Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

L. Ostedgaard · SciRah

Researcher profile · Semantic Scholar

L. Ostedgaard

Share profile

L. Ostedgaard — researcher profile on SciRah

h-index: 40
Works: 70
Citations: 7,493

Most-cited papers

Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs
C. Rogers, D. Stoltz, D. Meyerholz, L. Ostedgaard +24 more
2008Science792 citations Open access
Semantic Scholar
Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth
D. Stoltz, D. Meyerholz, Alejandro Antonio Pezzulo, S. Ramachandran +27 more
2010Science Translational Medicine502 citations Open access
Semantic Scholar
Mutations in CFTR associated with mild-disease-form CI- channels with altered pore properties
D. Sheppard, D. P. Rich, L. Ostedgaard, R. Gregory +2 more
1993Nature491 citations
Semantic Scholar
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.
R. Hall, L. Ostedgaard, R. Premont, J. Blitzer +3 more
1998Proceedings of the National Academy of Sciences of the United States of America432 citations Open access
Semantic Scholar
Impaired Mucus Detachment Disrupts Mucociliary Transport in a Piglet Model of Cystic Fibrosis
M. Hoegger, A. Fischer, James D. McMenimen, L. Ostedgaard +8 more
2014Science356 citations Open access
Semantic Scholar
Expression and characterization of the cystic fibrosis transmembrane conductance regulator
R. Gregory, Seng H. Cheng, D. P. Rich, J. Marshall +6 more
1990Nature321 citations
Semantic Scholar
Airway acidification initiates host defense abnormalities in cystic fibrosis mice
Viral S. Shah, D. Meyerholz, X. Tang, Leah R Reznikov +13 more
2016Science279 citations Open access
Semantic Scholar
The porcine lung as a potential model for cystic fibrosis.
C. Rogers, W. Abraham, K. Brogden, J. Engelhardt +11 more
2008American Journal of Physiology - Lung cellular and Molecular Physiology253 citations Open access
Semantic Scholar
Localization of cystic fibrosis transmembrane conductance regulator in chloride secretory epithelia.
G. Denning, L. Ostedgaard, Seng H. Cheng, Alan E. Smith +1 more
1992Journal of Clinical Investigation240 citations Open access
Semantic Scholar
Acidic pH increases airway surface liquid viscosity in cystic fibrosis.
X. Tang, L. Ostedgaard, M. Hoegger, T. Moninger +6 more
2016Journal of Clinical Investigation221 citations Open access
Semantic Scholar
The ΔF508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis-Like Disease in Pigs
L. Ostedgaard, D. Meyerholz, Jeng-Haur Chen, Alejandro Antonio Pezzulo +24 more
2011Science Translational Medicine212 citations Open access
Semantic Scholar
Cystic fibrosis transmembrane conductance regulator: A chloride channel with novel regulation
M. Welsh, Matthew P. Anderson, D. P. Rich, H. A. Berger +6 more
1992Neuron211 citations
Semantic Scholar
Identification of revertants for the cystic fibrosis delta F508 mutation using STE6-CFTR chimeras in yeast.
J. Teem, H. A. Berger, L. Ostedgaard, D. P. Rich +2 more
1993Cell195 citations
Semantic Scholar
Abnormal localization of cystic fibrosis transmembrane conductance regulator in primary cultures of cystic fibrosis airway epithelia
G. Denning, L. Ostedgaard, Michael J. Welsh
1992Journal of Cell Biology165 citations Open access
Semantic Scholar
Gel-forming mucins form distinct morphologic structures in airways
L. Ostedgaard, T. Moninger, James D. McMenimen, Nicholas M Sawin +10 more
2017Proceedings of the National Academy of Sciences of the United States of America154 citations Open access
Semantic Scholar
Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Cl− Channel by Its R Domain*
L. Ostedgaard, Ó. Baldursson, M. Welsh
2001Journal of Biological Chemistry129 citations Open access
Semantic Scholar
Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.
D. Stoltz, T. Rokhlina, S. Ernst, Alejandro Antonio Pezzulo +26 more
2013Journal of Clinical Investigation126 citations Open access
Semantic Scholar
Stoichiometry of recombinant cystic fibrosis transmembrane conductance regulator in epithelial cells and its functional reconstitution into cells in vitro.
J. Marshall, S. Fang, L. Ostedgaard, C. O'Riordan +6 more
1994Journal of Biological Chemistry125 citations Open access
