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Alejandro Antonio Pezzulo · SciRah

Researcher profile · Semantic Scholar

Alejandro Antonio Pezzulo

University of Iowa
Carver College of Medicine
Pappajohn Biomedical Institute

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Alejandro Antonio Pezzulo — researcher profile on SciRah

ORCID iD 0000-0001-7544-5109

h-index: 31
Works: 104
Citations: 5,512

Most-cited papers

Reduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung
Alejandro Antonio Pezzulo, X. Tang, M. Hoegger, M. A. Abou Alaiwa +12 more
2012Nature817 citations Open access
Semantic Scholar
Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs
C. Rogers, D. Stoltz, D. Meyerholz, L. Ostedgaard +24 more
2008Science792 citations Open access
Semantic Scholar
Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth
D. Stoltz, D. Meyerholz, Alejandro Antonio Pezzulo, S. Ramachandran +27 more
2010Science Translational Medicine502 citations Open access
Semantic Scholar
The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia.
Alejandro Antonio Pezzulo, T. Starner, T. Scheetz, G. Traver +5 more
2011American Journal of Physiology - Lung cellular and Molecular Physiology388 citations Open access
Semantic Scholar
Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia
Jeng-Haur Chen, D. Stoltz, Philip H. Karp, S. Ernst +8 more
2010Cell240 citations Open access
Semantic Scholar
The ΔF508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis-Like Disease in Pigs
L. Ostedgaard, D. Meyerholz, Jeng-Haur Chen, Alejandro Antonio Pezzulo +24 more
2011Science Translational Medicine212 citations Open access
Semantic Scholar
Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children.
D. Meyerholz, D. Stoltz, E. Namati, S. Ramachandran +10 more
2010American Journal of Respiratory and Critical Care Medicine191 citations Open access
Semantic Scholar
Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19
L. Wong, Jian Zheng, Kevin Wilhelmsen, Kun Li +19 more
2022Nature155 citations Open access
Semantic Scholar
Pathology of gastrointestinal organs in a porcine model of cystic fibrosis.
D. Meyerholz, D. Stoltz, Alejandro Antonio Pezzulo, M. Welsh
2010American Journal of Pathology155 citations Open access
Semantic Scholar
Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract
Miguel E. Ortiz, A. Thurman, Alejandro Antonio Pezzulo, Mariah R Leidinger +6 more
2020EBioMedicine134 citations Open access
Semantic Scholar
Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.
D. Stoltz, T. Rokhlina, S. Ernst, Alejandro Antonio Pezzulo +26 more
2013Journal of Clinical Investigation126 citations Open access
Semantic Scholar
Glucose Depletion in the Airway Surface Liquid Is Essential for Sterility of the Airways
Alejandro Antonio Pezzulo, Jeydith Gutierrez, Kelly S. Duschner, Kelly McConnell +7 more
2011PLoS ONE123 citations Open access
Semantic Scholar
Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth
M. Rogan, Leah R Reznikov, Alejandro Antonio Pezzulo, N. Gansemer +7 more
2010Proceedings of the National Academy of Sciences of the United States of America106 citations Open access
Semantic Scholar
Quantitative Chest CT Assessment of Small Airways Disease in Post-Acute SARS-CoV-2 Infection
Josalyn L. Cho, Raul Villacreses, P. Nagpal, Junfeng Guo +8 more
2022Radiology102 citations Open access
Semantic Scholar
Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract
Miguel E. Ortiz Bezara, A. Thurman, Alejandro Antonio Pezzulo, Mariah R Leidinger +6 more
2020bioRxiv102 citations Open access
Semantic Scholar
Neonates with Cystic Fibrosis Have a Reduced Nasal Liquid pH; A Small Pilot Study
M. A. Abou Alaiwa, Alison M Beer, Alejandro Antonio Pezzulo, J. Launspach +5 more
2014Journal of Cystic Fibrosis83 citations Open access
Semantic Scholar
GLYCEMIC REGULATION AND INSULIN SECRETION ARE ABNORMAL IN CYSTIC FIBROSIS PIGS DESPITE SPARING OF ISLET CELL MASS
A. Uc, A. Olivier, Michelle A Griffin, D. Meyerholz +19 more
