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H. Loetscher · SciRah

Researcher profile · Semantic Scholar

H. Loetscher

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H. Loetscher — researcher profile on SciRah

h-index: 45
Works: 78
Citations: 9,344

Most-cited papers

Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
D. Banner, A. D'Arcy, W. Janes, R. Gentz +4 more
1993Cell1,144 citations
Semantic Scholar
Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor.
H. Loetscher, Y. Pan, H. Lahm, R. Gentz +3 more
1990Cell885 citations
Semantic Scholar
Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.
M. Brockhaus, Hans-Joachim Schoenfeld, E. Schlaeger, W. Hunziker +2 more
1990Proceedings of the National Academy of Sciences of the United States of America659 citations Open access
Semantic Scholar
Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle.
J. Niewoehner, B. Bohrmann, L. Collin, E. Urich +9 more
2014Neuron565 citations Open access
Semantic Scholar
Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab.
S. Ostrowitzki, D. Deptula, L. Thurfjell, F. Barkhof +8 more
2012Archives of Neurology404 citations Open access
Semantic Scholar
Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55
F. Mackay, H. Loetscher, D. Stueber, G. Gehr +1 more
1993Journal of Experimental Medicine402 citations Open access
Semantic Scholar
Gantenerumab: A Novel Human Anti-Aβ Antibody Demonstrates Sustained Cerebral Amyloid-β Binding and Elicits Cell-Mediated Removal of Human Amyloid-β
B. Bohrmann, K. Baumann, J. Benz, F. Gerber +12 more
2012Journal of Alzheimer's Disease355 citations Open access
Semantic Scholar
Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences.
Z. Dembić, H. Loetscher, U. Gubler, Y. Pan +4 more
1990Cytokine274 citations
Semantic Scholar
Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor
T. Espevik, Manfred Brockhaus, H. Loetscher, U. Nonstad +1 more
1990Journal of Experimental Medicine262 citations Open access
Semantic Scholar
Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor.
P. Piguet, G. E. Grau, C. Vesin, H. Loetscher +2 more
1992Immunology255 citations
Semantic Scholar
Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors.
H. Loetscher, D. Stueber, D. Banner, F. Mackay +1 more
1993Journal of Biological Chemistry212 citations Open access
Semantic Scholar
PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation
J. Richards, G. Higgins, A. Ouagazzal, L. Ozmen +10 more
2003Journal of Neuroscience197 citations Open access
Semantic Scholar
Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors
M. Shalaby, A. Sundan, H. Loetscher, M. Brockhaus +2 more
1990Journal of Experimental Medicine194 citations Open access
Semantic Scholar
Human TNF mutants with selective activity on the p55 receptor
X. Van Ostade, P. Vandenabeele, B. Everaerdt, H. Loetscher +6 more
1993Nature186 citations Open access
Semantic Scholar
Protective effect of 55- but not 75-kD soluble tumor necrosis factor receptor-immunoglobulin G fusion proteins in an animal model of gram- negative sepsis
T. Evans, D. Moyes, A. Carpenter, R. Martin +3 more
1994Journal of Experimental Medicine179 citations Open access
Semantic Scholar
Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis.
Eva Carro, José Luis Trejo, A. Gerber, H. Loetscher +3 more
2006Neurobiology of Aging175 citations Open access
Semantic Scholar
Role of Caspase-3 Activation in Cerebral Ischemia-Induced Neurodegeneration in Adult and Neonatal Brain
R. Gill, M. A. Soriano, K. Blomgren, H. Hagberg +7 more
2002Journal of Cerebral Blood Flow and Metabolism164 citations Open access
Semantic Scholar
Tumor necrosis factor receptors-structure and function
J. Rothe, G. Gehr, H. Loetscher, W. Lesslauer
