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D. Malfacini · SciRah

Researcher profile · Semantic Scholar

D. Malfacini

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D. Malfacini — researcher profile on SciRah

h-index: 18
Works: 63
Citations: 1,290

Most-cited papers

Lack of beta-arrestin signaling in the absence of active G proteins
Manuel Grundmann, Nicole Merten, D. Malfacini, A. Inoue +20 more
2018Nature Communications344 citations Open access
Semantic Scholar
The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors
Stephen P. H. Alexander, Anthony P. Davenport, E. Kelly, Alasdair J. Gibb +203 more
2025British Journal of Pharmacology108 citations Open access
Semantic Scholar
The importance of ligand-receptor conformational pairs in stabilization: spotlight on the N/OFQ G protein-coupled receptor
Rebecca L. Miller, A. Thompson, C. Trapella, R. Guerrini +7 more
2015Structure75 citations Open access
Semantic Scholar
Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonist
A. Rizzi, M. Cerlesi, C. Ruzza, D. Malfacini +6 more
2016Pharmacology Research & Perspectives62 citations Open access
Semantic Scholar
Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq-Signaling Inhibitor FR900359.
M. Crüsemann, R. Reher, I. Schamari, Alexander Brachmann +21 more
2018Angewandte Chemie58 citations
Semantic Scholar
Pharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2
D. Malfacini, C. Ambrosio, Maria Cristina Grò, M. Sbraccia +6 more
2015PLoS ONE55 citations Open access
Semantic Scholar
Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo)
M. F. Bird, M. Cerlesi, Mark Brown, D. Malfacini +8 more
2016PLoS ONE46 citations Open access
Semantic Scholar
Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands
L. Asth, C. Ruzza, D. Malfacini, I. Medeiros +4 more
2016Neuropharmacology44 citations Open access
Semantic Scholar
A novel and facile synthesis of tetra branched derivatives of nociceptin/orphanin FQ.
R. Guerrini, E. Marzola, C. Trapella, M. Pela +6 more
2014Bioorganic & Medicinal Chemistry38 citations
Semantic Scholar
In vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivatives
A. Rizzi, D. Malfacini, M. Cerlesi, C. Ruzza +7 more
2014British Journal of Pharmacology36 citations Open access
Semantic Scholar
In vitro pharmacological characterization of a novel unbiased NOP receptor‐selective nonpeptide agonist AT‐403
F. Ferrari, D. Malfacini, Blair V. Journigan, M. F. Bird +5 more
2017Pharmacology Research & Perspectives31 citations Open access
Semantic Scholar
Pharmacological Investigations of N-Substituent Variation in Morphine and Oxymorphone: Opioid Receptor Binding, Signaling and Antinociceptive Activity
Tanila Ben Haddou, S. Béni, S. Hosztafi, D. Malfacini +3 more
2014PLoS ONE31 citations Open access
Semantic Scholar
Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK‐21273 in comparison with SB‐612111
Matteo Marti, Flora Mela, Mirco Budri, Mattia Volta +7 more
2013British Journal of Pharmacology31 citations Open access
Semantic Scholar
Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity
D. Malfacini, Julian Patt, S. Annala, K. Harpsøe +13 more
2019Journal of Biological Chemistry25 citations Open access
Semantic Scholar
Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt1]N/OFQ(1-13)
M. Cerlesi, Hui-Ping Ding, M. F. Bird, N. Kiguchi +8 more
2016European Journal of Pharmacology24 citations Open access
Semantic Scholar
Pharmacological characterization of endomorphin-2-based cyclic pentapeptides with methylated phenylalanine residues.
R. Perlikowska, D. Malfacini, M. Cerlesi, G. Calo +7 more
2014Peptides24 citations
Semantic Scholar
GPCR in Adipose Tissue Function—Focus on Lipolysis
