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R. Scheper · SciRah

Researcher profile · Semantic Scholar

R. Scheper

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R. Scheper — researcher profile on SciRah

h-index: 87
Works: 453
Citations: 28K

Most-cited papers

The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models
G. C. Limandjaja, F. Niessen, R. Scheper, S. Gibbs
2020Frontiers in Cell and Developmental Biology318 citations Open access
Semantic Scholar
Hypertrophic scars and keloids: Overview of the evidence and practical guide for differentiating between these abnormal scars
G. C. Limandjaja, F. Niessen, R. Scheper, S. Gibbs
2020Experimental Dermatology172 citations Open access
Semantic Scholar
Defining the critical hurdles in cancer immunotherapy
B. Fox, D. Schendel, L. Butterfield, S. Aamdal +101 more
2011Journal of Translational Medicine158 citations Open access
Semantic Scholar
Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts
C. M. A. Reijnders, A. van Lier, S. Roffel, D. Kramer +2 more
2015Tissue Engineering. Part A136 citations Open access
Semantic Scholar
Inactivating PSMB5 Mutations and P-Glycoprotein (Multidrug Resistance-Associated Protein/ATP-Binding Cassette B1) Mediate Resistance to Proteasome Inhibitors: Ex Vivo Efficacy of (Immuno)Proteasome Inhibitors in Mononuclear Blood Cells from Patients with Rheumatoid Arthritis
Sue Ellen Verbrugge, Y. Assaraf, B. Dijkmans, G. Scheffer +10 more
2012Journal of Pharmacology and Experimental Therapeutics119 citations
Semantic Scholar
Proteasome inhibitors as experimental therapeutics of autoimmune diseases
Sue Ellen Verbrugge, R. Scheper, W. Lems, T. D. de Gruijl +1 more
2015Arthritis Research & Therapy115 citations Open access
Semantic Scholar
Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1, CCR10, CXCR1, CXCR2, and CXCR3.
K. Kroeze, M. Boink, S. Sampat-Sardjoepersad, Taco Waaijman +2 more
2012Journal of Investigative Dermatology107 citations Open access
Semantic Scholar
Myeloid derived suppressor and dendritic cell subsets are related to clinical outcome in prostate cancer patients treated with prostate GVAX and ipilimumab
S. Santegoets, A. Stam, S. Lougheed, H. Gall +8 more
2014Journal of Immunotherapy for Cancer100 citations Open access
Semantic Scholar
IL-21 promotes the expansion of CD27+CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells
S. Santegoets, Annelies W. Turksma, M. Suhoski, A. Stam +8 more
2013Journal of Translational Medicine86 citations Open access
Semantic Scholar
Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis.
G. Kooij, Mark R Mizee, J. van Horssen, A. Reijerkerk +9 more
2011Brain : a journal of neurology86 citations
Semantic Scholar
Hypertrophic and keloid scars fail to progress from the CD34−/α‐smooth muscle actin (α‐SMA)+ immature scar phenotype and show gradient differences in α‐SMA and p16 expression
G. C. Limandjaja, J. Belien, R. Scheper, F. Niessen +1 more
2020British Journal of Dermatology82 citations Open access
Semantic Scholar
Differential Response of Human Adipose Tissue-Derived Mesenchymal Stem Cells, Dermal Fibroblasts, and Keratinocytes to Burn Wound Exudates: Potential Role of Skin-Specific Chemokine CCL27
L. van den Broek, K. Kroeze, Taco Waaijman, Melanie Breetveld +5 more
2013Tissue Engineering. Part A66 citations Open access
Semantic Scholar
Tumor-mediated inhibition of human dendritic cell differentiation and function is consistently counteracted by combined p38 MAPK and STAT3 inhibition
D. Oosterhoff, S. Lougheed, R. van de Ven, J. Lindenberg +7 more
2012Oncoimmunology66 citations Open access
Semantic Scholar
Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model
M. Verhoeven, S. Bystrova, L. Winnubst, Hammad F. Qureshi +3 more
201262 citations Open access
Semantic Scholar
Arming the Melanoma Sentinel Lymph Node through Local Administration of CpG-B and GM-CSF: Recruitment and Activation of BDCA3/CD141+ Dendritic Cells and Enhanced Cross-Presentation
B. J. Sluijter, M. V. D. van den Hout, Bas D. Koster, P. V. van Leeuwen +9 more
2015Cancer immunology research61 citations Open access
Semantic Scholar
Development, validation and testing of a human tissue engineered hypertrophic scar model.
L. J. van den Broek, F. Niessen, R. Scheper, S. Gibbs
2012ALTEX61 citations Open access
Semantic Scholar
