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L. Moore · SciRah

Researcher profile · Semantic Scholar

L. Moore

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L. Moore — researcher profile on SciRah

h-index: 36
Works: 55
Citations: 18K

Most-cited papers

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ) (*)
J. Lehmann, L. Moore, T. Smith-Oliver, W. Wilkison +2 more
1995Journal of Biological Chemistry3,595 citations Open access
Semantic Scholar
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.
B. Goodwin, Stacey A. Jones, R. Price, M. Watson +9 more
2000Molecules and Cells1,932 citations Open access
Semantic Scholar
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).
J. Lehmann, L. Moore, T. Smith-Oliver, W. Wilkison +2 more
1995Journal of Biological Chemistry1,418 citations
Semantic Scholar
Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway*
J. Lehmann, S. Kliewer, L. Moore, T. Smith-Oliver +7 more
1997Journal of Biological Chemistry1,303 citations Open access
Semantic Scholar
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.
L. Moore, B. Goodwin, Stacey A. Jones, G. Wisely +4 more
2000Proceedings of the National Academy of Sciences of the United States of America935 citations Open access
Semantic Scholar
Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands*
L. Moore, D. Parks, Stacey A. Jones, R. Bledsoe +8 more
2000Journal of Biological Chemistry852 citations Open access
Semantic Scholar
The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity
R. Watkins, G. Wisely, L. Moore, J. L. Collins +5 more
2001Science762 citations
Semantic Scholar
The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
Stacey A. Jones, L. Moore, J. L. Shenk, G. Wisely +8 more
2000Molecular Endocrinology676 citations
Semantic Scholar
The structure - Activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones
T. Willson, J. Cobb, C. John, R. Wiethe +6 more
1996671 citations Open access
Semantic Scholar
Cloning and Characterization of Human Estrogen Receptor β Isoforms
J. Moore, D. D. McKee, K. Slentz-Kesler, L. Moore +6 more
1998546 citations
Semantic Scholar
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors
H. Xu, M. Lambert, V. Montana, K. D. Plunket +8 more
2001Proceedings of the National Academy of Sciences of the United States of America536 citations Open access
Semantic Scholar
Identification of a chemical tool for the orphan nuclear receptor FXR.
P. Maloney, D. Parks, C. Haffner, Adam M. Fivush +8 more
2000Journal of Medicinal Chemistry522 citations Open access
Semantic Scholar
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.
J. L. Collins, Adam M. Fivush, M. Watson, C. Galardi +12 more
2002Journal of Medicinal Chemistry440 citations Open access
Semantic Scholar
Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes*
J. M. Maglich, D. Parks, L. Moore, J. L. Collins +7 more
2003Journal of Biological Chemistry427 citations Open access
Semantic Scholar
Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.
B. Goodwin, L. Moore, C. Stoltz, D. D. McKee +1 more
2001Molecular Pharmacology390 citations
Semantic Scholar
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.
L. Moore, J. M. Maglich, D. D. McKee, B. Wisely +4 more
2002Molecular Endocrinology358 citations Open access
Semantic Scholar
2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin.
R. Watkins, J. M. Maglich, L. Moore, G. Wisely +5 more
2003Biochemistry315 citations
Semantic Scholar
A peroxisome proliferator-activated receptor g ligand inhibits adipocyte differentiation
Jennifer L. Oberfield, Jon L. Collins, C. Holmes, Onna M. Goreham +15 more
1999224 citations
Semantic Scholar
Cloning and characterization of human estrogen receptor beta isoforms.
J. Moore, D. D. McKee, K. Slentz-Kesler, L. Moore +6 more
1998Biochemical and Biophysical Research Communications - BBRC217 citations
Semantic Scholar
A Structural Basis for Constitutive Activity in the Human CAR/RXRα Heterodimer
Robert X. Xu, M. Lambert, B. Wisely, E. Warren +7 more
2004204 citations Open access
Semantic Scholar
Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.
J. Chrencik, J. Orans, L. Moore, Yu Xue +6 more
2005Molecular Endocrinology200 citations
Semantic Scholar
Expression of wild-type estrogen receptor beta and variant isoforms in human breast cancer.
S. Fuqua, R. Schiff, Irma Parra, W. Friedrichs +6 more
1999Cancer Research193 citations
Semantic Scholar
X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.
S. Williams, R. Bledsoe, J. L. Collins, Sharon D. Boggs +10 more
2003Journal of Biological Chemistry189 citations Open access
Semantic Scholar
A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta.
B. R. Henke, Thomas G. Consler, N. Go, Ron L. Hale +15 more
2002Journal of Medicinal Chemistry152 citations Open access
Semantic Scholar
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.
P. J. Brown, D. Winegar, K. D. Plunket, L. Moore +9 more
1999Journal of Medicinal Chemistry131 citations Open access
