T. Darton

Most-cited papers

1. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

   M. Voysey, S. A. Clemens, S. Madhi, L. Weckx +78 more

   2020The Lancet4,062 citations Open access

   Semantic Scholar

   Save

2. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

   Obbina Ali Fatima Mustafa Sadia Hakam Alfie Nabeel Ashraf Abani Abbas Abbas Abbas Abbasi Abbass Abbott Abdal, O. Abani, A. Abbas, F. Abbas +496 more

   2021The Lancet1,685 citations Open access

   Semantic Scholar

   Save

3. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

   M. Voysey, S. A. Costa Clemens, S. Madhi, L. Weckx +76 more

   2021The Lancet1,060 citations Open access

   Semantic Scholar

   Save

4. Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial

   Katherine Emary, T. Golubchik, P. Aley, C. Ariani +60 more

   2021The Lancet474 citations Open access

   Semantic Scholar

   Save

5. Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

   Eugenia Mustafa Sadia Alfie Ashraf Sherif Mohamed Basir Al Abaleke Abbas Abbasi Abbott Abdelaziz Abdelbadiee , E. Abaleke, M. Abbas, Sadia Abbasi +496 more

   2021The Lancet289 citations Open access

   Semantic Scholar

   Save

6. Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)

   A. Flaxman, N. Marchevsky, D. Jenkin, Jeremy Aboagye +183 more

   2021The Lancet217 citations Open access

   Semantic Scholar

   Save

7. Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial

   Arabella S. V. Stuart, Robert Shaw, Xin-Xue Liu, M. Greenland +39 more

   2021The Lancet187 citations Open access

   Semantic Scholar

   Save

8. Design, recruitment, and microbiological considerations in human challenge studies.

   T. Darton, Christoph J. Blohmke, V. Moorthy, D. Altmann +5 more

   2015Lancet. Infectious Diseases (Print)124 citations

   Semantic Scholar

   Save

9. Ethics of controlled human infection to address COVID-19

   Seema K. Shah, F. Miller, T. Darton, Devan M. Duenas +18 more

   2020Science106 citations

   Semantic Scholar

   Save

10. Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial

    O. A. F. J. K. M. S. H. A. Abani Abbas Abbas Abbas Abbas Abbas Abbasi Abbass, O. Abani, A. Abbas, F. Abbas +496 more

    2023The Lancet103 citations Open access

    Semantic Scholar

    Save

11. Burden of enteric fever at three urban sites in Africa and Asia: a multicentre population-based study

    J. Meiring, M. Shakya, F. Khanam, M. Voysey +19 more

    2021Lancet Global Health86 citations Open access

    Semantic Scholar

    Save

12. Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection

    A. Mentzer, D. O'Connor, S. Bibi, I. Chelysheva +65 more

    2022Nature Medicine84 citations Open access

    Semantic Scholar

    Save

13. Evaluation of the Clinical and Microbiological Response to Salmonella Paratyphi A Infection in the First Paratyphoid Human Challenge Model

    H. Dobinson, M. Gibani, Claire Jones, H. Thomaides-Brears +20 more

    2017Clinical Infectious Diseases77 citations Open access

    Semantic Scholar

    Save

14. Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a

    T. Darton, Claire Jones, Christoph J. Blohmke, C. Waddington +19 more

    2016PLoS Neglected Tropical Diseases76 citations Open access

    Semantic Scholar

    Save

15. Efficacy of ChAdOx1 nCoV-19 (AZD1222) Vaccine Against SARS-CoV-2 VOC 202012/01 (B.1.1.7)

    Katherine Emary, T. Golubchik, P. Aley, C. Ariani +61 more

    2021Social Science Research Network72 citations Open access

    Semantic Scholar

    Save

16. The STRATAA study protocol: a programme to assess the burden of enteric fever in Bangladesh, Malawi and Nepal using prospective population census, passive surveillance, serological studies and healthcare utilisation surveys

    T. Darton, J. Meiring, S. Tonks, Md Arifuzzaman Khan +16 more

    2017BMJ Open68 citations Open access

    Semantic Scholar

    Save

17. Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial

    K. Hardt, A. Vandebosch, J. Sadoff, Mathieu le Gars +284 more

    2022Lancet. Infectious Diseases (Print)65 citations Open access

    Semantic Scholar

    Save

18. Challenge of Humans with Wild-type Salmonella enterica Serovar Typhi Elicits Changes in the Activation and Homing Characteristics of Mucosal-Associated Invariant T Cells

