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G. H. Waetzig · SciRah

Researcher profile · Semantic Scholar

G. H. Waetzig

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G. H. Waetzig — researcher profile on SciRah

h-index: 39
Works: 86
Citations: 7,184

Most-cited papers

Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection.
S. Ott, G. H. Waetzig, A. Rehman, Jacqueline Moltzau-Anderson +8 more
2017Gastroenterology617 citations Open access
Semantic Scholar
Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases.
S. Nikolaus, B. Schulte, Natalie Al-Massad, F. Thieme +14 more
2017Gastroenterology555 citations Open access
Semantic Scholar
Genetic variation in DLG5 is associated with inflammatory bowel disease
M. Stoll, B. Corneliussen, C. Costello, G. H. Waetzig +14 more
2004Nature Genetics494 citations Open access
Semantic Scholar
TNF-α and IFN-γ regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells ☆ ☆☆ ★ ★★ ♢
P. Rosenstiel, M. Fantini, K. Bräutigam, T. Kühbacher +3 more
2003406 citations Open access
Semantic Scholar
The IL-6/sIL-6R complex as a novel target for therapeutic approaches
S. Rose-John, G. H. Waetzig, J. Scheller, J. Grötzinger +1 more
2007Expert opinion on therapeutic targets392 citations
Semantic Scholar
p38 Mitogen-Activated Protein Kinase Is Activated and Linked to TNF-α Signaling in Inflammatory Bowel Disease1
G. H. Waetzig, D. Seegert, P. Rosenstiel, S. Nikolaus +1 more
2002Journal of Immunology364 citations Open access
Semantic Scholar
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation.
Björn Rabe, A. Chalaris, U. May, G. H. Waetzig +5 more
2008Blood255 citations
Semantic Scholar
Transsignaling of Interleukin-6 Crucially Contributes to Atherosclerosis in Mice
H. Schuett, R. Oestreich, G. H. Waetzig, W. Annema +12 more
2012Arteriosclerosis, Thrombosis and Vascular Biology249 citations Open access
Semantic Scholar
Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients with Inflammatory Bowel Diseases.
K. Aden, A. Rehman, S. Waschina, W. Pan +20 more
2019Gastroenterology244 citations Open access
Semantic Scholar
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays
C. Costello, N. Mah, R. Häsler, P. Rosenstiel +13 more
2005PLoS Medicine241 citations Open access
Semantic Scholar
The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling
Paul Baran, S. Hansen, G. H. Waetzig, M. Akbarzadeh +5 more
2018Journal of Biological Chemistry206 citations Open access
Semantic Scholar
Therapeutic IL-6 trans-signalling inhibition by olamkicept (sgp130Fc) in patients with active inflammatory bowel disease.
S. Schreiber, K. Aden, J. P. Bernardes, C. Conrad +20 more
2021Gastroenterology192 citations Open access
Semantic Scholar
Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor*
Christoph Garbers, Wolfgang M. Thaiss, Gareth W. Jones, G. H. Waetzig +8 more
2011Journal of Biological Chemistry182 citations Open access
Semantic Scholar
p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease.
G. H. Waetzig, D. Seegert, P. Rosenstiel, S. Nikolaus +1 more
2002Journal of Immunology172 citations
Semantic Scholar
Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model*
T. Barkhausen, T. Tschernig, P. Rosenstiel, M. van Griensven +9 more
2011Critical Care Medicine171 citations
Semantic Scholar
TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.
P. Rosenstiel, M. Fantini, K. Bräutigam, T. Kühbacher +3 more
2003Gastroenterology171 citations
Semantic Scholar
Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing.
Katja Prystaz, Kathrin Kaiser, Anna Kovtun, M. Haffner-Luntzer +7 more
2017American Journal of Pathology130 citations Open access
Semantic Scholar
Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.
J. Lokau, Rebecca Nitz, M. Agthe, N. Monhasery +10 more
2016Cell Reports127 citations Open access
Semantic Scholar
An Interleukin-6 Receptor-dependent Molecular Switch Mediates Signal Transduction of the IL-27 Cytokine Subunit p28 (IL-30) via a gp130 Protein Receptor Homodimer*
Christoph Garbers, Björn Spudy, Samadhi Aparicio-Siegmund, G. H. Waetzig +6 more
2012Journal of Biological Chemistry123 citations Open access
Semantic Scholar
A short isoform of NOD2/CARD15, NOD2-S, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways.
P. Rosenstiel, K. Huse, A. Till, J. Hampe +8 more
2006Proceedings of the National Academy of Sciences of the United States of America121 citations
Semantic Scholar
Inhibition of IL‐6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer
Freya A. Goumas, Reinhild Holmer, J. Egberts, Artur Gontarewicz +10 more
2015International Journal of Cancer110 citations
Semantic Scholar
Soluble tumor necrosis factor (TNF) receptor‐1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor‐β1
G. H. Waetzig, P. Rosenstiel, A. Arlt, A. Till +5 more
2005106 citations
Semantic Scholar
Interleukin-6: a villain in the drama of pancreatic cancer development and progression.
Reinhild Holmer, Freya A. Goumas, G. H. Waetzig, S. Rose-John +1 more
2014Hepatobiliary & Pancreatic Diseases International104 citations
Semantic Scholar
Hitting a complex target: an update on interleukin-6 trans-signalling
G. H. Waetzig, S. Rose-John
2012Expert opinion on therapeutic targets96 citations
Semantic Scholar
Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans
D. Fangmann, E. Theismann, K. Türk, D. Schulte +18 more
