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C. Ladel · SciRah

Researcher profile · Semantic Scholar

C. Ladel

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C. Ladel — researcher profile on SciRah

h-index: 38
Works: 117
Citations: 5,124

Most-cited papers

Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
Heike Brötz-Oesterhelt, D. Beyer, H. Kroll, R. Endermann +9 more
2005Nature Medicine496 citations
Semantic Scholar
Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location.
J. Hess, C. Ladel, D. Miko, Stefan H. E. Kaufmann
1996Journal of Immunology437 citations Open access
Semantic Scholar
Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis.
J. Hess, I. Gentschev, D. Miko, Manuela Welzel +3 more
1996Proceedings of the National Academy of Sciences of the United States of America229 citations Open access
Semantic Scholar
The OMERACT-OARSI Core Domain Set for Measurement in Clinical Trials of Hip and/or Knee Osteoarthritis
Toby O. Smith, G. Hawker, D. Hunter, L. March +24 more
2019Journal of Rheumatology168 citations Open access
Semantic Scholar
Osteoarthritis--a case for personalized health care?
M. Karsdal, C. Christiansen, C. Ladel, K. Henriksen +2 more
2014Osteoarthritis and Cartilage161 citations Open access
Semantic Scholar
Osteoarthritis endotype discovery via clustering of biochemical marker data
F. Angelini, P. Widera, A. Mobasheri, J. Blair +12 more
2022Annals of the Rheumatic Diseases147 citations Open access
Semantic Scholar
Contribution of α/β and γ/δ T lymphocytes to immunity against Mycobacterium bovis Bacillus Calmette Guérin: studies with T cell receptor‐deficient mutant mice
C. Ladel, J. Hess, S. Daugelat, P. Mombaerts +2 more
1995131 citations
Semantic Scholar
Control of natural killer cell-mediated innate resistance against the intracellular pathogen Listeria monocytogenes by gamma/delta T lymphocytes
C. Ladel, Carmen Blum, S. H. Kaufmann
1996Infection and Immunity123 citations Open access
Semantic Scholar
Interleukin-12 secretion by Mycobacterium tuberculosis-infected macrophages
C. Ladel, Gudrun Szalay, Detlev D. Riedel, Stefan H. E. Kaufmann
1997Infection and Immunity115 citations Open access
Semantic Scholar
Long-term structural and symptomatic effects of intra-articular sprifermin in patients with knee osteoarthritis: 5-year results from the FORWARD study
F. Eckstein, M. Hochberg, H. Guehring, F. Moreau +9 more
2021Annals of the Rheumatic Diseases102 citations Open access
Semantic Scholar
Cutting edge: anti-CD1 monoclonal antibody treatment reverses the production patterns of TGF-beta 2 and Th1 cytokines and ameliorates listeriosis in mice.
Gudrun Szalay, C. Ladel, Carmen Blum, L. Brossay +2 more
1999Journal of Immunology91 citations
Semantic Scholar
Cohort profile: The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers
E. V. van Helvoort, W. V. van Spil, M. Jansen, P. Welsing +16 more
2020BMJ Open72 citations Open access
Semantic Scholar
Identification of Fibroblast Growth Factor-18 as a Molecule to Protect Adult Articular Cartilage by Gene Expression Profiling*
Yoshifumi Mori, Taku Saito, Song-Ho Chang, Hiroshi Kobayashi +4 more
2014Journal of Biological Chemistry72 citations Open access
Semantic Scholar
Protective role of gamma/delta T cells and alpha/beta T cells in tuberculosis.
C. Ladel, C. Blum, A. Dreher, K. Reifenberg +1 more
1995European Journal of Immunology70 citations
Semantic Scholar
Multi-classifier prediction of knee osteoarthritis progression from incomplete imbalanced longitudinal data
P. Widera, P. Welsing, C. Ladel, J. Loughlin +6 more
2019Scientific Reports64 citations Open access
Semantic Scholar
Protection against murine tuberculosis by an attenuated recombinant Salmonella typhimurium vaccine strain that secretes the 30-kDa antigen of Mycobacterium bovis BCG.
JÃ¼rgen Hess, L. Grode, J. Hellwig, Peter Conradt +4 more
2000FEMS Immunology & Medical Microbiology64 citations
Semantic Scholar
A first-in-human, double-blind, randomised, placebo-controlled, dose ascending study of intra-articular rhFGF18 (sprifermin) in patients with advanced knee osteoarthritis.