Semantic Scholar
A microRNA network regulates expression and biosynthesis of wild-type and ΔF508 mutant cystic fibrosis transmembrane conductance regulator
S. Ramachandran, Philip H. Karp, Peng Jiang, L. Ostedgaard +10 more
2012Proceedings of the National Academy of Sciences of the United States of America118 citations Open access
Semantic Scholar
Processing and function of CFTR-ΔF508 are species-dependent
L. Ostedgaard, C. Rogers, Qian Dong, C. Randak +4 more
2007Proceedings of the National Academy of Sciences of the United States of America118 citations Open access
Semantic Scholar
A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution.
L. Ostedgaard, Olafur Baldursson, Daniel W Vermeer, Michael J. Welsh +1 more
2000Proceedings of the National Academy of Sciences of the United States of America117 citations Open access
Semantic Scholar
The amino-terminal portion of CFTR forms a regulated CI− channel
D. Sheppard, L. Ostedgaard, D. P. Rich, M. Welsh
1994117 citations
Semantic Scholar
Alteration of protein function by a silent polymorphism linked to tRNA abundance
S. Kirchner, Z. Cai, Robert Rauscher, Nicolai Kastelić +7 more
2017PLoS Biology115 citations Open access
Semantic Scholar
A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia.
L. Ostedgaard, T. Rokhlina, Philip H. Karp, Philip E. Lashmit +6 more
2005Proceedings of the National Academy of Sciences of the United States of America107 citations Open access
Semantic Scholar
Curcumin Stimulates Cystic Fibrosis Transmembrane Conductance Regulator Cl– Channel Activity*
Allan L. Berger, C. Randak, L. Ostedgaard, Philip H. Karp +2 more
2005Journal of Biological Chemistry97 citations Open access
Semantic Scholar
Mechanism of dysfunction of two nucleotide binding domain mutations in cystic fibrosis transmembrane conductance regulator that are associated with pancreatic sufficiency.
D. Sheppard, L. Ostedgaard, M. Winter, M. Welsh
1995EMBO Journal97 citations Open access
Semantic Scholar
Effect of Cystic Fibrosis-associated Mutations in the Fourth Intracellular Loop of Cystic Fibrosis Transmembrane Conductance Regulator*
Joseph F. Cotten, L. Ostedgaard, M. R. Carson, M. Welsh
1996Journal of Biological Chemistry96 citations Open access
Semantic Scholar
CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes
B. Steines, David D. Dickey, J. Bergen, K. Excoffon +15 more
2016JCI Insight94 citations Open access
Semantic Scholar
Expression of cystic fibrosis transmembrane conductance regulator in a model epithelium.
D. N. Sheppard, M. R. Carson, L. Ostedgaard, G. Denning +1 more
1994American Journal of Physiology79 citations
Semantic Scholar
Effects of C-terminal deletions on cystic fibrosis transmembrane conductance regulator function in cystic fibrosis airway epithelia
L. Ostedgaard, C. Randak, T. Rokhlina, Philip H. Karp +3 more
2003Proceedings of the National Academy of Sciences of the United States of America75 citations Open access
Semantic Scholar
Relationships among CFTR expression, HCO3− secretion, and host defense may inform gene- and cell-based cystic fibrosis therapies
Viral S. Shah, S. Ernst, X. Tang, Philip H. Karp +3 more
2016Proceedings of the National Academy of Sciences of the United States of America74 citations Open access
Semantic Scholar
Association of domains within the cystic fibrosis transmembrane conductance regulator.
L. Ostedgaard, D. P. Rich, Lisa G. DeBerg, Michael J. Welsh
1997Biochemistry74 citations
Semantic Scholar
GLYCEMIC REGULATION AND INSULIN SECRETION ARE ABNORMAL IN CYSTIC FIBROSIS PIGS DESPITE SPARING OF ISLET CELL MASS
A. Uc, A. Olivier, Michelle A Griffin, D. Meyerholz +19 more
2015Clinical science70 citations Open access
Semantic Scholar
CFTR with a partially deleted R domain corrects the cystic fibrosis chloride transport defect in human airway epithelia in vitro and in mouse nasal mucosa in vivo
L. Ostedgaard, J. Zabner, Daniel W Vermeer, T. Rokhlina +4 more
2002Proceedings of the National Academy of Sciences of the United States of America69 citations Open access
Semantic Scholar
Processing and function of CFTR-DeltaF508 are species-dependent.
L. Ostedgaard, C. Rogers, Qian Dong, C. Randak +4 more
