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S. Neuteboom · SciRah

Researcher profile · Semantic Scholar

S. Neuteboom

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S. Neuteboom — researcher profile on SciRah

h-index: 17
Works: 45
Citations: 2,155

Most-cited papers

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib.
D. Chauhan, L. Catley, Gui-Lan Li, K. Podar +14 more
2005Cancer Cell688 citations Open access
Semantic Scholar
Marizomib, a Proteasome Inhibitor for All Seasons: Preclinical Profile and a Framework for Clinical Trials
B. Potts, M. Albitar, Kenneth C. Anderson, S. Baritaki +25 more
2011Current Cancer Drug Targets248 citations Open access
Semantic Scholar
NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent
B. Nicholson, G. Lloyd, B. Miller, M. Palladino +3 more
2006Anti-Cancer Drugs234 citations
Semantic Scholar
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
K. Ahn, G. Sethi, T. Chao, S. Neuteboom +4 more
2007Blood136 citations Open access
Semantic Scholar
Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes.
I. W. Cheney, S. Neuteboom, M. Vaillancourt, Murali Ramachandra +1 more
1999Cancer Research129 citations
Semantic Scholar
Synthesis and Structure−Activity Relationship Study of Antimicrotubule Agents Phenylahistin Derivatives with a Didehydropiperazine-2,5-dione Structure
Yuri Yamazaki, Koji Tanaka, B. Nicholson, Gordafaried Deyanat-Yazdi +18 more
201295 citations Open access
Semantic Scholar
Phase 1 First-in-Human Trial of the Vascular Disrupting Agent Plinabulin (NPI-2358) in Patients with Solid Tumors or Lymphomas
M. Mita, M. Spear, L. Yee, A. Mita +12 more
2010Clinical Cancer Research91 citations Open access
Semantic Scholar
NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model
J. Cusack, Rong Liu, Li-Jun Xia, T. Chao +5 more
2006Clinical Cancer Research88 citations Open access
Semantic Scholar
Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome.
Kathleen A. Reed, R. Manam, Scott S. Mitchell, Jianlin Xu +6 more
2007Journal of Natural Products72 citations
Semantic Scholar
The product of the candidate prostate cancer susceptibility gene ELAC2 interacts with the γ‐tubulin complex
W. Korver, Claudia I. Guevara, Yang Chen, S. Neuteboom +3 more
2003International Journal of Cancer69 citations Open access
Semantic Scholar
Selective Activation of Liver X Receptors by Acanthoic Acid-Related Diterpenes
P. Través, S. Hortelano, Miriam Zeini, T. Chao +6 more
2007Molecular Pharmacology49 citations Open access
Semantic Scholar
Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents.
Yuri Yamazaki, Makiko Sumikura, Y. Masuda, Yoshiki Hayashi +10 more
2012Bioorganic & Medicinal Chemistry41 citations
Semantic Scholar
Antiprotealide is a natural product.
R. Manam, V. Macherla, Ginger Tsueng, Chris W Dring +4 more
2009Journal of Natural Products32 citations
Semantic Scholar
Phase 1 Clinical Trial of the Novel Structure Proteasome Inhibitor NPI-0052 in Patients with Relapsed and Relapsed/Refractory Multiple Myeloma (MM).
P. Richardson, C. Hofmeister, A. Jakubowiak, T. Zimmerman +9 more
200931 citations
Semantic Scholar
Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011
C. Boyer, P. Karjian, G. Wahl, M. Pegram +1 more
2002Anti-Cancer Drugs25 citations
Semantic Scholar
Lajollamycin, a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic from the marine actinomycete Streptomyces nodosus.