L. Dahlberg, A. Aydemir, N. Muurahainen, H. Gühring +4 more
2016Clinical and Experimental Rheumatology62 citations
Semantic Scholar
IL-4 neutralization or TNF-alpha treatment ameliorate disease by an intracellular pathogen in IFN-gamma receptor-deficient mice.
Gudrun Szalay, C. Ladel, Carmen Blum, S. H. Kaufmann
1996Journal of Immunology62 citations Open access
Semantic Scholar
Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo
D. Reker, C. Kjelgaard-Petersen, A. S. Siebuhr, M. Michaelis +4 more
2017Journal of Translational Medicine60 citations Open access
Semantic Scholar
Role of signaling pathways in age-related orthopedic diseases: focus on the fibroblast growth factor family
Heng-Zhen Li, Jinglve Zhang, Dong‐liang Yuan, Wen-Qing Xie +3 more
2024Military Medical Research57 citations Open access
Semantic Scholar
A consensus-based framework for conducting and reporting osteoarthritis phenotype research
W. V. van Spil, S. Bierma-Zeinstra, L. Deveza, N. Arden +21 more
2020Arthritis Research & Therapy56 citations Open access
Semantic Scholar
Trajectory of Cartilage Loss within Four Years of Knee Replacement
F. Eckstein, R. Boudreau, Zhi-Jie Wang, M. Hannon +10 more
2013Osteoarthritis and Cartilage51 citations Open access
Semantic Scholar
The effects of sprifermin on symptoms and structure in a subgroup at risk of progression in the FORWARD knee osteoarthritis trial.
H. Guehring, F. Moreau, B. Daelken, C. Ladel +6 more
2021Seminars in Arthritis & Rheumatism50 citations Open access
Semantic Scholar
A Novel High Sensitivity Type II Collagen Blood-Based Biomarker, PRO-C2, for Assessment of Cartilage Formation
Yunyun Luo, Yi He, D. Reker, N. Gudmann +7 more
2018International Journal of Molecular Sciences48 citations Open access
Semantic Scholar
Participation of group 2 CD1 molecules in the control of murine tuberculosis.
G. Szalay, Ulrich Zügel, C. Ladel, Stefan H. E. Kaufmann
1999Microbes and infection47 citations Open access
Semantic Scholar
Synovitis biomarkers: ex vivo characterization of three biomarkers for identification of inflammatory osteoarthritis
C. Kjelgaard-Petersen, A. S. Siebuhr, T. Christiansen, C. Ladel +2 more
2015Biomarkers45 citations Open access
Semantic Scholar
Comparison of Radiographic Joint Space Width and Magnetic-Resonance-Imaging for Prediction of Knee Replacement – A Longitudinal Case-Control Study from the Osteoarthritis Initiative
F. Eckstein, R. Boudreau, Zhi-Jie Wang, M. Hannon +11 more
2015European Radiology43 citations Open access
Semantic Scholar
From biochemical markers to molecular endotypes of osteoarthritis: a review on validated biomarkers
M. Hannani, C. Thudium, M. Karsdal, C. Ladel +6 more
2024Expert Review of Molecular Diagnostics42 citations Open access
Semantic Scholar
The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo
A. S. Siebuhr, D. Werkmann, A. Bay-Jensen, C. Thudium +5 more
2020International Journal of Molecular Sciences39 citations Open access
Semantic Scholar
Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors.
N. Sharma, P. Drobinski, A. Kayed, Zhi-Zhong Chen +8 more
2019Osteoarthritis and Cartilage38 citations Open access
Semantic Scholar
Neuropathic pain in the IMI-APPROACH knee osteoarthritis cohort: prevalence and phenotyping
E. V. van Helvoort, P. Welsing, M. Jansen, W. Gielis +15 more
2021RMD Open35 citations Open access
Semantic Scholar
Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis
A. Bay-Jensen, A. Bihlet, I. Byrjalsen, J. R. Andersen +6 more
2021Scientific Reports34 citations Open access
Semantic Scholar
Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies
P. Haselmayer, M. Camps, Mathilde Muzerelle, S. el Bawab +16 more
2014Frontiers in Immunology34 citations Open access
Semantic Scholar
THE ASSOCIATION BETWEEN BIOCHEMICAL MARKERS OF BONE TURNOVER AND BONE CHANGES ON IMAGING – DATA FROM THE OSTEOARTHRITIS INITIATIVE
L. Deveza, V. Kraus, J. Collins, A. Guermazi +5 more
2017Arthritis care & research31 citations Open access
Semantic Scholar
Quantitative measurement of cartilage morphology in osteoarthritis: current knowledge and future directions
W. Wirth, C. Ladel, S. Maschek, A. Wisser +2 more
