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Ryan T. Strachan · SciRah

Researcher profile · Semantic Scholar

Ryan T. Strachan

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Ryan T. Strachan — researcher profile on SciRah

h-index: 26
Works: 37
Citations: 4,687

Most-cited papers

Distinct Phosphorylation Sites on the β2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin
K. Nobles, K. Xiao, Seungkirl Ahn, A. Shukla +9 more
2011Science Signaling636 citations Open access
Semantic Scholar
GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling
A. R. B. Thomsen, B. Plouffe, T. Cahill, A. Shukla +13 more
2016Cell530 citations Open access
Semantic Scholar
“TRUPATH, an Open-Source Biosensor Platform for Interrogating the GPCR Transducerome”
R. Olsen, J. DiBerto, J. English, Alexis M. Glaudin +7 more
2020Nature Chemical Biology525 citations Open access
Semantic Scholar
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
Makoto R. Hara, Jeffrey J. Kovacs, E. Whalen, S. Rajagopal +11 more
2011Nature405 citations Open access
Semantic Scholar
Structure of a nanobody-stabilized active state of the kappa opioid receptor
T. Che, S. Majumdar, Saheem A. Zaidi, P. Ondachi +20 more
2018Cell331 citations Open access
Semantic Scholar
Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation
D. Staus, Ryan T. Strachan, A. Manglik, Biswaranjan Pani +14 more
2016Nature237 citations Open access
Semantic Scholar
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
S. Foster, A. Hauser, Line Vedel, Ryan T. Strachan +9 more
2019Cell227 citations Open access
Semantic Scholar
Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors
Gianluigi Pironti, Ryan T. Strachan, Dennis M. Abraham, S. Yu +6 more
2015Circulation225 citations Open access
Semantic Scholar
Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling
Kelly A Jones, D. Srivastava, John A. Allen, Ryan T. Strachan +2 more
2009Proceedings of the National Academy of Sciences of the United States of America211 citations Open access
Semantic Scholar
Regulation of Beta-2-Adrenergic Receptor Function by Conformationally Selective Single-domain Intrabodies
D. Staus, L. Wingler, Ryan T. Strachan, S. Rasmussen +5 more
2013142 citations
Semantic Scholar
Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library
Seungkirl Ahn, Alem W. Kahsai, Biswaranjan Pani, Qin-Ting Wang +21 more
2017Proceedings of the National Academy of Sciences of the United States of America140 citations Open access
Semantic Scholar
Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)*
Ryan T. Strachan, Jin-Peng Sun, D. Rominger, Jonathan D. Violin +6 more
2014Journal of Biological Chemistry126 citations Open access
Semantic Scholar
Conformation Guides Molecular Efficacy in Docking Screens of Activated β-2 Adrenergic G Protein Coupled Receptor
Dahlia R. Weiss, Seungkirl Ahn, Maria F. Sassano, A. Kleist +5 more
2013ACS Chemical Biology110 citations Open access
Semantic Scholar
reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
D. Staus, Ryan T. Strachan, A. Manglik, Biswaranjan Pani +17 more
2016100 citations
Semantic Scholar
VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells
J. English, R. Olsen, K. Lansu, Michael Patel +6 more
2019Cell92 citations Open access
Semantic Scholar
Strain-dependent beta-adrenergic receptor function influences myocardial responses to isoproterenol stimulation in mice.
M. Faulx, P. Ernsberger, D. Vatner, R. Hoffman +3 more
2005American Journal of Physiology. Heart and Circulatory Physiology74 citations
Semantic Scholar
Conformationally Selective RNA Aptamers Allosterically Modulate the β2-Adrenoceptor
Alem W. Kahsai, James W. Wisler, Jungmin Lee, Seungkirl Ahn +14 more
2016Nature Chemical Biology69 citations Open access
Semantic Scholar
Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator
B. Krumm, J. DiBerto, R. Olsen, H. Kang +11 more
2022bioRxiv68 citations Open access
