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Kang-Quan Hu · SciRah

Researcher profile · Semantic Scholar

Kang-Quan Hu

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Kang-Quan Hu — researcher profile on SciRah

h-index: 26
Works: 54
Citations: 2,517

Most-cited papers

Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation
R. Foster, Kang-Quan Hu, Yu Lu, K. Nolan +2 more
1996Molecular and Cellular Biology295 citations Open access
Semantic Scholar
The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development.
M. Brouns, S. F. Matheson, Kang-Quan Hu, I. Delalle +4 more
2000Development230 citations
Semantic Scholar
Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes.
K. Nolan, K. Barrett, Yu Lu, Kang-Quan Hu +2 more
1998Genes & Development221 citations Open access
Semantic Scholar
The Biochemical Characterization of Ferret Carotene-9′, 10′-Monooxygenase Catalyzing Cleavage of Carotenoids in Vitro and in Vivo*
Kang-Quan Hu, Chun Liu, H. Ernst, N. Krinsky +2 more
2006Journal of Biological Chemistry209 citations Open access
Semantic Scholar
Tandem SH2 binding sites mediate the RasGAP–RhoGAP interaction: a conformational mechanism for SH3 domain regulation
Kang-Quan Hu, J. Settleman
1997EMBO Journal151 citations Open access
Semantic Scholar
Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development.
Raffaella Sordella, M. Classon, Kang-Quan Hu, S. F. Matheson +6 more
2002Developmental Cell136 citations Open access
Semantic Scholar
Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect.
I. Hariharan, Kang-Quan Hu, H. Asha, Adrian Quintanilla +2 more
1995EMBO Journal119 citations
Semantic Scholar
Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice
Blanche C. Ip, Kang-Quan Hu, Chun Liu, Donald E. Smith +3 more
2013Cancer Prevention Research88 citations Open access
Semantic Scholar
Tobacco carcinogen (NNK) induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation
K. Aizawa, Chun Liu, Sanyuan Tang, Sudipta Veeramachaneni +3 more
2016International Journal of Cancer86 citations Open access
Semantic Scholar
Apo-10'-lycopenoic acid, a lycopene metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice.
Jayong Chung, K. Koo, F. Lian, Kang-Quan Hu +2 more
2012Journal of NutriLife82 citations Open access
Semantic Scholar
Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice
Cheng-Chung Li, Chun Liu, Maobin Fu, Kang-Quan Hu +6 more
2018Molecular Nutrition & Food Research72 citations Open access
Semantic Scholar
β‐Cryptoxanthin suppresses the growth of immortalized human bronchial epithelial cells and non‐small‐cell lung cancer cells and up‐regulates retinoic acid receptor β expression
F. Lian, Kang-Quan Hu, Robert M. Russell, Xiang-Dong Wang
200665 citations Open access
Semantic Scholar
β-Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J Mice
A. Iskandar, Chun Liu, Donald E. Smith, Kang-Quan Hu +3 more
2012Cancer Prevention Research60 citations Open access
Semantic Scholar
p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly
R. Foster, Kang-Quan Hu, D. Shaywitz, Jeffrey Settleman
1994Molecular and Cellular Biology55 citations Open access
Semantic Scholar
Endothelin stimulates a sustained 1,2-diacylglycerol increase and protein kinase C activation in bovine aortic smooth muscle cells.
Tian-Shing Lee, T. Chao, Kang-Quan Hu, George L. King
1989Biochemical and Biophysical Research Communications - BBRC55 citations
Semantic Scholar
Dietary Tomato Powder Inhibits High-Fat Diet–Promoted Hepatocellular Carcinoma with Alteration of Gut Microbiota in Mice Lacking Carotenoid Cleavage Enzymes
Hui Xia, Chun Liu, Cheng-Chung Li, Maobin Fu +7 more
2018Cancer Prevention Research53 citations
Semantic Scholar
Isocaloric Pair-Fed High-Carbohydrate Diet Induced More Hepatic Steatosis and Inflammation than High-Fat Diet Mediated by miR-34a/SIRT1 Axis in Mice
Xinli Li, F. Lian, Chun Liu, Kang-Quan Hu +1 more
2015Scientific Reports52 citations Open access
Semantic Scholar
β-Carotene and β-Apo-14′-Carotenoic Acid Prevent the Reduction of Retinoic Acid Receptor β in Benzo[a]pyrene-Treated Normal Human Bronchial Epithelial Cells