2007Proceedings of the National Academy of Sciences of the United States of America67 citations
Semantic Scholar
Cystic Fibrosis Transmembrane Conductance Regulator in Sarcoplasmic Reticulum of Airway Smooth Muscle. Implications for Airway Contractility.
Daniel P Cook, M. Rector, D. Bouzek, A. S. Michalski +12 more
2016American Journal of Respiratory and Critical Care Medicine64 citations Open access
Semantic Scholar
Erythrocyte Incorporation of Ingested 58-Iron by Infants
S. Fomon, M. Janghorbani, B. Ting, E. Ziegler +4 more
1988Pediatric Research63 citations
Semantic Scholar
Mucus strands from submucosal glands initiate mucociliary transport of large particles.
A. Fischer, Maria I Pino-Argumedo, Brieanna M. Hilkin, Cullen R. Shanrock +9 more
2019JCI Insight44 citations Open access
Semantic Scholar
Pancreatic and biliary secretion are both altered in cystic fibrosis pigs.
A. Uc, Radhamma L Giriyappa, D. Meyerholz, Michelle A Griffin +9 more
2012American Journal of Physiology - Gastrointestinal and Liver Physiology43 citations Open access
Semantic Scholar
Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus
Ashley L. Cooney, Brajesh K. Singh, L. M. Loza, I. Thornell +8 more
2018Nucleic Acids Research40 citations Open access
Semantic Scholar
Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling
Suifang Mao, Alok S Shah, T. Moninger, L. Ostedgaard +10 more
2018Proceedings of the National Academy of Sciences of the United States of America39 citations Open access
Semantic Scholar
Ovarian and haemolymph titres of ecdysteroid during the gonadotrophic cycle in Diploptera punctata
B. Stay, L. Ostedgaard, S. Tobe, A. Strambi +1 more
198439 citations
Semantic Scholar
Cystic Fibrosis Transmembrane Conductance Regulator Cl− Channels with R Domain Deletions and Translocations Show Phosphorylation-dependent and -independent Activity*
Ó. Baldursson, L. Ostedgaard, T. Rokhlina, Joseph F. Cotten +1 more
2001Journal of Biological Chemistry34 citations Open access
Semantic Scholar
Dysfunction of CFTR bearing the ΔF508 mutation
M. Welsh, G. Denning, L. Ostedgaard, Matthew P. Anderson
1993Journal of Cell Science33 citations
Semantic Scholar
Processing of CFTR bearing the P574H mutation differs from wild-type and deltaF508-CFTR.
L. Ostedgaard, B. Zeiher, Michael J. Welsh
1999Journal of Cell Science32 citations
Semantic Scholar
Lack of airway submucosal glands impairs respiratory host defenses
L. Ostedgaard, M. Price, K. Whitworth, M. A. Abou Alaiwa +22 more
2020eLife29 citations Open access
Semantic Scholar
Human–mouse cystic fibrosis transmembrane conductance regulator (CFTR) chimeras identify regions that partially rescue CFTR-ΔF508 processing and alter its gating defect
Qian Dong, L. Ostedgaard, C. Rogers, Daniel W Vermeer +2 more
2011Proceedings of the National Academy of Sciences of the United States of America24 citations Open access
Semantic Scholar
Structural biology: The ABC of a versatile engine
M. Welsh, A. D. Robertson, L. Ostedgaard
1998Nature22 citations
Semantic Scholar
Cholesterol turnover and ecdysone content in tissues of normal and de‐eyestalked crabs (Cancer antennarius)
W. H. Vensel, E. Spaziani, L. Ostedgaard
198421 citations
Semantic Scholar
Early Pathogenesis of Cystic Fibrosis Gallbladder Disease in a Porcine Model
Keyan Zarei, M. Stroik, N. Gansemer, A. Thurman +7 more
2020Laboratory Investigation20 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

M. Welsh×33
Invite
M. Welsh — researcher profile on SciRah
D. Stoltz×17
Invite
D. Stoltz — researcher profile on SciRah
Philip H. Karp×15
Invite
Philip H. Karp — researcher profile on SciRah
D. Meyerholz×13
Invite
D. Meyerholz — researcher profile on SciRah

×10

Invite

T. Rokhlina — researcher profile on SciRah

Invite

J. Zabner — researcher profile on SciRah

Invite

N. Gansemer — researcher profile on SciRah

Alejandro Antonio Pezzulo×7

Invite

Alejandro Antonio Pezzulo — researcher profile on SciRah

Invite

P. McCray — researcher profile on SciRah

M. A. Abou Alaiwa×7

Invite

M. A. Abou Alaiwa — researcher profile on SciRah

Daniel W Vermeer×7

Invite

Daniel W Vermeer — researcher profile on SciRah

Peter J. Taft×6

Invite

Peter J. Taft — researcher profile on SciRah