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A. S. Siebuhr · SciRah

Researcher profile · Semantic Scholar

A. S. Siebuhr

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A. S. Siebuhr — researcher profile on SciRah

h-index: 22
Works: 111
Citations: 2,075

Most-cited papers

The good and the bad collagens of fibrosis – Their role in signaling and organ function
M. Karsdal, S. Nielsen, D. Leeming, L. Langholm +9 more
2017Advanced Drug Delivery Reviews465 citations
Semantic Scholar
Dermal fibroblasts have different extracellular matrix profiles induced by TGF-β, PDGF and IL-6 in a model for skin fibrosis
P. Juhl, Sandie Bondesen, C. Hawkins, M. Karsdal +3 more
2020Scientific Reports135 citations Open access
Semantic Scholar
The active form of MMP-3 is a marker of synovial inflammation and cartilage turnover in inflammatory joint diseases
Shu Sun, A. Bay-Jensen, M. Karsdal, A. S. Siebuhr +4 more
2014BMC Musculoskeletal Disorders129 citations Open access
Semantic Scholar
Association between biomarkers of tissue inflammation and progression of osteoarthritis: evidence from the Rotterdam study cohort
Fatemeh Saberi Hosnijeh, A. S. Siebuhr, A. Uitterlinden, E. Oei +5 more
2016Arthritis Research & Therapy108 citations Open access
Semantic Scholar
Identification and characterisation of osteoarthritis patients with inflammation derived tissue turnover.
A. S. Siebuhr, K. Petersen, L. Arendt-Nielsen, L. Egsgaard +6 more
2014Osteoarthritis and Cartilage107 citations Open access
Semantic Scholar
Association Between Experimental Pain Biomarkers and Serologic Markers in Patients With Different Degrees of Painful Knee Osteoarthritis
L. Arendt-Nielsen, T. Eskehave, L. Egsgaard, K. K. Petersen +6 more
2014Arthritis & Rheumatology92 citations
Semantic Scholar
Type X collagen levels are elevated in serum from human osteoarthritis patients and associated with biomarkers of cartilage degradation and inflammation
Yi He, A. S. Siebuhr, N. Brandt-Hansen, Jian-Xia Wang +9 more
2014BMC Musculoskeletal Disorders84 citations Open access
Semantic Scholar
Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo
D. Reker, C. Kjelgaard-Petersen, A. S. Siebuhr, M. Michaelis +4 more
2017Journal of Translational Medicine60 citations Open access
Semantic Scholar
Biological relevance of citrullinations: diagnostic, prognostic and therapeutic options
N. Gudmann, N. B. Hansen, A. Bay Jensen, M. Karsdal +1 more
2015Autoimmunity56 citations
Semantic Scholar
Sensitization and Serological Biomarkers in Knee Osteoarthritis Patients With Different Degrees of Synovitis
K. Petersen, A. S. Siebuhr, T. Graven-Nielsen, O. Simonsen +5 more
2016The Clinical Journal of Pain50 citations
Semantic Scholar
Synovitis biomarkers: ex vivo characterization of three biomarkers for identification of inflammatory osteoarthritis
C. Kjelgaard-Petersen, A. S. Siebuhr, T. Christiansen, C. Ladel +2 more
2015Biomarkers45 citations Open access
Semantic Scholar
Early changes in blood-based joint tissue destruction biomarkers are predictive of response to tocilizumab in the LITHE study
A. Bay-Jensen, A. Platt, A. S. Siebuhr, C. Christiansen +2 more
2016Arthritis Research & Therapy43 citations Open access
Semantic Scholar
The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo
A. S. Siebuhr, D. Werkmann, A. Bay-Jensen, C. Thudium +5 more
2020International Journal of Molecular Sciences39 citations Open access
Semantic Scholar
Cartilage Turnover Reflected by Metabolic Processing of Type II Collagen: A Novel Marker of Anabolic Function in Chondrocytes
N. Gudmann, Jian-Xia Wang, S. Hoielt, Ping-Pin Chen +5 more
2014International Journal of Molecular Sciences38 citations Open access
Semantic Scholar
Serum biomarkers of collagen turnover as potential diagnostic tools in diffuse systemic sclerosis: A cross-sectional study
P. Juhl, A. Bay-Jensen, M. Karsdal, A. S. Siebuhr +2 more
2018PLoS ONE32 citations Open access
Semantic Scholar
Circulating collagen neo-epitopes and their role in the prediction of fibrosis in patients with systemic sclerosis: a multicentre cohort study.
R. Dobrota, S. Jordan, P. Juhl, B. Maurer +9 more
2021The Lancet Rheumatology27 citations
Semantic Scholar