1992Immunologic research162 citations
Semantic Scholar
Presenilins Are Processed by Caspase-type Proteases*
H. Loetscher, U. Deuschle, M. Brockhaus, D. Reinhardt +5 more
1997Journal of Biological Chemistry154 citations Open access
Semantic Scholar
Both tumor necrosis factor receptor types mediate proliferative signals in human mononuclear cell activation.
G. Gehr, R. Gentz, M. Brockhaus, H. Loetscher +1 more
1992Journal of Immunology152 citations
Semantic Scholar
Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma
P. Vandenabeele, W. Declercq, D. Vercammen, M. van de Craen +5 more
1992Journal of Experimental Medicine131 citations Open access
Semantic Scholar
Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span.
M. von Kienlin, B. Künnecke, F. Metzger, G. Steiner +4 more
2005Neurobiology of Disease116 citations Open access
Semantic Scholar
Region-specific permeability of the blood–brain barrier upon pericyte loss
Roberto Villaseñor, B. Kuennecke, L. Ozmen, Michelle Ammann +5 more
2017Journal of Cerebral Blood Flow and Metabolism111 citations Open access
Semantic Scholar
Expression and characterisation of plasmepsin I from Plasmodium falciparum.
R. Moon, Lorraine Tyas, Ulrich Certa, Katharina Rupp +9 more
1997European Journal of Biochemistry102 citations
Semantic Scholar
Purification and partial amino acid sequence analysis of two distinct tumor necrosis factor receptors from HL60 cells.
H. Loetscher, E. Schlaeger, H. Lahm, Y. Pan +2 more
1990Journal of Biological Chemistry99 citations
Semantic Scholar
Tumor necrosis factor: receptors and inhibitors.
H. Loetscher, M. Steinmetz, W. Lesslauer
1991Cancer cells97 citations
Semantic Scholar
Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis.
H. Steiner, H. Romig, B. Pesold, U. Philipp +5 more
1999Biochemistry96 citations
Semantic Scholar
Disturbed Cross Talk between Insulin-Like Growth Factor I and AMP-Activated Protein Kinase as a Possible Cause of Vascular Dysfunction in the Amyloid Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease
C. López-López, Marcelo O. Dietrich, F. Metzger, H. Loetscher +1 more
2007Journal of Neuroscience92 citations Open access
Semantic Scholar
Bifunctional effects of tumor necrosis factor alpha (TNF alpha) on the growth of mature and primitive human hematopoietic progenitor cells: involvement of p55 and p75 TNF receptors.
L. Rusten, F. W. Jacobsen, W. Lesslauer, H. Loetscher +2 more
1994Blood88 citations
Semantic Scholar
Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier
Roberto Villaseñor, L. Ozmen, N. Messaddeq, F. Grüninger +5 more
2016Scientific Reports85 citations Open access
Semantic Scholar
55-kd tumor necrosis factor receptor is expressed by human keratinocytes and plays a pivotal role in regulation of human keratinocyte ICAM-1 expression.
U. Trefzer, M. Brockhaus, H. Loetscher, F. Parlow +3 more
1991Journal of Investigative Dermatology81 citations Open access
Semantic Scholar
A human tumor necrosis factor (TNF) alpha mutant that binds exclusively to the p55 TNF receptor produces toxicity in the baboon
K. Van Zee, S. A. Stackpole, W. J. Montegut, M. Rogy +6 more
1994Journal of Experimental Medicine73 citations Open access
Semantic Scholar
Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer’s Disease
E. Borroni, B. Bohrmann, Fiona Grueninger, E. Prinssen +12 more
2017Journal of Pharmacology and Experimental Therapeutics72 citations Open access
Semantic Scholar
Efficient purification of recombinant human tumor necrosis factor beta from Escherichia coli yields biologically active protein with a trimeric structure that binds to both tumor necrosis factor receptors.
Hans-Joachim Schoenfeld, B. Poeschl, J. R. Frey, H. Loetscher +3 more
1991Journal of Biological Chemistry72 citations Open access
