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P. Orlean · SciRah

Researcher profile · Semantic Scholar

P. Orlean

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P. Orlean — researcher profile on SciRah

h-index: 35
Works: 62
Citations: 4,787

Most-cited papers

Glycoprotein biosynthesis in yeast
A. Herscovics, P. Orlean
1993The FASEB Journal502 citations
Semantic Scholar
Architecture and Biosynthesis of the Saccharomyces cerevisiae Cell Wall
P. Orlean
2012Genetics470 citations Open access
Semantic Scholar
Thematic review series: Lipid Posttranslational Modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids Published, JLR Papers in Press, March 14, 2007.
P. Orlean, A. Menon
2007Journal of Lipid Research351 citations Open access
Semantic Scholar
Multi-Target Drug Discovery for Tuberculosis and Other Infectious Diseases
Kai Li, L. Schurig-Briccio, Xinxin Feng, A. Upadhyay +24 more
2014Journal of Medicinal Chemistry218 citations Open access
Semantic Scholar
Cloning and sequencing of the yeast gene for dolichol phosphate mannose synthase, an essential protein.
P. Orlean, C. Albright, P. Robbins
1988Journal of Biological Chemistry195 citations
Semantic Scholar
Structure of the yeast endoplasmic reticulum: Localization of ER proteins using immunofluorescence and immunoelectron microscopy
D. Preuss, J. Mulholland, C. Kaiser, P. Orlean +4 more
1991Yeast188 citations
Semantic Scholar
Dolichol phosphate mannose synthase is required in vivo for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and N glycosylation of protein in Saccharomyces cerevisiae
P. Orlean
1990Molecular and Cellular Biology172 citations Open access
Semantic Scholar
The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG‐A, PIG‐H, PIG‐C and GPI1
R. Watanabe, N. Inoue, B. Westfall, C. Taron +3 more
1998EMBO Journal171 citations Open access
Semantic Scholar
3 Biogenesis of Yeast Wall and Surface Components
P. Orlean
1997168 citations
Semantic Scholar
A conditionally lethal yeast mutant blocked at the first step in glycosyl phosphatidylinositol anchor synthesis.
S. Leidich, D. Drapp, P. Orlean
1994Journal of Biological Chemistry168 citations
Semantic Scholar
Two chitin synthases in Saccharomyces cerevisiae.
P. Orlean
1987Journal of Biological Chemistry160 citations Open access
Semantic Scholar
Topography of glycosylation in yeast: characterization of GDPmannose transport and lumenal guanosine diphosphatase activities in Golgi-like vesicles.
C. Abeijon, P. Orlean, P. Robbins, C. Hirschberg
1989Proceedings of the National Academy of Sciences of the United States of America149 citations Open access
Semantic Scholar
MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast.
E. Gaynor, Guillaume Mondésert, Stephen J. Grimme, S. Reed +2 more
1999Molecular Biology of the Cell129 citations Open access
Semantic Scholar
Biosynthesis of Glycosylphosphatidylinositols in Mammals and Unicellular Microbes
Andreas Tiede, I. Bastisch, J. Schubert, P. Orlean +1 more
1999Biological chemistry120 citations
Semantic Scholar
Temperature-sensitive Yeast GPI Anchoring Mutants gpi2 and gpi3 Are Defective in the Synthesis of N-Acetylglucosaminyl Phosphatidylinositol.
S. Leidich, Zlatka Kostova, R. Latek, Lisa C. Costello +4 more
1995Journal of Biological Chemistry119 citations Open access
Semantic Scholar
Gpi1, a Saccharomyces cerevisiae Protein That Participates in the First Step in Glycosylphosphatidylinositol Anchor Synthesis*
S. Leidich, P. Orlean
1996Journal of Biological Chemistry87 citations Open access
Semantic Scholar
Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe.
P. Colussi, C. Taron, J. Mack, P. Orlean
1997Proceedings of the National Academy of Sciences of the United States of America80 citations Open access
Semantic Scholar
Human Smp3p Adds a Fourth Mannose to Yeast and Human Glycosylphosphatidylinositol Precursors in Vivo*
Barbara W Taron, P. Colussi, Jill M. Wiedman, P. Orlean +1 more
2004Journal of Biological Chemistry74 citations Open access
