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J. Lokau · SciRah

Researcher profile · Semantic Scholar

J. Lokau

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J. Lokau — researcher profile on SciRah

h-index: 29
Works: 73
Citations: 2,410

Most-cited papers

Therapeutic IL-6 trans-signalling inhibition by olamkicept (sgp130Fc) in patients with active inflammatory bowel disease.
S. Schreiber, K. Aden, J. P. Bernardes, C. Conrad +20 more
2021Gastroenterology192 citations Open access
Semantic Scholar
The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.
Christoph Garbers, N. Monhasery, Samadhi Aparicio-Siegmund, J. Lokau +5 more
2014Biochimica et Biophysica Acta148 citations Open access
Semantic Scholar
Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation
Steffen Riethmueller, P. Somasundaram, J. C. Ehlers, Chien-Wen Hung +20 more
2017PLoS Biology129 citations Open access
Semantic Scholar
Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.
J. Lokau, Rebecca Nitz, M. Agthe, N. Monhasery +10 more
2016Cell Reports127 citations Open access
Semantic Scholar
Jak-Stat Signaling Induced by Interleukin-6 Family Cytokines in Hepatocellular Carcinoma
J. Lokau, V. Schoeder, J. Haybaeck, Christoph Garbers
2019Cancers111 citations Open access
Semantic Scholar
The metalloprotease ADAM17 in inflammation and cancer.
Stefan Düsterhöft, J. Lokau, Christoph Garbers
2019Pathology, Research and Practice103 citations
Semantic Scholar
Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17
Steffen Riethmueller, J. C. Ehlers, J. Lokau, Stefan Düsterhöft +6 more
2016Scientific Reports96 citations Open access
Semantic Scholar
Control of ADAM17 activity by regulation of its cellular localisation
I. Lorenzen, J. Lokau, Yvonne Korpys, Mirja Oldefest +6 more
2016Scientific Reports96 citations Open access
Semantic Scholar
The membrane‐proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin‐6 receptor and interleukin‐1 receptor II
I. Lorenzen, J. Lokau, Stefan Düsterhöft, Ahmad Trad +4 more
2012FEBS Letters73 citations
Semantic Scholar
ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling
Stefanie Schmidt, Neele Schumacher, Jeanette Schwarz, S. Tangermann +29 more
2018Journal of Experimental Medicine72 citations Open access
Semantic Scholar
A Disintegrin and Metalloprotease 17 Dynamic Interaction Sequence, the Sweet Tooth for the Human Interleukin 6 Receptor*
Stefan Düsterhöft, Katharina Höbel, Mirja Oldefest, J. Lokau +7 more
2014Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Function and proteolytic generation of the soluble interleukin-6 receptor in health and disease.
Tim Schumertl, J. Lokau, S. Rose-John, Christoph Garbers
2021Biochimica et biophysica acta. Molecular cell research62 citations Open access
Semantic Scholar
Biological functions and therapeutic opportunities of soluble cytokine receptors.
J. Lokau, Christoph Garbers
2020Cytokine & growth factor reviews62 citations
Semantic Scholar
Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling
P. Arnold, Inga Boll, M. Rothaug, Neele Schumacher +13 more
2017Scientific Reports55 citations Open access
Semantic Scholar
Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation
J. Lokau, M. Agthe, Christoph Garbers
2016Mediators of Inflammation54 citations Open access
Semantic Scholar
Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling
Charlotte M. Flynn, Yvonne Garbers, J. Lokau, D. Wesch +5 more
2019Scientific Reports53 citations Open access
Semantic Scholar
Proteolytic control of Interleukin-11 and Interleukin-6 biology.
J. Lokau, M. Agthe, Charlotte M. Flynn, Christoph Garbers
2017Biochimica et biophysica acta. Molecular cell research48 citations Open access
Semantic Scholar
Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells
J. Lokau, Florian Kleinegger, Yvonne Garbers, G. H. Waetzig +4 more
2020PLoS ONE47 citations Open access
Semantic Scholar
Kinetics of cytokine receptor trafficking determine signaling and functional selectivity
Jonathan Martínez-Fábregas, S. Wilmes, Luo-Pin Wang, M. Hafer +9 more
2019bioRxiv43 citations Open access
Semantic Scholar
The cytokine interleukin-11 crucially links bone formation, remodeling and resorption.
Birte Kespohl, Tim Schumertl, J. Bertrand, J. Lokau +1 more
2021Cytokine & growth factor reviews38 citations
Semantic Scholar
The soluble IL‐2 receptor α/CD25 as a modulator of IL‐2 function
J. Lokau, Lynn M Petasch, Christoph Garbers
2023Immunology35 citations Open access
Semantic Scholar
Interleukin‐11 (IL‐11) receptor cleavage by the rhomboid protease RHBDL2 induces IL‐11 trans‐signaling
L. Koch, Birte Kespohl, M. Agthe, Tim Schumertl +4 more
2021The FASEB Journal33 citations Open access
Semantic Scholar
Modular organization of Interleukin-6 and Interleukin-11 α-receptors.
Rebecca Nitz, J. Lokau, Samadhi Aparicio-Siegmund, J. Scheller +1 more
2015Biochimie33 citations
Semantic Scholar
Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice.
M. Agthe, Julian Brügge, Yvonne Garbers, Marieke Wandel +11 more
2018Cell Reports32 citations Open access
Semantic Scholar
IL-6 Signaling in Immunopathology: From Basic Biology to Selective Therapeutic Intervention
Tim Schumertl, J. Lokau, C. Garbers
2025ImmunoTargets and Therapy31 citations Open access
Semantic Scholar
Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance
A. Reif, K. Lam, Sascha Weidler, Marie Lott +17 more
2021Angewandte Chemie31 citations Open access
Semantic Scholar
Activating mutations of the gp130/JAK/STAT pathway in human diseases.
J. Lokau, Christoph Garbers
2019Advances in Protein Chemistry and Structural Biology31 citations
Semantic Scholar
Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles
P. Arnold, Wiebke Lückstädt, Wenjia Li, Inga Boll +5 more
2020Cells30 citations Open access
Semantic Scholar
Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor.
N. Monhasery, Jens M. Moll, C. Cuman, M. Franke +10 more
2016Cell Reports29 citations Open access
Semantic Scholar
Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP
Martin Sammel, Florian Peters, J. Lokau, Franka Scharfenberg +5 more
2019International Journal of Molecular Sciences26 citations Open access
Semantic Scholar
The SNP rs4252548 (R112H) which is associated with reduced human height compromises the stability of IL-11.
J. Lokau, Sascha Göttert, P. Arnold, Stefan Düsterhöft +3 more
2018Biochimica et biophysica acta. Molecular cell research26 citations Open access
Semantic Scholar
The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo
Sophia Kirschke, Iretiolu M. Ogunsulire, Balachandar Selvakumar, Neele Schumacher +5 more
2022Journal of Biological Chemistry25 citations Open access
Semantic Scholar
The role of proteolysis in interleukin-11 signaling.
J. Lokau, Birte Kespohl, Sophia Kirschke, Christoph Garbers
2021Biochimica et biophysica acta. Molecular cell research25 citations Open access
Semantic Scholar
Recombinant p35 from Bacteria Can Form Interleukin (IL-)12, but Not IL-35
Samadhi Aparicio-Siegmund, Jens M. Moll, J. Lokau, M. Grusdat +7 more
2014PLoS ONE25 citations Open access
Semantic Scholar
Case Report: Arterial Wall Inflammation in Atherosclerotic Cardiovascular Disease is Reduced by Olamkicept (sgp130Fc)
D. Schulte, G. H. Waetzig, H. Schuett, Marlies Marx +14 more
2022Frontiers in Pharmacology24 citations Open access
Semantic Scholar
A single aromatic residue in sgp130Fc/olamkicept allows the discrimination between interleukin-6 and interleukin-11 trans-signaling
J. Lokau, Yvonne Garbers, J. Grötzinger, Christoph Garbers
2021iScience21 citations Open access
Semantic Scholar
Long-term increase in soluble interleukin-6 receptor levels in convalescents after mild COVID-19 infection
J. Lokau, Yvonne Garbers, Manuel M. Vicente, Anna Dittrich +5 more
2025Frontiers in Immunology20 citations Open access
Semantic Scholar
The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release
Stefan Düsterhöft, Selcan Kahveci-Türköz, Justyna Woźniak, Anke Seifert +10 more
2021Cellular and Molecular Life Sciences20 citations Open access
Semantic Scholar
Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation
Neele Schumacher, Stefanie Schmidt, Jeanette Schwarz, Dana Dohr +6 more
2016Journal of Immunology20 citations Open access
Semantic Scholar
Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro
Charlotte M. Flynn, Yvonne Garbers, Stefan Düsterhöft, Rielana Wichert +8 more
2020Scientific Reports19 citations Open access
Semantic Scholar
Interleukin-6 controls recycling and degradation, but not internalization of its receptors
Charlotte M. Flynn, Birte Kespohl, T. Daunke, Yvonne Garbers +6 more
2021Journal of Biological Chemistry18 citations Open access
Semantic Scholar
Molecular characterization of the craniosynostosis‐associated interleukin‐11 receptor variants p.T306_S308dup and p.E364_V368del
Birte Kespohl, Anna Hegele, Stefan Düsterhöft, Hans Bakker +4 more
2023The FEBS Journal15 citations Open access
Semantic Scholar
The interleukin-11 receptor variant p.W307R results in craniosynostosis in humans
I. Ahmad, J. Lokau, Birte Kespohl, N. A. Malik +12 more
2023Scientific Reports14 citations Open access
Semantic Scholar
Enhancing Interleukin-6 and Interleukin-11 receptor cleavage.
J. Lokau, Marieke Wandel, Christoph Garbers
2017International Journal of Biochemistry and Cell Biology13 citations
Semantic Scholar
The biology of interleukin-6 family cytokines is regulated by glycosylation
Lisa Kohrs, Falk F. R. Buettner, J. Lokau, Christoph Garbers
2025Biochemical Journal12 citations
Semantic Scholar
The length of the interleukin-11 receptor stalk determines its capacity for classic signaling
J. Lokau, Christoph Garbers
2018Journal of Biological Chemistry12 citations Open access
Semantic Scholar
Die Rolle von Interleukin-11 beim Osteosarkom
J. Lokau, V. Schoeder, C. Garbers
2020Der Pathologe11 citations
Semantic Scholar
Therapeutic blockade of the interleukin‐6 receptor (IL‐6R) allows sIL‐6R generation by proteolytic cleavage
Niklas Prenißl, J. Lokau, S. Rose-John, J. Haybaeck +1 more
2019Cytokine11 citations Open access
Semantic Scholar
Activation and targetability of TYMP–IL-6–TF signaling in the skin microenvironment in uremic calciphylaxis
M. Napoleon, Xiaosheng Yang, Yi-Chi Zhang, Austin Morrissey +20 more
2025Science Translational Medicine10 citations
Semantic Scholar
Cytokines of the interleukin-6 family as emerging targets in inflammatory bowel disease
Christoph Garbers, J. Lokau
2024Expert opinion on therapeutic targets10 citations
Semantic Scholar

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