Xiang-Qing Yu

Most-cited papers

1. A multifunctional bispecific antibody protects against Pseudomonas aeruginosa

   A. DiGiandomenico, A. Keller, Cuihua Gao, G. Rainey +15 more

   2014Science Translational Medicine264 citations

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2. Improving target cell specificity using a novel monovalent bispecific IgG design

   Y. Mazor, V. Oganesyan, Chun-Ning Yang, Anna Hansen +10 more

   2015mAbs141 citations Open access

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3. Safety, Tolerability, and Pharmacokinetics of MEDI4893, an Investigational, Extended-Half-Life, Anti-Staphylococcus aureus Alpha-Toxin Human Monoclonal Antibody, in Healthy Adults

   Xiang-Qing Yu, G. Robbie, Yu-Ling Wu, Mark T. Esser +5 more

   2016Antimicrobial Agents and Chemotherapy129 citations Open access

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4. pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling

   M. Jack Borrok, Yan-Li Wu, Nurten Beyaz, Xiang-Qing Yu +3 more

   2014Journal of Biological Chemistry97 citations Open access

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5. Phase I Dose-Escalation Study of MEDI-573, a Bispecific, Antiligand Monoclonal Antibody against IGFI and IGFII, in Patients with Advanced Solid Tumors

   P. Haluska, M. Menefee, E. Plimack, J. Rosenberg +9 more

   2014Clinical Cancer Research56 citations Open access

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6. Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics.

   Pamela Thompson, Ryan L. Fleming, Binyam Z Bezabeh, Feng-Ying Huang +17 more

   2016Journal of Controlled Release50 citations

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7. Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections

   V. Le, C. Tkaczyk, Sally Chau, Renee L. Rao +15 more

   2016Antimicrobial Agents and Chemotherapy41 citations Open access

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8. Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates

   M. Hinrichs, P. Ryan, B. Zheng, Shameen Afif-Rider +17 more

   2017Clinical Cancer Research34 citations Open access

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9. Three monthly doses of palivizumab are not adequate for 5-month protection: a population pharmacokinetic analysis.

   W. L. La Via, G. Notario, Xiang-Qing Yu, Shringi Sharma +2 more

   2013Pulmonary Pharmacology & Therapeutics30 citations Open access

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10. Characterisation of anti‐alpha toxin antibody levels and colonisation status after administration of an investigational human monoclonal antibody, MEDI4893, against Staphylococcus aureus alpha toxin

    A. Ruzin, Yu-Ling Wu, Li Yu, Xiang-Qing Yu +8 more

    2018Clinical & Translational Immunology27 citations Open access

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11. Sirolimus Oral Absorption in Rats Is Increased by Ketoconazole but Is Not Affected by d-α-Tocopheryl Poly(Ethylene Glycol 1000) Succinate

    V. Wacher, J. Silverman, Susan D. Wong, Paulina Tran-Tau +5 more

    2002Journal of Pharmacology and Experimental Therapeutics24 citations Open access

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12. Enhancement of antibody functions through Fc multiplications

    Qun Wang, Yan Chen, M. Pelletier, R. Cvitkovic +10 more

    2017mAbs18 citations Open access

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13. Insertion of scFv into the hinge domain of full-length IgG1 monoclonal antibody results in tetravalent bispecific molecule with robust properties

    Binyam Z Bezabeh, Ryan L. Fleming, Christine Fazenbaker, H. Zhong +9 more

    2017mAbs17 citations Open access

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14. Generation and Characterization of an IgG4 Monomeric Fc Platform

    Shan Lu, Magali Colazet, K. Rosenthal, Xiang-Qing Yu +7 more

    2016PLoS ONE16 citations Open access

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15. Abstract 2970: MEDI4276, a HER2-targeting antibody tubulysin conjugate, displays potent invitroandin vivoactivity in preclinical studies

    John Y Li, D. Toader, S. R. Perry, Vanessa M. Muniz-Medina +14 more

    20169 citations

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16. pH-dependent FcRn binding and IgG clearance 1 pH-Dependent Binding Engineering Reveals An FcRn Affinity Threshold Which Governs IgG Recycling

    M. Borrok, Yan-Li Wu, Nurten Beyaz, Xiang-Qing Yu +3 more

    20143 citations

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17. A Phase 1 study to evaluate the safety, pharmacokinetics, immunogenicity, and antitumor activity of MEDI4276 in patients with select HER2-expressing advanced solid tumors.

    E. Hamilton, M. Patel, M. Pegram, A. Tan +4 more

    20162 citations

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18. Safety, pharmacokinetics, and antitumor activity of MEDI-573, an investigational monoclonal antibody that targets IGF-I and IGF-II, in adult patients with advanced solid tumors.

    P. Haluska, M. Menefee, E. Plimack, Jonathan E. Rosenberg +6 more

    20122 citations

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19. Abstract 948: A novel antibody-drug conjugate that induces long-term tumor regression and anticancer stem cell activity

    Jay Harper, Chris Lloyd, Shen-Lan Mao, Xinrui Lin +25 more

    20151 citations

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20. Corrigendum

    Y. Mazor, V. Oganesyan, Chun-Ning Yang, Anna Hansen +10 more

    2016mAbs0 citations Open access

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21. 6-262ra155 SM

    A. DiGiandomenico, A. Keller, Cuihua Gao, G. Rainey +15 more

    20140 citations

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22. 609 A Phase 1 Study of MEDI-573, an Investigational Monoclonal Antibody That Targets IGF-I and IGF-II: Safety, Pharmacokinetics, and Antitumor Activity in Adults with Advanced Solid Tumors

    P. Haluska, M. Menefee, E. Plimack, J. Rosenberg +6 more

    20120 citations

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