2017Diabetes Care93 citations Open access
Semantic Scholar
Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling*
J. Wolf, G. H. Waetzig, A. Chalaris, T. Reinheimer +3 more
2016Journal of Biological Chemistry88 citations Open access
Semantic Scholar
Structure-guided Optimization of the Interleukin-6 Trans-signaling Antagonist sgp130*
S. Tenhumberg, G. H. Waetzig, A. Chalaris, Björn Rabe +4 more
2008Journal of Biological Chemistry73 citations Open access
Semantic Scholar
A Disintegrin and Metalloprotease 17 Dynamic Interaction Sequence, the Sweet Tooth for the Human Interleukin 6 Receptor*
Stefan Düsterhöft, Katharina Höbel, Mirja Oldefest, J. Lokau +7 more
2014Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma
Kathrin Kaiser, Katja Prystaz, Anna Vikman, M. Haffner-Luntzer +5 more
2018Naunyn-Schmiedeberg's Archives of Pharmacology69 citations Open access
Semantic Scholar
Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses
Larissa Lamertz, Franziska Rummel, Robin Polz, Paul Baran +5 more
2018Science Signaling68 citations
Semantic Scholar
Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis.
Jan Sodenkamp, G. H. Waetzig, J. Scheller, D. Seegert +4 more
2012Immunobiology65 citations
Semantic Scholar
Localization of hydrogen peroxide during the defence response of Arabidopsis thaliana against the plant-parasitic nematode Heterodera glycines
G. H. Waetzig, M. Sobczak, F. Grundler
199965 citations
Semantic Scholar
N-Linked Glycosylation Is Essential for the Stability but Not the Signaling Function of the Interleukin-6 Signal Transducer Glycoprotein 130*
G. H. Waetzig, A. Chalaris, P. Rosenstiel, Jan Suthaus +9 more
2009Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases
S. Nikolaus, G. H. Waetzig, Sven Butzin, Monika Ziolkiewicz +9 more
2018International Journal of Colorectal Disease59 citations Open access
Semantic Scholar
Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells
J. Lokau, Florian Kleinegger, Yvonne Garbers, G. H. Waetzig +4 more
2020PLoS ONE47 citations Open access
Semantic Scholar
The IL-6-neutralizing sIL-6R/sgp130 buffer system is disturbed in patients with type 2 diabetes.
Samadhi Aparicio-Siegmund, Yvonne Garbers, Charlotte M. Flynn, G. H. Waetzig +6 more
2019American Journal of Physiology. Endocrinology and Metabolism45 citations Open access
Semantic Scholar
Differential p38 mitogen-activated protein kinase target phosphorylation in responders and nonresponders to infliximab.
G. H. Waetzig, P. Rosenstiel, S. Nikolaus, D. Seegert +1 more
2003Gastroenterology45 citations
Semantic Scholar
Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-beta1.
G. H. Waetzig, P. Rosenstiel, A. Arlt, A. Till +5 more
2005The FASEB Journal43 citations
Semantic Scholar
p38 Mitogen-Activated Protein Kinase Is Activated and Linked to TNF- Signaling in Inflammatory Bowel Disease
Nikolaus, S. Schreiber, G. H. Waetzig, D. Seegert +1 more
200240 citations
Semantic Scholar
Alternative Intronic Polyadenylation Generates the Interleukin-6 Trans-signaling Inhibitor sgp130-E10*
Jan Sommer, Christoph Garbers, J. Wolf, Ahmad Trad +7 more
2014Journal of Biological Chemistry39 citations Open access
Semantic Scholar
Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling.
Sven Malchow, Wolfgang M. Thaiss, Nathalie Jänner, G. H. Waetzig +5 more
2011Biochimica et Biophysica Acta39 citations Open access
Semantic Scholar
Mitogen‐activated protein kinases in chronic intestinal inflammation — targeting ancient pathways to treat modern diseases
G. H. Waetzig, Stefan Schreiber
2003Alimentary Pharmacology and Therapeutics36 citations Open access
Semantic Scholar
Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair
K. Aden, A. Breuer, A. Rehman, H. Geese +8 more
2016Oncogenesis33 citations Open access
Semantic Scholar
Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice.
M. Agthe, Julian Brügge, Yvonne Garbers, Marieke Wandel +11 more
2018Cell Reports32 citations Open access
Semantic Scholar
Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits TH17 cell expansion
Denise Heise, Alicia Derrac Soria, S. Hansen, Christine Dambietz +8 more
2021Science Signaling31 citations
Semantic Scholar
Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling.
Jan Sommer, T. Effenberger, E. Volpi, G. H. Waetzig +6 more
2012Journal of Biological Chemistry30 citations Open access
Semantic Scholar
RAID3 - An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity
F. Mittelberger, Cindy Meyer, G. H. Waetzig, M. Zacharias +7 more
2015RNA Biology28 citations Open access
Semantic Scholar
Case Report: Arterial Wall Inflammation in Atherosclerotic Cardiovascular Disease is Reduced by Olamkicept (sgp130Fc)
D. Schulte, G. H. Waetzig, H. Schuett, Marlies Marx +14 more
2022Frontiers in Pharmacology24 citations Open access
Semantic Scholar
Differential modulation of p38 mitogen activated protein kinase and STAT3 signalling pathways by infliximab and etanercept in intestinal T cells from patients with Crohn's disease.
P. Rosenstiel, J. Agnholt, J. Kelsen, V. Medici +3 more
2005Gut18 citations
Semantic Scholar
Differential activity and expression of mitogen-activated protein kinases in inflammatory bowel disease
G. H. Waetzig, D. Seegert, S. Nikolaus, P. Rosenstiel +2 more
200116 citations
Semantic Scholar

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