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W. C. Lumma · SciRah

Researcher profile · Semantic Scholar

W. C. Lumma

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W. C. Lumma — researcher profile on SciRah

h-index: 21
Works: 60
Citations: 1,916

Most-cited papers

L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase
S. D. Young, S. F. Britcher, Lekhanh O. Tran, L. S. Payne +6 more
1995Antimicrobial Agents and Chemotherapy410 citations Open access
Semantic Scholar
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
R. Lobell, C. Omer, M. Abrams, H. Bhimnathwala +17 more
2001Cancer Research246 citations
Semantic Scholar
Statins suppress THP‐1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation
B. Wong, W. C. Lumma, A. Smith, J. Sisko +2 more
2001Journal of Leukocyte Biology173 citations
Semantic Scholar
Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position.
T. Tucker, S. F. Brady, W. C. Lumma, S. Lewis +17 more
1998Journal of Medicinal Chemistry91 citations Open access
Semantic Scholar
An investigation of tautomerism in adenine and guanine
Michael Sabio, S. Topiol, W. C. Lumma
199076 citations
Semantic Scholar
Design of novel, potent, noncovalent inhibitors of thrombin with nonbasic P-1 substructures: rapid structure-activity studies by solid-phase synthesis.
W. C. Lumma, K. M. Witherup, T. J. Tucker, S. F. Brady +5 more
1998Journal of Medicinal Chemistry70 citations Open access
Semantic Scholar
Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
T. J. Tucker, T. Lyle, C. Wiscount, S. F. Britcher +6 more
1994Journal of Medicinal Chemistry62 citations Open access
Semantic Scholar
Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on solid support.
S. F. Brady, K. J. Stauffer, W. C. Lumma, Graham M. Smith +15 more
1998Journal of Medicinal Chemistry61 citations Open access
Semantic Scholar
Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site.
T. J. Tucker, W. C. Lumma, Anne M. Mulichak, Zhongguo Chen +5 more
1997Journal of Medicinal Chemistry61 citations Open access
Semantic Scholar
Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy.
T. J. Tucker, W. C. Lumma, S. Lewis, Stephen J. Gardell +9 more
1997Journal of Medicinal Chemistry54 citations Open access
Semantic Scholar
Inhibitors of gastric acid secretion: 3,4-diamino-1,2,5-thiadiazole 1-oxides and 1,1-dioxides as urea equivalents in a series of histamine H2-receptor antagonists.
W. C. Lumma, P. Anderson, J. Baldwin, W. A. Bolhofer +12 more
1982Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
Piperazinylimidazo[1,2-a]pyrazines with selective affinity for in vitro alpha-adrenergic receptor subtypes.
W. C. Lumma, W. Randall, E. L. Cresson, J. Huff +2 more
1983Journal of Medicinal Chemistry38 citations
Semantic Scholar
The chemistry of cephamycins. IV. Acylation of amides in the presence of neutral acid scavengers
L. M. Weinstock, S. Karady, F. Roberts, A. Hoinowski +4 more
197536 citations
Semantic Scholar
Piperazinylquinoxalines with central serotoninmimetic activity.
W. C. Lumma, R. D. Hartman, W. Saari, E. Engelhardt +2 more
1981Journal of Medicinal Chemistry33 citations
Semantic Scholar
Rational design of 4-[(methylsulfonyl)amino]benzamides as class III antiarrhythmic agents.
W. C. Lumma, R. A. Wohl, D. Davey, Thomas M. Argentieri +6 more
1987Journal of Medicinal Chemistry31 citations
Semantic Scholar
Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position.
T. J. Tucker, W. C. Lumma, S. Lewis, Stephen J. Gardell +13 more
1997Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
Symbiotic approach to drug design: antihypertensive beta-adrenergic blocking agents.
John J. Baldwin, W. C. Lumma, G. F. Lundell, Gerald S. Ponticello +5 more
1979Journal of Medicinal Chemistry28 citations
Semantic Scholar
exo-2-Phenyl-1-aza-7-oxabicyclo[2.2.1]heptane, a novel heterobicyclic ring system
W. C. Lumma
196928 citations
Semantic Scholar
Synthesis of two benzothiacyclanones via a novel two-carbon ring expansion of thiolactones with vinyllithium
W. C. Lumma, G. A. Dutra, C. A. Voeker
197027 citations
Semantic Scholar
Anions Modulate the Potency of Geranylgeranyl-Protein Transferase I Inhibitors*
H. Huber, R. Robinson, Aubrey Watkins, Deborah D. Nahas +11 more
2001Journal of Biological Chemistry22 citations Open access
Semantic Scholar
2-Heterocyclic indole-3-sulfones as inhibitors of HIV-1 reverse transcriptase
S. D. Young, M. Amblard, S. F. Britcher, Vanessa E. Grey +7 more
199522 citations
Semantic Scholar
Synthesis of novel 3-(alkylthio)-2-halopyridines and related derivatives
G. Ponticello, R. D. Hartman, W. C. Lumma, J. Baldwin
197919 citations
Semantic Scholar
Piperazinylpyrazines with central serotoninmimetic activity.
W. C. Lumma, R. D. Hartman, W. Saari, E. Engelhardt +4 more
1978Journal of Medicinal Chemistry19 citations
Semantic Scholar
Modification of the Passerini reaction: facile synthesis of analogs of isoproterenol and (aryloxy)propanolamine .beta.-adrenergic blocking agents
W. C. Lumma
198118 citations
Semantic Scholar
