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S. Lougheed · SciRah

Researcher profile · Semantic Scholar

S. Lougheed

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S. Lougheed — researcher profile on SciRah

h-index: 24
Works: 59
Citations: 2,156

Most-cited papers

Prostanoids Play a Major Role in the Primary Tumor-Induced Inhibition of Dendritic Cell Differentiation
C. Sombroek, A. Stam, A. Masterson, S. Lougheed +6 more
2002Journal of Immunology238 citations Open access
Semantic Scholar
MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+ precursors.
A. Masterson, C. Sombroek, T. D. de Gruijl, Y. Graus +5 more
2002Blood187 citations
Semantic Scholar
Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression
S. Baglio, T. Lagerweij, Maria Pérez-Lanzón, Xuan D. Ho +22 more
2017Clinical Cancer Research166 citations Open access
Semantic Scholar
Sensing of latent EBV infection through exosomal transfer of 5′pppRNA
S. R. Baglio, M. van Eijndhoven, Danijela Koppers-Lalic, J. Berenguer +20 more
2016Proceedings of the National Academy of Sciences of the United States of America153 citations Open access
Semantic Scholar
Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation.
R. van de Ven, M. V. D. van den Hout, J. Lindenberg, B. J. Sluijter +6 more
2011Blood105 citations Open access
Semantic Scholar
Myeloid derived suppressor and dendritic cell subsets are related to clinical outcome in prostate cancer patients treated with prostate GVAX and ipilimumab
S. Santegoets, A. Stam, S. Lougheed, H. Gall +8 more
2014Journal of Immunotherapy for Cancer100 citations Open access
Semantic Scholar
A Postmigrational Switch among Skin-Derived Dendritic Cells to a Macrophage-Like Phenotype Is Predetermined by the Intracutaneous Cytokine Balance1
T. D. de Gruijl, C. Sombroek, S. Lougheed, D. Oosterhoff +4 more
2006Journal of Immunology92 citations Open access
Semantic Scholar
A CD34+ human cell line model of myeloid dendritic cell differentiation: evidence for a CD14+CD11b+ Langerhans cell precursor
S. Santegoets, A. Masterson, P. C. van der Sluis, S. Lougheed +5 more
2006Journal of Leukocyte Biology91 citations Open access
Semantic Scholar
T cell profiling reveals high CD4+CTLA-4+ T cell frequency as dominant predictor for survival after Prostate GVAX/ipilimumab treatment
S. Santegoets, A. Stam, S. Lougheed, H. Gall +12 more
2013Cancer Immunology and Immunotherapy89 citations
Semantic Scholar
Prolonged Maturation and Enhanced Transduction of Dendritic Cells Migrated from Human Skin Explants After In Situ Delivery of CD40-Targeted Adenoviral Vectors1
T. D. de Gruijl, S. A. Luykx-de Bakker, Bryan W. Tillman, A. V. D. van den Eertwegh +9 more
2002Journal of Immunology83 citations Open access
Semantic Scholar
A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells
R. D. de Bruin, J. Veluchamy, S. Lougheed, F. Schneiders +13 more
2018Oncoimmunology79 citations Open access
Semantic Scholar
Human telomerase reverse transcriptase Æ MoDC : Monocyte-derived dendritic cell Æ D NGFR : Truncated form of nerve growth factor receptor Æ PBMC : Peripheral blood mononuclear cell
S. Santegoets, M. Schreurs, A. Masterson, Ying-Poi Liu +8 more
200670 citations
Semantic Scholar
Tumor-mediated inhibition of human dendritic cell differentiation and function is consistently counteracted by combined p38 MAPK and STAT3 inhibition
D. Oosterhoff, S. Lougheed, R. van de Ven, J. Lindenberg +7 more
2012Oncoimmunology66 citations Open access
Semantic Scholar
CD40-targeted adenoviral gene transfer to dendritic cells through the use of a novel bispecific single-chain Fv antibody enhances cytotoxic T cell activation.
Joana G. Brandao, R. Scheper, S. Lougheed, D. Curiel +6 more
2003Vaccine58 citations
Semantic Scholar
TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients
Gijs G. Zom, M. Welters, N. Loof, R. Goedemans +10 more
2016OncoTarget54 citations Open access
Semantic Scholar
Local delivery of low-dose anti–CTLA-4 to the melanoma lymphatic basin leads to systemic Treg reduction and effector T cell activation
K. V. van Pul, J. Notohardjo, M. Fransen, Bas D. Koster +10 more
2022Science immunology53 citations
Semantic Scholar