Semantic Scholar
A 13-amino acid peptide in three yeast glycosyltransferases may be involved in dolichol recognition.
Charles F. Albright, P. Orlean, P. W. Robbins
1989Proceedings of the National Academy of Sciences of the United States of America74 citations Open access
Semantic Scholar
Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast
Y. Oh, Kuang-Jung Chang, P. Orlean, C. Wloka +2 more
2012Molecular Biology of the Cell72 citations Open access
Semantic Scholar
Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER.
Andrew K. Sobering, R. Watanabe, Martin J. Romeo, Benjamin C. Yan +4 more
2004Cell71 citations Open access
Semantic Scholar
The Essential Smp3 Protein Is Required for Addition of the Side-branching Fourth Mannose during Assembly of Yeast Glycosylphosphatidylinositols*
Stephen J. Grimme, B. Westfall, Jill M. Wiedman, C. Taron +1 more
2001Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Inositol acylation of a potential glycosyl phosphoinositol anchor precursor from yeast requires acyl coenzyme A.
Lisa C. Costello, P. Orlean
1992Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Chemical and numerical taxonomy of strains received as Gordona aurantiaca
M. Goodfellow, P. Orlean, M. Collins, L. Alshamaony +1 more
197868 citations Open access
Semantic Scholar
Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose.
C. Taron, Jill M. Wiedman, Stephen J. Grimme, P. Orlean
2000Molecular Biology of the Cell65 citations Open access
Semantic Scholar
Saccharomyces cerevisiae sec59 cells are deficient in dolichol kinase activity.
L. Heller, P. Orlean, W. Adair
1992Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
Semantic Scholar
Synthesis of an O-glycosylated cell surface protein induced in yeast by α factor
P. Orlean, H. Ammer, M. Watzele, W. Tanner
198654 citations Open access
Semantic Scholar
(1,3)-beta-D-Glucan synthase from budding and filamentous cultures of the dimorphic fungus Candida albicans.
P. Orlean
1982European Journal of Biochemistry52 citations
Semantic Scholar
Identification of pathogenic fungi with an optoelectronic nose
Yi-Nan Zhang, J. Askim, Wenxuan Zhong, P. Orlean +1 more
2014In Analysis48 citations Open access
Semantic Scholar
Photoaffinity labelling with P3-(4-azidoanilido)uridine 5'-triphosphate identifies gpi3p as the UDP-GlcNAc-binding subunit of the enzyme that catalyses formation of GlcNAc-phosphatidylinositol, the first glycolipid intermediate in glycosylphosphatidylinositol synthesis.
Zlatka Kostova, David Rancour, A. Menon, P. Orlean
2000Biochemical Journal48 citations Open access
Semantic Scholar
Enzymes that recognize dolichols participate in three glycosylation pathways and are required for protein secretion.
P. Orlean
1992Biochemistry and cell biology = Biochimie et biologie cellulaire42 citations
Semantic Scholar
Deficiencies in the essential Smp3 mannosyltransferase block glycosylphosphatidylinositol assembly and lead to defects in growth and cell wall biogenesis in Candida albicans.
Stephen J. Grimme, P. Colussi, C. Taron, P. Orlean
2004Microbiology36 citations Open access
Semantic Scholar
Dolichol phosphate mannose synthase from the filamentous fungus Trichoderma reesei belongs to the human and Schizosaccharomyces pombe class of the enzyme.
J. Kruszewska, M. Saloheimo, A. Migdalski, P. Orlean +2 more
2000Glycobiology36 citations Open access
Semantic Scholar
Deficiencies in the endoplasmic reticulum (ER)-membrane protein Gab1p perturb transfer of glycosylphosphatidylinositol to proteins and cause perinuclear ER-associated actin bar formation.
Stephen J. Grimme, Xiang-Dong Gao, Pau Martin, Kim Tu +5 more
2004Molecular Biology of the Cell35 citations Open access
Semantic Scholar
Ynl038wp (Gpi15p) is the Saccharomyces cerevisiae homologue of human Pig‐Hp and participates in the first step in glycosylphosphatidylinositol assembly
Benjamin C. Yan, Barbara A. Westfall, P. Orlean
2001Yeast35 citations
Semantic Scholar
