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W. Lesslauer · SciRah

Researcher profile · Semantic Scholar

W. Lesslauer

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W. Lesslauer — researcher profile on SciRah

h-index: 39
Works: 88
Citations: 12K

Most-cited papers

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor.
M. Grell, E. Douni, H. Wajant, Matthias Löhden +7 more
1995Cell1,439 citations Open access
Semantic Scholar
Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes
J. Rothe, W. Lesslauer, H. Lötscher, Y. Lang +6 more
1993Nature1,334 citations
Semantic Scholar
Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
D. Banner, A. D'Arcy, W. Janes, R. Gentz +4 more
1993Cell1,144 citations
Semantic Scholar
Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor.
H. Loetscher, Y. Pan, H. Lahm, R. Gentz +3 more
1990Cell885 citations
Semantic Scholar
Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.
M. Brockhaus, Hans-Joachim Schoenfeld, E. Schlaeger, W. Hunziker +2 more
1990Proceedings of the National Academy of Sciences of the United States of America659 citations Open access
Semantic Scholar
TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study
Arnason Bgw., G. Jacobs, M. Hanlon, B. Clay +43 more
1999Neurology483 citations Open access
Semantic Scholar
Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55
F. Mackay, H. Loetscher, D. Stueber, G. Gehr +1 more
1993Journal of Experimental Medicine402 citations Open access
Semantic Scholar
p55 Tumor Necrosis Factor Receptor Fusion Protein in the Treatment of Patients With Severe Sepsis and Septic Shock: A Randomized Controlled Multicenter Trial
E. Abraham, M. Glauser, T. Butler, J. Garbino +9 more
1997361 citations
Semantic Scholar
Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: A randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients
E. Abraham, P. Laterre, J. Garbino, S. Pingleton +16 more
2001Critical Care Medicine321 citations Open access
Semantic Scholar
Blockade of p38 Mitogen-activated Protein Kinase Pathway Inhibits Inducible Nitric-oxide Synthase Expression in Mouse Astrocytes*
Jean da Silva, B. Pierrat, J. Mary, W. Lesslauer
1997Journal of Biological Chemistry318 citations Open access
Semantic Scholar
Ectopic LTαβ Directs Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted Sulfotransferase
Danielle L. Drayton, Xiao-Yang Ying, Jason Lee, W. Lesslauer +1 more
2003Journal of Experimental Medicine276 citations Open access
Semantic Scholar
Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences.
Z. Dembić, H. Loetscher, U. Gubler, Y. Pan +4 more
1990Cytokine274 citations
Semantic Scholar
p55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group.
Edward Abraham, M. Glauser, T. Butler, J. Garbino +9 more
1997Journal of the American Medical Association (JAMA)267 citations
Semantic Scholar
Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide‐induced lethality
W. Lesslauer, H. Tabuchi, R. Gentz, M. Brockhaus +6 more
1991European Journal of Immunology248 citations
Semantic Scholar
Electrical properties of bimolecular phospholipid membranes.
P. Läuger, W. Lesslauer, E. Martı́, J. Richter
1967Biochimica et Biophysica Acta223 citations
Semantic Scholar
Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice.
L. Mori, S. Iselin, G. de Libero, W. Lesslauer
1996Journal of Immunology219 citations
Semantic Scholar
Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors.
H. Loetscher, D. Stueber, D. Banner, F. Mackay +1 more
1993Journal of Biological Chemistry212 citations Open access
Semantic Scholar
Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors
M. Shalaby, A. Sundan, H. Loetscher, M. Brockhaus +2 more