Intradermal Delivery of TLR Agonists in a Human Explant Skin Model: Preferential Activation of Migratory Dendritic Cells by Polyribosinic-Polyribocytidylic Acid and Peptidoglycans
D. Oosterhoff, M. Heusinkveld, S. Lougheed, I. Kosten +6 more
2013Journal of Immunology44 citations Open access
Semantic Scholar
Functional characterization of a STAT3-dependent dendritic cell-derived CD14+ cell population arising upon IL-10-driven maturation
J. Lindenberg, R. van de Ven, S. Lougheed, A. Zomer +8 more
2013Oncoimmunology41 citations Open access
Semantic Scholar
IL-10 Conditioning of Human Skin Affects the Distribution of Migratory Dendritic Cell Subsets and Functional T Cell Differentiation
J. Lindenberg, D. Oosterhoff, C. Sombroek, S. Lougheed +11 more
2013PLoS ONE39 citations Open access
Semantic Scholar
S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteine.
J. Sipkens, Nynke E. Hahn, H. Blom, S. Lougheed +5 more
2012Atherosclerosis39 citations
Semantic Scholar
Intradermal Delivery of Adenoviral Type-35 Vectors Leads to High Efficiency Transduction of Mature, CD8+ T Cell-Stimulating Skin-Emigrated Dendritic Cells
T. D. de Gruijl, O. Ophorst, J. Goudsmit, S. Verhaagh +4 more
2006Journal of Immunology37 citations Open access
Semantic Scholar
The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial
C. M. Huijts, S. Lougheed, Z. Bodalal, C. V. van Herpen +6 more
2019Cancer Immunology and Immunotherapy35 citations Open access
Semantic Scholar
Highly specific and potently activating Vγ9Vδ2-T cell specific nanobodies for diagnostic and therapeutic applications.
R. D. de Bruin, S. Lougheed, Liza van der Kruk, A. Stam +6 more
2016Clinical Immunology32 citations Open access
Semantic Scholar
Attenuation of invariant natural killer T-cell anergy induction through intradermal delivery of alpha-galactosylceramide.
H. Bontkes, M. Moreno, B. Hangalapura, J. Lindenberg +7 more
2010Clinical Immunology28 citations
Semantic Scholar
Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8+ T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma
J. Rotman, A. Heeren, A. Gassama, S. Lougheed +8 more
2020Clinical Cancer Research22 citations Open access
Semantic Scholar
High Levels of EBV-Encoded RNA 1 (EBER1) Trigger Interferon and Inflammation-Related Genes in Keratinocytes Expressing HPV16 E6/E7
Sirinart Aromseree, Jaap M Middeldorp, C. Pientong, M. van Eijndhoven +5 more
2017PLoS ONE21 citations Open access
Semantic Scholar
Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells
I. Glykofridis, J. Knol, Jesper A. Balk, Denise Westland +17 more
2021eLife20 citations Open access
Semantic Scholar
4-1BB-mediated expansion affords superior detection of in vivo primed effector memory CD8+ T cells from melanoma sentinel lymph nodes.
B. J. Sluijter, M. V. D. van den Hout, A. Stam, S. Lougheed +9 more
2010Clinical Immunology18 citations
Semantic Scholar
A Reconstructed Human Melanoma-in-Skin Model to Study Immune Modulatory and Angiogenic Mechanisms Facilitating Initial Melanoma Growth and Invasion
E. Michielon, Marta López González, Dorian A. Stolk, J. G. Stolwijk +5 more
2023Cancers17 citations Open access
Semantic Scholar
Phase 1 study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell carcinoma
C. M. Huijts, I. M. Werter, S. Lougheed, R. S. Goedegebuure +7 more
2018Cancer Immunology and Immunotherapy16 citations Open access
Semantic Scholar
Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression
Marta López González, D. Oosterhoff, J. Lindenberg, I. Milenova +16 more
2019Oncoimmunology14 citations Open access
Semantic Scholar
Glioblastoma-induced inhibition of Langerhans cell differentiation from CD34(+) precursors is mediated by IL-6 but unaffected by JAK2/STAT3 inhibition.
H. van Cruijsen, D. Oosterhoff, J. Lindenberg, S. Lougheed +7 more
2011Immunotherapy12 citations
Semantic Scholar
Systemic immunomodulation by irreversible electroporation versus stereotactic ablative body radiotherapy in locally advanced pancreatic cancer: the CROSSFIRE trial
B. Geboers, Florentine E. F. Timmer, D. Vos, H. Scheffer +13 more
2025Journal for ImmunoTherapy of Cancer10 citations Open access
Semantic Scholar
Longitudinal immune monitoring of patients with resectable esophageal adenocarcinoma treated with Neoadjuvant PD-L1 checkpoint inhibition
T. van den Ende, Aiarpi A Ezdoglian, Lisanne M. Baas, Joyce Bakker +14 more