Synthesis, cardiac electrophysiology, and beta-blocking activity of novel arylpiperazines with potential as class II/III antiarrhythmic agents.
G. Phillips, T. K. Morgan, W. C. Lumma, R. Gomez +4 more
1992Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
The role of intramolecular hydrogen bonding as a determinant of the conformational profiles of cGMP and cAMP
S. Topiol, T. Morgan, Michael Sabio, W. C. Lumma
199017 citations
Semantic Scholar
Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogues related to cimetidine and tiotidine.
J. M. Hoffman, A. M. Pietruszkiewicz, Charles N. Habecker, B. T. Phillips +5 more
1983Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Photochemistry of isothiochroman-4-one
W. C. Lumma, G. A. Berchtold
196717 citations
Semantic Scholar
Condensation of unsymmetrical aliphatic ketones with formaldehyde in trifluoroacetic acid
W. C. Lumma, O.-H. Ma
197016 citations
Semantic Scholar
Synthesis and cardiac electrophysiological activity of N-substituted-4-(1H-imidazol-1-yl)benzamides--new selective class III agents.
T. K. Morgan, R. Lis, W. C. Lumma, K. Nickisch +6 more
1990Journal of Medicinal Chemistry15 citations
Semantic Scholar
An approach to peripheral vasodilator-beta-adrenergic blocking agents.
J. Baldwin, R. Hirschmann, P. Lumma, W. C. Lumma +3 more
1977Journal of Medicinal Chemistry15 citations
Semantic Scholar
Novel condensation of 2,3-epoxybutanal with 2-aminopyridine and 2-aminopyrazine. Synthesis and stability of 3-(1-hydroxyethyl)imidazo[1,2-a]azines
W. C. Lumma, J. P. Springer
198114 citations
Semantic Scholar
2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase.
B. Trotter, Amy G. Quigley, W. C. Lumma, J. Sisko +13 more
2001Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.
T. Tucker, M. Abrams, C. Buser, J. Davide +12 more
2002Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Synthesis and pharmacological studies of N-[4-[2-hydroxy-3-[[2-[4-(1H-imidazol-1- yl)phenoxy]ethyl]amino]propoxy]phenyl]methanesulfonamide, a novel antiarrhythmic agent with class II and class III activities.
T. K. Morgan, R. Lis, W. C. Lumma, R. Wohl +5 more
199011 citations Open access
Semantic Scholar
Convenient synthesis of 4-methylhistamine and racemic .alpha.,4-dimethylhistamine and .alpha.,4-dimethylhistidine
D. Davey, W. C. Lumma
19899 citations
Semantic Scholar
4-Alkyl(aryl)-3-amino-1,2,5-thiadiazole 1,1-dioxides: Notes
A. M. Pietruszkiewicz, J. Baldwin, W. A. Bolhofer, J. M. Hoffman +1 more
19838 citations
Semantic Scholar
Structure-activity, theoretical, and X-ray studies on the intramolecular interactions in a series of novel histamine H2 receptor antagonists.
W. C. Lumma, J. Baldwin, John B. Bicking, William A. Bolhofer +9 more
1984Journal of Medicinal Chemistry7 citations
Semantic Scholar
Product stereospecificity in the microbial reduction of imidazol-1-yl methyl aryl ketones
R. Lis, W. B. Caldwell, G. Rudd, W. C. Lumma +4 more
19876 citations
Semantic Scholar
Synthesis and class III antiarrhythmic activity of (phenylbut-2-enyl)ammonium salts. Effect of conformation on activity.
T. K. Morgan, R. Wohl, W. C. Lumma, C.-N. Wan +6 more
1986Journal of Medicinal Chemistry5 citations
Semantic Scholar
Development of nonnucleoside HIV reverse transcriptase inhibitors.
T. Tucker, W. C. Lumma, J. Culberson
1996Methods in Enzymology4 citations
Semantic Scholar
Synthesis of a Series of 4-(Arylethynyl)-6-chloro-4-cyclopropyl-3,4- dihydroquinazolin-2(1H)-ones as Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors.
T. Tucker, T. Lyle, C. Wiscount, S. F. Britcher +11 more
19944 citations
Semantic Scholar
Direct synthesis of trisubstituted isothiazole 1,1-dioxides. Regioselective substitution reactions at C-3 and C-4
S. F. Britcher, D. Cochran, B. T. Phillips, J. P. Springer +1 more
19834 citations
Semantic Scholar
Structure-activity studies and antiviral properties of hydroxyethylene transition state inhibitors of HIV-1 protease
L. Payne, S. D. Young, T. Lyle, C. Wiscount +11 more
19921 citations
Semantic Scholar
β-Methylsulfonylamino phenethylamines and aryloxypropylamines as potential β-adrenergic agents
R. Goehring, W. C. Lumma, P. Erhardt, S. Topiol +6 more
19871 citations
Semantic Scholar
4‐ALKYL(ARYL)‐3‐AMINO‐1,2,5‐THIADIAZOLE 1,1‐DIOXIDES
A. M. Pietruszkiewicz, J. Baldwin, W. A. Bolhofer, J. M. Hoffman +1 more
19831 citations
Semantic Scholar
Synthesis of some 2,3‐14C‐quinoxaline derivatives
W. Saari, W. C. Lumma
19781 citations
Semantic Scholar
Crystal structure of thrombin in complex with compound 14b
T. Tucker, S. F. Brady, W. C. Lumma, S. Lewis +17 more
20040 citations
Semantic Scholar
Crystal structure of thrombin in complex with compound 1
T. Tucker, S. F. Brady, W. C. Lumma, S. Lewis +17 more
20040 citations
Semantic Scholar
Preclinical Models Geranylgeranyl : Protein Transferase Inhibitor Combinations in Evaluation of Farnesyl : Protein Transferase and Updated
R. Lobell, C. Omer, M. Abrams, H. Bhimnathwala +17 more
20010 citations
Semantic Scholar

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