R. Manam, Sy Teisan, Donald J. White, B. Nicholson +6 more
2005Journal of Natural Products20 citations Open access
Semantic Scholar
Tubulin Photoaffinity Labeling with Biotin‐Tagged Derivatives of Potent Diketopiperazine Antimicrotubule Agents
Yuri Yamazaki, K. Kohno, H. Yasui, Y. Kiso +7 more
2008ChemBioChem19 citations
Semantic Scholar
Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction.
S. Neuteboom, P. Karjian, C. Boyer, Malgorzhata Beryt +3 more
2002Molecular Cancer Therapeutics16 citations
Semantic Scholar
Molecular characterization of the virulence gene virA of the Agrobacterium tumefaciens octopine Ti plasmid
L. Melchers, Dave V. Thompson, K. Idler, S. Neuteboom +3 more
1987Plant Molecular Biology14 citations
Semantic Scholar
Chapter 12:From Natural Product to Clinical Trials: NPI-0052 (Salinosporamide A), a Marine Actinomycete-Derived Anticancer Agent
Kin S. Lam, G. Lloyd, S. Neuteboom, M. Palladino +3 more
200911 citations
Semantic Scholar
Phase 1 Clinical Trial of the Novel Structure Proteasome Inhibitor NPI-0052.
A. Spencer, M. Millward, P. Mainwaring, Simon Harrison +10 more
20099 citations
Semantic Scholar
450 POSTER NPI-2358, a novel tumor vascular disrupting agent potentiates the anti-tumor activity of docetaxel in the non small cell lung cancer model MV522
S. Neuteboom, E. Medina, M. Palladino, M. Spear +2 more
20087 citations
Semantic Scholar
In planta analysis of the Agrobacterium tumefaciens T-cyt gene promoter: identification of an upstream region essential for promoter activity in leaf, stem and root cells of transgenic tobacco
S. Neuteboom, E. Hulleman, R. Schilperoort, J. Hoge
1993Plant Molecular Biology7 citations
Semantic Scholar
NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint
R. Dellinger, P. Karjian, S. Neuteboom
2003Anti-Cancer Drugs6 citations
Semantic Scholar
Phase 1 Clinical Trial of a Novel Proteasome Inhibitor (NPI-0052) in Patients with Lymphomas and Solid Tumors.
R. Kurzrock, P. Hamlin, A. Younes, D. Hong +9 more
20075 citations
Semantic Scholar
A Novel Orally Available Proteasome Inhibitor NPI-0052 Induces Killing in Multiple Myeloma (MM) Cells Resistant to Conventional and Bortezomib Therapies.
D. Chauhan, Gui-Lan Li, K. Podar, T. Hideshima +10 more
20045 citations
Semantic Scholar
Abstract A107: Clinical trial combining proteasome (NPI‐0052) and HDAC (vorinostat) inhibition in melanoma, pancreatic, and lung cancer
M. Millward, M. Spear, A. Townsend, C. Sweeney +6 more
20092 citations
Semantic Scholar
Abstract C33: A two‐arm phase 1 clinical trial with NPI‐0052, a novel proteasome inhibitor
T. Price, M. Millward, P. Mainwaring, S. Harrison +10 more
20092 citations
Semantic Scholar
The pharmacodynamic profile of NPI-0052 is cell-type specific
T. Chao, A. Barral, K. Lloyd, M. Spear +2 more
20082 citations
Semantic Scholar
Cancer Therapy : Clinical Phase 1 First-inHuman Trial of the Vascular Disrupting Agent Plinabulin ( NPI-2358 ) in Patients with Solid Tumors or Lymphomas
M. Mita, M. Spear, L. Yee, A. Mita +12 more
20101 citations
Semantic Scholar
Application of intramolecular migration reaction in peptide chemistry to chemical biology, chemical pharmaceutics and medicinal chemistry.
Y. Hayashi, Yuri Yamazaki, M. Skwarczynski, Youhei Sohma +7 more
2009Advances in Experimental Medicine and Biology1 citations
Semantic Scholar
