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Christoph J. Blohmke · SciRah

Researcher profile · Semantic Scholar

Christoph J. Blohmke

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Christoph J. Blohmke — researcher profile on SciRah

h-index: 26
Works: 63
Citations: 2,035

Most-cited papers

Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial
C. Jin, M. Gibani, M. Moore, H. Juel +12 more
2017The Lancet300 citations Open access
Semantic Scholar
Design, recruitment, and microbiological considerations in human challenge studies.
T. Darton, Christoph J. Blohmke, V. Moorthy, D. Altmann +5 more
2015Lancet. Infectious Diseases (Print)124 citations
Semantic Scholar
Structural and Functional Characterization of Falcipain-2, a Hemoglobinase from the Malarial Parasite Plasmodium falciparum*
T. Hogg, K. Nagarajan, S. Herzberg, Li-li Chen +6 more
2006Journal of Biological Chemistry112 citations Open access
Semantic Scholar
An Appraisal of the Clinical Features of Pediatric Enteric Fever: Systematic Review and Meta-analysis of the Age-Stratified Disease Occurrence
Carl D. Britto, A. Pollard, M. Voysey, Christoph J. Blohmke
2017Clinical Infectious Diseases82 citations Open access
Semantic Scholar
Rescue of Dysfunctional Autophagy Attenuates Hyperinflammatory Responses from Cystic Fibrosis Cells
M. Mayer, Christoph J. Blohmke, R. Falsafi, C. Fjell +3 more
2013Journal of Immunology82 citations Open access
Semantic Scholar
TLR5 as an Anti-Inflammatory Target and Modifier Gene in Cystic Fibrosis
Christoph J. Blohmke, Julie E. Park, A. Hirschfeld, Rachel E. Victor +10 more
2010Journal of Immunology80 citations Open access
Semantic Scholar
Evaluation of the Clinical and Microbiological Response to Salmonella Paratyphi A Infection in the First Paratyphoid Human Challenge Model
H. Dobinson, M. Gibani, Claire Jones, H. Thomaides-Brears +20 more
2017Clinical Infectious Diseases77 citations Open access
Semantic Scholar
Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a
T. Darton, Claire Jones, Christoph J. Blohmke, C. Waddington +19 more
2016PLoS Neglected Tropical Diseases76 citations Open access
Semantic Scholar
Atypical Activation of the Unfolded Protein Response in Cystic Fibrosis Airway Cells Contributes to p38 MAPK-Mediated Innate Immune Responses
Christoph J. Blohmke, M. Mayer, A. Tang, A. Hirschfeld +9 more
2012Journal of Immunology69 citations Open access
Semantic Scholar
The Pseudomonas aeruginosa Autoinducer 3O-C12 Homoserine Lactone Provokes Hyperinflammatory Responses from Cystic Fibrosis Airway Epithelial Cells
M. Mayer, Jared A. Sheridan, Christoph J. Blohmke, S. Turvey +1 more
2011PLoS ONE69 citations Open access
Semantic Scholar
Challenge of Humans with Wild-type Salmonella enterica Serovar Typhi Elicits Changes in the Activation and Homing Characteristics of Mucosal-Associated Invariant T Cells
R. Salerno-Gonçalves, David Luo, S. Fresnay, L. Magder +8 more
2017Frontiers in Immunology64 citations Open access
Semantic Scholar
Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans
S. Fresnay, Monica A. McArthur, L. Magder, T. Darton +7 more
2016Journal of Translational Medicine64 citations Open access
Semantic Scholar
Typhoid epidemiology, diagnostics and the human challenge model
T. Darton, Christoph J. Blohmke, A. Pollard
2014Current Opinion in Gastroenterology56 citations
Semantic Scholar
Activation of Salmonella Typhi-Specific Regulatory T Cells in Typhoid Disease in a Wild-Type S. Typhi Challenge Model
Monica A. McArthur, S. Fresnay, L. Magder, T. Darton +8 more
2015PLoS Pathogens53 citations Open access
Semantic Scholar
Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model
M. Gibani, E. Jones, Amber J. Barton, C. Jin +23 more
2019Nature Medicine47 citations Open access
Semantic Scholar
Interferon-driven alterations of the host’s amino acid metabolism in the pathogenesis of typhoid fever
Christoph J. Blohmke, T. Darton, Claire Jones, N. Suárez +23 more
