, A. Shukla +9 more
2011Science Signaling636 citations Open access
Semantic Scholar
Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors
E. Reiter, Seungkirl Ahn, A. Shukla, R. Lefkowitz
2011Annual Review of Pharmacology and Toxicology604 citations Open access
Semantic Scholar
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
S. Rajagopal, Jihee Kim, Seungkirl Ahn, S. Craig +4 more
2009Proceedings of the National Academy of Sciences of the United States of America578 citations Open access
Semantic Scholar
Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase*
Y. Daaka, L. Luttrell, Seungkirl Ahn, G. D. Della Rocca +3 more
1998Journal of Biological Chemistry571 citations Open access
Semantic Scholar
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
James W. Wisler, S. Dewire, E. Whalen, Jonathan D. Violin +4 more
2007Proceedings of the National Academy of Sciences of the United States of America556 citations Open access
Semantic Scholar
Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor*
Seungkirl Ahn, Sudha K. Shenoy, Hui-Jun Wei, R. Lefkowitz
2004Journal of Biological Chemistry551 citations Open access
Semantic Scholar
The β2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor*
Stuart Maudsley, K. L. Pierce, A. M. Zamah, W. Miller +4 more
2000Journal of Biological Chemistry407 citations Open access
Semantic Scholar
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
Makoto R. Hara, Jeffrey J. Kovacs, E. Whalen, S. Rajagopal +11 more
2011Nature405 citations Open access
Semantic Scholar
Quantifying Ligand Bias at Seven-Transmembrane Receptors
S. Rajagopal, Seungkirl Ahn, D. Rominger, W. Gowen-MacDonald +4 more
2011Molecular Pharmacology390 citations Open access
Semantic Scholar
Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation*
D. Gesty‐Palmer, Min-Yong Chen, E. Reiter, Seungkirl Ahn +7 more
2006Journal of Biological Chemistry388 citations Open access
Semantic Scholar
Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling.
Jihee Kim, Seungkirl Ahn, Xiu-Rong Ren, E. Whalen +3 more
2005Proceedings of the National Academy of Sciences of the United States of America373 citations Open access
Semantic Scholar
Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.
Xiu-Rong Ren, E. Reiter, Seungkirl Ahn, Jihee Kim +2 more
2005Proceedings of the National Academy of Sciences of the United States of America359 citations Open access
Semantic Scholar
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
Wei Chen, D. ten Berge, Jeffrey D. Brown, Seungkirl Ahn +6 more
2003Science351 citations
Semantic Scholar
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.
Hui-Jun Wei, Seungkirl Ahn, Sudha K. Shenoy, S. Karnik +3 more
2003Proceedings of the National Academy of Sciences of the United States of America295 citations
Semantic Scholar
A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.
James W. Wisler, S. Dewire, E. Whalen, Jonathan D. Violin +4 more
2007Proceedings of the National Academy of Sciences of the United States of America255 citations
Semantic Scholar
Multiple ligand-specific conformations of the β2-adrenergic receptor
Alem W. Kahsai, K. Xiao, S. Rajagopal, Seungkirl Ahn +4 more
2011Nature Chemical Biology253 citations Open access
Semantic Scholar
Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference
Seungkirl Ahn, C. D. Nelson, T. R. Garrison, W. Miller +1 more
2003Proceedings of the National Academy of Sciences of the United States of America253 citations Open access
Semantic Scholar
Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation
D. Staus, Ryan T. Strachan, A. Manglik, Biswaranjan Pani +14 more
2016Nature237 citations Open access
Semantic Scholar
Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9
L. Luttrell, Jia-Lu Wang, B. Plouffe, Jeffrey S. Smith +15 more
2018Science Signaling196 citations Open access
Semantic Scholar
β-Arrestin1 Interacts with the Catalytic Domain of the Tyrosine Kinase c-SRC
W. Miller, Stuart Maudsley, Seungkirl Ahn, K. Khan +2 more
2000Journal of Biological Chemistry195 citations Open access
Semantic Scholar
Reciprocal Regulation of Angiotensin Receptor-activated Extracellular Signal-regulated Kinases by β-Arrestins 1 and 2*
Seungkirl Ahn, Hui-Jun Wei, T. R. Garrison, R. Lefkowitz
2004Journal of Biological Chemistry189 citations Open access
Semantic Scholar
Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure
Xiangyu Liu, Seungkirl Ahn, Alem W. Kahsai, Kai-Cheng Meng +9 more
2017Nature186 citations Open access
Semantic Scholar
Epidermal Growth Factor (EGF) Receptor-dependent ERK Activation by G Protein-coupled Receptors
K. L. Pierce, Akira Tohgo, Seungkirl Ahn, M. Field +2 more
2001Journal of Biological Chemistry166 citations Open access
Semantic Scholar
β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
Seungkirl Ahn, Jihee Kim, Makoto R. Hara, Xiu-Rong Ren +1 more
2009Journal of Biological Chemistry165 citations Open access
Semantic Scholar
Src-dependent Tyrosine Phosphorylation Regulates Dynamin Self-assembly and Ligand-induced Endocytosis of the Epidermal Growth Factor Receptor*
Seungkirl Ahn, Jihee Kim, C. Lucaveche, M. Reedy +3 more
2002Journal of Biological Chemistry150 citations Open access
Semantic Scholar
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
Sudha K. Shenoy, Aalok Modi, A. Shukla, K. Xiao +5 more
2009Proceedings of the National Academy of Sciences of the United States of America147 citations Open access
Semantic Scholar
Regulation of Beta-2-Adrenergic Receptor Function by Conformationally Selective Single-domain Intrabodies
D. Staus, L. Wingler, Ryan T. Strachan, S. Rasmussen +5 more
