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M. Damschroder · SciRah

Researcher profile · Semantic Scholar

M. Damschroder

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M. Damschroder — researcher profile on SciRah

h-index: 26
Works: 50
Citations: 2,956

Most-cited papers

MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function.
R. Kolbeck, A. Kozhich, M. Koike, Li Peng +16 more
2010Journal of Allergy and Clinical Immunology591 citations
Semantic Scholar
Targeting CD73 in the tumor microenvironment with MEDI9447
Carl M. Hay, Erin Sult, Qi-Hui Huang, K. Mulgrew +14 more
2016Oncoimmunology260 citations Open access
Semantic Scholar
Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms
V. Oganesyan, M. Damschroder, Kimberly E. Cook, Qing Li +3 more
2014Journal of Biological Chemistry237 citations Open access
Semantic Scholar
Assessment of an Anti-Alpha-Toxin Monoclonal Antibody for Prevention and Treatment of Staphylococcus aureus-Induced Pneumonia
Lei Hua, J. Hilliard, Y. Shi, C. Tkaczyk +15 more
2013Antimicrobial Agents and Chemotherapy173 citations Open access
Semantic Scholar
B-Cell Depletion In Vitro and In Vivo with an Afucosylated Anti-CD19 Antibody
R. Herbst, Yue Wang, S. Gallagher, N. Mittereder +17 more
2010Journal of Pharmacology and Experimental Therapeutics144 citations
Semantic Scholar
Modulation of the Effector Functions of a Human IgG1 through Engineering of Its Hinge Region
W. Dall'acqua, Kimberly E. Cook, M. Damschroder, Robert M. Woods +1 more
2006Journal of Immunology143 citations Open access
Semantic Scholar
Molecular basis for antagonistic activity of anifrolumab, an anti-interferon–α receptor 1 antibody
Li Peng, V. Oganesyan, Herren Wu, W. Dall'acqua +1 more
2015mAbs121 citations Open access
Semantic Scholar
Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action
James C. Geoghegan, G. Diedrich, Xiaojun Lu, K. Rosenthal +4 more
2016mAbs105 citations Open access
Semantic Scholar
Structural characterization of a human Fc fragment engineered for extended serum half-life.
V. Oganesyan, M. Damschroder, Robert M. Woods, Kimberly E. Cook +2 more
2009Molecular Immunology88 citations
Semantic Scholar
Direct targeting of αvβ3 integrin on tumor cells with a monoclonal antibody, Abegrin™
K. Mulgrew, Krista Kinneer, Xiao-Tao Yao, B. K. Ward +8 more
2006Molecular Cancer Therapeutics88 citations Open access
Semantic Scholar
Structural characterization of a mutated, ADCC-enhanced human Fc fragment.
V. Oganesyan, M. Damschroder, W. Leach, Herren Wu +1 more
2008Molecular Immunology87 citations
Semantic Scholar
Antibody humanization by framework shuffling.
W. Dall'acqua, M. Damschroder, Jingli Zhang, Robert M. Woods +3 more
2005Methods73 citations
Semantic Scholar
Mechanisms of Neutralization of a Human Anti-α-toxin Antibody
V. Oganesyan, Li Peng, M. Damschroder, Li Cheng +5 more
2014Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody
V. Oganesyan, Li Peng, Jared S. Bee, John Y Li +11 more
2018Journal of Biological Chemistry58 citations Open access
Semantic Scholar
Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering
James C. Geoghegan, Ryan L. Fleming, M. Damschroder, Steven M. Bishop +2 more
2016mAbs58 citations Open access
Semantic Scholar
Developability Assessment of Engineered Monoclonal Antibody Variants with a Complex Self-Association Behavior Using Complementary Analytical and in Silico Tools.
Shan Lu, N. Mody, Pietro Sormani, K. Rosenthal +2 more
2018Molecular Pharmaceutics55 citations Open access
Semantic Scholar
MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo
D. Jenkins, Sarah J. Ross, Margaret H Veldman-Jones, I. Foltz +14 more
2012Molecular Cancer Therapeutics55 citations