P. Prakash, Chun Liu, Kang-Quan Hu, N. Krinsky +2 more
200446 citations Open access
Semantic Scholar
Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver‐mesenteric adipose tissue fatty acid mobilization
Junrui Cheng, Chun Liu, Kang-Quan Hu, A. Greenberg +4 more
2017Biochimica et Biophysica Acta - Molecular Basis of Disease42 citations Open access
Semantic Scholar
β-Cryptoxanthin reduced lung tumor multiplicity and inhibited lung cancer cell motility by down-regulating nicotinic acetylcholine receptor α7 signaling
A. Iskandar, Benchun Miao, Xinli Li, Kang-Quan Hu +2 more
2016Cancer Prevention Research42 citations Open access
Semantic Scholar
Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway.
Ji-Ye Lim, Chun Liu, Kang-Quan Hu, Donald E. Smith +1 more
2018Archives of Biochemistry and Biophysics34 citations Open access
Semantic Scholar
Characterization of Endothelin Receptors and Effects of Endothelin on Diacylglycerol and Protein Kinase C in Retinal Capillary Pericytes
Tian-Shing Lee, Kang-Quan Hu, T. Chao, G. King
1989Diabetes33 citations Open access
Semantic Scholar
Apo-10'-lycopenoic acid inhibits cancer cell migration and angiogenesis and induces peroxisome proliferator-activated receptor γ.
Junrui Cheng, Benchun Miao, Kang-Quan Hu, Xueyan Fu +1 more
2018Journal of Nutritional Biochemistry32 citations
Semantic Scholar
Beta-cryptoxanthin suppresses the growth of immortalized human bronchial epithelial cells and non-small-cell lung cancer cells and up-regulates retinoic acid receptor beta expression.
F. Lian, Kang-Quan Hu, R. Russell, Xiang-Dong Wang
2006International Journal of Cancer30 citations
Semantic Scholar
A Functional Screen in Human Cells Identifies UBF2 as an RNA Polymerase II Transcription Factor That Enhances the β-Catenin Signaling Pathway
D. Grueneberg, L. Pablo, Kang-Quan Hu, P. August +2 more
2003Molecular and Cellular Biology30 citations Open access
Semantic Scholar
Modulation of the insulin growth factor II/mannose 6-phosphate receptor in microvascular endothelial cells by phorbol ester via protein kinase C.
Kang-Quan Hu, Jonathan M. Backer, G. Sahagian, E. Feener +1 more
1990Journal of Biological Chemistry30 citations Open access
Semantic Scholar
Distinct but Overlapping Functions for the Closely Related p190 RhoGAPs in Neural Development
S. F. Matheson, Kang-Quan Hu, M. Brouns, Raffaella Sordella +2 more
2006Developmental Neuroscience26 citations
Semantic Scholar
Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice
Xinli Li, Chun Liu, Blanche C. Ip, Kang-Quan Hu +3 more
2015Journal of experimental & clinical cancer research : CR24 citations Open access
Semantic Scholar
Development of ferret as a human lung cancer model by injecting 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
K. Aizawa, Chun Liu, Sudipta Veeramachaneni, Kang-Quan Hu +2 more
2013Lung Cancer23 citations Open access
Semantic Scholar
Characterization of phorbol ester-stimulated serine phosphorylation of the human insulin receptor.
E. Feener, T. Shiba, Kang-Quan Hu, P. Wilden +2 more
1994Biochemical Journal18 citations Open access
Semantic Scholar
Dietary β-Cryptoxanthin Inhibits High-Refined Carbohydrate Diet-Induced Fatty Liver via Differential Protective Mechanisms Depending on Carotenoid Cleavage Enzymes in Male Mice.
Ji-Ye Lim, Chun Liu, Kang-Quan Hu, Donald E. Smith +4 more
2019Journal of NutriLife17 citations Open access
Semantic Scholar
Beta-carotene and beta-apo-14'-carotenoic acid prevent the reduction of retinoic acid receptor beta in benzo[a]pyrene-treated normal human bronchial epithelial cells.
P. Prakash, Chun Liu, Kang-Quan Hu, N. Krinsky +2 more
2004Journal of NutriLife16 citations
Semantic Scholar
Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype
Chisaka Kuehnemann, Kang-Quan Hu, Kayla Butera, S. Patel +4 more
2022Frontiers in Endocrinology13 citations Open access
Semantic Scholar
Xanthophyll β-Cryptoxanthin Inhibits High-Refined Carbohydrate Diet-Promoted Hepatocellular Carcinoma Progression in Mice.
