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Raffaella Sordella · SciRah

Researcher profile · Semantic Scholar

Raffaella Sordella

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Raffaella Sordella — researcher profile on SciRah

h-index: 29
Works: 65
Citations: 9,370

Most-cited papers

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
T. J. Lynch, D. Bell, Raffaella Sordella, S. Gurubhagavatula +10 more
2004New England Journal of Medicine1,790 citations
Semantic Scholar
Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways
Raffaella Sordella, D. Bell, D. Haber, J. Settleman
2004Science1,663 citations
Semantic Scholar
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib.
E. Kwak, Raffaella Sordella, D. Bell, N. Godin-Heymann +13 more
2005Proceedings of the National Academy of Sciences of the United States of America977 citations Open access
Semantic Scholar
Protein interaction mapping in C. elegans using proteins involved in vulval development.
A. Walhout, Raffaella Sordella, Xiao-Wei Lu, J. Hartley +4 more
2000Science807 citations
Semantic Scholar
Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752
G. Smolen, Raffaella Sordella, Beth Muir, G. Mohapatra +9 more
2006Proceedings of the National Academy of Sciences of the United States of America540 citations
Semantic Scholar
Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR
D. Bell, I. Gore, R. Okimoto, N. Godin-Heymann +7 more
2005Nature Genetics516 citations
Semantic Scholar
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling
U. McDermott, Sreenath V. Sharma, L. Dowell, P. Greninger +21 more
2007Proceedings of the National Academy of Sciences of the United States of America354 citations Open access
Semantic Scholar
TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
Z. Yao, Silvia Fenoglio, Ding-Cheng Gao, M. Camiolo +8 more
2010Proceedings of the National Academy of Sciences of the United States of America344 citations Open access
Semantic Scholar
Resource A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference
P. Premsrirut, Lukas E. Dow, S. Y. Kim, M. Camiolo +10 more
2011275 citations
Semantic Scholar
DOCK4, a GTPase activator, is disrupted during tumorigenesis.
V. Yajnik, Charles Paulding, Raffaella Sordella, A. McClatchey +8 more
2003Cell244 citations Open access
Semantic Scholar
DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.
W. Xue, A. Krasnitz, R. Lucito, Raffaella Sordella +8 more
2008Genes & Development200 citations Open access
Semantic Scholar
Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib.
Roseann Mulloy, Audrey Ferrand, Youngjo Kim, Raffaella Sordella +4 more
2007Cancer Research197 citations Open access
Semantic Scholar
Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization
S. Senturk, Nitin H. Shirole, D. Nowak, V. Corbo +6 more
2017Nature Communications156 citations Open access
Semantic Scholar
Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development.
Raffaella Sordella, M. Classon, Kang-Quan Hu, S. F. Matheson +6 more
2002Developmental Cell136 citations Open access
Semantic Scholar
SHP-2 Positively Regulates Myogenesis by Coupling to the Rho GTPase Signaling Pathway
Maria I. Kontaridis, Seda Eminaga, M. Fornaro, C. Zito +3 more
2004Molecular and Cellular Biology109 citations Open access
Semantic Scholar
Molecular targeted therapy of lung cancer: EGFR mutations and response to EGFR inhibitors.
D. Haber, D. Bell, Raffaella Sordella, E. Kwak +4 more
2005Cold Spring Harbor Symposia on Quantitative Biology108 citations Open access
Semantic Scholar
p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling
Davide Barberis, Andrea Casazza, Raffaella Sordella, S. Corso +4 more
2005Journal of Cell Science103 citations Open access
Semantic Scholar
Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor
Virendra K. Chaudhri, Gregory G. Salzler, Salihah Dick, Melanie S. Buckman +7 more
2013Molecular Cancer Research91 citations Open access
Semantic Scholar
p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state
S. Senturk, Z. Yao, M. Camiolo, B. Stiles +10 more
2014Proceedings of the National Academy of Sciences of the United States of America90 citations Open access
Semantic Scholar
Increased Prevalence of EGFR-Mutant Lung Cancer in Women and in East Asian Populations: Analysis of Estrogen-Related Polymorphisms
D. Bell, Brian W. Brannigan, K. Matsuo, D. Finkelstein +4 more
2008Clinical Cancer Research90 citations Open access
Semantic Scholar
Myc drives Pten/p53-deficient proliferation and metastasis due to Il6-secretion and Akt-suppression via Phlpp2
D. Nowak, Hyejin Cho, Tali Herzka, Kaitlin Watrud +14 more
2015Cancer Discovery81 citations Open access
Semantic Scholar
TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
Nitin H. Shirole, Debjani Pal, E. Kastenhuber, S. Senturk +8 more
2016eLife76 citations Open access
Semantic Scholar
Towards patient-based cancer therapeutics
S. Schreiber, Alykhan F. Shamji, P. Clemons, Cindy S. Hon +35 more
2010Nature Biotechnology67 citations Open access
Semantic Scholar
An FF domain-dependent protein interaction mediates a signaling pathway for growth factor-induced gene expression.
Wei Jiang, Raffaella Sordella, Guang-Chao Chen, S. Hakre +2 more
2005Molecules and Cells60 citations Open access
Semantic Scholar
TAp73 is essential for germ cell adhesion and maturation in testis