235 POSTER Preclinical and clinical monitoring of cell-and circulating plasma specific proteasome biomarkers after treatment with the proteasome inhibitor, NPI-0052
M. Palladino, T. Chao, S. Neuteboom, M. Spear +2 more
20081 citations
Semantic Scholar
Pharmacodynamic profiling defines the significant biological activities of the novel proteasome inhibitor NPI-0052: Comparison with Velcade® (Bortezomib)
T. Chao, D. Chauhan, Gordafaried Deyanat-Yazdi, L. Catley +5 more
20061 citations
Semantic Scholar
The Novel, Orally Active Proteasome Inhibitor, NPI-0052, Induces Apoptosis in Leukemia Lymphoma Cell Lines and Patient Specimens.
C. Miller, Kechen Ban, S. Ruiz, S. Neuteboom +3 more
20051 citations
Semantic Scholar
In vitro and in vivo proteasome activity profiles of bortezomib and a novel proteasome inhibitor NPI-0052
D. Chauhan, T. Chao, L. Catley, B. Nicholson +7 more
20051 citations
Semantic Scholar
Lymphomas Plinabulin ( NPI-2358 ) in Patients with Solid Tumors or Phase 1 First-inHuman Trial of the Vascular Disrupting Agent
M. Mita, M. Spear, L. Yee, A. Mita +12 more
20100 citations
Semantic Scholar
Synthesis of biotin-tagged diketopiperazine-based anti-microtubule agents and tubulin photoaffinity labeling.
Yuri Yamazaki, K. Kohno, H. Yasui, Y. Kiso +5 more
2009Advances in Experimental Medicine and Biology0 citations
Semantic Scholar
Development of Biotin-Tagged Tubulin Photoaffinity Probes Derivatized from Diketopiperazine Based Anti-Microtubule Agents
Yuri Yamazaki, K. Kohno, H. Yasui, Y. Kiso +7 more
20090 citations
Semantic Scholar
237 POSTER Leaving groups prolong the duration of 20S proteasome inhibition and enhance the inhibition profile of salinosporamides
B. Potts, R. Manam, V. Macherla, T. Chao +6 more
20080 citations
Semantic Scholar
Phase 1 clinical trials of NPI-2358 (a novel vascular disrupting agent) in patients with solid tumors and lymphomas
P. LoRusso, L.-K. Yee, K. Papadopoulos, A. Tolcher +10 more
20070 citations
Semantic Scholar
Results from phase 1 dose escalation study of the proteasome inhibitor NPI-0052 in patients with solid tumors and lymphomas
R. Kurzrock, P. Hamlin, A. Younes, D. Hong +9 more
20070 citations
Semantic Scholar
New Aspects of Potent Anti-Microtubule Agents Phenylahistin and Tubulin Photoaffinity Labeling
Y. Hayashi, Yuri Yamazaki, K. Kohno, A. Oda +7 more
20070 citations
Semantic Scholar
P-518 DEVELOPMENT OF POTENT ANTI-MICROTUBULE AGENTS BASED ON NATURAL DIKETOPIPERAZINE PHENYLAHISTIN AND TUBULIN PHOTOAFFINITY LABELING
Y. Hayashi, Yuri Yamazaki, S. Neuteboom, A. Barral +2 more
20060 citations
Semantic Scholar
Targeting therapy for resistant multiple myeloma with a novel inhibitor of NF-KB, NPI-1387.
D. Chauhan, T. Chao, De-Liu He, T. Hideshima +6 more
20050 citations
Semantic Scholar
A novel non-peptide and orally active proteasome inhibitor overcomes bortezomib-resistance in multiple myeloma (MM) cells
D. Chauhan, L. Catley, Gui-Lan Li, M. Sattler +8 more
20050 citations
Semantic Scholar

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M. Palladino×22
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G. Lloyd×22
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M. Spear×15
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B. Potts×13
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T. Chao — researcher profile on SciRah

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Y. Kiso — researcher profile on SciRah

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