    R. Salerno-Gonçalves, David Luo, S. Fresnay, L. Magder +8 more

    2017Frontiers in Immunology64 citations Open access

    Semantic Scholar

    Save

19. Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans

    S. Fresnay, Monica A. McArthur, L. Magder, T. Darton +7 more

    2016Journal of Translational Medicine64 citations Open access

    Semantic Scholar

    Save

20. A 23-year retrospective investigation of Salmonella Typhi and Salmonella Paratyphi isolated in a tertiary Kathmandu hospital

    Raphaël M. Zellweger, B. Basnyat, P. Shrestha, Krishna G. Prajapati +9 more

    2017PLoS Neglected Tropical Diseases57 citations Open access

    Semantic Scholar

    Save

21. Activation of Salmonella Typhi-Specific Regulatory T Cells in Typhoid Disease in a Wild-Type S. Typhi Challenge Model

    Monica A. McArthur, S. Fresnay, L. Magder, T. Darton +8 more

    2015PLoS Pathogens53 citations Open access

    Semantic Scholar

    Save

22. Treatment Response in Enteric Fever in an Era of Increasing Antimicrobial Resistance: An Individual Patient Data Analysis of 2092 Participants Enrolled into 4 Randomized, Controlled Trials in Nepal

    C. Thompson, A. Karkey, S. Dongol, A. Arjyal +7 more

    2017Clinical Infectious Diseases49 citations Open access

    Semantic Scholar

    Save

23. Azithromycin Resistance in Shigella spp. in Southeast Asia

    T. Darton, H. T. Tuyen, Hao Chung The, P. Newton +9 more

    2018Antimicrobial Agents and Chemotherapy46 citations Open access

    Semantic Scholar

    Save

24. Interferon-driven alterations of the host’s amino acid metabolism in the pathogenesis of typhoid fever

    Christoph J. Blohmke, T. Darton, Claire Jones, N. Suárez +23 more

    2016Journal of Experimental Medicine46 citations Open access

    Semantic Scholar

    Save

25. Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans

    T. Darton, Christoph J. Blohmke, E. Giannoulatou, C. Waddington +6 more

    2015PLoS Neglected Tropical Diseases46 citations Open access

    Semantic Scholar

    Save

26. Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia

    T. Darton, Liqing Zhou, Christoph J. Blohmke, Claire Jones +3 more

    2017Journal of Infection43 citations Open access

    Semantic Scholar

    Save

27. Identification of Novel Serodiagnostic Signatures of Typhoid Fever Using a Salmonella Proteome Array

    T. Darton, S. Baker, A. Randall, S. Dongol +17 more

    2017Frontiers in Microbiology37 citations Open access

    Semantic Scholar

    Save

28. Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins

    R. Kuehn, N. Stoesser, D. Eyre, T. Darton +2 more

    2022Cochrane Database of Systematic Reviews36 citations Open access

    Semantic Scholar

    Save

29. The serodominant secreted effector protein of Salmonella, SseB, is a strong CD4 antigen containing an immunodominant epitope presented by diverse HLA class II alleles

    C. Reynolds, Claire Jones, Christoph J. Blohmke, T. Darton +6 more

    2014Immunology36 citations Open access

    Semantic Scholar

    Save

30. (2021). Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. The Lancet, 397(10269), 99-111.

    S. C. Clemens, S. Madhi, L. Weckx, P. Folegatti +59 more

    202035 citations

    Semantic Scholar

    Save

31. Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model

    S. Fresnay, Monica A. McArthur, L. Magder, T. Darton +7 more

    2017Frontiers in Immunology34 citations Open access

    Semantic Scholar

    Save

32. Promoting Ethical Payment in Human Infection Challenge Studies

    H. Lynch, T. Darton, Jae Levy, F. McCormick +6 more

    2021American Journal of Bioethics33 citations Open access

    Semantic Scholar

    Save

33. Homologous and heterologous re-challenge with Salmonella Typhi and Salmonella Paratyphi A in a randomised controlled human infection model

    M. Gibani, C. Jin, Sonu Shrestha, M. Moore +21 more

    2020PLoS Neglected Tropical Diseases33 citations Open access

    Semantic Scholar

    Save

34. The Impact of Vaccination and Prior Exposure on Stool Shedding of Salmonella Typhi and Salmonella Paratyphi in 6 Controlled Human Infection Studies