2015Clinical science70 citations Open access
Semantic Scholar
Sinus Hypoplasia Precedes Sinus Infection in a Porcine Model of Cystic Fibrosis
Eugene H. Chang, Alejandro Antonio Pezzulo, D. Meyerholz, Andrea E. Potash +11 more
2012The Laryngoscope70 citations Open access
Semantic Scholar
Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions
D. Lorentzen, L. Durairaj, Alejandro Antonio Pezzulo, Y. Nakano +8 more
2011Free Radical Biology & Medicine64 citations Open access
Semantic Scholar
HSP90 inhibitor geldanamycin reverts IL-13– and IL-17–induced airway goblet cell metaplasia
Alejandro Antonio Pezzulo, R. Tudas, Carley G. Stewart, L. G. V. Buonfiglio +4 more
2019Journal of Clinical Investigation60 citations Open access
Semantic Scholar
Lentiviral Vector Gene Transfer to Porcine Airways
P. Sinn, Ashley L. Cooney, Mayumi Oakland, D. Dylla +4 more
2012Molecular Therapy: Nucleic Acids50 citations Open access
Semantic Scholar
Abundant DNase I-Sensitive Bacterial DNA in Healthy Porcine Lungs and Its Implications for the Lung Microbiome
Alejandro Antonio Pezzulo, Patrick Kelly, B. Nassar, C. Rutland +5 more
2013Applied and Environmental Microbiology49 citations Open access
Semantic Scholar
Inflammatory cytokines TNFα and IL-17 enhance the efficacy of cystic fibrosis transmembrane conductance regulator modulators.
Tayyab Ur Rehman, Philip H. Karp, Ping Tan, Brian J. Goodell +9 more
2021Journal of Clinical Investigation46 citations Open access
Semantic Scholar
Effect of vitamin D3 on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial
L. V. Vargas Buonfiglio, M. Cano, Alejandro Antonio Pezzulo, O. V. Vanegas Calderón +3 more
2017BMJ Open Respiratory Research46 citations Open access
Semantic Scholar
Idiopathic hyperammonemia after solid organ transplantation: Primarily a lung problem? A single‐center experience and systematic review
Dustin Krutsinger, Alejandro Antonio Pezzulo, A. Blevins, R. Reed +2 more
2017Clinical Transplantation43 citations
Semantic Scholar
Pancreatic and biliary secretion are both altered in cystic fibrosis pigs.
A. Uc, Radhamma L Giriyappa, D. Meyerholz, Michelle A Griffin +9 more
2012American Journal of Physiology - Gastrointestinal and Liver Physiology43 citations Open access
Semantic Scholar
CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia.
Xiaopeng Li, A. P. Comellas, Philip H. Karp, S. Ernst +10 more
2012American Journal of Physiology - Lung cellular and Molecular Physiology42 citations Open access
Semantic Scholar
Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs.
J. Bartlett, M. Albertolle, C. Wohlford-Lenane, Alejandro Antonio Pezzulo +5 more
2013American Journal of Physiology - Lung cellular and Molecular Physiology37 citations Open access
Semantic Scholar
Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus.
J. Bartlett, S. Ramachandran, C. Wohlford-Lenane, Carrie K. Barker +6 more
2016American Journal of Respiratory and Critical Care Medicine34 citations Open access
Semantic Scholar
Coal Fly Ash Impairs Airway Antimicrobial Peptides and Increases Bacterial Growth
Jennifer A. Borcherding, Haihan Chen, J. Caraballo, J. Baltrusaitis +4 more
2013PLoS ONE33 citations Open access
Semantic Scholar
Measles virus exits human airway epithelia within dislodged metabolically active infectious centers
C. Hippee, Brajesh K. Singh, A. Thurman, Ashley L. Cooney +3 more
2021PLoS Pathogens31 citations Open access
Semantic Scholar
TNFα and IL-17 alkalinize airway surface liquid through CFTR and pendrin
Tayyab Ur Rehman, I. Thornell, Alejandro Antonio Pezzulo, A. Thurman +5 more
2020American Journal of Physiology - Cell Physiology27 citations Open access
Semantic Scholar
Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19
Jian Zheng, L. Wong, Kevin Wilhelmsen, Kun Li +19 more
2021bioRxiv24 citations Open access
Semantic Scholar
Differential gene expression analysis for multi-subject single-cell RNA-sequencing studies with aggregateBioVar
A. Thurman, Jason A. Ratcliff, M. Chimenti, Alejandro Antonio Pezzulo