D. Malfacini, A. Pfeifer
2023Biomedicines22 citations Open access
Semantic Scholar
In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations
F. Ferrari, M. Cerlesi, D. Malfacini, Laila Asth +11 more
2016European Journal of Pharmacology21 citations Open access
Semantic Scholar
NOP receptor pharmacological profile – A dynamic mass redistribution study
D. Malfacini, Katharina Simon, C. Trapella, R. Guerrini +3 more
2018PLoS ONE18 citations Open access
Semantic Scholar
Pharmacological characterization of tachykinin tetrabranched derivatives
C. Ruzza, A. Rizzi, D. Malfacini, Maria Camilla Cerlesi +8 more
2014British Journal of Pharmacology16 citations Open access
Semantic Scholar
Novel Mixed NOP/Opioid Receptor Peptide Agonists
S. Pacifico, Valentina Albanese, Davide Illuminati, E. Marzola +16 more
2021Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor
Tanila Ben Haddou, D. Malfacini, G. Calo, M. Aceto +5 more
2014Molecular Pain15 citations Open access
Semantic Scholar
Unraveling binding mechanism and kinetics of macrocyclic Gαq protein inhibitors.
J. Voss, Jessica Nagel, Muhammad Rafehi, Ramon Guixà-González +9 more
2021Pharmacological Research13 citations Open access
Semantic Scholar
In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative
C. Ruzza, A. Rizzi, D. Malfacini, A. Pulga +6 more
2015Pharmacology Research & Perspectives12 citations Open access
Semantic Scholar
A Multi-Angle Approach to Predict Peptide-GPCR Complexes: The N/OFQ-NOP System as a Successful AlphaFold Application Case Study
A. Ciancetta, D. Malfacini, Matteo Gozzi, E. Marzola +3 more
2024Journal of Chemical Information and Modeling11 citations
Semantic Scholar
Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists
Joaquim Azevedo, C. Ruzza, C. Sturaro, D. Malfacini +3 more
2021Frontiers in Neuroscience11 citations Open access
Semantic Scholar
Pharmacology of Kappa Opioid Receptors: Novel Assays and Ligands
C. Sturaro, D. Malfacini, M. Argentieri, F. Djeujo +6 more
2022Frontiers in Pharmacology10 citations Open access
Semantic Scholar
Opioid receptors in GtoPdb v.2021.3
A. Borsodi, M. Bruchas, G. Calo, C. Chavkin +27 more
2021IUPHAR/BPS Guide to Pharmacology CITE9 citations Open access
Semantic Scholar
In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant.
C. Ruzza, A. Rizzi, D. Malfacini, S. Molinari +4 more
2015Peptides9 citations
Semantic Scholar
Structure activity studies of nociceptin/orphanin FQ(1-13)-NH2 derivatives modified in position 5.
R. Guerrini, E. Marzola, C. Trapella, S. Pacifico +7 more
2015Bioorganic & Medicinal Chemistry9 citations
Semantic Scholar
Synthesis, enantiomeric separation and docking studies of spiropiperidine analogues as ligands of the nociceptin/orphanin FQ receptor
U. Battisti, Sandra Corrado, C. Sorbi, A. Cornia +5 more
20149 citations Open access
Semantic Scholar
Pharmacological characterization of naloxegol: in vitro and in vivo studies.
A. Costanzini, C. Ruzza, Joaquim Azevedo, C. Sturaro +4 more
2021European Journal of Pharmacology8 citations
Semantic Scholar
In vitro and in vivo study of butyrylfentanyl and 4‐fluorobutyrylfentanyl in female and male mice: Role of the CRF1 receptor in cardiorespiratory impairment
S. Bilel, Joaquim Azevedo, M. Tirri, Giorgia Corli +7 more
2024British Journal of Pharmacology7 citations Open access
Semantic Scholar
Functional selectivity of EM-2 analogs at the mu-opioid receptor
Justyna Piekielna-Ciesielska, D. Malfacini, F. Djeujo, Chantal Marconato +3 more
2023Frontiers in Pharmacology7 citations Open access
Semantic Scholar
Synthesis and Structure–Activity Relationships of Triazaspirodecanone Derivatives as Nociceptin/Orphanin FQ Receptor Ligands