Semantic Scholar
Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design
Daniel A. Cannon, Shan Lu, Qun Du, Lena Shirinian +8 more
2019PLoS Comput. Biol.54 citations Open access
Semantic Scholar
Direct targeting of alphavbeta3 integrin on tumor cells with a monoclonal antibody, Abegrin.
K. Mulgrew, Krista Kinneer, Xiao-Tao Yao, B. K. Ward +8 more
2006Molecular Cancer Therapeutics49 citations
Semantic Scholar
Antibody-dependent cell-mediated cytotoxicity effector-enhanced EphA2 agonist monoclonal antibody demonstrates potent activity against human tumors.
E. Bruckheimer, Christine Fazenbaker, S. Gallagher, K. Mulgrew +13 more
2009Neoplasia44 citations Open access
Semantic Scholar
Abstract 30: Medi3622, a monoclonal antibody to ADAM17, inhibits tumor growth by inhibiting EGFR- and non-EGFR-mediated pathways
Darrin Sabol, J. Rios-Doria, Jon Chesebrough, David Stewart +23 more
201541 citations
Semantic Scholar
Framework shuffling of antibodies to reduce immunogenicity and manipulate functional and biophysical properties.
M. Damschroder, Lusiana Widjaja, P. Gill, V. Krasnoperov +3 more
2007Molecular Immunology37 citations
Semantic Scholar
Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein
M. Oberst, C. Augé, Chad Morris, S. Kentner +18 more
2018Molecular Cancer Therapeutics36 citations Open access
Semantic Scholar
The CEA/CD3-Bispecific Antibody MEDI-565 (MT111) Binds a Nonlinear Epitope in the Full-Length but Not a Short Splice Variant of CEA
Li Peng, M. Oberst, Jiaqi Huang, Philip Z. Brohawn +9 more
2012PLoS ONE32 citations Open access
Semantic Scholar
Molecular basis for the mechanism of action of an anti-TACE antibody
Li Peng, Kimberly E. Cook, Linda Xu, Li Cheng +4 more
2016mAbs30 citations Open access
Semantic Scholar
Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody.
Li Peng, V. Oganesyan, M. Damschroder, Herren Wu +1 more
2011Journal of Molecular Biology26 citations
Semantic Scholar
Tissue-specific expression of messenger RNAs encoding endogenous viral superantigens.
C. Jarvis, R. Germain, G. Hager, M. Damschroder +1 more
1994Journal of Immunology25 citations
Semantic Scholar
Developability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies
A. Dippel, Austin Gallegos, V. Aleti, Arnita S. Barnes +28 more
2022mAbs21 citations Open access
Semantic Scholar
Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule electrostatic interactions
Qun Du, M. Damschroder, Timothy M. Pabst, Alan K. Hunter +2 more
2019mAbs21 citations Open access
Semantic Scholar
Molecular basis for the antagonistic activity of an anti-CXCR4 antibody
Li Peng, M. Damschroder, Kimberly E. Cook, Herren Wu +1 more
2015mAbs21 citations Open access
Semantic Scholar
Blocking endothelial lipase with monoclonal antibody MEDI5884 durably increases high density lipoprotein in nonhuman primates and in a phase 1 trial
John E. Le Lay, Qun Du, M. B. Mehta, N. Bhagroo +19 more
2021Science Translational Medicine20 citations
Semantic Scholar
Formation of transient highly-charged mAb clusters strengthens interactions with host cell proteins and results in poor clearance of host cell proteins by protein A chromatography.
Hai-Bin Luo, Qun Du, Chen Qian, Michelle Mlynarczyk +4 more
2022Journal of Chromatography A18 citations
Semantic Scholar
A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non–EGFR-Mediated Pathways
J. Rios-Doria, Darrin Sabol, Jon Chesebrough, David Stewart +17 more
2015Molecular Cancer Therapeutics17 citations Open access
Semantic Scholar
Generation and Characterization of an IgG4 Monomeric Fc Platform
Shan Lu, Magali Colazet, K. Rosenthal, Xiang-Qing Yu +7 more
2016PLoS ONE16 citations Open access
Semantic Scholar