1990Journal of Experimental Medicine194 citations Open access
Semantic Scholar
Human TNF mutants with selective activity on the p55 receptor
X. Van Ostade, P. Vandenabeele, B. Everaerdt, H. Loetscher +6 more
1993Nature186 citations Open access
Semantic Scholar
Protective effect of 55- but not 75-kD soluble tumor necrosis factor receptor-immunoglobulin G fusion proteins in an animal model of gram- negative sepsis
T. Evans, D. Moyes, A. Carpenter, R. Martin +3 more
1994Journal of Experimental Medicine179 citations Open access
Semantic Scholar
Tumor necrosis factor receptors-structure and function
J. Rothe, G. Gehr, H. Loetscher, W. Lesslauer
1992Immunologic research162 citations
Semantic Scholar
RSK-B, a Novel Ribosomal S6 Kinase Family Member, Is a CREB Kinase under Dominant Control of p38α Mitogen-activated Protein Kinase (p38αMAPK)*
B. Pierrat, J. da Silva Correia, J. Mary, M. Tomás-Zuber +1 more
1998Journal of Biological Chemistry157 citations Open access
Semantic Scholar
Both tumor necrosis factor receptor types mediate proliferative signals in human mononuclear cell activation.
G. Gehr, R. Gentz, M. Brockhaus, H. Loetscher +1 more
1992Journal of Immunology152 citations
Semantic Scholar
TNF-alpha receptor fusion protein prevents experimental auto-immune encephalomyelitis and demyelination in Lewis rats: an overview.
W. Klinkert, K. Kojima, W. Lesslauer, W. Rinner +2 more
1997Journal of Neuroimmunology139 citations
Semantic Scholar
Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma
P. Vandenabeele, W. Declercq, D. Vercammen, M. van de Craen +5 more
1992Journal of Experimental Medicine131 citations Open access
Semantic Scholar
High sensitivity of transgenic mice expressing soluble TNFR1 fusion protein to mycobacterial infections: Synergistic action of TNF and IFN‐γ in the differentiation of protective granulomas
I. Garcia, Yoshitaka Miyazaki, G. Marchal, W. Lesslauer +1 more
1997European Journal of Immunology115 citations Open access
Semantic Scholar
X-ray diffraction studies of lecithin bimolecular leaflets with incorporated fluorescent probes.
W. Lesslauer, J. Cain, J. Blasie
1972Proceedings of the National Academy of Sciences of the United States of America109 citations Open access
Semantic Scholar
Involvement of the 55- and 75-kDa tumor necrosis factor receptors in the generation of lymphokine-activated killer cell activity and proliferation of natural killer cells.
B. Naume, R. Shalaby, W. Lesslauer, T. Espevik
1991Journal of Immunology102 citations Open access
Semantic Scholar
Tumor necrosis factor: receptors and inhibitors.
H. Loetscher, M. Steinmetz, W. Lesslauer
1991Cancer cells97 citations
Semantic Scholar
On the location of 1-anilino-8-naphthalene-sulfonate in lipid model systems
W. Lesslauer, J. Cain, J. Blasie
197180 citations
Semantic Scholar
Tumor necrosis factor-alpha-induced expression of heat shock protein 72 in adult feline cardiac myocytes.
M. Nakano, A. Knowlton, T. Yokoyama, W. Lesslauer +1 more
1996American Journal of Physiology79 citations
Semantic Scholar
Independent regulation of 55‐kDa and 75‐kDa tumor necrosis factor receptors during activation of human peripheral blood B lymphocytes
Bjørn K. Erikstein, E. Smeland, H. Blomhoff, S. Funderud +3 more
1991European Journal of Immunology73 citations
Semantic Scholar
Tumor necrosis factor alpha induces endothelial galactosyl transferase activity and verocytotoxin receptors. Role of specific tumor necrosis factor receptors and protein kinase C.
NC van de Kar, T. Kooistra, M. Vermeer, W. Lesslauer +2 more
1995Blood68 citations
Semantic Scholar
Tumor Necrosis Factor-a Inhibits Stem Cell Factor-induced Proliferation of Human Bone Marrow Progenitor Cells In Vitro Role of p55 and p75 Tumor Necrosis Factor Receptors
