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R. Deshaies · SciRah

Researcher profile · Semantic Scholar

R. Deshaies

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R. Deshaies — researcher profile on SciRah

h-index: 90
Works: 216
Citations: 35K

Most-cited papers

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adapter NPL4
Zdenek Skrott, M. Mistrik, K. K. Andersen, S. Friis +24 more
2017Nature719 citations Open access
Semantic Scholar
2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition
Soojay Banerjee, A. Bartesaghi, A. Merk, P. Rao +12 more
2016Science338 citations Open access
Semantic Scholar
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy
R. Deshaies
2014BMC Biology334 citations Open access
Semantic Scholar
Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways
T. Chou, Steven J. Brown, D. Minond, B. Nordin +10 more
2011Proceedings of the National Academy of Sciences of the United States of America329 citations Open access
Semantic Scholar
Cand1 Promotes Assembly of New SCF Complexes Through Dynamic Exchange of F-box Proteins
N. Pierce, J. E. Lee, Xing Liu, M. Sweredoski +8 more
2013Cell261 citations Open access
Semantic Scholar
Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells
Senthil K. Radhakrishnan, Candy S. Lee, P. Young, A. Beskow +2 more
2010Molecules and Cells250 citations Open access
Semantic Scholar
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome
R. Verma, Robert S. Oania, Natalie J. Kolawa, R. Deshaies
2013eLife236 citations Open access
Semantic Scholar
Multispecific drugs herald a new era of biopharmaceutical innovation
R. Deshaies
2020Nature229 citations
Semantic Scholar
p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition
Senthil K. Radhakrishnan, W. den Besten, R. Deshaies
2013bioRxiv217 citations Open access
Semantic Scholar
Cdc48/p97 mediates UV-dependent turnover of RNA Pol II.
R. Verma, Robert S. Oania, Ruihua Fang, Geoffrey T. Smith +1 more
2011Molecules and Cells210 citations Open access
Semantic Scholar
A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins
Min-Kyung Sung, Tanya R. Porras-Yakushi, Justin M. Reitsma, F. Huber +4 more
2016eLife183 citations Open access
Semantic Scholar
Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy
E. Blythe, Kristine C Olson, V. Chau, R. Deshaies
2017Proceedings of the National Academy of Sciences of the United States of America181 citations Open access
Semantic Scholar
Harnessing the Power of Proteolysis for Targeted Protein Inactivation.
R. Verma, Dane A. Mohl, R. Deshaies
2020Molecules and Cells173 citations Open access
Semantic Scholar
Glutamine triggers acetylation-dependent degradation of glutamine synthetase via the thalidomide receptor cereblon
T. Van Nguyen, J. E. Lee, M. Sweredoski, Seung‐joo Yang +11 more
2016Molecules and Cells159 citations Open access
Semantic Scholar
Protein degradation: Prime time for PROTACs.
R. Deshaies
2015Nature Chemical Biology154 citations
Semantic Scholar
Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11
Jing Li, Tanya Yakushi, F. Parlati, A. Mackinnon +18 more
2017Nature Chemical Biology147 citations Open access
Semantic Scholar
Structure-Activity Relationship Study Reveals ML240 and ML241 as Potent and Selective Inhibitors of p97 ATPase
T. Chou, Ke-Lin Li, Kevin J. Frankowski, F. Schoenen +1 more
2013ChemMedChem137 citations Open access
Semantic Scholar
Composition and regulation of the cellular repertoire of SCF ubiquitin ligases
Justin M. Reitsma, Xing Liu, K. Reichermeier, A. Moradian +3 more
2017Cell133 citations Open access
Semantic Scholar
Essential role for ubiquitin–ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate
Anjanabha Saha, S. Lewis, Gary Kleiger, B. Kuhlman +1 more
2011Molecules and Cells129 citations Open access
Semantic Scholar
Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor
Mariam Aghajanyy, Nao Jonai, K. Flick, Fei Fu +19 more
2010Nature Biotechnology126 citations Open access
Semantic Scholar
Vms1/Ankzf1 peptidyl-tRNA hydrolase releases nascent chains from stalled ribosomes
R. Verma, K. Reichermeier, A. Burroughs, Robert S. Oania +3 more
2018Nature125 citations Open access
Semantic Scholar
Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase domains
T. Chou, Stacie L. Bulfer, C. Weihl, Ke-Lin Li +6 more
2014Journal of Molecular Biology121 citations Open access
Semantic Scholar
Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases
Linda Lauinger, Jing Li, A. Shostak, I. A. Cemel +15 more
2017Nature Chemical Biology120 citations Open access
Semantic Scholar
Rsp5/Nedd4 is the major ubiquitin ligase that targets cytosolic misfolded proteins upon heat-stress
Nancy N. Fang, Gerard T. Chan, Mang Zhu, S. Comyn +5 more
2014Nature Cell Biology119 citations Open access
Semantic Scholar
Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism
E. Emberley, Ruzbeh Mosadeghi, R. Deshaies
2012Journal of Biological Chemistry118 citations Open access
Semantic Scholar
Ribosomal proteins produced in excess are degraded by the ubiquitin–proteasome system
Min-Kyung Sung, Justin M. Reitsma, M. Sweredoski, Sonja Hess +1 more
2016Molecular Biology of the Cell115 citations Open access