2013142 citations
Semantic Scholar
Ubiquitination of β-Arrestin Links Seven-transmembrane Receptor Endocytosis and ERK Activation*
Sudha K. Shenoy, L. Barak, K. Xiao, Seungkirl Ahn +4 more
2007Journal of Biological Chemistry141 citations Open access
Semantic Scholar
Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library
Seungkirl Ahn, Alem W. Kahsai, Biswaranjan Pani, Qin-Ting Wang +21 more
2017Proceedings of the National Academy of Sciences of the United States of America140 citations Open access
Semantic Scholar
Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)*
Ryan T. Strachan, Jin-Peng Sun, D. Rominger, Jonathan D. Violin +6 more
2014Journal of Biological Chemistry126 citations Open access
Semantic Scholar
Conformation Guides Molecular Efficacy in Docking Screens of Activated β-2 Adrenergic G Protein Coupled Receptor
Dahlia R. Weiss, Seungkirl Ahn, Maria F. Sassano, A. Kleist +5 more
2013ACS Chemical Biology110 citations Open access
Semantic Scholar
Arresting a Transient Receptor Potential (TRP) Channel
A. Shukla, Jihee Kim, Seungkirl Ahn, K. Xiao +3 more
2010Journal of Biological Chemistry108 citations Open access
Semantic Scholar
Independent β-Arrestin2 and Gq/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor
Jihee Kim, Seungkirl Ahn, Keshava Rajagopal, R. Lefkowitz
2009Journal of Biological Chemistry108 citations Open access
Semantic Scholar
β-Arrestin-mediated Signaling Regulates Protein Synthesis*
S. Dewire, Jihee Kim, E. Whalen, Seungkirl Ahn +2 more
2008Journal of Biological Chemistry104 citations Open access
Semantic Scholar
reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
D. Staus, Ryan T. Strachan, A. Manglik, Biswaranjan Pani +17 more
2016100 citations
Semantic Scholar
Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling
D. Heitzler, Guillaume Durand, N. Gallay, Aurélien Rizk +12 more
2012Molecular Systems Biology89 citations Open access
Semantic Scholar
Stable Interaction between β-Arrestin 2 and Angiotensin Type 1A Receptor Is Required for β-Arrestin 2-mediated Activation of Extracellular Signal-regulated Kinases 1 and 2*
Hui-Jun Wei, Seungkirl Ahn, W. Barnes, R. Lefkowitz
2004Journal of Biological Chemistry83 citations Open access
Semantic Scholar
Epidermal Growth Factor (EGF) Receptor-dependent ERK Activation by G Protein-coupled Receptors A CO-CULTURE SYSTEM FOR IDENTIFYING INTERMEDIATES UPSTREAM AND DOWNSTREAM OF HEPARIN-BINDING EGF SHEDDING*
K. L. Pierce, Akira Tohgo, Seungkirl Ahn, M. Field +2 more
200178 citations
Semantic Scholar
Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries
Seungkirl Ahn, Biswaranjan Pani, Alem W. Kahsai, E. Olsen +15 more
2018Molecular Pharmacology74 citations Open access
Semantic Scholar
Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor
Tonia Aristotelous, Seungkirl Ahn, A. Shukla, Sylwia Gawron +14 more
2013ACS Medicinal Chemistry Letters71 citations Open access
Semantic Scholar
Conformationally Selective RNA Aptamers Allosterically Modulate the β2-Adrenoceptor
Alem W. Kahsai, James W. Wisler, Jungmin Lee, Seungkirl Ahn +14 more
2016Nature Chemical Biology69 citations Open access
Semantic Scholar
Mechanism of β2AR regulation by an intracellular positive allosteric modulator
Xiangyu Liu, A. Masoudi, Alem W. Kahsai, Li-Yin Huang +10 more
2019Science68 citations Open access
Semantic Scholar
G protein–coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor
Minjung Choi, D. Staus, L. Wingler, Seungkirl Ahn +3 more
2018Science Signaling62 citations
Semantic Scholar
Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin
Alem W. Kahsai, Kunal S Shah, Paul J. Shim, Mason A Lee +8 more
2023Proceedings of the National Academy of Sciences of the United States of America58 citations Open access
Semantic Scholar
Regulation of epidermal growth factor receptor internalization by G protein-coupled receptors.
Jihee Kim, Seungkirl Ahn, R. Guo, Y. Daaka
2003Biochemistry57 citations
Semantic Scholar
Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator
Xiangyu Liu, A. Masoudi, Alem W. Kahsai, Li-Yin Huang +5 more
201951 citations Open access
Semantic Scholar
Loss of biased signaling at a G protein-coupled receptor in overexpressed systems
A. Li, Samuel Liu, Rennica Huang, Seungkirl Ahn +1 more
2023PLoS ONE38 citations Open access
Semantic Scholar

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R. Lefkowitz×45
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R. Lefkowitz — researcher profile on SciRah
Sudha K. Shenoy×13
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Sudha K. Shenoy — researcher profile on SciRah
L. Luttrell×11
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L. Luttrell — researcher profile on SciRah
Jihee Kim×11
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Jihee Kim — researcher profile on SciRah

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Alem W. Kahsai — researcher profile on SciRah

Biswaranjan Pani×10

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Ryan T. Strachan×9

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Ryan T. Strachan — researcher profile on SciRah

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D. Staus — researcher profile on SciRah

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L. Wingler — researcher profile on SciRah

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A. Shukla — researcher profile on SciRah

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S. Dewire — researcher profile on SciRah

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Hui-Jun Wei — researcher profile on SciRah