Analysis of human and primate CD2 molecules by protein sequence and epitope mapping with anti-human CD2 antibodies.
M. Damschroder, A. Kozhich, Robert M. Woods, Li Cheng +9 more
2004Molecular Immunology13 citations
Semantic Scholar
Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy
R. Varkey, Qun Du, J. Karnell, Xiao-Dong Xiao +9 more
2019PLoS ONE9 citations Open access
Semantic Scholar
In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance
Shan Lu, N. van Dyk, N. Haskins, Kimberly M. Cook +9 more
2021Communications Biology8 citations Open access
Semantic Scholar
Crystallization and preliminary X-ray diffraction analysis of the complex of a human anti-ephrin type-A receptor 2 antibody fragment and its cognate antigen.
V. Oganesyan, M. Damschroder, Sandrina S. Phipps, Susan D. Wilson +3 more
2010Acta Crystallographica. Section F : Structural Biology and Crystallization Communications5 citations Open access
Semantic Scholar
Bi-Epitope SPR Surfaces: A Solution to Develop Robust Immunoassays
Li Peng, M. Damschroder, Herren Wu, W. Dall'acqua
2014PLoS ONE3 citations Open access
Semantic Scholar
Abstract 2584: The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope present in the full-length but not a short splice variant of CEA
Li Peng, M. Oberst, Jiaqi Huang, Philip Z. Brohawn +11 more
20103 citations
Semantic Scholar
Long-acting antibody ligand mimetics for HER4-selective agonism
Shan Lu, Kimberly M. Cook, N. Haskins, Bilal Omar +8 more
2020Scientific Reports2 citations Open access
Semantic Scholar
Structural Biology and Crystallization Communications Crystallization and Preliminary X-ray Diffraction Analysis of the Complex between a Human Anti-interferon Antibody Fragment and Human Interferon A-2a
V. Oganesyan, M. Damschroder, Kimberly E. Cook, Herren Wu +1 more
2 citations
Semantic Scholar
5-1-2018 Potent Immune Modulation by MEDI 6383 , an Engineered Human OX 40 Ligand IgG 4 P Fc Fusion Protein
M. Oberst, C. Augé, Chad Morris, S. Kentner +20 more
20191 citations
Semantic Scholar
Human OX40 ligand fusion protein (MEDI6383) as a potent OX40 agonist and immuno-modulator in vitro and in vivo.
S. Hammond, Chad Morris, C. Augé, Qun Du +10 more
20151 citations
Semantic Scholar
Abstract 5098: A mouse DLL4 cross-reactive variant of MEDI0639 disrupts functional vessel formation and inhibits tumor growth in preclinical models.
S. Cho, D. Jenkins, P. Strout, Martin Korade +16 more
20131 citations
Semantic Scholar
Abstract B233: c‐Met antagonist Avimer™ polypeptide that exhibits potent in vivo and in vitro inhibitor activity
Cho Song, Richard Smith, Amy N. Duguay, Peng Li +17 more
20091 citations
Semantic Scholar
Formation of Transient Highly-Charged Mab Clusters Strengthens Interactions with Host Cell Proteins (Hcps) and Results in Poor Hcp Removal by Protein a Chromatography
Hai-Bin Luo, Qun Du, Chen Qian, Michelle Mlynarczyk +4 more
2022Social Science Research Network0 citations Open access
Semantic Scholar
Correction: Upregulation of annexin A1 protein expression in the intratumoral vasculature of human non–small-cell lung carcinoma and rodent tumor models
Kevin L. Allen, J. Cann, Weiguang Zhao, Norman Peterson +8 more
2021PLoS ONE0 citations Open access
Semantic Scholar
Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-interferon antibody fragment and human interferon a-2 A
V. Oganesyan, M. Damschroder, Kimberly E. Cook, Herren Wu +1 more
20080 citations
Semantic Scholar
Humanized anti-CD19 antibodies and their use in the treatment of tumors, autoimmune diseases and transplantation
A. Coyle, W. Dall'acqua, M. Damschroder, R. Herbst +2 more
20070 citations
Semantic Scholar

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