Local Adjuvant Treatment with Low-Dose CpG-B Offers Durable Protection against Disease Recurrence in Clinical Stage I–II Melanoma: Data from Two Randomized Phase II Trials
Bas D. Koster, M. V. D. van den Hout, B. J. Sluijter, B. Molenkamp +7 more
2017Clinical Cancer Research59 citations
Semantic Scholar
A potential in vitro epidermal equivalent assay to determine sensitizer potency.
G. G. dos Santos, S. Spiekstra, S. Sampat-Sardjoepersad, J. Reinders +2 more
2011Toxicology in Vitro57 citations
Semantic Scholar
Use of a Collagen–Elastin Matrix as Transport Carrier System to Transfer Proliferating Epidermal Cells to Human Dermis in Vitro
Taco Waaijman, Melanie Breetveld, M. Ulrich, E. Middelkoop +2 more
2010Cell Transplantation51 citations Open access
Semantic Scholar
Comparison of a novel CXCL12/CCL5 dependent migration assay with CXCL8 secretion and CD86 expression for distinguishing sensitizers from non-sensitizers using MUTZ-3 Langerhans cells.
K. Ouwehand, S. Spiekstra, J. Reinders, R. Scheper +2 more
2010Toxicology in Vitro50 citations
Semantic Scholar
Melanoma Sequentially Suppresses Different DC Subsets in the Sentinel Lymph Node, Affecting Disease Spread and Recurrence
M. V. D. van den Hout, Bas D. Koster, B. J. Sluijter, B. Molenkamp +6 more
2017Cancer immunology research49 citations Open access
Semantic Scholar
Irritant-induced migration of Langerhans cells coincides with an IL-10-dependent switch to a macrophage-like phenotype.
K. Ouwehand, D. Oosterhoff, Melanie Breetveld, R. Scheper +2 more
2011Journal of Investigative Dermatology44 citations Open access
Semantic Scholar
Potent antitumor immunity generated by a CD40-targeted adenoviral vaccine.
B. Hangalapura, D. Oosterhoff, J. D. de Groot, L. Boon +8 more
2011Cancer Research43 citations Open access
Semantic Scholar
Functional characterization of a STAT3-dependent dendritic cell-derived CD14+ cell population arising upon IL-10-driven maturation
J. Lindenberg, R. van de Ven, S. Lougheed, A. Zomer +8 more
2013Oncoimmunology41 citations Open access
Semantic Scholar
Characterization of In Vitro Reconstructed Human Normotrophic, Hypertrophic, and Keloid Scar Models
G. C. Limandjaja, L. van den Broek, Melanie Breetveld, Taco Waaijman +5 more
2018Tissue Engineering. Part C, Methods40 citations Open access
Semantic Scholar
IL-10 Conditioning of Human Skin Affects the Distribution of Migratory Dendritic Cell Subsets and Functional T Cell Differentiation
J. Lindenberg, D. Oosterhoff, C. Sombroek, S. Lougheed +11 more
2013PLoS ONE39 citations Open access
Semantic Scholar
CCL5 and CCL20 mediate immigration of Langerhans cells into the epidermis of full thickness human skin equivalents.
K. Ouwehand, S. Spiekstra, Taco Waaijman, Melanie Breetveld +3 more
2012European Journal of Cell Biology39 citations
Semantic Scholar
Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR
Sue Ellen Verbrugge, Marjon Al, Y. Assaraf, Sarah Kammerer +16 more
2015OncoTarget35 citations Open access
Semantic Scholar
Reconstructed human skin shows epidermal invagination towards integrated neopapillae indicating early hair follicle formation in vitro
Irit Vahav, L. van den Broek, M. Thon, H. N. Monsuur +7 more
2020Journal of Tissue Engineering and Regenerative Medicine34 citations Open access
Semantic Scholar
Selective Transduction of Dendritic Cells in Human Lymph Nodes and Superior Induction of High-avidity Melanoma-reactive Cytotoxic T Cells by a CD40-targeted Adenovirus
B. Hangalapura, D. Oosterhoff, S. Aggarwal, P. G. J. B. Wijnands +9 more
2010Journal of immunotherapy32 citations
Semantic Scholar
Reconstructed human keloid models show heterogeneity within keloid scars
G. C. Limandjaja, L. J. van den Broek, Taco Waaijman, Melanie Breetveld +4 more
2018Archives of Dermatological Research28 citations Open access
Semantic Scholar
Autologous skin substitute for hard‐to‐heal ulcers: Retrospective analysis on safety, applicability, and efficacy in an outpatient and hospitalized setting
C. Blok, L. Vink, E. D. de Boer, C. van Montfrans +10 more
2013Wound Repair and Regeneration26 citations
Semantic Scholar
CD1d-Restricted Antigen Presentation by Vγ9Vδ2-T Cells Requires Trogocytosis
F. Schneiders, Jan Prodöhl, J. Ruben, T. O'Toole +6 more
2014Cancer immunology research25 citations Open access
Semantic Scholar
Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors
Sue Ellen Verbrugge, Marjon Al, Y. Assaraf, D. Niewerth +14 more
2013Experimental Hematology & Oncology25 citations Open access