2023Oncoimmunology8 citations Open access
Semantic Scholar
309 The role of tumor-draining lymph nodes in the tuning of systemic T cell immunity by CTLA-4 blockade is revealed by local delivery of tremelimumab in early-stage melanoma: data from a Phase-I trial
J. Notohardjo, K. V. van Pul, A. Stam, Dafni Chondronasiou +6 more
20204 citations Open access
Semantic Scholar
Metronomic cyclophosphamide attenuates mTOR-mediated expansion of regulatory T cells, but does not impact clinical outcome in patients with metastatic renal cell cancer treated with everolimus
I. M. Werter, C. M. Huijts, S. Lougheed, P. Hamberg +8 more
2019Cancer Immunology and Immunotherapy4 citations Open access
Semantic Scholar
Induction of dendritic cell maturation in the skin microenvironment by soluble factors derived from colon carcinoma
J. Lindenberg, R. van de Ven, D. Oosterhoff, C. Sombroek +6 more
2014Human Vaccines & Immunotherapeutics4 citations Open access
Semantic Scholar
Targeting the immunoproteasome with the second generation proteasome inhibitor ONX 0914: effects on IFN-alpha-induced monocyte-derived dendritic cells (119.4)
Sue Ellen Verbrugge, D. Emal, Marjon Al, S. Lougheed +5 more
2012Journal of Immunology2 citations
Semantic Scholar
Differentiation Tumor-Induced Inhibition of Dendritic Cell Prostanoids Play a Major Role in the Primary
R. Scheper, T. D. de Gruijl, Meijer, H. Pinedo +7 more
20022 citations
Semantic Scholar
Exploring the dynamics of T‐cell responses: a combined approach using EdU incorporation and proliferation dye dilution assay
Hilde Raaphorst, S. Lougheed, Latifa Saou, Nadine D. van Kleef +4 more
2024Immunology and Cell Biology1 citations Open access
Semantic Scholar
Abstract 5512: Immune correlates of clinical response and survival in castration-resistant prostate cancer patients treated with prostate GVAX and anti-CTLA4 immunotherapy
S. Santegoets, A. V. D. van den Eertwegh, A. Stam, R. Scheper +13 more
20111 citations
Semantic Scholar
Abstract B20: Immune vs. clinical response monitoring in patients with metastatic hormone-refractory prostate cancer receiving combined prostate GVAX and anti-CTLA4 immunotherapy
S. Santegoets, A. V. D. van den Eertwegh, A. Stam, R. Scheper +10 more
20101 citations
Semantic Scholar
In vitro priming of tumor-specific cytotoxic T lymphocytes from healthy donors using allogeneic dendritic cells derived from the MUTZ-3 cell line (NMDC)
S. Santegoets, M. Schreurs, A. Masterson, H. Baumeister +7 more
20041 citations
Semantic Scholar
Phase-1 trial of neoadjuvant durvalumab immunotherapy (DURVIT) delivered peritumorally in early-stage cervical cancer: safety and immune efficacy data
M. Strikwerda, J. Rotman, E. Jordanova, J. Bakker +9 more
2026International Journal of Gynecological Cancer0 citations
Semantic Scholar
Author response: Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells
I. Glykofridis, J. Knol, Jesper A. Balk, Denise Westland +17 more
20200 citations Open access
Semantic Scholar
Abstract B138: Single low-dose administration of anti-CTLA-4/tremelimumab at the tumor excision site boosts systemic antitumor immunity in early-stage melanoma patients: Results from a Phase-1 study
A. Stam, K. V. van Pul, Bas D. Koster, Dafni Chondronasiou +6 more
20160 citations
Semantic Scholar
Abstract P5-04-01: Breast cancer related immune suppression in the sentinel lymph node can be effectively countered by combined CpG-B administration and JAK2/STAT3 inhibition
K. V. van Pul, R. Vuylsteke, S. Lougheed, L. T. Velde +4 more
20150 citations
Semantic Scholar
S48. Biomarker development for ipilimumab and prostate GVAX treatment
T. D. de Gruijl, S. Santegoets, A. Stam, S. Lougheed +6 more
2014Journal of Immunotherapy for Cancer0 citations Open access
Semantic Scholar
2 IL-10 conditioning of human skin affects the distribution of migratory dendritic cell subsets and functional T cell differentiation
J. Lindenberg, D. Oosterhoff, C. Sombroek, S. Lougheed +3 more
20140 citations
Semantic Scholar
Glycogen Synthase Kinase-3β as a key regulator of human dendritic cell development and suppression
D. Oosterhoff, J. Lindenberg, S. Lougheed, H. Dekker +7 more
20140 citations
Semantic Scholar

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