2016Journal of Experimental Medicine46 citations Open access
Semantic Scholar
Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans
T. Darton, Christoph J. Blohmke, E. Giannoulatou, C. Waddington +6 more
2015PLoS Neglected Tropical Diseases46 citations Open access
Semantic Scholar
Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia
T. Darton, Liqing Zhou, Christoph J. Blohmke, Claire Jones +3 more
2017Journal of Infection43 citations Open access
Semantic Scholar
Identification of Novel Serodiagnostic Signatures of Typhoid Fever Using a Salmonella Proteome Array
T. Darton, S. Baker, A. Randall, S. Dongol +17 more
2017Frontiers in Microbiology37 citations Open access
Semantic Scholar
The serodominant secreted effector protein of Salmonella, SseB, is a strong CD4 antigen containing an immunodominant epitope presented by diverse HLA class II alleles
C. Reynolds, Claire Jones, Christoph J. Blohmke, T. Darton +6 more
2014Immunology36 citations Open access
Semantic Scholar
Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model
S. Fresnay, Monica A. McArthur, L. Magder, T. Darton +7 more
2017Frontiers in Immunology34 citations Open access
Semantic Scholar
Homologous and heterologous re-challenge with Salmonella Typhi and Salmonella Paratyphi A in a randomised controlled human infection model
M. Gibani, C. Jin, Sonu Shrestha, M. Moore +21 more
2020PLoS Neglected Tropical Diseases33 citations Open access
Semantic Scholar
Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses
G. Napolitani, Prathiba Kurupati, K. Teng, M. Gibani +26 more
2018Nature Immunology33 citations
Semantic Scholar
Transcriptomics in Human Challenge Models
Amber J. Barton, J. Hill, A. Pollard, Christoph J. Blohmke
2017Frontiers in Immunology32 citations Open access
Semantic Scholar
Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease
F. Toapanta, P. Bernal, S. Fresnay, T. Darton +8 more
2015PLoS Neglected Tropical Diseases30 citations Open access
Semantic Scholar
Compositional and Functional Differences in the Human Gut Microbiome Correlate with Clinical Outcome following Infection with Wild-Type Salmonella enterica Serovar Typhi
Yan Zhang, Arthur Brady, Cheron Jones, Yang Song +8 more
2018mBio28 citations Open access
Semantic Scholar
Diagnostic host gene signature for distinguishing enteric fever from other febrile diseases
Christoph J. Blohmke, Julius Muller, M. Gibani, H. Dobinson +14 more
2019EMBO Molecular Medicine25 citations Open access
Semantic Scholar
Salmonella Typhi Bactericidal Antibodies Reduce Disease Severity but Do Not Protect against Typhoid Fever in a Controlled Human Infection Model
H. Juel, H. Thomaides-Brears, T. Darton, Claire Jones +11 more
2018Frontiers in Immunology25 citations Open access
Semantic Scholar
Host restriction, pathogenesis and chronic carriage of typhoidal Salmonella
Amber J. Barton, J. Hill, Christoph J. Blohmke, Andrew J. Pollard
2021FEMS Microbiology Reviews22 citations Open access
Semantic Scholar
Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease
F. Toapanta, P. Bernal, S. Fresnay, L. Magder +8 more
2016PLoS Neglected Tropical Diseases17 citations Open access
Semantic Scholar
The Current Status of Enteric Fever Diagnostics and Implications for Disease Control
S. Baker, Christoph J. Blohmke, M. Maes, Peter I Johnston +1 more
2020Clinical Infectious Diseases16 citations Open access
Semantic Scholar
Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study
Z. Dyson, P. M. Ashton, F. Khanam, Angeziwa Chunga Chirambo +38 more
2024The Lancet Microbe15 citations Open access
Semantic Scholar
Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever
Christoph J. Blohmke, J. Hill, T. Darton, Matheus Carvalho-Burger +7 more
2017Frontiers in Immunology14 citations Open access
Semantic Scholar
RodZ and PgsA Play Intertwined Roles in Membrane Homeostasis of Bacillus subtilis and Resistance to Weak Organic Acid Stress