Semantic Scholar
Cand1-mediated adaptive exchange mechanism enables variation in F-box protein expression
Xing Liu, Justin M. Reitsma, Jennifer L Mamrosh, Ya-Ru Zhang +2 more
2018Molecules and Cells95 citations Open access
Semantic Scholar
Control of cullin-ring ubiquitin ligase activity by nedd8.
R. Deshaies, E. Emberley, Anjanabha Saha
2010Sub-cellular biochemistry92 citations
Semantic Scholar
Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle
Ruzbeh Mosadeghi, K. Reichermeier, Martin Winkler, Anne Schreiber +12 more
2016bioRxiv86 citations Open access
Semantic Scholar
p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates
T. Van Nguyen, Jing Li, Chin-Chun Lu, Jennifer L Mamrosh +3 more
2017Proceedings of the National Academy of Sciences of the United States of America79 citations Open access
Semantic Scholar
Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration
E. Lobanova, Stella Finkelstein, Jing Li, A. Travis +5 more
2018Nature Communications76 citations Open access
Semantic Scholar
NEDD8 links Cullin–Ring ubiquitin Ligase function to the p97 pathway
W. den Besten, R. Verma, Gary Kleiger, Robert S. Oania +1 more
2012Nature Structural &Molecular Biology76 citations Open access
Semantic Scholar
Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1
T. Gomez, Natalie J. Kolawa, Marvin H. Gee, M. Sweredoski +1 more
2011BMC Biology75 citations Open access
Semantic Scholar
Multisystem proteinopathy (MSP) mutations in VCP/p97 increase NPLOC4·UFD1L binding and substrate processing
E. Blythe, S. Gates, R. Deshaies, Andreas Martin
2019Structure72 citations Open access
Semantic Scholar
Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast
Y. Oh, Kuang-Jung Chang, P. Orlean, C. Wloka +2 more
2012Molecular Biology of the Cell72 citations Open access
Semantic Scholar
Discovery of an Inhibitor of the Proteasome Subunit Rpn11
Christian Perez, Jing Li, Frank Parlati, Matthieu Rouffet +6 more
2017Journal of Medicinal Chemistry71 citations Open access
Semantic Scholar
PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network.
K. Reichermeier, R. Straube, Justin M. Reitsma, M. Sweredoski +10 more
2020Molecules and Cells70 citations Open access
Semantic Scholar
Quantitative Cell-based Protein Degradation Assays to Identify and Classify Drugs That Target the Ubiquitin-Proteasome System
T. Chou, R. Deshaies
2011Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Development of p97 AAA ATPase inhibitors
T. Chou, R. Deshaies
2011Autophagy60 citations Open access
Semantic Scholar
Assembly and Regulation of CRL Ubiquitin Ligases.
Kankan Wang, R. Deshaies, Xing Liu
2020Advances in Experimental Medicine and Biology57 citations
Semantic Scholar
The TFIIH subunit Tfb3 regulates cullin neddylation.
Gwenaël Rabut, Gaëlle Le Dez, R. Verma, Taras Makhnevych +5 more
2011Molecules and Cells53 citations Open access
Semantic Scholar
Valosin-containing protein (VCP)–Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor *
L. Xue, E. Blythe, Elyse C. Freiberger, Jennifer L Mamrosh +5 more
2016Molecular & Cellular Proteomics50 citations Open access
Semantic Scholar
Epidithiodiketopiperazines inhibit protein degradation by targeting proteasome deubiquitinase Rpn11
Jing Li, Ya-Ru Zhang, Bruno Da Silva Sil Dos Santos, Feng Wang +8 more
2018Cell Chemical Biology41 citations Open access
Semantic Scholar
Protein Interaction Profiling of the p97 Adaptor UBXD1 Points to a Role for the Complex in Modulating ERGIC-53 Trafficking*
D. Haines, J. E. Lee, Stephen L. Beauparlant, Dane B. Kyle +5 more
2012Molecular & Cellular Proteomics39 citations Open access
Semantic Scholar
Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline
Mary J. Pulvino, Luo-Jing Chen, D. Oleksyn, Jing Li +14 more
2015OncoTarget37 citations Open access
Semantic Scholar
Designer Reagents for Mass Spectrometry-Based Proteomics: Clickable Cross-Linkers for Elucidation of Protein Structures and Interactions
Chang Ho Sohn, Heather D. Agnew, J. E. Lee, M. Sweredoski +8 more
2012Analytical Chemistry37 citations Open access
Semantic Scholar
Nrf1 can be processed and activated in a proteasome-independent manner
Janakiram R. Vangala, F. Sotzny, Elke Krüger, R. Deshaies +1 more
2016Current Biology35 citations Open access
Semantic Scholar
Click Chemistry Facilitates Formation of Reporter Ions and Simplified Synthesis of Amine-Reactive Multiplexed Isobaric Tags for Protein Quantification
Chang Ho Sohn, J. E. Lee, M. Sweredoski, Robert L. J. Graham +6 more
2012Journal of the American Chemical Society34 citations Open access
Semantic Scholar
Perturbations to the Ubiquitin Conjugate Proteome in Yeast Δubx Mutants Identify Ubx2 as a Regulator of Membrane Lipid Composition
Natalie J. Kolawa, M. Sweredoski, Robert L. J. Graham, Robert S. Oania +2 more
2013Molecular & Cellular Proteomics33 citations Open access
Semantic Scholar
Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway.
Celeste N Alverez, Stacie L. Bulfer, R. Chakrasali, Michael S. Chimenti +14 more
2016ACS Medicinal Chemistry Letters32 citations Open access
Semantic Scholar

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