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K. Jarnagin · SciRah

Researcher profile · Semantic Scholar

K. Jarnagin

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K. Jarnagin — researcher profile on SciRah

h-index: 31
Works: 76
Citations: 4,776

Most-cited papers

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.
Y. Ebina, L. Ellis, K. Jarnagin, M. Edery +8 more
1985Cell1,247 citations
Semantic Scholar
Expression cloning of a rat B2 bradykinin receptor.
Adrienne E. Mceachern, Earl R. Shelton, Sunil Bhakta, Rena Obernolte +5 more
1991Proceedings of the National Academy of Sciences of the United States of America403 citations Open access
Semantic Scholar
Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action.
B. Ganter, S. Tugendreich, C. Pearson, E. Ayanoğlu +35 more
2005Journal of Biotechnology286 citations
Semantic Scholar
Identification of the Binding Site for a Novel Class of CCR2b Chemokine Receptor Antagonists
T. Mirzadegan, F. Diehl, Bettina Ebi, Sunil Bhakta +9 more
2000Journal of Biological Chemistry250 citations Open access
Semantic Scholar
Monomeric Monocyte Chemoattractant Protein-1 (MCP-1) Binds and Activates the MCP-1 Receptor CCR2B*
C. Paavola, S. Hemmerich, D. Grunberger, Irene Polsky +9 more
1998Journal of Biological Chemistry204 citations Open access
Semantic Scholar
Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2.
S. Hemmerich, C. Paavola, Adam Bloom, Sunil Bhakta +14 more
1999Biochemistry154 citations
Semantic Scholar
Classification of a large microarray data set: algorithm comparison and analysis of drug signatures.
G. Natsoulis, L. El Ghaoui, Gert R. G. Lanckriet, Alexander M. Tolley +6 more
2005Genome Research125 citations Open access
Semantic Scholar
Probing for the bradykinin B2 receptor in rat kidney by anti-peptide and anti-ligand antibodies.
C. Figueroa, C. González, S. Grigoriev, S. A. Abd Alla +3 more
1995Journal of Histochemistry and Cytochemistry123 citations Open access
Semantic Scholar
Identification of surface residues of the monocyte chemotactic protein 1 that affect signaling through the receptor CCR2.
K. Jarnagin, D. Grunberger, Mary Mulkins, Belinda Wong +11 more
1999Biochemistry116 citations
Semantic Scholar
Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis
B. Nare, S. Wring, C. Bacchi, B. Beaudet +23 more
2010Antimicrobial Agents and Chemotherapy102 citations Open access
Semantic Scholar
A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity
M. Fielden, B. Eynon, G. Natsoulis, K. Jarnagin +2 more
2005Toxicologic pathology (Print)101 citations
Semantic Scholar
Boron‐based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center
Y. Freund, Tsutomu Akama, M. R. K. Alley, Joana Antunes +11 more
2012FEBS Letters99 citations Open access
Semantic Scholar
Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast.
Ed Perkins, Dongxu Sun, Allen T. Q. Nguyen, Suzana Tulac +12 more
2001Cancer Research97 citations
Semantic Scholar
Extracellular Domains of the Bradykinin B2 Receptor Involved in Ligand Binding and Agonist Sensing Defined by Anti-peptide Antibodies (*)
S. A. Alla, U. Quitterer, S. Grigoriev, A. Maidhof +3 more
1996Journal of Biological Chemistry93 citations Open access
Semantic Scholar
The liver pharmacological and xenobiotic gene response repertoire
G. Natsoulis, C. Pearson, J. Gollub, B. Eynon +8 more
2008Molecular Systems Biology84 citations Open access
Semantic Scholar
Crisaborole Topical Ointment, 2%: A Nonsteroidal, Topical, Anti-Inflammatory Phosphodiesterase 4 Inhibitor in Clinical Development for the Treatment of Atopic Dermatitis.
K. Jarnagin, S. Chanda, Dina J. Coronado, V. Ciaravino +3 more
2016Journal of Drugs in Dermatology82 citations
Semantic Scholar
Treatment of Skin Inflammation with Benzoxaborole Phosphodiesterase Inhibitors: Selectivity, Cellular Activity, and Effect on Cytokines Associated with Skin Inflammation and Skin Architecture Changes