Sprifermin (rhFGF18) versus vehicle induces a biphasic process of extracellular matrix remodeling in human knee OA articular cartilage ex vivo
D. Reker, A. S. Siebuhr, C. Thudium, T. Gantzel +7 more
2020Scientific Reports26 citations Open access
Semantic Scholar
Chondrocyte activity is increased in psoriatic arthritis and axial spondyloarthritis
N. Gudmann, H. Munk, A. F. Christensen, L. Ejstrup +7 more
2016Arthritis Research & Therapy26 citations Open access
Semantic Scholar
Type IV collagen metabolism is associated with disease activity, radiographic progression and response to tocilizumab in rheumatoid arthritis.
N. Gudmann, P. Junker, P. Juhl, C. Thudium +4 more
2018Clinical and Experimental Rheumatology25 citations
Semantic Scholar
Serological Biomarkers of Joint Tissue Turnover Predict Tocilizumab Response at Baseline
A. Bay-Jensen, I. Byrjalsen, A. S. Siebuhr, C. Christiansen +2 more
2014Journal of clinical rheumatology22 citations Open access
Semantic Scholar
Biomarkers of cartilage and surrounding joint tissue.
A. S. Siebuhr, Yi He, N. Gudmann, A. Gram +4 more
2014Biomarkers in Medicine21 citations
Semantic Scholar
Correlation between serological biomarkers of extracellular matrix turnover and lung fibrosis and pulmonary artery hypertension in patients with systemic sclerosis
S. Kubo, A. S. Siebuhr, A. Bay-Jensen, P. Juhl +6 more
2020International Journal of Rheumatic Diseases19 citations
Semantic Scholar
Metabolites of type I, II, III, and IV collagen may serve as markers of disease activity in axial spondyloarthritis
M. Hušáková, A. Bay-Jensen, Š. Forejtová, K. Zegzulková +7 more
2019Scientific Reports18 citations Open access
Semantic Scholar
Metabolites of C-reactive protein and vimentin are associated with disease activity of axial spondyloarthritis.
A. S. Siebuhr, M. Hušáková, Š. Forejtová, K. Zegzulková +6 more
2019Clinical and Experimental Rheumatology16 citations
Semantic Scholar
Type I and III collagen turnover is increased in axial spondyloarthritis and psoriatic arthritis. Associations with disease activity and diagnostic capacity.
N. Gudmann, A. S. Siebuhr, A. F. Christensen, L. Ejstrup +6 more
2017Clinical and Experimental Rheumatology16 citations
Semantic Scholar
Fibroblasts are not just fibroblasts: clear differences between dermal and pulmonary fibroblasts’ response to fibrotic growth factors
S. F. Madsen, J. Sand, P. Juhl, M. Karsdal +3 more
2023Scientific Reports15 citations Open access
Semantic Scholar
Association of metabolites reflecting type III and VI collagen formation with modified Rodnan skin score in systemic sclerosis – a cross-sectional study
P. Juhl, Line Vinderslev Iversen, T. Karlsmark, Morten Asser Karsdal +3 more
2019Biomarkers15 citations
Semantic Scholar
Citrullinated vimentin and biglycan protein fingerprints as candidate serological biomarkers for disease activity in systemic sclerosis: a pilot study
A. S. Siebuhr, P. Juhl, A. Bay-Jensen, M. Karsdal +2 more
2018Biomarkers15 citations
Semantic Scholar
Connective tissue remodelling is differently modulated by tocilizumab versus methotrexate monotherapy in patients with early rheumatoid arthritis: the AMBITION study
P. Drobinski, A. Bay-Jensen, M. Karsdal, S. Sardar +1 more
2020Arthritis Research & Therapy14 citations Open access
Semantic Scholar
Suppression of active, but not total MMP-3, is associated with treatment response in a phase III clinical study of rheumatoid arthritis.
A. S. Siebuhr, C. Kjelgaard-Petersen, Shu Sun, I. Byrjalsen +3 more
2018Clinical and Experimental Rheumatology14 citations
Semantic Scholar
IL-6 receptor inhibition modulates type III collagen and C-reactive protein degradation in rheumatoid arthritis patients with an inadequate response to anti-tumour necrosis factor therapy: analysis of connective tissue turnover in the tocilizumab RADIATE study.
P. Juhl, C. Thudium, N. Gudmann, M. Karsdal +2 more
2018Clinical and Experimental Rheumatology14 citations
Semantic Scholar
Type III, IV, and VI Collagens Turnover in Systemic Sclerosis – a Longitudinal Study
P. Juhl, A. Bay-Jensen, R. Hesselstrand, A. S. Siebuhr +1 more
2020Scientific Reports13 citations Open access
Semantic Scholar
Association between biochemical cartilage markers and clinical symptoms in patients with hip osteoarthritis: cohort study with 2-year follow-up.