    M. Gibani, M. Voysey, C. Jin, Claire Jones +12 more

    2018Clinical Infectious Diseases30 citations Open access

    Semantic Scholar

    Save

35. Current challenges and possible solutions to improve access to care and treatment for hepatitis C infection in Vietnam: a systematic review

    A. Berto, J. Day, Chau van Vinh Nguyen, G. Thwaites +3 more

    2017BMC Infectious Diseases30 citations Open access

    Semantic Scholar

    Save

36. Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease

    F. Toapanta, P. Bernal, S. Fresnay, T. Darton +8 more

    2015PLoS Neglected Tropical Diseases30 citations Open access

    Semantic Scholar

    Save

37. Compositional and Functional Differences in the Human Gut Microbiome Correlate with Clinical Outcome following Infection with Wild-Type Salmonella enterica Serovar Typhi

    Yan Zhang, Arthur Brady, Cheron Jones, Yang Song +8 more

    2018mBio28 citations Open access

    Semantic Scholar

    Save

38. Evaluating use cases for human challenge trials in accelerating SARS-CoV-2 vaccine development

    Linh Chi Nguyen, Christopher W. Bakerlee, T. McKelvey, Sophie M Rose +10 more

    2020Clinical Infectious Diseases27 citations Open access

    Semantic Scholar

    Save

39. Diagnostic host gene signature for distinguishing enteric fever from other febrile diseases

    Christoph J. Blohmke, Julius Muller, M. Gibani, H. Dobinson +14 more

    2019EMBO Molecular Medicine25 citations Open access

    Semantic Scholar

    Save

40. Salmonella Typhi Bactericidal Antibodies Reduce Disease Severity but Do Not Protect against Typhoid Fever in a Controlled Human Infection Model

    H. Juel, H. Thomaides-Brears, T. Darton, Claire Jones +11 more

    2018Frontiers in Immunology25 citations Open access

    Semantic Scholar

    Save

41. Understanding paratyphoid infection: study protocol for the development of a human model of Salmonella enterica serovar Paratyphi A challenge in healthy adult volunteers

    David J. McCullagh, H. Dobinson, T. Darton, Danielle Campbell +9 more

    2015BMJ Open25 citations Open access

    Semantic Scholar

    Save

42. Changing Antimicrobial Resistance Trends in Kathmandu, Nepal: A 23-Year Retrospective Analysis of Bacteraemia

    Raphaël M. Zellweger, B. Basnyat, P. Shrestha, Krishna G. Prajapati +9 more

    2018Frontiers in Medicine22 citations Open access

    Semantic Scholar

    Save

43. Tourniquet Test for Dengue Diagnosis: Systematic Review and Meta-analysis of Diagnostic Test Accuracy

    A. J. Grande, Hamish Reid, E. Thomas, C. Foster +1 more

    2016PLoS Neglected Tropical Diseases22 citations Open access

    Semantic Scholar

    Save

44. Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children’s hospital

    N. D. Toan, T. Darton, N. T. Huong, L. T. H. Nhat +16 more

    2022PLOS Global Public Health21 citations Open access

    Semantic Scholar

    Save

45. Characterizing altruistic motivation in potential volunteers for SARS-CoV-2 challenge trials

    Sophie M Rose, V. Schmit, T. Darton, N. Eyal +5 more

    2021medRxiv18 citations Open access

    Semantic Scholar

    Save

46. T-cell mediated immunity after AZD1222 vaccination: A polyfunctional spike-specific Th1 response with a diverse TCR repertoire

    Phillip A. Swanson, M. Padilla, W. Hoyland, K. McGlinchey +61 more

    2021medRxiv18 citations Open access

    Semantic Scholar

    Save

47. Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust

    D. Hodgson, H. Colton, Hailey R. Hornsby, Rebecca Brown +19 more

    2021medRxiv18 citations Open access

    Semantic Scholar

    Save

48. Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease

    F. Toapanta, P. Bernal, S. Fresnay, L. Magder +8 more

    2016PLoS Neglected Tropical Diseases17 citations Open access

    Semantic Scholar

    Save

49. The Current Status of Enteric Fever Diagnostics and Implications for Disease Control

    S. Baker, Christoph J. Blohmke, M. Maes, Peter I Johnston +1 more

    2020Clinical Infectious Diseases16 citations Open access

    Semantic Scholar

    Save

50. Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study

    Z. Dyson, P. M. Ashton, F. Khanam, Angeziwa Chunga Chirambo +38 more

    2024The Lancet Microbe15 citations Open access

    Semantic Scholar

    Save