J. V. van Beilen, Christoph J. Blohmke, H. Folkerts, R. De Boer +5 more
2016Frontiers in Microbiology14 citations Open access
Semantic Scholar
Development and Evaluation of a Blood Culture PCR Assay for Rapid Detection of Salmonella Paratyphi A in Clinical Samples
Liqing Zhou, Claire Jones, M. Gibani, H. Dobinson +5 more
2016PLoS ONE14 citations Open access
Semantic Scholar
Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever
R. Salerno-Gonçalves, S. Fresnay, L. Magder, T. Darton +6 more
2022Cellular Immunology12 citations Open access
Semantic Scholar
Systems analysis of human responses to an aluminium hydroxide-adsorbed TLR7 agonist (AS37) adjuvanted vaccine reveals a dose-dependent and specific activation of the interferon-mediated antiviral response.
Emilio Siena, F. Schiavetti, E. Borgogni, M. Taccone +21 more
2022Vaccine12 citations Open access
Semantic Scholar
The use of systems biology and immunological big data to guide vaccine development
Christoph J. Blohmke, D. O'Connor, A. Pollard
2015Genome Medicine12 citations Open access
Semantic Scholar
Molecular correlates of vaccine-induced protection against typhoid fever
Henderson Zhu, I. Chelysheva, D. Cross, L. Blackwell +9 more
2023Journal of Clinical Investigation11 citations Open access
Semantic Scholar
Vi-Vaccinations Induce Heterogeneous Plasma Cell Responses That Associate With Protection From Typhoid Fever
D. Cross, M. Verheul, Michael D. Leipold, G. Obermoser +9 more
2020Frontiers in Immunology11 citations Open access
Semantic Scholar
Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers
A. Barton, J. Hill, S. Bibi, Li-Ye Chen +11 more
2021bioRxiv10 citations Open access
Semantic Scholar
Assessment and Translation of the Antibody-in-Lymphocyte Supernatant (ALS) Assay to Improve the Diagnosis of Enteric Fever in Two Controlled Human Infection Models and an Endemic Area of Nepal
T. Darton, Claire Jones, S. Dongol, M. Voysey +11 more
2017Frontiers in Microbiology10 citations Open access
Semantic Scholar
Direct inference and control of genetic population structure from RNA sequencing data
Muhamad Fachrul, A. Karkey, M. Shakya, L. Judd +43 more
2023bioRxiv8 citations Open access
Semantic Scholar
Dissecting in Vitro the Activation of Human Immune Response Induced by Shigella sonnei GMMA
Serena Tondi, Bruna Clemente, C. Esposito, Chiara Sammicheli +9 more
2022Frontiers in Cellular and Infection Microbiology7 citations Open access
Semantic Scholar
Gene expression profiles are different in venous and capillary blood: Implications for vaccine studies.
D. Stein, Daniel H. O'Connor, Christoph J. Blohmke, M. Sadarangani +1 more
2016Vaccine7 citations Open access
Semantic Scholar
Evaluating the relationship between ciprofloxacin prescription and non-susceptibility in Salmonella Typhi in Blantyre, Malawi: an observational study
P. M. Ashton, Angeziwa Chunga Chirambo, J. Meiring, P. Patel +31 more
2024The Lancet Microbe6 citations Open access
Semantic Scholar
Computational modeling of microfluidic data provides high-throughput affinity estimates for monoclonal antibodies
S. Budroni, F. Buricchi, Andrea Cavallone, G. Volpini +6 more
2021Computational and Structural Biotechnology Journal4 citations Open access
Semantic Scholar
Role of circulating T follicular helper subsets following Ty21a immunization and oral challenge with wild type S. Typhi in humans
Jayaum S. Booth, R. R. Rapaka, Monica A. McArthur, S. Fresnay +7 more
2024Frontiers in Immunology3 citations Open access
Semantic Scholar
Early transcriptional responses to human enteric fever challenge
A. Barton, J. Hill, D. O'Connor, Claire Jones +10 more
2023Infection and Immunity3 citations Open access
Semantic Scholar
Diagnostic host gene signature to accurately distinguish enteric fever from other febrile diseases
Christoph J. Blohmke, Julius Muller, M. Gibani, H. Dobinson +14 more
2018bioRxiv3 citations Open access
Semantic Scholar

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