Sandra Corrado, U. Battisti, C. Sorbi, A. Tait +4 more
2015Chemical Biology and Drug Design6 citations Open access
Semantic Scholar
Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice.
C. Sturaro, Pietro Pola, M. Argentieri, Alessia Frezza +11 more
2025British Journal of Pharmacology5 citations Open access
Semantic Scholar
In vitro pharmacological evaluation of the novel NOP receptor partial agonist sunobinop.
Riccardo Camilotto, D. Malfacini, Pietro Pola, Erika Morrone +8 more
2025Biochemical Pharmacology4 citations Open access
Semantic Scholar
Molecular characterization of G-protein-coupled receptor (GPCR) and protein kinase A (PKA) cDNA in Perinereis aibuhitensis and expression during benzo(a)pyrene exposure
Hua-He Yi, Jia Sun, P. Han, He-Lin Zhao +84 more
2019PeerJ4 citations Open access
Semantic Scholar
Synthesis and Pharmacological Characterization of Nociceptin/Orphanin FQ Dimeric Ligands
Valentina Albanese, Pietro Pola, M. Argentieri, Tiziano De Ventura +13 more
2025Journal of Medicinal Chemistry3 citations Open access
Semantic Scholar
1,4-Dioxolane-triazaspirodecanone derivatives as nociceptin/orphanin FQ receptor ligands
Sandra Corrado, C. Sorbi, A. Tait, U. Battisti +4 more
2014Medicinal Chemistry Research3 citations Open access
Semantic Scholar
Pharmacological Assays for Investigating the NOP Receptor.
D. Malfacini, G. Calo
2019Handbook of Experimental Pharmacology2 citations
Semantic Scholar
[d-Pen(p-tBuBzl)5]NPS, a novel ligand for the neuropeptide S receptor: structure activity and pharmacological studies
C. Ruzza, L. del Zoppo, D. Malfacini, M. Pela +5 more
2014Medicinal Chemistry Research2 citations
Semantic Scholar
Design of New Potent, Selective, and Long-Acting NOP Receptor Agonists through Multiple Sequential d‑Amino Acid Substitutions of [Arg14 Lys15]N/OFQ(1–15)-NH2
C. Sturaro, A. Rizzo, Erika Morrone, E. Marzola +13 more
2026Journal of Medicinal Chemistry1 citations Open access
Semantic Scholar
Opioid receptors in GtoPdb v.2025.1
A. Borsodi, L. Liu-Chen, D. Malfacini, D. Massot +27 more
2025IUPHAR/BPS Guide to Pharmacology CITE1 citations Open access
Semantic Scholar
Probing non-peptide agonists binding at the human nociceptin/orphanin FQ receptor: a molecular modelling study.
Matteo Gozzi, D. Malfacini, Valentina Albanese, S. Pacifico +4 more
2024RSC Medicinal Chemistry1 citations Open access
Semantic Scholar
Dupilumab antagonizes the stimulatory effects of IL-13 on mucin production by human bronchial epithelium cells.
Francine Medjiofack Djeujo, D. Malfacini, Marco Negrini, G. Natali +3 more
2024Airway pharmacology and treatment1 citations
Semantic Scholar
In vitro pharmacological characterization of growth hormone secretagogue receptor ligands using the dynamic mass redistribution and calcium mobilization assays.
C. Sturaro, C. Ruzza, F. Ferrari, Pietro Pola +8 more
2024European Journal of Pharmacology1 citations Open access
Semantic Scholar
(L)-Monomethyl Tyrosine (Mmt): New Synthetic Strategy via Bulky ‘Forced-Traceless’ Regioselective Pd-Catalyzed C(sp2)–H Activation
Davide Illuminati, C. Trapella, V. Zanirato, R. Guerrini +7 more
2023Pharmaceuticals1 citations Open access
Semantic Scholar
Heterologe Expression, Biosynthese und ökologische Funktion des selektiven Gq‐Signaltransduktionsinhibitors FR900359
M. Crüsemann, R. Reher, I. Schamari, Alexander O. Brachmann +21 more
20181 citations
Semantic Scholar
1,4-Dioxolane-triazaspirodecanone derivatives as nociceptin/orphanin FQ receptor ligands
Sandra Corrado, C. Sorbi, A. Tait, U. Battisti +4 more
2014Medicinal Chemistry Research1 citations Open access
Semantic Scholar

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