C. Dong, Charlotte Virtucio, Olga Zemska, Grober Baltazar +11 more
2016Journal of Pharmacology and Experimental Therapeutics81 citations Open access
Semantic Scholar
Fed-batch culture of insect cells: a method to increase the yield of recombinant human nerve growth factor (rhNGF) in the baculovirus expression system.
B. Nguyen, K. Jarnagin, Sandra Williams, H. Chan +1 more
1993Journal of Biotechnology76 citations
Semantic Scholar
Crisaborole and its potential role in treating atopic dermatitis: overview of early clinical studies.
L. Zane, S. Chanda, K. Jarnagin, D. Nelson +2 more
2016Immunotherapy74 citations Open access
Semantic Scholar
The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family.
R. Obernolte, Sunil Bhakta, R. Alvarez, C. Bach +4 more
1993Gene72 citations
Semantic Scholar
Mutations in the B2 Bradykinin Receptor Reveal a Different Pattern of Contacts for Peptidic Agonists and Peptidic Antagonists*
K. Jarnagin, Sunil Bhakta, Patty Zuppan, C. Yee +6 more
1996Journal of Biological Chemistry66 citations Open access
Semantic Scholar
Purification and characterization of the receptor for insulin-like growth factor I.
David O. Morgan, K. Jarnagin, Richard A. Roth
1986Biochemistry59 citations
Semantic Scholar
Differential Distribution of Bradykinin B2 Receptors in the Rat and Human Cardiovascular System
C. Figueroa, A. Marchant, U. Novoa, U. Förstermann +3 more
2001HYPERTENSION54 citations Open access
Semantic Scholar
Linking Phenotype to Kinase: Identification of a Novel Benzoxaborole Hinge-Binding Motif for Kinase Inhibition and Development of High-Potency Rho Kinase Inhibitors
Tsutomu Akama, C. Dong, Charlotte Virtucio, D. Sullivan +9 more
2013Journal of Pharmacology and Experimental Therapeutics53 citations
Semantic Scholar
Calcitriol but no other metabolite of vitamin D is essential for normal bone growth and development in the rat.
A. Parfitt, C. Mathews, R. Brommage, K. Jarnagin +1 more
1984Journal of Clinical Investigation52 citations Open access
Semantic Scholar
NSAID-Induced Acute Phase Response is Due to Increased Intestinal Permeability and Characterized by Early and Consistent Alterations in Hepatic Gene Expression
S. Tugendreich, C. Pearson, J. W. Sagartz, K. Jarnagin +1 more
2006Toxicologic pathology (Print)46 citations Open access
Semantic Scholar
Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis.
R. Obernolte, James Ratzliff, P. Baecker, D. V. Daniels +3 more
1997Biochimica et Biophysica Acta43 citations
Semantic Scholar
Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target
Thavy Long, Liliana Rojo‐Arreola, Da Shi, Nelly El-Sakkary +12 more
2017PLoS Neglected Tropical Diseases39 citations Open access
Semantic Scholar
Na+ ions binding to the bradykinin B2 receptor suppress agonist-independent receptor activation.
U. Quitterer, Said Abdalla, K. Jarnagin, W. Müller-Esterl
1996Biochemistry39 citations
Semantic Scholar
Use of a mixed tissue RNA design for performance assessments on multiple microarray formats
Karol L. Thompson, B. Rosenzweig, P. Pine, J. Retief +22 more
2005Nucleic Acids Research35 citations Open access
Semantic Scholar
Considerations for development of therapies for cutaneous neurofibroma
S. Verma, V. Riccardi, Scott R. Plotkin, H. Weinberg +4 more
2018Neurology31 citations Open access
Semantic Scholar
Distribution of bradykinin B2 receptors in target cells of kinin action. Visualization of the receptor protein in A431 cells, neutrophils and kidney sections.
M. Haasemann, C. Figueroa, L. Henderson, S. Grigoriev +6 more
1994Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas31 citations
Semantic Scholar
1,25-Dihydroxyvitamin D3-stimulated mRNAs in rat small intestine.
Mark A. Kessler, L. Lamm, K. Jarnagin, H. DeLuca
1986Archives of Biochemistry and Biophysics29 citations
Semantic Scholar
