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A. Mogk · SciRah

Researcher profile · Semantic Scholar

A. Mogk

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A. Mogk — researcher profile on SciRah

h-index: 71
Works: 146
Citations: 17K

Most-cited papers

Cellular strategies for controlling protein aggregation
J. Tyedmers, A. Mogk, B. Bukau
2010Nature reviews. Molecular cell biology916 citations
Semantic Scholar
Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils
Xuechao Gao, M. Carroni, C. Nussbaum-Krammer, A. Mogk +6 more
2015Molecules and Cells391 citations Open access
Semantic Scholar
Cellular Handling of Protein Aggregates by Disaggregation Machines.
A. Mogk, B. Bukau, H. Kampinga
2018Molecules and Cells336 citations Open access
Semantic Scholar
Remodelling of VipA/VipB tubules by ClpV‐mediated threading is crucial for type VI protein secretion
Gabriele Bönemann, A. Pietrosiuk, Alexander V. Diemand, H. Zentgraf +1 more
2009EMBO Journal327 citations Open access
Semantic Scholar
Chaperone-based procedure to increase yields of soluble recombinant proteins produced in E. coli
A. de Marco, E. Deuerling, A. Mogk, T. Tomoyasu +1 more
2007BMC Biotechnology306 citations Open access
Semantic Scholar
Compartment‐specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition
Stephanie B. M. Miller, Chi‐ting Ho, J. Winkler, M. Khokhrina +8 more
2015EMBO Journal283 citations Open access
Semantic Scholar
Quantitative and spatio‐temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing
J. Winkler, A. Seybert, Lars König, Sabine Pruggnaller +6 more
2010EMBO Journal282 citations Open access
Semantic Scholar
The N-end rule pathway for regulated proteolysis: prokaryotic and eukaryotic strategies.
A. Mogk, R. Schmidt, B. Bukau
2007Trends in Cell Biology275 citations
Semantic Scholar
Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae
S. Specht, Stephanie B. M. Miller, A. Mogk, B. Bukau
2011Journal of Cell Biology270 citations Open access
Semantic Scholar
The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease
J. Kirstein, A. Hoffmann, H. Lilie, R. Schmidt +4 more
2009EMBO Molecular Medicine222 citations Open access
Semantic Scholar
Coordination of translational control and protein homeostasis during severe heat stress.
V. Cherkasov, Sarah Hofmann, Silke Druffel-Augustin, A. Mogk +3 more
2013Current Biology221 citations Open access
Semantic Scholar
Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation
J. Winkler, J. Tyedmers, B. Bukau, A. Mogk
2012Journal of Cell Biology218 citations Open access
Semantic Scholar
Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation
Peter Tessarz, A. Mogk, B. Bukau
2008Molecular Microbiology193 citations Open access
Semantic Scholar
Spatially organized aggregation of misfolded proteins as cellular stress defense strategy.
Stephanie B. M. Miller, A. Mogk, B. Bukau
2015Journal of Molecular Biology180 citations
Semantic Scholar
Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces
F. Seyffer, E. Kummer, Yuki Oguchi, J. Winkler +5 more
2012Nature Structural &Molecular Biology176 citations
Semantic Scholar
M domains couple the ClpB threading motor with the DnaK chaperone activity.
Tobias Haslberger, Jimena Weibezahn, R. Zahn, Sukyeong Lee +3 more
2007Molecules and Cells173 citations Open access
Semantic Scholar
Cellular Functions and Mechanisms of Action of Small Heat Shock Proteins.
A. Mogk, Carmen Ruger-Herreros, B. Bukau
2019Annual Review of Microbiology170 citations Open access
Semantic Scholar
Tubules and donuts: a type VI secretion story
Gabriele Bönemann, A. Pietrosiuk, A. Mogk
2010Molecular Microbiology167 citations Open access
Semantic Scholar
Cooperation of Hsp70 and Hsp100 chaperone machines in protein disaggregation
A. Mogk, E. Kummer, B. Bukau
2015Frontiers in Molecular Biosciences166 citations Open access
Semantic Scholar
Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding
Sophia Ungelenk, F. Moayed, Chi‐ting Ho, Tomáš Groušl +6 more
2016Nature Communications165 citations Open access
Semantic Scholar
Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments
Tobias Haslberger, A. Zdanowicz, Ingo L. Brand, J. Kirstein +3 more
2008Nature Structural &Molecular Biology150 citations
Semantic Scholar
Hsp70 displaces small heat shock proteins from aggregates to initiate protein refolding
Szymon Żwirowski, Agnieszka A. Klosowska, Igor Obuchowski, Nadinath B. Nillegoda +5 more
2017EMBO Journal148 citations Open access
Semantic Scholar
A tightly regulated molecular toggle controls AAA+ disaggregase
Yuki Oguchi, E. Kummer, F. Seyffer, M. Berynskyy +5 more
2012Nature Structural &Molecular Biology139 citations
Semantic Scholar
ClpV recycles VipA/VipB tubules and prevents non‐productive tubule formation to ensure efficient type VI protein secretion
Nicole Kapitein, Gabriele Bönemann, A. Pietrosiuk, F. Seyffer +3 more
2013Molecular Microbiology137 citations Open access
Semantic Scholar
Chaperone networks in protein disaggregation and prion propagation.
J. Winkler, J. Tyedmers, B. Bukau, A. Mogk
2012Journal of Structural Biology136 citations
Semantic Scholar
The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation
Ryo Yonashiro, Erich B. Tahara, M. Bengtson, M. Khokhrina +10 more
2016eLife135 citations Open access
Semantic Scholar
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species
Eliana Nachman, A. Wentink, K. Madiona, L. Bousset +9 more
2019Journal of Biological Chemistry132 citations Open access
Semantic Scholar
Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase
C. Deville, M. Carroni, K. B. Franke, M. Topf +3 more
2017Science Advances125 citations Open access
Semantic Scholar
Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation
M. Carroni, E. Kummer, Yuki Oguchi, P. Wendler +6 more
2014eLife123 citations Open access
Semantic Scholar
Molecular Basis for the Unique Role of the AAA+ Chaperone ClpV in Type VI Protein Secretion*
A. Pietrosiuk, E. D. Lenherr, S. Falk, Gabriele Bönemann +4 more
2011Journal of Biological Chemistry112 citations Open access
Semantic Scholar
Deadly syringes: type VI secretion system activities in pathogenicity and interbacterial competition.
Nicole Kapitein, A. Mogk
2013Current Opinion in Microbiology102 citations
Semantic Scholar
Role of sHsps in organizing cytosolic protein aggregation and disaggregation
A. Mogk, B. Bukau
2017Cell stress & chaperones (Print)101 citations Open access
Semantic Scholar
Processive extrusion of polypeptide loops by a Hsp100 disaggregase
Mario J. Avellaneda, K. B. Franke, V. Sunderlikova, B. Bukau +2 more
2020Nature100 citations
Semantic Scholar
Integrating protein homeostasis strategies in prokaryotes.
A. Mogk, Damon Huber, B. Bukau
2011Cold Spring Harbor Perspectives in Biology99 citations Open access
Semantic Scholar
ClpS is the recognition component for Escherichia coli substrates of the N‐end rule degradation pathway
R. Schmidt, R. Zahn, B. Bukau, A. Mogk
2009Molecular Microbiology91 citations Open access
Semantic Scholar
The diverse functions of small heat shock proteins in the proteostasis network.
Kevin Reinle, A. Mogk, B. Bukau
2021Journal of Molecular Biology84 citations
Semantic Scholar
The Yeast AAA+ Chaperone Hsp104 Is Part of a Network That Links the Actin Cytoskeleton with the Inheritance of Damaged Proteins
Peter Tessarz, Michal Schwarz, A. Mogk, B. Bukau
2009Molecular and Cellular Biology84 citations Open access
Semantic Scholar
Common and specific mechanisms of AAA+ proteins involved in protein quality control.
A. Mogk, Tobias Haslberger, Peter Tessarz, B. Bukau
2008Biochemical Society Transactions82 citations
Semantic Scholar
The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α‐synuclein species
Jessica Tittelmeier, Carl Alexander Sandhof, H. Ries, Silke Druffel-Augustin +3 more
2020EMBO Journal76 citations Open access
Semantic Scholar
Incomplete proteasomal degradation of green fluorescent proteins in the context of tandem fluorescent protein timers
Anton Khmelinskii, M. Meurer, Chi‐ting Ho, B. Besenbeck +5 more
2015bioRxiv73 citations Open access
Semantic Scholar
Systemic control of protein synthesis through sequestration of translation and ribosome biogenesis factors during severe heat stress
V. Cherkasov, Tomáš Groušl, P. Theer, Y. Vainshtein +7 more
2015FEBS Letters73 citations Open access
Semantic Scholar
Structure and Function of a Novel Type of ATP-dependent Clp Protease
Fredrik I. Andersson, Anders Tryggvesson, M. Sharon, Alexander V. Diemand +10 more
2009Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Towards a unifying mechanism for ClpB/Hsp104-mediated protein disaggregation and prion propagation.
Tobias Haslberger, B. Bukau, A. Mogk
2010Biochemistry and cell biology = Biochimie et biologie cellulaire70 citations
Semantic Scholar
Structure of the VipA/B type VI secretion complex suggests a contraction-state-specific recycling mechanism.
Sebastian Kube, Nicole Kapitein, Tomasz Zimniak, Franz Herzog +2 more
2014Cell Reports68 citations Open access
Semantic Scholar
A prion-like domain in Hsp42 drives chaperone-facilitated aggregation of misfolded proteins
Tomáš Groušl, Sophia Ungelenk, Stephanie B. M. Miller, Chi‐ting Ho +4 more
2018Journal of Cell Biology67 citations Open access
Semantic Scholar
Signature of protein unfolding in chemical exchange saturation transfer imaging
S. Goerke, M. Zaiss, P. Kunz, K. Klika +5 more
2015NMR in Biomedicine66 citations
Semantic Scholar
Prolonged starvation drives reversible sequestration of lipid biosynthetic enzymes and organelle reorganization in Saccharomyces cerevisiae
H. Suresh, Aline Xavier da Silveira dos Santos, W. Kukulski, J. Tyedmers +3 more
2015Molecular Biology of the Cell66 citations Open access
Semantic Scholar
Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions
Fabian den Brave, L. Cairo, Chandhuru Jagadeesan, Carmen Ruger-Herreros +3 more
2020Cell Reports65 citations Open access
Semantic Scholar
Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis
Chi‐ting Ho, Tomáš Groušl, Oren Shatz, Areeb Jawed +6 more
2019Nature Communications63 citations Open access
Semantic Scholar
Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor
C. Deville, K. B. Franke, A. Mogk, B. Bukau +1 more
2019Cell Reports57 citations Open access
Semantic Scholar

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