Semantic Scholar
Functional and structural comparison of PXR and CAR.
J. Moore, L. Moore, J. M. Maglich, S. Kliewer
2003Biochimica et Biophysica Acta126 citations
Semantic Scholar
Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen.
P. Desai, S. Nallani, R. Sane, L. Moore +3 more
2002Drug Metabolism And Disposition125 citations
Semantic Scholar
The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor.
Hongwei Wang, Hao Li, L. Moore, M. Johnson +16 more
2008Molecular Endocrinology123 citations Open access
Semantic Scholar
Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha.
Thomas A. Spencer, Dan-Su Li, J. Russel, Jon L. Collins +10 more
2001Journal of Medicinal Chemistry123 citations Open access
Semantic Scholar
A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.
Robert X. Xu, M. Lambert, B. Wisely, E. Warren +7 more
2004Molecules and Cells102 citations
Semantic Scholar
Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition.
Yu Xue, L. Moore, J. Orans, Li Peng +3 more
2007Molecular Endocrinology101 citations Open access
Semantic Scholar
A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation.
Jennifer L. Oberfield, Jon L. Collins, C. Holmes, D. Goreham +14 more
1999Proceedings of the National Academy of Sciences of the United States of America83 citations Open access
Semantic Scholar
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.
T. Willson, J. Cobb, D. Cowan, R. Wiethe +6 more
1996Journal of Medicinal Chemistry77 citations
Semantic Scholar
Human PXR forms a tryptophan zipper-mediated homodimer.
S. Noble, Virginia E Carnahan, L. Moore, T. Luntz +10 more
2006Biochemistry71 citations Open access
Semantic Scholar
Paralogous vitamin D receptors in teleosts: transition of nuclear receptor function.
Deanna L. Howarth, S. Law, B. Barnes, J. M. Hall +5 more
2008Endocrinology47 citations Open access
Semantic Scholar
Subtype specific effects of peroxisome proliferator-activated receptor ligands on corepressor affinity.
T. Stanley, L. M. Leesnitzer, V. Montana, C. Galardi +6 more
2003Biochemistry44 citations Open access
Semantic Scholar
Recombinant Baculoviruses Used to Study Estrogen Receptor Function in Human Osteosarcoma Cells
W. C. Clay, J. Condreay, L. Moore, Susan L. Weaver +3 more
2003Assay and drug development technologies33 citations
Semantic Scholar
Williams, S. et al. X-ray crystal structure of the liver X receptor ligand binding domain: regulation by a histidine-tryptophan switch. J. Biol. Chem. 278, 27138-27143
S. Williams, R. Bledsoe, J. L. Collins, Sharon D. Boggs +10 more
200330 citations
Semantic Scholar
Bone targeted drugs: 2. Synthesis of estrogens with hydroxyapatite affinity
T. Willson, B. R. Henke, Tanya M. Momtahen, D. Garrison +3 more
199615 citations
Semantic Scholar
Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates.
Stacey A. Jones, L. Moore, G. Wisely, S. Kliewer
2002Methods in Enzymology14 citations
Semantic Scholar
X-ray Crystal Structure of the Liver X Receptor β Ligand Binding Domain
S. Williams, R. Bledsoe, J. L. Collins, Sharon D. Boggs +10 more
2003Journal of Biological Chemistry13 citations Open access
Semantic Scholar
CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.
T. Tippin, G. Hamilton, L. Moore, Elizabeth J. Beaudet +14 more
2003Drug Metabolism And Disposition10 citations
Semantic Scholar
crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid, and 5b-pregnane-3,20-dione.
Robert X. Xu, M. Lambert, B. Wisely, E. Warren +6 more
20041 citations
Semantic Scholar
X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol
S. Williams, R. Bledsoe, J. L. Collins, Sharon D. Boggs +10 more
20031 citations
Semantic Scholar
Plant Antitumor Agents. Part 30. Synthesis and Structure Activity of Novel Camptothecin Analogs, e.g. (I).
M. Wall, M. Wani, A. W. Nicholas, G. Manikumar +5 more
19931 citations
Semantic Scholar
Bone Targeted Drugs. Part 2. Synthesis of Estrogens with Hydroxyapatite Affinity
T. Willson, B. R. Henke, Tanya M. Momtahen, D. Garrison +3 more
20100 citations
Semantic Scholar
Erratum: Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition (Molecular Endocrinology (2007) 21, 5, (1028-1038))
Yu Xue, L. Moore, J. Orans, Peng Li +3 more
20070 citations Open access
Semantic Scholar
crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid and CITCO
R.-X. Xu, M. Lambert, B. Wisely, E. Warren +6 more
20040 citations
Semantic Scholar
Crystal Structure of the Human Pregane X Receptor Ligand Binding Domain in Complex with Hyperforin, a Constituent of St. John's Wort
R. Watkins, J. M. Maglich, L. Moore, G. Wisely +5 more
20030 citations
Semantic Scholar
Front-line drug recognition in humans by the nuclear receptor PXR
M. Redinbo, R. Watkins, S. Noble, G. Wisely +3 more
20020 citations Open access
Semantic Scholar

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Stacey A. Jones×8

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Stacey A. Jones — researcher profile on SciRah