Semantic Scholar
Caspase‐mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling
M. Brockhaus, J. Grünberg, Sascha Röhrig, H. Loetscher +4 more
1998NeuroReport70 citations
Semantic Scholar
Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family.
J. Grünberg, J. Walter, H. Loetscher, U. Deuschle +2 more
1998Biochemistry70 citations
Semantic Scholar
Differential responses of fibroblasts from wild-type and TNF-R55-deficient mice to mouse and human TNF-alpha activation.
F. Mackay, J. Rothe, H. Bluethmann, H. Loetscher +1 more
1994Journal of Immunology69 citations
Semantic Scholar
Tumor Necrosis Factor-a Inhibits Stem Cell Factor-induced Proliferation of Human Bone Marrow Progenitor Cells In Vitro Role of p55 and p75 Tumor Necrosis Factor Receptors
L. Rusten, E. Smeland, F. Jacobsen, Eli Lien +5 more
65 citations
Semantic Scholar
Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from Plasmodium falciparum
N. Bernstein, M. Cherney, H. Loetscher, R. Ridley +1 more
1999Nature Structural Biology64 citations
Semantic Scholar
A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon
M. Welborn, K. Van Zee, Paul D. Edwards, Jeffrey H. Pruitt +13 more
1996Journal of Experimental Medicine62 citations Open access
Semantic Scholar
Protection against lethal Escherichia coli bacteremia in baboons (Papio anubis) by pretreatment with a 55-kDa TNF receptor (CD120a)-Ig fusion protein, Ro 45-2081.
K. Van Zee, L. Moldawer, H. Oldenburg, William A. Thompson +14 more
1996Journal of Immunology62 citations Open access
Semantic Scholar
Tumor necrosis factor-alpha induces activation of coagulation and fibrinolysis in baboons through an exclusive effect on the p55 receptor.
T. van der Poll, P. Jansen, K. Van Zee, M. Welborn +6 more
1996Blood61 citations
Semantic Scholar
Expression of a transgenic T cell receptor beta chain enhances collagen- induced arthritis
L. Mori, H. Loetscher, Kiichi Kakimoto, H. Bluethmann +1 more
1992Journal of Experimental Medicine54 citations Open access
Semantic Scholar
Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia?
H. Loetscher, Olivier Niederhauser, John D. Kemp, R. Gill
2001Drug Discovery Today51 citations
Semantic Scholar
The Influence of Endoproteolytic Processing of Familial Alzheimer's Disease Presenilin 2 on Aβ42 Amyloid Peptide Formation*
H. Jacobsen, D. Reinhardt, M. Brockhaus, D. Bur +5 more
1999Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Cargo Delivery into the Brain by in vivo identified Transport Peptides
E. Urich, Roland Schmucki, N. Ruderisch, E. Kitas +7 more
2015Scientific Reports43 citations Open access
Semantic Scholar
Separation of Fast from Slow Anabolism by Site-specific PEGylation of Insulin-like Growth Factor I (IGF-I)*
F. Metzger, Waseem Sajid, S. Saenger, C. Staudenmaier +15 more
2011Journal of Biological Chemistry42 citations Open access
Semantic Scholar
Toxicity in neuronal cells caused by cerebrospinal fluid from pneumococcal and gram-negative meningitis.
M. Täuber, M. Sachdeva, S. L. Kennedy, H. Loetscher +1 more
1992Journal of Infectious Diseases36 citations Open access
Semantic Scholar
In vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu®) and active metabolite
L. Lindemann, H. Jacobsen, D. Schuhbauer, F. Knoflach +8 more
2009European Journal of Pharmacology34 citations Open access
Semantic Scholar
Structure and membrane topology of the high-affinity receptor for human IFN-gamma: requirements for binding IFN-gamma. One single 90-kilodalton IFN-gamma receptor can lead to multiple cross-linked products and isolated proteins.
M. Fountoulakis, M. Kania, Laurence Ozmen, H. Loetscher +2 more
1989Journal of Immunology27 citations
Semantic Scholar

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