Semantic Scholar
Screening the receptorome: an efficient approach for drug discovery and target validation.
Ryan T. Strachan, Gina Ferrara, B. Roth
2006Drug Discovery Today68 citations
Semantic Scholar
PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?
T. Kenakin, Ryan T. Strachan
2018TIPS - Trends in Pharmacological Sciences67 citations
Semantic Scholar
Allosteric Modulation of β-Arrestin-biased Angiotensin II Type 1 Receptor Signaling by Membrane Stretch*
Wei-Bing Tang, Ryan T. Strachan, R. Lefkowitz, H. Rockman
2014Journal of Biological Chemistry66 citations Open access
Semantic Scholar
Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies
M. Davies, V. Setola, Ryan T. Strachan, Douglas J. Sheffler +3 more
2006The Pharmacogenomics Journal49 citations Open access
Semantic Scholar
Chronic treatment in vivo with β‐adrenoceptor agonists induces dysfunction of airway β2‐adrenoceptors and exacerbates lung inflammation in mice
Rui Lin, S. Degan, Barbara S. Theriot, B. M. Fischer +8 more
2012British Journal of Pharmacology41 citations Open access
Semantic Scholar
Ribosomal S6 Kinase 2 Directly Phosphorylates the 5-Hydroxytryptamine 2A (5-HT2A) Serotonin Receptor, Thereby Modulating 5-HT2A Signaling*
Ryan T. Strachan, Douglas J. Sheffler, B. Willard, M. Kinter +2 more
2009Journal of Biological Chemistry33 citations Open access
Semantic Scholar
Genetic Deletion of p90 Ribosomal S6 Kinase 2 Alters Patterns of 5-Hydroxytryptamine2A Serotonin Receptor Functional Selectivity
Ryan T. Strachan, N. Sciaky, M. Cronan, W. Kroeze +1 more
2010Molecular Pharmacology30 citations Open access
Semantic Scholar
Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.
P. Jean-Charles, Samuel Mon-Wei Yu, Dennis M. Abraham, R. Kommaddi +10 more
2017JCI Insight27 citations Open access
Semantic Scholar
Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor
Anat Levit Kaplan, Ryan T. Strachan, J. Bráz, Veronica Craik +8 more
2021bioRxiv19 citations Open access
Semantic Scholar
P90 RIBOSOMAL S6 KINASE 2, A NOVEL GPCR KINASE, IS REQUIRED FOR GROWTH FACTOR-MEDIATED ATTENUATION OF GPCR SIGNALING
Ryan T. Strachan, John A. Allen, Douglas J. Sheffler, B. Roth
2010Biochemistry19 citations Open access
Semantic Scholar
VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells
J. English, R. Olsen, K. Lansu, Michael Patel +6 more
2019Cell9 citations Open access
Semantic Scholar
Quantification of Beta Adrenergic Receptor Subtypes in Beta-Arrestin Knockout Mouse Airways
Akhil Hegde, Ryan T. Strachan, Julia K. L. Walker
2015PLoS ONE9 citations Open access
Semantic Scholar
Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor
Tao Che, S. Majumdar, Saheem A. Zaidi, C. Kormos +20 more
20183 citations
Semantic Scholar
Regulation of b 2 -Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies s
D. Staus, L. Wingler, Ryan T. Strachan, S. Rasmussen +5 more
20142 citations
Semantic Scholar
P90 Ribosomal S6 Kinase 2 (RSK2) Directly Phosphorylates the 5-HT2A Serotonin Receptor thereby Modulating Signaling
Ryan T. Strachan
20092 citations
Semantic Scholar
Cell-type selective deletion of RSK2 reveals insights into altered signaling in Coffin-Lowry Syndrome
Hu Zhu, Ryan T. Strachan, D. Urban, M. Farrell +4 more
2017bioRxiv1 citations Open access
Semantic Scholar
Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60
D. Staus, Ryan T. Strachan, A. Manglik, Biswaranjan Pani +14 more
20161 citations
Semantic Scholar
Conformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules
Samuel Liu, Peng Xiao, M. Elgeti, Eve J. Fine +25 more
2026bioRxiv0 citations Open access
Semantic Scholar
Establish a Barcode That Encodes Differential Functions of { beta }-Arrestin Distinct Phosphorylation Sites on the { beta } 2-Adrenergic Receptor `
Makoto R. Hara, Sudha K. Shenoy, S. Gygi, R. Lefkowitz +9 more
20110 citations
Semantic Scholar

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