D. Dorleijn, P. Luijsterburg, A. Bay-Jensen, A. S. Siebuhr +4 more
2014Osteoarthritis and Cartilage13 citations Open access
Semantic Scholar
Cartilage collagen type II seromarker patterns in axial spondyloarthritis and psoriatic arthritis: associations with disease activity, smoking and HLA-B27
H. Munk, N. Gudmann, A. F. Christensen, L. Ejstrup +5 more
2016Rheumatology International12 citations
Semantic Scholar
CRP and a biomarker of type I collagen degradation, C1M, can differentiate anti-inflammatory treatment response in ankylosing spondylitis.
A. S. Siebuhr, A. Bay-Jensen, M. Karsdal, R. Lories +1 more
2016Biomarkers in Medicine12 citations
Semantic Scholar
Effect of n-3 PUFA on extracellular matrix protein turnover in patients with psoriatic arthritis: a randomized, double-blind, placebo-controlled trial
S. Holm Nielsen, S. Sardar, A. S. Siebuhr, A. Schlemmer +5 more
2021Rheumatology International11 citations Open access
Semantic Scholar
The anti-ADAMTS-5 nanobody®, M6495, protects against cartilage breakdown in cartilage and synovial joint tissue explant models
A. S. Siebuhr, A. Bay-Jensen, C. Thudium, M. Karsdal +5 more
201811 citations Open access
Semantic Scholar
Development of a Neo-Epitope Specific Assay for Serological Assessment of Type VII Collagen Turnover and Its Relevance in Fibroproliferative Disorders
J. Sand, P. Lamy, P. Juhl, A. S. Siebuhr +8 more
2018Assay and drug development technologies11 citations
Semantic Scholar
Is radiographic progression in radiographic axial spondyloarthritis related to matrix metalloproteinase degradation of extracellular matrix?
A. S. Siebuhr, D. M. van der Heijde, A. Bay-Jensen, M. Karsdal +3 more
2018RMD Open10 citations Open access
Semantic Scholar
Objective and noninvasive biochemical markers in rheumatoid arthritis: where are we and where are we going?
A. Bay-Jensen, A. S. Siebuhr, D. Damgaard, P. Drobinski +3 more
2021Espert Review of Proteomics8 citations
Semantic Scholar
Changes of patient-reported outcomes and protein fingerprint biomarkers after exercise therapy for axial spondyloarthritis
M. Hušáková, A. S. Siebuhr, K. Pavelka, M. Špiritović +2 more
2017Clinical Rheumatology8 citations
Semantic Scholar
Dysregulation of circulating collagen turnover markers in very early systemic sclerosis
R. Dobrota, S. Jordan, P. Juhl, N. Del Papa +7 more
2024RMD Open6 citations Open access
Semantic Scholar
Pharmacokinetic and pharmacodynamic modelling of the novel anti-ADAMTS-5 nanobody M6495 using the neo-epitope ARGS as a biomarker
J. Pereira, I. Ottevaere, B. Serruys, E. Dejonckheere +5 more
20186 citations Open access
Semantic Scholar
Intercritical circulating levels of neo-epitopes reflecting matrixmetalloprotease-driven degradation as markers of gout and frequent gout attacks.
A. Valdes, T. Manon-Jensen, A. Abhishek, Wendy D. Jenkins +7 more
2016Rheumatology6 citations
Semantic Scholar
Development of a highly sensitive chemiluminescence immunoassay for quantification of aggrecanase-generated ARGS aggrecan fragments in serum
Yi He, Kamilla E. Jensen, A. S. Siebuhr, M. Karsdal +2 more
2021Osteoarthritis and Cartilage Open5 citations Open access
Semantic Scholar
Elevated levels of CRPM, an inflammatory biomarker correlating with disease activity in RA, are prognostic of radiographic knee OA
A. Bay-Jensen, A. Bihlet, I. Byrjalsen, J. R. Andersen +9 more
20175 citations Open access
Semantic Scholar
AB0167 TOFACITINIB AND NINTEDANIB MODULATE COLLAGEN FORMATION IN DERMAL FIBROBLASTS
A. S. Siebuhr, M. Karsdal, P. Juhl, A. Bay-Jensen
2020Annals of the Rheumatic Diseases2 citations Open access
Semantic Scholar
Establishment of a Human Synovium and Cartilage Co-Culture
C. Kjelgaard-Petersen, A. Bay-Jensen, T. Christiansen, M. Karsdal +3 more
20172 citations Open access
Semantic Scholar
Chapter 31 – Structural Biomarkers
A. Bay-Jensen, J. Sand, F. Genovese, A. S. Siebuhr +4 more
20162 citations
Semantic Scholar
AB0086 PTH Stimulates Cartilage Formation in Low Turnover Patients – a Possible Systemic Anabolic Treatment for OA?
A. S. Siebuhr, N. Gudmann, K. Musa, Stephanie Nina Kehlet +8 more
20152 citations
Semantic Scholar

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