Semantic Scholar
Simple wound exudate collection method identifies bioactive cytokines and chemokines in (arterio) venous ulcers
K. Kroeze, L. Vink, E. M. Boer, R. Scheper +2 more
2012Wound Repair and Regeneration25 citations
Semantic Scholar
Delivery route, MyD88 signaling and cross-priming events determine the anti-tumor efficacy of an Adenovirus based melanoma vaccine
B. Hangalapura, D. Oosterhoff, T. Gupta, J. D. de Groot +8 more
2011Vaccine23 citations Open access
Semantic Scholar
Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury).
Dessy Rachmawati, Inás W. A. Alsalem, H. Bontkes, M. Verstege +4 more
2015Toxicology in Vitro22 citations
Semantic Scholar
T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A+CD141+ cDC1 and CD14+ antigen-presenting cell recruitment
Bas D. Koster, Marta López González, M. V. D. van den Hout, Annelies W. Turksma +9 more
2021Journal for ImmunoTherapy of Cancer20 citations Open access
Semantic Scholar
Inactivating PSMB 5 Mutations and P-Glycoprotein ( Multidrug Resistance-Associated Protein / ATP-Binding Cassette B 1 ) Mediate Resistance to Proteasome Inhibitors : Ex Vivo Efficacy of ( Immuno ) Proteasome Inhibitors in Mononuclear Blood Cells from Patients with Rheumatoid Arthritis
Sue Ellen Verbrugge, Y. Assaraf, B. Dijkmans, G. Scheffer +10 more
201219 citations
Semantic Scholar
Exposure of CD34+ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy
R. van de Ven, A. Reurs, P. G. J. B. Wijnands, S. van Wetering +5 more
2012Cancer Immunology and Immunotherapy19 citations Open access
Semantic Scholar
Activated iNKT cells promote Vγ9Vδ2-T cell anti-tumor effector functions through the production of TNF-α.
F. Schneiders, R. D. de Bruin, S. Santegoets, M. Bonneville +5 more
2012Clinical Immunology18 citations
Semantic Scholar
Response of MUTZ-3 dendritic cells to the different components of the Haemophilus influenzae type B conjugate vaccine: towards an in vitro assay for vaccine immunogenicity.
M. Hoefnagel, J. Vermeulen, R. Scheper, R. Vandebriel
2011Vaccine18 citations
Semantic Scholar
Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression
Marta López González, D. Oosterhoff, J. Lindenberg, I. Milenova +16 more
2019Oncoimmunology14 citations Open access
Semantic Scholar
Methotrexate analogues display enhanced inhibition of TNF-α production in whole blood from RA patients
J. W. van der Heijden, Y. Assaraf, A. Gerards, R. Oerlemans +4 more
2014Scandinavian Journal of Rheumatology13 citations
Semantic Scholar
Glioblastoma-induced inhibition of Langerhans cell differentiation from CD34(+) precursors is mediated by IL-6 but unaffected by JAK2/STAT3 inhibition.
H. van Cruijsen, D. Oosterhoff, J. Lindenberg, S. Lougheed +7 more
2011Immunotherapy12 citations
Semantic Scholar
Comparison of advanced therapy medicinal product gingiva and skin substitutes and their in vitro wound healing potentials
M. Boink, S. Roffel, Melanie Breetveld, M. Thon +5 more
2017Journal of Tissue Engineering and Regenerative Medicine9 citations Open access
Semantic Scholar
Immunostimulatory capacity of dental casting alloys on endotoxin responsiveness
Dessy Rachmawati, M. V. von Blomberg, C. Kleverlaan, R. Scheper +1 more
2017The Journal of prosthetic dentistry (Print)9 citations
Semantic Scholar
Chapter 7 Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR 1 , CCR 10 , CXCR 1 , CXCR 2 and CXCR 3
K. Kroeze, M. Boink, S. Sampat-Sardjoepersad, Taco Waaijman +2 more
20129 citations
Semantic Scholar
High susceptibility of c-KIT+CD34+ precursors to prolonged doxorubicin exposure interferes with Langerhans cell differentiation in a human cell line model
R. van de Ven, Sue Ellen Verbrugge, A. Reurs, H. Bontkes +5 more
2011Cancer Immunology and Immunotherapy9 citations Open access
Semantic Scholar
Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide
R. Oerlemans, C. Berkers, Y. Assaraf, G. Scheffer +10 more
2018Investigational new drugs7 citations Open access
Semantic Scholar

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T. D. de Gruijl×28
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T. D. de Gruijl — researcher profile on SciRah
S. Gibbs×19
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A. V. D. van den Eertwegh×12
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F. Niessen — researcher profile on SciRah

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