L. Holembowski, D. Kramer, D. Riedel, Raffaella Sordella +3 more
2014Journal of Cell Biology53 citations Open access
Semantic Scholar
The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein
Muhan Chen, D. Nowak, N. Narula, B. Robinson +22 more
2017Journal of Cell Biology43 citations Open access
Semantic Scholar
TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells
Debjani Pal, A. Pertot, Nitin H. Shirole, Zhan Yao +13 more
2017eLife41 citations Open access
Semantic Scholar
The Evolution of TP53 Mutations: From Loss-of-Function to Separation-of-Function Mutants
Madison A. Miller, Nitin H. Shirole, Ruxiao Tian, Debjani Pal +1 more
2016Journal of cancer biology & research36 citations
Semantic Scholar
A rapid and scalable system for studying gene function in mice using conditional RNA interference
P. Premsrirut, Lukas E. Dow, S. Y. Kim, M. Camiolo +10 more
2011Cell35 citations Open access
Semantic Scholar
Distinct but Overlapping Functions for the Closely Related p190 RhoGAPs in Neural Development
S. F. Matheson, Kang-Quan Hu, M. Brouns, Raffaella Sordella +2 more
2006Developmental Neuroscience26 citations
Semantic Scholar
Driving actin dynamics under the influence of alcohol.
Raffaella Sordella, L. Van Aelst
2006Cell16 citations Open access
Semantic Scholar
An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression
Polona Safaric-Tepes, Debjani Pal, Trine Lindsted, I. Ibarra +13 more
2021bioRxiv14 citations Open access
Semantic Scholar
Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance
D. Gerhard, P. Clemons, Alykhan F. Shamji, Cindy S. Hon +65 more
2016Molecular Cancer Research12 citations Open access
Semantic Scholar
Dialogue between RhoA/ROCK and members of the Par complex in cell polarity.
Raffaella Sordella, L. Van Aelst
2008Developmental Cell12 citations Open access
Semantic Scholar
Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma
Polona Safaric-Tepes, Danilo Segovia, Sania Jevtic, Daniel C. Ramirez +2 more
2021Laboratory Investigation7 citations Open access
Semantic Scholar
Effectors and potential targets selectively upregulated in human KRAS-mutant lung adenocarcinomas
Jinyu Li, Raffaella Sordella, S. Powers
2016Scientific Reports7 citations Open access
Semantic Scholar
Correction: TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
Nitin H. Shirole, Debjani Pal, E. Kastenhuber, S. Senturk +8 more
2017eLife5 citations Open access
Semantic Scholar
A rapid and tunable method to temporally control Cas9 expression enables the identification of essential genes and the interrogation of functional gene interactions in vitro and in vivo
S. Senturk, Nitin H. Shirole, Dawid Nowak, V. Corbo +6 more
2015bioRxiv4 citations Open access
Semantic Scholar
Modulation of CREB activity by the Rho GTPase determines cell size during embryonic development
Raffaella Sordella, M. Classon, Kang-Quan Hu, S. F. Matheson +4 more
20013 citations
Semantic Scholar
Erratum
Raffaella Sordella, Wei Jiang, Guang-Chao Chen, M. Curto +1 more
2003Cell2 citations Open access
Semantic Scholar
Author response: TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells
Debjani Pal, A. Pertot, Nitin H. Shirole, Z. Yao +13 more
20161 citations Open access
Semantic Scholar
A Novel Platform for Proteomic Analysis of Proximal Source Pulmonary Venous Blood Identifies Potential Biomarkers for Non-Small Cell Lung Cancer (NSCLC)
Christopher J. Agrusa, Raffaella Sordella, S. Paul, P. Lee +3 more
20141 citations
Semantic Scholar
A method for determining the responsiveness of a tumor to treatments with the epidermal growth factor receptor as a target
D. Haber, P. Janne, B. Johnson, T. Lynch +6 more
20051 citations
Semantic Scholar
A fluidized bed moisture-based direct air capture system for carbon capture and utilization applications
Z. Lopez-Reyes, Wesley Hopwood, R. Canevesi, J. Jones +3 more
2026Chemical Engineering Journal0 citations Open access
Semantic Scholar
Unveiling the developmental and tumor-suppressive roles of the p53 variant p53psi
Chiara Gorrini, S. Jafari, G. Duncan, Bryan E. Snow +15 more
2026Proceedings of the National Academy of Sciences of the United States of America0 citations Open access
Semantic Scholar
Decarbonizing desert greenhouse crop production with direct air capture–based CO2 enrichment
Z. Lopez-Reyes, W. Hopwood, J. Jones, Rod A. Wing +3 more
2026npj Sustainable Agriculture0 citations Open access
Semantic Scholar
Correction for Smolen et al., Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752
A. Smolen, Raffaella Sordella, Beth Muir, Gayatry Mohapatra +9 more
2024Proceedings of the National Academy of Sciences of the United States of America0 citations Open access
Semantic Scholar
A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization.
Polona Safaric-Tepes, Raffaella Sordella
2021Journal of Visualized Experiments0 citations
Semantic Scholar
Author response: An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression
Polona Safaric-Tepes, Debjani Pal, Trine Lindsted, I. Ibarra +13 more
20210 citations Open access
Semantic Scholar
Myc drives Pten / p 53-deficient proliferation and metastasis due to Il 6-secretion and Akt-suppression via Phlpp 2 RUNNING TITLE : Il 6 drives Myc in Pten-mutant prostate metastasis
D. Nowak, Hyejin Cho, Tali Herzka, Kaitlin Watrud +14 more
20150 citations
Semantic Scholar

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