2021Bioinform.22 citations Open access
Semantic Scholar
Polarized AAVR Expression Determines Infectivity by AAV Gene Therapy Vectors
Bradley A. Hamilton, Xiaopeng Li, Alejandro Antonio Pezzulo, M. A. Abou Alaiwa +1 more
2019Gene Therapy22 citations Open access
Semantic Scholar
Cellular and molecular architecture of submucosal glands in wild-type and cystic fibrosis pigs
Wenjie Yu, T. Moninger, A. Thurman, Yuliang Xie +6 more
2022Proceedings of the National Academy of Sciences of the United States of America20 citations Open access
Semantic Scholar
Early Pathogenesis of Cystic Fibrosis Gallbladder Disease in a Porcine Model
Keyan Zarei, M. Stroik, N. Gansemer, A. Thurman +7 more
2020Laboratory Investigation20 citations Open access
Semantic Scholar
IL-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption
G. S. Romano Ibarra, Lei Lei, Wenjie Yu, Andrew L. Thurman +6 more
2024Journal of Clinical Investigation18 citations Open access
Semantic Scholar
Expression of Human Paraoxonase 1 Decreases Superoxide Levels and Alters Bacterial Colonization in the Gut of Drosophila melanogaster
Alejandro Antonio Pezzulo, Emma E. Hornick, M. Rector, Miriam Estin +7 more
2012PLoS ONE17 citations Open access
Semantic Scholar
Effects of vitamin D supplementation on alveolar macrophage gene expression: preliminary results of a randomized, controlled trial
A. Gerke, Alejandro Antonio Pezzulo, Fan Tang, J. Cavanaugh +4 more
2014Multidisciplinary Respiratory Medicine15 citations Open access
Semantic Scholar
A Single-Cell Atlas of Large and Small Airways at Birth in a Porcine Model of Cystic Fibrosis.
A. Thurman, Xiaopeng Li, Raul Villacreses, Wenjie Yu +9 more
2022American Journal of Respiratory Cell and Molecular Biology14 citations Open access
Semantic Scholar
Lentiviral vectors transduce lung stem cells without disrupting plasticity
Ashley L. Cooney, A. Thurman, P. McCray, Alejandro Antonio Pezzulo +1 more
2020bioRxiv13 citations Open access
Semantic Scholar
Epithelial responses to CFTR modulators are improved by inflammatory cytokines and impaired by antiinflammatory drugs
Tayyab Ur Rehman, Alejandro Antonio Pezzulo, Andrew L. Thurman, R. Zemans +1 more
2024JCI Insight11 citations Open access
Semantic Scholar
Early Lung Disease Exhibits Bacterial-Dependent and -Independent Abnormalities in Cystic Fibrosis Pigs.
D. Bouzek, M. A. Abou Alaiwa, Ryan J. Adam, Alejandro Antonio Pezzulo +10 more
2021American Journal of Respiratory and Critical Care Medicine11 citations Open access
Semantic Scholar
Paracellular Bicarbonate Flux across Human Cystic Fibrosis Airway Epithelia Tempers Changes in Airway Surface Liquid pH
I. Thornell, Tayyab Ur Rehman, Alejandro Antonio Pezzulo, M. Welsh
2020Journal of Physiology11 citations Open access
Semantic Scholar
MRSA Strains with Distinct Accessory Genes Predominate at Different Ages in Cystic Fibrosis
H. Porterfield, Lucas J Maakestad, M. Lamarche, A. Thurman +13 more
2021Pediatric Pulmonology8 citations Open access
Semantic Scholar
Inhaled hypertonic saline in adults hospitalised for exacerbation of cystic fibrosis lung disease: a retrospective study
Alejandro Antonio Pezzulo, D. Stoltz, D. Hornick, L. Durairaj
2012BMJ Open8 citations Open access
Semantic Scholar
DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation
Athmane Teghanemt, Kara Misel-Wuchter, Jace Heath, A. Thurman +7 more
2023EMBO Reports7 citations Open access
Semantic Scholar
Vitamin D-mediated effects on airway innate immunity in vitro
E. Stapleton, Kathy Keck, R. Windisch, M. Stroik +6 more
2022PLoS ONE6 citations Open access
Semantic Scholar
Do cell junction protein mutations cause an airway phenotype in mice or humans?
Eugene H. Chang, Alejandro Antonio Pezzulo, J. Zabner
2011American Journal of Respiratory Cell and Molecular Biology6 citations Open access
Semantic Scholar

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D. Stoltz×24
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