L. Rusten, E. Smeland, F. Jacobsen, Eli Lien +5 more
65 citations
Semantic Scholar
Tumor Necrosis Factor Receptors (Tnfr) in Mouse Fibroblasts Deficient in Tnfr1 or Tnfr2 are Signaling Competent and Activate the Mitogen-activated Protein Kinase Pathway with Differential Kinetics*
A. Kalb, H. Bluethmann, M. Moore, W. Lesslauer
1996Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Tumor necrosis factor-alpha induces activation of coagulation and fibrinolysis in baboons through an exclusive effect on the p55 receptor.
T. van der Poll, P. Jansen, K. Van Zee, M. Welborn +6 more
1996Blood61 citations
Semantic Scholar
RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK).
B. Pierrat, J. S. Correia, J. Mary, M. Tomás-Zuber +1 more
1998Journal of Biological Chemistry54 citations
Semantic Scholar
T90/44 (9.3 antigen). A cell surface molecule with a function in human T cell activation
W. Lesslauer, F. Koning, T. Ottenhoff, M. Giphart +2 more
1986European Journal of Immunology53 citations Open access
Semantic Scholar
Direct determination of the structure of barium stearate multilayers by x-ray diffraction.
W. Lesslauer, J. Blasie
1972Biophysical Journal40 citations Open access
Semantic Scholar
C-terminal Elements Control Location, Activation Threshold, and p38 Docking of Ribosomal S6 Kinase B (RSKB)*
M. Tomás-Zuber, J. Mary, F. Lamour, D. Bur +1 more
2001Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Genomic organization and promoter function of the murine tumor necrosis factor receptor β gene
J. Rothe, H. Bluethmann, R. Gentz, W. Lesslauer +1 more
199338 citations
Semantic Scholar
Some Electrical Properties of Bimolecular Phosphatidyl Inositol Membranes
W. Lesslauer, J. Richter, P. Läuger
1967Nature38 citations
Semantic Scholar
Control Sites of Ribosomal S6 Kinase B and Persistent Activation through Tumor Necrosis Factor*
M. Tomás-Zuber, J. Mary, W. Lesslauer
2000Journal of Biological Chemistry37 citations Open access
Semantic Scholar
A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation.
Ulrike Utans-Schneitz, H. Lorez, W. Klinkert, Jean da Silva +1 more
1998Journal of Neuroimmunology32 citations
Semantic Scholar
X‐ray holographic interferometry in the determination of planar multilayer structures. Theory and experimental observations
W. Lesslauer, J. Blasie
197130 citations
Semantic Scholar
Differential Activities of Secreted Lymphotoxin-α3 and Membrane Lymphotoxin-α1β2 in Lymphotoxin-Induced Inflammation: Critical Role of TNF Receptor 1 Signaling
R. Sacca, C. Cuff, W. Lesslauer, N. Ruddle
1998Journal of Immunology27 citations Open access
Semantic Scholar
Transgenic LacZ under control of Hec-6st regulatory sequences recapitulates endogenous gene expression on high endothelial venules
S. Liao, K. Bentley, Marielle Lebrun, W. Lesslauer +2 more
2007Proceedings of the National Academy of Sciences of the United States of America23 citations Open access
Semantic Scholar
X-ray diffraction from fatty-acid multilayers. Significance of intensity data in low-angle diffraction
W. Lesslauer
197422 citations Open access
Semantic Scholar
Lymphocyte traffic in lymphoid organ neogenesis: differential roles of Ltalpha and LTalphabeta.
Danielle L. Drayton, K. Chan, W. Lesslauer, Jason Lee +2 more
2002Advances in Experimental Medicine and Biology15 citations
Semantic Scholar
Pretreatment with a 55-kDa tumor necrosis factor receptor-immunoglobulin fusion protein attenuates activation of coagulation, but not of fibrinolysis, during lethal bacteremia in baboons.
T. van der Poll, Patty M. Jansen, K. Van Zee, C. Hack +5 more
1997Journal of Infectious Diseases15 citations Open access
Semantic Scholar

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