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R. Mangadu · SciRah

Researcher profile · Semantic Scholar

R. Mangadu

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R. Mangadu — researcher profile on SciRah

h-index: 13
Works: 26
Citations: 1,019

Most-cited papers

SD-208, a Novel Transforming Growth Factor β Receptor I Kinase Inhibitor, Inhibits Growth and Invasiveness and Enhances Immunogenicity of Murine and Human Glioma Cells In vitro and In vivo
M. Uhl, Steffen Aulwurm, J. Wischhusen, M. Weiler +11 more
2004Cancer Research436 citations Open access
Semantic Scholar
Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells
I. Chan, R. Jain, Marlowe S. Tessmer, Dan Gorman +18 more
2013Mucosal Immunology137 citations Open access
Semantic Scholar
A Selective p38α Mitogen-Activated Protein Kinase Inhibitor Reverses Cartilage and Bone Destruction in Mice with Collagen-Induced Arthritis
S. Medicherla, Jing Y. Ma, R. Mangadu, Ye-Bin Jiang +11 more
2006Journal of Pharmacology and Experimental Therapeutics74 citations
Semantic Scholar
Peripheral and central p38 MAPK mediates capsaicin‐induced hyperalgesia
S. Sweitzer, M. Peters, J.-Y. Ma, I. Kerr +6 more
2004Pain54 citations
Semantic Scholar
Antitumor Activity of TGF-β, Inhibitor is Dependent on the Microenvironment
S. Medicherla, Ling-Yun Li, Jing Y. Ma, A. Kapoun +8 more
200748 citations
Semantic Scholar
Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells.
S. Sukumar, Douglas C. Wilson, Yingxin Yu, Jerelyn Wong +18 more
2017Cancer Research47 citations Open access
Semantic Scholar
A selective p38 alpha mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritis.
S. Medicherla, Jing Y. Ma, R. Mangadu, Ye-Bin Jiang +11 more
2006Journal of Pharmacology and Experimental Therapeutics45 citations
Semantic Scholar
p38 MAPK inhibition reduces diabetes-induced impairment of wound healing
S. Medicherla, S. Wadsworth, B. Cullen, D. Silcock +8 more
2009Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy40 citations Open access
Semantic Scholar
Antitumor activity of TGF-beta inhibitor is dependent on the microenvironment.
S. Medicherla, Ling-Yun Li, Jing Y. Ma, A. Kapoun +8 more
2007Anticancer Research34 citations
Semantic Scholar
Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death
Shih-Chieh Chang, Pooja Gopal, Shu-Hui Lim, Xiao-Na Wei +8 more
2022bioRxiv28 citations Open access
Semantic Scholar
Selective p38α mitogen-activated protein kinase inhibitor attenuates lung inflammation and fibrosis in IL-13 transgenic mouse model of asthma
Jing Y. Ma, S. Medicherla, I. Kerr, R. Mangadu +2 more
2008Journal of Asthma and Allergy16 citations Open access
Semantic Scholar
Preventive and Therapeutic Potential of p38α-Selective Mitogen-Activated Protein Kinase Inhibitor in Nonobese Diabetic Mice with Type 1 Diabetes
S. Medicherla, A. Protter, Jing Y. Ma, R. Mangadu +12 more
2006Journal of Pharmacology and Experimental Therapeutics15 citations
Semantic Scholar
STUB1 is an intracellular checkpoint for interferon gamma sensing
Simon Ng, Shu-Hui Lim, A. C. Sim, R. Mangadu +16 more
2020Scientific Reports14 citations Open access
Semantic Scholar
In vivo anti-tumor efficacy of afucosylated anti-CS1 monoclonal antibody produced in glycoengineered Pichia pastoris.
S. Gomathinayagam, D. Laface, N. R. Houston-Cummings, R. Mangadu +6 more
2015Journal of Biotechnology11 citations
Semantic Scholar
A Selective p 38 Mitogen-Activated Protein Kinase Inhibitor Reverses Cartilage and Bone Destruction in Mice with Collagen-Induced Arthritis
S. Medicherla, Jing Y. Ma, R. Mangadu, Ye-Bin Jiang +11 more
200610 citations
Semantic Scholar
A T-cell-dependent antibody response study using a murine surrogate anti-PD-1 monoclonal antibody as an alternative to a non-human primate model
L. Plitnick, B. Hutchins, Sheri A. Dubey, Nian-Yu Li +6 more
2020Journal of Immunotoxicology4 citations Open access
Semantic Scholar
Abstract 543: Preclinical combination strategies to enhance the efficacy of the anti-PD-1 antibody pembrolizumab
E. Pinheiro, Marlene C. Hinton, R. Mangadu, Mingmei Cai +10 more
20162 citations
Semantic Scholar
Characterization of MK-4166, a clinical agonistic mAb that targets human GITR and inhibits the generation and activity of Tregs
S. Sukumar, D. Wison, Yingxin Yu, Jerelyn Wong +13 more
20162 citations
Semantic Scholar
Abstract 4364: Preclinical pharmacokinetics and pharmacodynamics of MK-4464, a novel NK cell engager targeting CEACAM5
T. Nayak, Yan-Yan Zheng, Li Li, Sophie Li +8 more
2025Cancer Research1 citations
Semantic Scholar
A Light sheet fluorescence microscopy and machine learning-based approach to investigate drug and biomarker distribution in whole organs and tumors
Niyanta Kumar, Petr Hrobař, Martin Vagenknecht, Jindrich Soukup +9 more
2023bioRxiv1 citations Open access
Semantic Scholar
High-Resolution Ex Vivo Tissue Clearing, Lightsheet Imaging, and Data Analysis to Support Macromolecular Drug and Biomarker Distribution in Whole Organs and Tumors
Niyanta N. Kumar, P. Hrobař, Martin Vagenknecht, Jindrich Soukup +8 more
2022Microscopy and Microanalysis1 citations
Semantic Scholar
Development of the anti-IL-10 mAb MK-1966 in combination with in situ vaccination of a TLR9 agonist SD-101 for cancer immunotherapy
U. Phan, Roanna M. Ueda, R. Mangadu, Manjiri Sathe +11 more
20161 citations
Semantic Scholar
Abstract 269: Evaluation of the antitumor activity of anti-PD-1 immunotherapy as a single agent and in combination with approved agents in preclinical tumor models
E. Pinheiro, R. Mangadu, U. Phan, Mingmei Cai +10 more
20151 citations
Semantic Scholar
Abstract B114: Evaluation of the antitumor activity and molecular characterization of mouse syngeneic tumor models in response to anti-PD-1 treatment as a single agent and in combination with approved agents
H. Hirsch, R. Mangadu, Mingmei Cai, Yan-Hong Ma +7 more
20160 citations
Semantic Scholar
A Selective p38α MAPK Inhibitor Reverses Cartilage and Bone Destruction in Mice with Collagen-Induced Arthritis
S. Medicherla, R. Mangadu, Yebin, Jiang +11 more
20060 citations
Semantic Scholar
In vivo and In vitro Cells Enhances Immunogenicity of Murine and Human Glioma Kinase Inhibitor , Inhibits Growth and Invasiveness and Receptor I β SD-208 , a Novel Transforming Growth Factor
M. Uhl, Steffen Aulwurm, J. Wischhusen, M. Weiler +11 more
20040 citations
Semantic Scholar

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