2022Skeletal Radiology29 citations Open access
Semantic Scholar
Uptake of the OMERACT-OARSI Hip and Knee Osteoarthritis Core Outcome Set: Review of Randomized Controlled Trials from 1997 to 2017
Toby O. Smith, M. Mansfield, G. Hawker, D. Hunter +24 more
2019Journal of Rheumatology28 citations Open access
Semantic Scholar
Animal Models of Osteoarthritis Part 1–Preclinical Small Animal Models: Challenges and Opportunities for Drug Development
Jaqueline Lourdes Rios, Dora Sapède, F. Djouad, Anna E. Rapp +4 more
2022Current Protocols27 citations Open access
Semantic Scholar
Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort
F. Roemer, M. Jansen, A. C. Marijnissen, A. Guermazi +15 more
2022BMC Musculoskeletal Disorders26 citations Open access
Semantic Scholar
The inflammatory endotype in osteoarthritis: Reflections from the 2024 OARSI clinical trials symposium (CTS) with a special emphasis on feasibility for clinical development
M. Karsdal, Lucio C. Rovati, J. Tambiah, Olga Kubassova +7 more
2025Osteoarthritis and Cartilage Open25 citations Open access
Semantic Scholar
Rates and Sensitivity of Knee Cartilage Thickness Loss in Specific Central Reading Radiographic Strata from the Osteoarthritis Initiative
S. Maschek, W. Wirth, C. Ladel, M. L. le Graverand +1 more
2014Osteoarthritis and Cartilage25 citations Open access
Semantic Scholar
Osteoarthritis and Cartilage, brief report Automated MRI assessment confirms cartilage thickness modification in patients with knee osteoarthritis: post-hoc analysis from a phase II sprifermin study.
A. Brett, Michael A. Bowes, P. Conaghan, C. Ladel +3 more
2020Osteoarthritis and Cartilage23 citations Open access
Semantic Scholar
Protein p60 participates in intestinal host invasion by Listeria monocytogenes.
J. Hess, A. Dreher, Ivo Gentschev, Werner Goebel +3 more
1996Zentralblatt fur Bakteriologie : international journal of medical microbiology22 citations
Semantic Scholar
Low levels of type II collagen formation (PRO-C2) are associated with response to sprifermin: A pre-defined, exploratory biomarker analysis from the FORWARD study.
A. Bay-Jensen, Angela A. Manginelli, M. Karsdal, Yunyun Luo +4 more
2021Osteoarthritis and Cartilage21 citations Open access
Semantic Scholar
Biological Characterization of Novel Inhibitors of the Gram-Positive DNA Polymerase IIIC Enzyme
A. Kuhl, N. Svenstrup, C. Ladel, M. Otteneder +8 more
2005Antimicrobial Agents and Chemotherapy21 citations Open access
Semantic Scholar
Test-retest precision and longitudinal cartilage thickness loss in the IMI-APPROACH cohort.
W. Wirth, S. Maschek, A. C. Marijnissen, A. Lalande +13 more
2022Osteoarthritis and Cartilage20 citations Open access
Semantic Scholar
Pharmacologic P2X purinergic receptor antagonism in the treatment of collagen-induced arthritis.
V. Ardissone, E. Radaelli, P. Zaratin, M. Ardizzone +5 more
2011Arthritis & Rheumatism20 citations Open access
Semantic Scholar
Safety, Tolerability, and Pharmacodynamics of the ADAMTS‐5 Nanobody M6495: Two Phase 1, Single‐Center, Double‐Blind, Randomized, Placebo‐Controlled Studies in Healthy Subjects and Patients With Osteoarthritis
A. Bihlet, T. Balchen, K. Goteti, J. Sonne +7 more
2024ACR Open Rheumatology19 citations Open access
Semantic Scholar
Making the patient voice heard in a research consortium: experiences from an EU project (IMI-APPROACH)
Jane Taylor, Sjouke Dekker, Diny Jurg, J. Skandsen +8 more
2021Research Involvement and Engagement19 citations Open access
Semantic Scholar
Longitudinal stability of molecular endotypes of knee osteoarthritis patients.
M. Hannani, C. Thudium, A. Gellhorn, J. Larkin +16 more
2024Osteoarthritis and Cartilage18 citations Open access
Semantic Scholar
FGF18 augments osseointegration of intra-medullary implants in osteopenic FGFR3(-/-) mice.
A. Carli, Chan Gao, M. Khayyat-Kholghi, A. Li +4 more
2012European Cells & Materials17 citations Open access
Semantic Scholar

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A. Mobasheri×8
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I. Haugen — researcher profile on SciRah

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