The N-terminal Amino Group of [Tyr8]Bradykinin Is Bound Adjacent to Analogous Amino Acids of the Human and Rat B2 Receptor*
Said Abdalla, K. Jarnagin, W. Müller-Esterl, U. Quitterer
1996Journal of Biological Chemistry28 citations Open access
Semantic Scholar
Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent.
Tsutomu Akama, Charlotte Virtucio, C. Dong, Richard Kimura +12 more
2013Bioorganic & Medicinal Chemistry Letters26 citations
Semantic Scholar
1- but not 24-hydroxylation of vitamin D is required for skeletal mineralization in rats.
R. Brommage, K. Jarnagin, H. DeLuca, S. Yamada +1 more
1983American Journal of Physiology26 citations
Semantic Scholar
1- but not 24-hydroxylation of vitamin D is required for growth and reproduction in rats.
K. Jarnagin, R. Brommage, H. DeLuca, S. Yamada +1 more
1983American Journal of Physiology23 citations
Semantic Scholar
Early rapid identification of in vivo rat metabolites of AN6414, a novel boron-containing PDE4 inhibitor by QTRAP LC/MS/MS to support drug discovery.
Wei Bu, Tsutomu Akama, S. Chanda, D. Sullivan +8 more
2012Journal of Pharmaceutical and Biomedical Analysis21 citations
Semantic Scholar
Discovery and structure-activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents.
Tsutomu Akama, C. Dong, Charlotte Virtucio, Y. Freund +11 more
2013Bioorganic & Medicinal Chemistry Letters20 citations
Semantic Scholar
Physicochemical Characterization of Recombinant Human Nerve Growth Factor Produced in Insect Cells with a Baculovirus Vector
J. Barnett, J. Chow, B. Nguyen, Daryl K. Eggers +12 more
1991Journal of Neurochemistry19 citations
Semantic Scholar
Abating progressive tissue injury and preserving function after CNS trauma: The role of inflammation modulatory therapies.
D. Pearse, K. Jarnagin
2010Current opinion in investigational drugs16 citations
Semantic Scholar
Synthetic HIV-2 protease cleaves the GAG precursor of HIV-1 with the same specificity as HIV-1 protease.
John C. Wu, S. Carr, K. Jarnagin, Steven Kirsher +7 more
1990Archives of Biochemistry and Biophysics16 citations
Semantic Scholar
Inhibition of Toll-Like Receptor-Mediated Inflammation In Vitro and In Vivo by a Novel Benzoxaborole
C. Dong, H. Sexton, A. Gertrudes, Tsutomu Akama +10 more
2013Journal of Pharmacology and Experimental Therapeutics15 citations
Semantic Scholar
Metabolism and pharmacokinetics of 24,25-dihydroxyvitamin D3 in the vitamin D3-replete rat.
K. Jarnagin, S.-Y. Zeng, M. Phelps, H. DeLuca
1985Journal of Biological Chemistry15 citations Open access
Semantic Scholar
Bradykinin-B2 receptors in humans and rats: cDNA structures, gene structures, possible alternative splicing, and homology searching for subtypes.
J. Park, R. Freedman, C. Bach, C. Yee +4 more
1994Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas14 citations
Semantic Scholar
Use of diagnostic accuracy as a metric for evaluating laboratory proficiency with microarray assays using mixed-tissue RNA reference samples.
P. Pine, M. Boedigheimer, B. Rosenzweig, Y. Turpaz +7 more
2008Pharmacogenomics (London)13 citations
Semantic Scholar
Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs
Tsutomu Akama, Yvonne Freund, P. Berry, David S. Carter +23 more
2019ACS Infectious Diseases12 citations Open access
Semantic Scholar
Clinical trial design for cutaneous neurofibromas
A. Cannon, K. Jarnagin, B. Korf, B. Widemann +5 more
2018Neurology11 citations Open access
Semantic Scholar
A Precisely Humanized Fcrn Transgenic Mouse For Preclinical Pharmacokinetics Studies.
C. M. Conner, Don van Fossan, Kristen Read, D. Cowley +4 more
2023Biochemical Pharmacology8 citations
Semantic Scholar
Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor.
D. Artis, Christine E. Brotherton-Pleiss, J. Pease, C. Lin +5 more
2000Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar

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