Ji-Ye Lim, Chun Liu, Kang-Quan Hu, Donald E. Smith +4 more
2019Molecular Nutrition & Food Research13 citations Open access
Semantic Scholar
Abstract A37: Beta-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice
A. Iskandar, Chun Liu, Donald E. Smith, Kang-Quan Hu +3 more
2012Cancer Prevention Research9 citations
Semantic Scholar
β-Cryptoxanthin Attenuates Cigarette-Smoke-Induced Lung Lesions in the Absence of Carotenoid Cleavage Enzymes (BCO1/BCO2) in Mice
R. Chiaverelli, Kang-Quan Hu, Chun Liu, Ji-Ye Lim +5 more
2023Molecules4 citations Open access
Semantic Scholar
Modulation of CREB activity by the Rho GTPase determines cell size during embryonic development
Raffaella Sordella, M. Classon, Kang-Quan Hu, S. F. Matheson +4 more
20013 citations
Semantic Scholar
Sexually Dimorphic Responses to a High-Refined Carbohydrate Diet in a Nonalcoholic Fatty Liver Disease Mouse Model
M. Daniels, Chun Liu, Kang-Quan Hu, Xiang-Dong Wang
2020Current Developments in Nutrition1 citations Open access
Semantic Scholar
Ablation of Sirtuin 1 Deacetylase Activity Induces Pulmonary Emphysema by Inducing Cellular Senescence and Disrupting Circadian Clock in Mice (P01-022-19).
Xiang-Dong Wang, Kang-Quan Hu, Chun Liu, M. McBurney
2019Current Developments in Nutrition1 citations Open access
Semantic Scholar
β-Cryptoxanthin Prevents Non-alcoholic Fatty Liver Disease Through Different Mechanisms Depending on the Presence or Absence of Carotenoid Cleavage Enzymes (FS06-03-192).
Ji-Ye Lim, Chun Liu, Kang-Quan Hu, Donald E. Smith +4 more
2019Current Developments in Nutrition0 citations Open access
Semantic Scholar
β‐cryptoxanthin protection against cigarette smoke‐induced inflammatory responses in the lung is due to the action of its own molecule
Rachel A. Chiaverelli, Chun Liu, Kang-Quan Hu, Xiang-Dong Wang
2017The FASEB Journal0 citations Open access
Semantic Scholar
Dietary Tomato Powder Inhibits Hepatic Steatosis, Inflammation and Tumorigenesis in Beta‐carotene‐15, 15′‐oxygenase (BCO1) and Beta‐carotene‐9, 10′‐oxygenase (BCO2) Double Knockout Mice
Cheng-Chung Li, Chun Liu, Kang-Quan Hu, Donald E. Smith +2 more
20160 citations
Semantic Scholar
β‐Cryptoxanthin and Its Cleavage Metabolite, 3‐OH‐β‐Apo‐10′‐Carotenal, can Inhibit LPS‐induced Inflammatory Responses in Human Bronchial Epithelial Cells
Kang-Quan Hu, Jonathan R. Mein, Xiang-Dong Wang
20150 citations
Semantic Scholar
Tumor Progression Locus 2 Depletion Inhibits Hepatic Inflammation and Steatosis and Incidence of Hepatocellular Carcinoma
Xinli Li, Chun Liu, C. Stice, Blanche C. Ip +3 more
20150 citations
Semantic Scholar
High‐Carbohydrate Liquid Diet Induced Greater Severity in Hepatic Steatosis and Inflammatory Responses than High‐Fat Liquid Diet in Mice
Xinli Li, F. Lian, Chun Liu, Kang-Quan Hu +1 more
20150 citations
Semantic Scholar
Lycopene metabolite, apo‐10′‐lycopenoic acid, inhibits diet‐induced obesity‐promoted liver carcinogenesis via the up‐regulation of SIRT1 signaling and the decrease in liver inflammation.
Blanche C. Ip, Kang-Quan Hu, Chun Liu, Donald E. Smith +2 more
20130 citations
Semantic Scholar
Potential Biological Activities of the Xanthophyll Excentric Cleavage Product 3‐OH‐β‐apo‐10’‐carotenal in vitro
Jonathan R. Mein, Kang-Quan Hu, Xiang-Dong Wang
20110 citations
Semantic Scholar
Abstract 964: Chlormethiazole, an inhibitor of CYP2E1, prevented chemical carcinogen-initiated and alcohol-promoted hepatic carcinongenesis in rats.
Qin-Yuan Ye, P. R. Chavez, F. Lian, Yan Wang +4 more
20100 citations
Semantic Scholar
Abstract 2099: Apo-10’-lycopenoic acid functions as a peroxisome proliferator-activated receptor gamma activator and inhibits cell growth both in vitro and in vivo ob/ob mice treated with diethylnitrosamine
Kang-Quan Hu, Yan Wang, Donald E. Smith, R. Russell +1 more
20080 citations
Semantic Scholar
The biochemical characterization of ferret carotene‐9′,10′‐monooxygenase catalyzing cleavage of carotenoids in vitro
Kang-Quan Hu, Xiang-Dong Wang
20060 citations
Semantic Scholar

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