Gpi19, the Saccharomyces cerevisiae Homologue of Mammalian PIG-P, Is a Subunit of the Initial Enzyme for Glycosylphosphatidylinositol Anchor Biosynthesis
H. A. Newman, Martin J. Romeo, Sarah E. Lewis, Benjamin C. Yan +2 more
2005Eukaryotic Cell33 citations Open access
Semantic Scholar
Priming and elongation of chitin chains: Implications for chitin synthase mechanism
P. Orlean, Danielle Funai
2018The Cell Surface29 citations Open access
Semantic Scholar
Congenital disorders of glycosylation caused by defects in mannose addition during N-linked oligosaccharide assembly.
P. Orlean
2000Journal of Clinical Investigation28 citations Open access
Semantic Scholar
The Essential Schizosaccharomyces pombe gpi1+ Gene Complements a Bakers' Yeast GPI Anchoring Mutant and is Required for Efficient Cell Separation
P. Colussi, P. Orlean
1997Yeast25 citations Open access
Semantic Scholar
Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly
A. Fabre, P. Orlean, C. Taron
2005The FEBS Journal23 citations Open access
Semantic Scholar
Comparative importance in vivo of conserved glutamate residues in the EX7E motif retaining glycosyltransferase Gpi3p, the UDP-GlcNAc-binding subunit of the first enzyme in glycosylphosphatidylinositol assembly.
Zlatka Kostova, Benjamin C. Yan, S. Vainauskas, R. Schwartz +2 more
2003European Journal of Biochemistry23 citations Open access
Semantic Scholar
The GPI1 homologue from Plasmodium falciparum complements a Saccharomyces cerevisiae GPI1 anchoring mutant.
H. Shams-Eldin, N. Azzouz, M. Kedees, P. Orlean +2 more
2002Molecular and biochemical parasitology (Print)20 citations
Semantic Scholar
Apparent inhibition of glycoprotein synthesis by S.cerevisiae mating pheromones
P. Orlean, Elisabeth Arnold, W. Tanner
1985FEBS Letters19 citations Open access
Semantic Scholar
Analysis of a cellulose synthase catalytic subunit from the oomycete pathogen of crops Phytophthora capsici
Zhili Pang, L. McKee, V. Srivastava, Stefan Klinter +4 more
2020Cellulose18 citations Open access
Semantic Scholar
Sodium fluoride stimulates (1,3)-β-d-glucan synthase from Candida albicans
P. Orlean, S. M. Ward
198316 citations
Semantic Scholar
2-Acylamido Analogues of N-Acetylglucosamine Prime Formation of Chitin Oligosaccharides by Yeast Chitin Synthase 2
J. Gyore, Archana R. Parameswar, Carleigh F. F. Hebbard, Y. Oh +4 more
2014Journal of Biological Chemistry15 citations Open access
Semantic Scholar
In vivo characterization of the GPI assembly defect in yeast mcd4-174 mutants and bypass of the Mcd4p-dependent step in mcd4Delta cells.
Jill M. Wiedman, A. Fabre, Barbara W Taron, C. Taron +1 more
2007FEMS Yeast Research15 citations Open access
Semantic Scholar
Uptake of radiolabeled GlcNAc into Saccharomyces cerevisiae via native hexose transporters and its in vivo incorporation into GPI precursors in cells expressing heterologous GlcNAc kinase
John J. Scarcelli, P. Colussi, A. Fabre, E. Boles +2 more
2012FEMS Yeast Research13 citations Open access
Semantic Scholar
The action of 2-deoxy-D-glucose on the incorporation of glucose into (1----3)-beta-glucan in stationary phase cultures of Candida albicans.
E. F. Gale, F. Wayman, P. Orlean
1984Journal of General Microbiology12 citations
Semantic Scholar
Isolation and characterization of yeast glycosylphosphatidylinositol anchoring mutants.
S. Leidich, D. Drapp, P. Orlean
1995Methods in Enzymology10 citations
Semantic Scholar

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C. Taron×9
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C. Taron — researcher profile on SciRah
Stephen J. Grimme×5
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P. Colussi×5
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S. Leidich×4
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Jill M. Wiedman

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A. Menon — researcher profile on SciRah

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Er-Fei Bi — researcher profile on SciRah

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